Faculty

Institution

Unit

Venue

John Porco

Professor

Boston University

Affiliations

College of Arts & Sciences

Chemistry

Graduate Medical Sciences

John Porco is currently serving as a Chemistry Professor at Boston University.

Honors

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Experiences

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Education

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John Porco

Boston University

Professor

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organic synthesis chemistry organic chemistry pharmacology chemical synthesis medicinal chemistry oncology cancer research medicinal research drug discovery tumor biology enzyme inhibition immunology total synthesis medicine cancer biology cancer treatment anti-cancer agents enantioselective synthesis tumor targeting natural product synthesis pharmacotherapy transition metal chemistry synthetic chemistry cellular therapy molecular cancer natural product research combinatorial chemistry cancer genetics phytochemistry organometallic catalysis total syntheses skeletal diversity molecular science leukemia drug targeting lymphoid neoplasia catalytic synthesis heterocycle chemistry protein science cancer care pharmaceutical chemistry apoptosis cell regulation translation initiation asymmetric synthesis stereochemical assignment cell death biochemical sciences biological chemistry mammalian biology cancer genomics rna biology asymmetric catalysis biomimetic chemistry biological evaluation experimental medicine synthetic photochemistry polymer synthesis inorganic synthesis hematological malignancies high-throughput screening cancer prevention cancer management multidimensional screening nanoparticle catalysis multiple myeloma clinical medicine functional modification supramolecular photochemistry enantioselective photocycloaddition complex rocaglate oncogenic translation program solid-phase organic synthesis asymmetric syntheses tartrate-mediated nucleophilic epoxidation organic process research biomolecular engineering complex molecules organic chemistry frontier

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Chemical Screen Identifies Structurally Diverse Metal Chelators With Activity Against the Fungal Pathogen Candida Albicans. Microbiology Spectrum (2024)

Sara FallahDustin DuncanKyle D. ReichlMichael J. SmithWenyu WangJohn A. PorcoLauren E. BrownLuke WhitesellNicole RobbinsLeah E. Cowen

microbiologyfungal pathogensmolecular microbiologymicrobial pathogenesiscandida albicanschemical screen

Amidino-Rocaglates (Adrs), a Class of Synthetic Rocaglates, Are Potent Inhibitors of Sars-Cov-2 Replication Through Inhibition of Viral Protein Synthesis. Antiviral Research (2024)

Patrick T. KeiserWenhan ZhangMichael RiccaAlan WacquiezAutumn GriminsRegina CencicJ.J. PattenPranav ShahElias PadilhaJohn H. ConnorJerry PelletierShawn M. LyonsMohsan SaeedLauren E. BrownJohn A. PorcoRobert A. Davey

antiviral drug developmentviral protein synthesisantiviral researchsynthetic rocaglatesantiviral compoundssars-cov-2potent inhibitorspharmacologyantiviral drugssynthetic biologyantiviral therapysynthetic virologyvirus research

Asymmetric Synthesis of Nidulalin a and Nidulaxanthone a: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society (2024)

Kaijie JiRichard P. JohnsonJames McNeelyMd Al FarukJohn A. Porco

organic synthesisasymmetric synthesischemistryoxoammonium salt

Discovery of Rna-Protein Molecular Clamps Using Proteome-Wide Stability Assays. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Stanley I. GoldsteinAlice C. FanZihao WangSai K. NaineniJohan LengqvistAlexey ChernobrovkinSteve B. Garcia-GutierrezRegina CencicKesha PatelSidong HuangLauren E. BrownAndrew EmiliJohn A. Porco

rna-protein molecular clampsproteomicsrna biologymolecular biologyproteomic discovery

Evolution of a Strategy for the Unified, Asymmetric Total Syntheses of Dmoa-Derived Spiromeroterpenoids. The Journal of Organic Chemistry (2024)

Feng YangAmira OladokunJohn A. Porco

asymmetric total synthesesdmoa-derived spiromeroterpenoidsevolutionary biologysynthetic biologymolecular biology

Glabridin Hypnosis in Zebrafish Larvae is Associated With Effects on Multiple Anesthetic Target Receptors. Anesthesia & Analgesia (2024)

Aneesh AvanchaHelen HoytKieran BhaveMadyson MedeirosDaniel ChoLauren E. BrownDavinia Fernández GonzálezJohn A. PorcoStuart A. Forman

anesthesiaanesthetic pharmacologyzebrafish larvaeglabridin hypnosisanesthesiology

Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. ACS Central Science (2024)

Zihao WangRitesh P. ThakareShalaka ChitaleAlok K. MishraStanley I. GoldsteinAlice C. FanRui LiLihua Julie ZhuLauren E. BrownRegina CencicSidong HuangMichael R. GreenJerry PelletierSunil K. MaloniaJohn A. Porco

selective inhibitorspharmacologytherapeutic targetsgliomasinhibitory activityrocaglate acyl sulfamidestumor biologychemoprevention strategiesoncologycancer treatmentbrain tumor researchcancer discoveryanti-cancer agentsneuro-oncologytumor targetingmedicinal researchbiomolecular engineeringoncogenesmolecular biologyenzyme inhibitionglioblastoma stem cells

In Vitro Discovery of a Therapeutic Lead for Hfmd From a Library Screen of Rocaglates/Aglains. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Adrian OoAngel BorgeRegina Ching Hua LeeCyrill Kafi SalimWenyu WangMichael RiccaDeborah Yuhui FongSylvie AlonsoLauren E. BrownJohn A. PorcoJustin Jang Hann Chu

novel therapiesdrug developmentbiomedical engineeringtherapeutic targetsdrug discoverytherapeutic lead

Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Hannah L. ThirmanMadeline J. HayesLauren E. BrownJohn A. PorcoJonathan M. Irish

single celloncologycancer biologycell biologyleukemia

Structural Basis for the Improved Rna-Clamping of Amidino-Rocaglates to Eif4a1. bioRxiv (Cold Spring Harbor Laboratory) (2024)

James F. ConleyLauren E. BrownJames H. McNeelyJerry PelletierJohn A. PorcoKaren N. Allen

biomolecular structurebiochemistrystructural basismolecular biologyimproved rna-clampingstructural biology

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John Porco

Professor

Boston University

Affiliations

College of Arts & Sciences

Chemistry

Graduate Medical Sciences

John Porco is currently serving as a Chemistry Professor at Boston University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

John Porco

Boston University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Chemical Screen Identifies Structurally Diverse Metal Chelators With Activity Against the Fungal Pathogen Candida Albicans. Microbiology Spectrum (2024)

Sara FallahDustin DuncanKyle D. ReichlMichael J. SmithWenyu WangJohn A. PorcoLauren E. BrownLuke WhitesellNicole RobbinsLeah E. Cowen

microbiologyfungal pathogensmolecular microbiologymicrobial pathogenesiscandida albicanschemical screen

Amidino-Rocaglates (Adrs), a Class of Synthetic Rocaglates, Are Potent Inhibitors of Sars-Cov-2 Replication Through Inhibition of Viral Protein Synthesis. Antiviral Research (2024)

Asymmetric Synthesis of Nidulalin a and Nidulaxanthone a: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society (2024)

Kaijie JiRichard P. JohnsonJames McNeelyMd Al FarukJohn A. Porco

organic synthesisasymmetric synthesischemistryoxoammonium salt

Discovery of Rna-Protein Molecular Clamps Using Proteome-Wide Stability Assays. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Stanley I. GoldsteinAlice C. FanZihao WangSai K. NaineniJohan LengqvistAlexey ChernobrovkinSteve B. Garcia-GutierrezRegina CencicKesha PatelSidong HuangLauren E. BrownAndrew EmiliJohn A. Porco

rna-protein molecular clampsproteomicsrna biologymolecular biologyproteomic discovery

Evolution of a Strategy for the Unified, Asymmetric Total Syntheses of Dmoa-Derived Spiromeroterpenoids. The Journal of Organic Chemistry (2024)

Feng YangAmira OladokunJohn A. Porco

asymmetric total synthesesdmoa-derived spiromeroterpenoidsevolutionary biologysynthetic biologymolecular biology

Glabridin Hypnosis in Zebrafish Larvae is Associated With Effects on Multiple Anesthetic Target Receptors. Anesthesia & Analgesia (2024)

Aneesh AvanchaHelen HoytKieran BhaveMadyson MedeirosDaniel ChoLauren E. BrownDavinia Fernández GonzálezJohn A. PorcoStuart A. Forman

anesthesiaanesthetic pharmacologyzebrafish larvaeglabridin hypnosisanesthesiology

Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. ACS Central Science (2024)

In Vitro Discovery of a Therapeutic Lead for Hfmd From a Library Screen of Rocaglates/Aglains. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Adrian OoAngel BorgeRegina Ching Hua LeeCyrill Kafi SalimWenyu WangMichael RiccaDeborah Yuhui FongSylvie AlonsoLauren E. BrownJohn A. PorcoJustin Jang Hann Chu

novel therapiesdrug developmentbiomedical engineeringtherapeutic targetsdrug discoverytherapeutic lead

Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Hannah L. ThirmanMadeline J. HayesLauren E. BrownJohn A. PorcoJonathan M. Irish

single celloncologycancer biologycell biologyleukemia

Structural Basis for the Improved Rna-Clamping of Amidino-Rocaglates to Eif4a1. bioRxiv (Cold Spring Harbor Laboratory) (2024)

James F. ConleyLauren E. BrownJames H. McNeelyJerry PelletierJohn A. PorcoKaren N. Allen

biomolecular structurebiochemistrystructural basismolecular biologyimproved rna-clampingstructural biology

1
2
3
4
5
30
10 / page

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protein-protein interactions

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Iwao Ojima

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future medicinal chemistry

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future medicinal chemistry

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