Faculty

Institution

Unit

Venue

Michael Hilinski

Associate Professor of Chemistry

University of Virginia

Affiliations

College and Graduate School of Arts and Sciences

Department of Chemistry

Michael Hilinski is currently serving as a College And Graduate School Of Arts And Sciences Associate Professor of Chemistry at University of Virginia.

Honors

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Experiences

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Education

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Michael Hilinski

University of Virginia

Associate Professor of Chemistry

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chemistry organic chemistry chemical synthesis organic process research catalysis organic synthesis chemical sciences pharmacology novel organocatalysts chemical engineering organic chemistry frontier drug discovery biomolecular engineering transition metal chemistry sustainable chemistry medicinal chemistry organometallic catalysis organometallic chemistry enzyme inhibition medicinal research heterocycle chemistry therapeutic targets alkene metathesis synthetic chemistry coordination chemistry pharmacological research pharmaceutical chemistry iminium salt pharmaceutics cancer discovery natural product synthesis drug development anti-cancer agents asymmetric catalysis catalytic synthesis novel therapies rational drug design molecular catalysis homogeneous catalysis natural product research marine drug biological chemistry drug targeting heterocyclic drug targets crystal structures structure determination structure elucidation total synthesis applied pharmacology molecular structure bioorganometallic chemistry redox chemistry inhibitory activity receptor tyrosine kinases pharmaceutical sciences electrosynthesis chemical bond molecular chemistry tumor targeting diversity oriented synthesis crystal structure design complete selectivity lead diversification c-26 secondary alcohol hydrogen peroxide iminium salt organocatalyst mild reaction conditions -h hydroxylation dioxirane-mediated c-h hydroxylation aryl-substituted vinylcyclopropanes lewis acidity polar mechanism vitro biological stability rsk inhibitor sl0101 laulimalide series

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

A First-In-Class Small-Molecule Inhibitor Targeting Avil Exhibits Safety and Antitumor Efficacy in Preclinical Models of Glioblastoma. Science Translational Medicine (2026)

tumor targetingdrug targetinganti-cancer agentsgliomasantitumor efficacycell biologymedicinal researchbrain tumor researchmolecular cancersmall moleculesnovel therapiesavil exhibits safetycancer discoverypharmacologytherapeutic targetsdrug discoveryfirst-in-class small-molecule inhibitorneuro-oncology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicscrystal structurescrystal researchdeposited datasetstructural chemistryccdc 2157502crystal engineeringcrystallographystructure determinationstructure elucidationchemistrychemical structurecrystal diffraction study

Amine Organocatalysis of Remote, Chemoselective C(Sp 3 )–H Hydroxylation. ACS Catalysis (2022)

Philip L. HahnJared M. LoweYubo XuKevin L. BurnsMichael K. Hilinski

catalytic synthesischemical engineeringnovel organocatalystsmolecular catalysisamine organocatalysishomogeneous catalysissite selectivitycatalysischemical synthesissustainable chemistrychemistryorganic chemistryalcohol oxidationorganic process research

Vinylazaarenes as Dienophiles in Lewis Acid-Promoted Diels–Alder Reactions. Chemical Science (2021)

Anna E. DavisJared M. LoweMichael K. Hilinski

chemical sciencesorganic chemistry frontierlewis acid activationalkene metathesisunactivated dieneschemical engineeringcoordination chemistryorganic process researchchemical synthesistransition metal chemistrychemistryorganic chemistryheterocycle chemistryhigh yieldingorganometallic chemistryorganic synthesis

1,1,1‐Trifluoro‐2‐Hexanone. (2020)

Shea L. JohnsonMichael K. Hilinski

Ccdc 1895862: Experimental Crystal Structure Determination. The Cambridge Structural Database (2019)

Logan A. CombeeShea L. JohnsonJulie E. LaudenschlagerMichael K. Hilinski

biophysicscrystal structurescrystal researchdeposited datasetstructural chemistrycrystal engineeringcrystallographycrystal structure designstructure determinationccdc 1895862structure elucidationx-ray crystallographychemistrychemical structurestructural biologycrystal diffraction study

Intermolecular Scandium Triflate-Promoted Nitrene-Transfer [5 + 1] Cycloadditions of Vinylcyclopropanes. Organic & Biomolecular Chemistry (2019)

Julie E. LaudenschlagerLogan A. CombeeMichael K. Hilinski

chemical sciencesheterocyclic1,2,3,6-tetrahydropyridine scaffoldscoordination chemistryorganic process researchchemical synthesistransition metal chemistrychemistryorganic chemistryheterocycle chemistrymild conditionsorganometallic chemistrybiomolecular engineeringorganic synthesisantecedent work

Mechanism of Iminium Salt-Catalyzed C(Sp 3 )–H Amination: Factors Controlling Hydride Transfer Versus H-Atom Abstraction. ACS Catalysis (2019)

Madeline E. RotellaRobert M. B. DyerMichael K. HilinskiOsvaldo Gutierrez

chemical sciencesh-atom abstractionchemical bondiminium salt-catalyzed cbiochemistrytheoretical chemistrymolecular chemistryorganometallic catalysischemistryorganic chemistryphysical organic chemistrymolecular structuremolecular dynamics simulations

Organocatalytic Olefin Aziridination via Iminium-Catalyzed Nitrene Transfer: Scope, Limitations, and Mechanistic Insight. The Journal of Organic Chemistry (2019)

Shea L. JohnsonMichael K. Hilinski

asymmetric catalysisiminium catalysisorganocatalytic olefin aziridinationalkene metathesisiminium saltnovel organocatalystsorganic process researchcatalysischemical synthesistransition metal chemistrychemistryorganic chemistryheterocycle chemistryorganometallic catalysisorganometallic chemistrybiomolecular engineeringorganic synthesis

Rh(II)-Catalyzed Nitrene-Transfer [5 + 1] Cycloadditions of Aryl-Substituted Vinylcyclopropanes. Organic Letters (2019)

Logan A. CombeeShea L. JohnsonJulie E. LaudenschlagerMichael K. Hilinski

aryl-substituted vinylcyclopropaneschemical engineeringcoordination chemistryorganic process researchcatalysischemical synthesistransition metal chemistrychemistryorganic chemistryorganometallic catalysisheterocycle chemistrylewis acidityorganometallic chemistrypolar mechanismorganic synthesis

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Michael Hilinski

Associate Professor of Chemistry

University of Virginia

Affiliations

College and Graduate School of Arts and Sciences

Department of Chemistry

Michael Hilinski is currently serving as a College And Graduate School Of Arts And Sciences Associate Professor of Chemistry at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael Hilinski

University of Virginia

Associate Professor of Chemistry

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

A First-In-Class Small-Molecule Inhibitor Targeting Avil Exhibits Safety and Antitumor Efficacy in Preclinical Models of Glioblastoma. Science Translational Medicine (2026)

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Amine Organocatalysis of Remote, Chemoselective C(Sp 3 )–H Hydroxylation. ACS Catalysis (2022)

Philip L. HahnJared M. LoweYubo XuKevin L. BurnsMichael K. Hilinski

Vinylazaarenes as Dienophiles in Lewis Acid-Promoted Diels–Alder Reactions. Chemical Science (2021)

Anna E. DavisJared M. LoweMichael K. Hilinski

1,1,1‐Trifluoro‐2‐Hexanone. (2020)

Shea L. JohnsonMichael K. Hilinski

Ccdc 1895862: Experimental Crystal Structure Determination. The Cambridge Structural Database (2019)

Logan A. CombeeShea L. JohnsonJulie E. LaudenschlagerMichael K. Hilinski

Intermolecular Scandium Triflate-Promoted Nitrene-Transfer [5 + 1] Cycloadditions of Vinylcyclopropanes. Organic & Biomolecular Chemistry (2019)

Julie E. LaudenschlagerLogan A. CombeeMichael K. Hilinski

Mechanism of Iminium Salt-Catalyzed C(Sp 3 )–H Amination: Factors Controlling Hydride Transfer Versus H-Atom Abstraction. ACS Catalysis (2019)

Madeline E. RotellaRobert M. B. DyerMichael K. HilinskiOsvaldo Gutierrez

Organocatalytic Olefin Aziridination via Iminium-Catalyzed Nitrene Transfer: Scope, Limitations, and Mechanistic Insight. The Journal of Organic Chemistry (2019)

Shea L. JohnsonMichael K. Hilinski

Rh(II)-Catalyzed Nitrene-Transfer [5 + 1] Cycloadditions of Aryl-Substituted Vinylcyclopropanes. Organic Letters (2019)

Logan A. CombeeShea L. JohnsonJulie E. LaudenschlagerMichael K. Hilinski

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organic synthesis

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University of South Florida

biomolecular engineering

drug development

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Institution

Vanderbilt University

synthetic chemistry

biomolecular engineering

M Christina White

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microelectrode arrays

Barry Snider

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biomolecular engineering

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