Faculty

Institution

Unit

Venue

Paul Helquist

Professor

University of Notre Dame

Affiliations

College of Science

Chemistry and Biochemistry

Paul Helquist is currently serving as a Chemistry And Biochemistry Professor at University of Notre Dame.

Honors

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Experiences

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Education

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Paul Helquist

University of Notre Dame

Professor

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chemistry organic synthesis organic chemistry chemical synthesis transition metal chemistry pharmacology catalysis medicinal chemistry organometallic catalysis coordination chemistry drug discovery organometallic chemistry enzyme inhibition inorganic chemistry protein science chemical engineering catalytic synthesis synthetic chemistry cell biology medicinal research asymmetric catalysis pharmaceutical chemistry enantioselective synthesis redox biology molecular catalysis catalyst preparation material chemistry heterocyclic stereoselective synthesis natural product synthesis total synthesis ketone enolates liver physiology rational drug design heterocycle chemistry inorganic synthesis derivative (chemistry) mild conditions direct preparation pharmacotherapy chemical sciences clinical lipidology protein chemistry lipid disorders catalytic process apoptosis saturated ketones vascular biology quantum chemistry cellular biochemistry nanoparticle research pharmaceutics enzyme catalysis redox chemistry homogeneous catalysis fibroblast growth factors tumor targeting anti-cancer agents lipid chemistry lipid synthesis lipid science cholesterol accumulation histone deacetylase inhibitors lysosomal acid lipase dft study selective inhibition dyslipidemia hyperlipidemia lipoprotein metabolism epigenetic changes homology modeling molecular dynamics simulations long internal cavity histone deacetylase-like protein rapid virtual screening enantioselective catalysts synthetic organic chemistry asymmetric synthesis natural product research

Notable Scholarly Works

Notable Federal Grants

Collaborators

Finding Relevant Retrosynthetic Disconnections for Stereocontrolled Reactions. Journal of Chemical Information and Modeling (2024)

Olaf WiestChristoph BauerPaul HelquistPer-Ola NorrbySamuel Genheden

chemical engineeringcomputational chemistrychemistrystereoselective synthesisstereocontrolled reactions

Mutant Induced Neurons and Humanized Mice Enable Identification of Niemann-Pick Type C1 Proteostatic Therapies. JCI Insight (2024)

Ruth D. AzariaAdele B. CorreiaKylie J. SchacheManuela ZapataKoralege C. PathmasiriVarshasnata MohantyDharma T. NannapaneniBrandon L. AshfeldPaul HelquistOlaf WiestKenji OhganeQingqing LiRoss A. FredenburgBrian S.J. BlaggStephanie M. ColognaMark L. SchultzAndrew P. Lieberman

neurochemistryneuropharmacologyneuronsmedicinal researchneuroscienceneuroimmunologymolecular biologynervous systemmolecular neuroscienceneurotransmission

Ph-Dependent Reaction Triggering in Pmhmgr Crystals for Time-Resolved Crystallography. Biophysical Journal (2024)

Vatsal PurohitCalvin N. SteussyAnthony R. RosalesChandra J. CritchelowTim SchmidtPaul HelquistOlaf WiestAndrew MesecarAina E. CohenCynthia V. Stauffacher

biophysicsph-dependent reactionphysiologytime-resolved crystallographypmhmgr crystalsbiophysical chemistry

Short, Enantioselective Synthesis of Mevalonic Acid. (2024)

Ryan J. OconnellNicholas J. DolphinOlaf WiestPaul Helquist

biological engineeringenantioselective synthesismevalonic acidbiomolecular engineeringorganic synthesis

Synergistic Approaches to Elucidation of Enzyme Mechanisms/Dynamics. Biophysical Journal (2024)

Mikaela FarrugiaOlaf WiestPaul Helquist

biophysicsbiological engineeringenzymessynthetic biologystructure elucidationsystems biology

Synthesis of a Cholesterol Cross-Linker With a Photoaffinity Label and Alkyne Tag at Minimally Interfering Sites for Cellular Studies. (2024)

Yogesh B. NarkhedeRyan J. OconnellPaul HelquistOlaf Wiest

lipidsalkyne tagcholesterol cross-linkermolecular biologyoptical propertiessynthetic photochemistrymedicinal researchmedicinal chemistrybiochemistryphotochemistryphotoaffinity labelnovel interfacebottom-up synthesissurface reactivitycross-linkprotein sciencepeptide sciencemembrane biologytransition metal chemistryfree radical biologycellular studiesbiomolecular engineering

Synthesis of Caged Hmg-Coa Reductase Substrates for the Elucidation of Cellular Pathways. The Journal of Organic Chemistry (2024)

Ryan J. O’ConnellNicholas J. DolphinGuillermo FerraudiMijoon LeeCynthia V. StauffacherPaul HelquistOlaf Wiest

cellular pathwaysbiocatalysisbiochemistryhmg-coa reductase substratesorganic chemistry

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicscrystal structurescrystal researchdeposited datasetstructural chemistryccdc 2157502crystal engineeringcrystallographystructure determinationstructure elucidationchemistrychemical structurecrystal diffraction study

Computational Study of Base-Catalyzed Thiohemiacetal Decomposition in Pseudomonas Mevalonii Hmg-Coa Reductase. The Journal of Physical Chemistry B (2023)

Himani N. PatelBrandon E. HainesCynthia V. StauffacherPaul HelquistOlaf Wiest

biophysicsenzymesprotein scienceenzyme catalysisbiocatalysisphysical chemistrycomputational chemistrybiochemistrycatalysisbase-catalyzed thiohemiacetal decompositionmolecular biologycomputational studyredox biology

Development and Application of Computational Methods for the Study of Protein Dynamics With Pm-Hmgr as a Model System. Biophysical Journal (2023)

Mikaela FarrugiaHimani PatelTaylor QuinnBrandon HainesPaul HelquistPer-Ola NorrbyOlaf Wiest

biophysicsmodel systemprotein dynamicscomputational methodsstructural biology

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Paul Helquist

Professor

University of Notre Dame

Affiliations

College of Science

Chemistry and Biochemistry

Paul Helquist is currently serving as a Chemistry And Biochemistry Professor at University of Notre Dame.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Paul Helquist

University of Notre Dame

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Finding Relevant Retrosynthetic Disconnections for Stereocontrolled Reactions. Journal of Chemical Information and Modeling (2024)

Olaf WiestChristoph BauerPaul HelquistPer-Ola NorrbySamuel Genheden

chemical engineeringcomputational chemistrychemistrystereoselective synthesisstereocontrolled reactions

Mutant Induced Neurons and Humanized Mice Enable Identification of Niemann-Pick Type C1 Proteostatic Therapies. JCI Insight (2024)

neurochemistryneuropharmacologyneuronsmedicinal researchneuroscienceneuroimmunologymolecular biologynervous systemmolecular neuroscienceneurotransmission

Ph-Dependent Reaction Triggering in Pmhmgr Crystals for Time-Resolved Crystallography. Biophysical Journal (2024)

Vatsal PurohitCalvin N. SteussyAnthony R. RosalesChandra J. CritchelowTim SchmidtPaul HelquistOlaf WiestAndrew MesecarAina E. CohenCynthia V. Stauffacher

biophysicsph-dependent reactionphysiologytime-resolved crystallographypmhmgr crystalsbiophysical chemistry

Short, Enantioselective Synthesis of Mevalonic Acid. (2024)

Ryan J. OconnellNicholas J. DolphinOlaf WiestPaul Helquist

biological engineeringenantioselective synthesismevalonic acidbiomolecular engineeringorganic synthesis

Synergistic Approaches to Elucidation of Enzyme Mechanisms/Dynamics. Biophysical Journal (2024)

Mikaela FarrugiaOlaf WiestPaul Helquist

biophysicsbiological engineeringenzymessynthetic biologystructure elucidationsystems biology

Synthesis of a Cholesterol Cross-Linker With a Photoaffinity Label and Alkyne Tag at Minimally Interfering Sites for Cellular Studies. (2024)

Yogesh B. NarkhedeRyan J. OconnellPaul HelquistOlaf Wiest

Synthesis of Caged Hmg-Coa Reductase Substrates for the Elucidation of Cellular Pathways. The Journal of Organic Chemistry (2024)

Ryan J. O’ConnellNicholas J. DolphinGuillermo FerraudiMijoon LeeCynthia V. StauffacherPaul HelquistOlaf Wiest

cellular pathwaysbiocatalysisbiochemistryhmg-coa reductase substratesorganic chemistry

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Computational Study of Base-Catalyzed Thiohemiacetal Decomposition in Pseudomonas Mevalonii Hmg-Coa Reductase. The Journal of Physical Chemistry B (2023)

Himani N. PatelBrandon E. HainesCynthia V. StauffacherPaul HelquistOlaf Wiest

Development and Application of Computational Methods for the Study of Protein Dynamics With Pm-Hmgr as a Model System. Biophysical Journal (2023)

Mikaela FarrugiaHimani PatelTaylor QuinnBrandon HainesPaul HelquistPer-Ola NorrbyOlaf Wiest

biophysicsmodel systemprotein dynamicscomputational methodsstructural biology

1
2
3
4
5
20
10 / page

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Similar Faculty Members

Olaf G. Wiest

Institution

University of Notre Dame

organic chemistry

quantum chemistry

Jon T. Njardarson

Institution

University of Arizona

synthetic chemistry

biomolecular engineering

Eugene A. Mash

Institution

University of Arizona

environmental chemistry

general chemistry

Babak Borhan

Institution

Michigan State University

chemistry

organic chemistry

Rajeev Prabhakar

Institution

University of Miami

biochemistry

enzymes

Daniel Romo

Institution

Baylor University

organic synthesis

chemistry

Robin Polt

Institution

University of Arizona

lipid chemistry

biomolecular engineering

John Porco

Institution

Boston University

complex synthesis

complex chemical libraries

Stephen F Martin

Institution

University of Texas at Austin

synthetic biology

process biochemistry

Dean J Tantillo

Institution

University of California, Davis

organic chemistry

polycyclization reactions