Faculty

Institution

Unit

Venue

Paul R. Carlier

Professor of Pharmaceutical Sciences Professor of Chemistry

University of Illinois Chicago

Affiliations

College of Liberal Arts and Sciences

Chemistry

Herbert M. and Carol H. Retzky College of Pharmacy

Pharmaceutical Sciences

Paul R. Carlier is currently serving as a Chemistry Professor of Pharmaceutical Sciences Professor of Chemistry at University of Illinois Chicago.

Honors

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Experiences

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Education

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Paul R. Carlier

University of Illinois Chicago

Professor of Pharmaceutical Sciences Professor of Chemistry

You can click a keyword to filter the displayed items

pharmacology biochemistry chemistry organic chemistry drug discovery medicinal chemistry enzyme inhibition organic synthesis malaria neuropharmacology neuroscience enantioselective synthesis enzymes vector control insecticides insect biochemistry stereoselective synthesis antiparasitic agent medicinal research pesticide science pharmaceutical chemistry pest management alzheimer's disease transition metal chemistry pharmacotherapy insect science insect molecular biology neuroprotection rational drug design inhibitory activity biological chemistry drug development protein science vector-parasite relationship malaria mosquito tropical medicine pest control neurochemistry clinical chemistry pharmaceutical sciences heterocyclic coordination chemistry structural molecular biology biomolecular structure brain science enzyme catalysis computational studies receptor (biochemistry) neuroinflammation phlebotomus papatasi biological inorganic chemistry drug targeting pharmaceutical research g protein-coupled receptor ischemic injury protein chemistry catalytic synthesis molecular catalysis catalyst activation human acetylcholinesterase selective assembly fragmentation effect functional regulation clinical pharmacology macromolecular chemistry cellular neurobiology re-engineering aryl methylcarbamates ion-pair separation cyano-stabilized grignard reagent femtomolar inhibitor building blocks alkylene-linked tacrine dimers malaria box reaction vessel ligand-peripheral site interactions gametocytocidal screening parasitology antiviral drug discovery antiviral drug development infectious diseases parasite control infectious diseases (medical specialty)

Notable Scholarly Works

Notable Federal Grants

Collaborators

Benzo-Ring Modification on Malaria Box Hit Mmv008138: Effects on Antimalarial Potency and Microsomal Stability. RSC Medicinal Chemistry (2025)

tropical medicineinfectious diseasesantimalarial potencymalariaparasitologymedicinal researchantiparasitic agentmalaria boxneglected tropical diseasespharmacologydrug discoverybenzo-ring modificationparasite genomics

Recombinant Pichinde Reporter Virus as a Safe and Suitable Surrogate for High-Throughput Antiviral Screening Against Highly Pathogenic Arenaviruses. Antiviral Research (2025)

viral pathogenesisinfectious diseasesvirologyimmunologysuitable surrogatesars-cov-2antiviral researchsynthetic virologyviral diagnosticspathogenic arenavirusesvirus research

Solvent-, Enzyme-, and Structural-Dependence of Phenyl-Substituted Methyl Carbamate Inhibition of Acetylcholinesterase. Insect Biochemistry and Molecular Biology (2025)

organic chemistry frontierinhibitory activityenzymesenzyme catalysisbiocatalysisbiochemistrybioorganic chemistrypharmacologyenzyme inhibition

Stereospecific Resistance to N2-Acyl Tetrahydro-β-Carboline Antimalarials is Mediated by a Pfmdr1 Mutation That Confers Collateral Drug Sensitivity. ACS Infectious Diseases (2025)

Emily K. BremersJoshua H. ButlerLeticia S. Do AmaralEmilio F. MerinoHanan AlmolhimBo ZhouRodrigo P. BaptistaMaxim TotrovPaul R. CarlierMaria Belen Cassera

therapy resistancestereospecific resistanceresistance mutation (virology)pharmacologyclinical microbiologyinfectious diseasesdisease transmissioncollateral drug sensitivitymalariaantibiotic resistancedrug discoveryinfection controlmicrobiologydrug resistancefuture medicinal chemistryantimicrobial resistanceantiviral researchmolecular pharmacologymedical virologydrug treatment

Abstract 1063: G Protein 12 Alpha Subunit Covalent Binding to Alpha-Snap and Its Potential Role in Von Willebrand Factor Secretion. Arteriosclerosis Thrombosis and Vascular Biology (2024)

Luiza RusuLaura J BloemHui ChenHyun LeeKiira M RatiaLasanthi JayathilakaPaul R CarlierRichard D Minshall

vascular biologyalpha subunit covalentthrombosisatherosclerosisg protein-coupled receptormolecular biology

Recombinant Pichinde Reporter Virus as a Safe and Suitable Surrogate for High-Throughput Antiviral Screening Against Highly Pathogenic Arenaviruses. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Carolina Q. SacramentoRyan BottQinfeng HuangBrett EatonElena PostnikovaAhmad J. SabirMalaika D. ArgadeKiira RatiaManu AnantpadmaPaul R. CarlierHinh LyYuying LiangLijun Rong

antiviral drug developmentinfectious diseasesvirologyantiviral researchpathogenic arenavirusesvirus research

Β-Carboline-3-Carboxamide Antimalarials: Structure–Activity Relationship, Adme-Tox Studies, and Resistance Profiling. ACS Infectious Diseases (2024)

Jopaul MathewBo ZhouReagan S. HaneyKevin A. KunzLeticia S. Do AmaralRudraneel Roy ChowdhuryJoshua H. ButlerHaibo LiAmarraj J. ChakrabortyAnika TabassumEmily K. BremersEmilio F. MerinoRachael CoyleMarcus C. S. LeeDelphine BaudStephen BrandMaxim TotrovMaria Belen CasseraPaul R. Carlier

pharmacologytherapeutic targetsinfectious diseasesantiparasitic agentstructure-activity relationshipdrug discoveryinfection controlresistance profilingadme-tox studiesmedicinal chemistrydrug resistanceantimicrobial resistance genesfuture medicinal chemistryremedial actiondrug resistance analysisantimicrobial resistanceantiviral researchantimicrobial compoundspharmacological researchenzyme inhibitionbiomolecular engineering

Substituted Salicylic Acid Analogs Offer Improved Potency Against Multidrug-Resistant Neisseria Gonorrhoeae and Good Selectivity Against Commensal Vaginal Bacteria. Scientific Reports (2023)

Hanan AlmolhimAhmed E. M. ElhassannyNader S. AbutalebAbdallah S. AbdelsattarMohamed N. SeleemPaul R. Carlier

clinical microbiologycommensal vaginal bacteriaapplied microbiologyinfectious diseasesvirologysalicylic acid analogsmultidrug-resistant neisseria gonorrhoeaeimproved potencypharmacologyveterinary medicinehealth sciencesinfection control

Discovery of Two Inhibitors of the Type IV Pilus Assembly Atpase Pilb as Potential Antivirulence Compounds. Microbiology Spectrum (2022)

Keane J. DyeNancy J. VogelaarMegan O’HaraPablo SobradoWebster SantosPaul R. CarlierZhaomin Yang

clinical microbiologymedical microbiologybacteriologytype iv pilusmolecular microbiologyimmunologymicrobiologypharmacologydrug discoverypharmacotherapyenzyme inhibitionapplied microbiologyatpase pilb

Enantiopure Benzofuran-2-Carboxamides of 1-Aryltetrahydro-β-Carbolines Are Potent Antimalarials in Vitro. ACS Medicinal Chemistry Letters (2022)

Hanan AlmolhimSha DingJoshua H. ButlerEmily K. BremersGrant J. ButschekCarla SlebodnickEmilio F. MerinoZaira RizopoulosMaxim TotrovMaria B. CasseraPaul R. Carlier

medicinal chemistrybiochemistryclinical chemistrypharmacologydrug discovery

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Paul R. Carlier

Professor of Pharmaceutical Sciences Professor of Chemistry

University of Illinois Chicago

Affiliations

College of Liberal Arts and Sciences

Chemistry

Herbert M. and Carol H. Retzky College of Pharmacy

Pharmaceutical Sciences

Paul R. Carlier is currently serving as a Chemistry Professor of Pharmaceutical Sciences Professor of Chemistry at University of Illinois Chicago.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Paul R. Carlier

University of Illinois Chicago

Professor of Pharmaceutical Sciences Professor of Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Benzo-Ring Modification on Malaria Box Hit Mmv008138: Effects on Antimalarial Potency and Microsomal Stability. RSC Medicinal Chemistry (2025)

Recombinant Pichinde Reporter Virus as a Safe and Suitable Surrogate for High-Throughput Antiviral Screening Against Highly Pathogenic Arenaviruses. Antiviral Research (2025)

viral pathogenesisinfectious diseasesvirologyimmunologysuitable surrogatesars-cov-2antiviral researchsynthetic virologyviral diagnosticspathogenic arenavirusesvirus research

Solvent-, Enzyme-, and Structural-Dependence of Phenyl-Substituted Methyl Carbamate Inhibition of Acetylcholinesterase. Insect Biochemistry and Molecular Biology (2025)

organic chemistry frontierinhibitory activityenzymesenzyme catalysisbiocatalysisbiochemistrybioorganic chemistrypharmacologyenzyme inhibition

Stereospecific Resistance to N2-Acyl Tetrahydro-β-Carboline Antimalarials is Mediated by a Pfmdr1 Mutation That Confers Collateral Drug Sensitivity. ACS Infectious Diseases (2025)

Emily K. BremersJoshua H. ButlerLeticia S. Do AmaralEmilio F. MerinoHanan AlmolhimBo ZhouRodrigo P. BaptistaMaxim TotrovPaul R. CarlierMaria Belen Cassera

Abstract 1063: G Protein 12 Alpha Subunit Covalent Binding to Alpha-Snap and Its Potential Role in Von Willebrand Factor Secretion. Arteriosclerosis Thrombosis and Vascular Biology (2024)

Luiza RusuLaura J BloemHui ChenHyun LeeKiira M RatiaLasanthi JayathilakaPaul R CarlierRichard D Minshall

vascular biologyalpha subunit covalentthrombosisatherosclerosisg protein-coupled receptormolecular biology

Recombinant Pichinde Reporter Virus as a Safe and Suitable Surrogate for High-Throughput Antiviral Screening Against Highly Pathogenic Arenaviruses. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Carolina Q. SacramentoRyan BottQinfeng HuangBrett EatonElena PostnikovaAhmad J. SabirMalaika D. ArgadeKiira RatiaManu AnantpadmaPaul R. CarlierHinh LyYuying LiangLijun Rong

antiviral drug developmentinfectious diseasesvirologyantiviral researchpathogenic arenavirusesvirus research

Β-Carboline-3-Carboxamide Antimalarials: Structure–Activity Relationship, Adme-Tox Studies, and Resistance Profiling. ACS Infectious Diseases (2024)

Substituted Salicylic Acid Analogs Offer Improved Potency Against Multidrug-Resistant Neisseria Gonorrhoeae and Good Selectivity Against Commensal Vaginal Bacteria. Scientific Reports (2023)

Hanan AlmolhimAhmed E. M. ElhassannyNader S. AbutalebAbdallah S. AbdelsattarMohamed N. SeleemPaul R. Carlier

Discovery of Two Inhibitors of the Type IV Pilus Assembly Atpase Pilb as Potential Antivirulence Compounds. Microbiology Spectrum (2022)

Keane J. DyeNancy J. VogelaarMegan O’HaraPablo SobradoWebster SantosPaul R. CarlierZhaomin Yang

clinical microbiologymedical microbiologybacteriologytype iv pilusmolecular microbiologyimmunologymicrobiologypharmacologydrug discoverypharmacotherapyenzyme inhibitionapplied microbiologyatpase pilb

Enantiopure Benzofuran-2-Carboxamides of 1-Aryltetrahydro-β-Carbolines Are Potent Antimalarials in Vitro. ACS Medicinal Chemistry Letters (2022)

Hanan AlmolhimSha DingJoshua H. ButlerEmily K. BremersGrant J. ButschekCarla SlebodnickEmilio F. MerinoZaira RizopoulosMaxim TotrovMaria B. CasseraPaul R. Carlier

medicinal chemistrybiochemistryclinical chemistrypharmacologydrug discovery

1
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10 / page

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Similar Faculty Members

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University of Arizona

lipid chemistry

biomolecular engineering

Charles E. McKenna

Institution

University of Southern California

future medicinal chemistry

medicinal chemistry

Bruce Ganem

Institution

Cornell University

synthetic chemistry

biomolecular engineering

Richard B. Silverman

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pharmacology

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Institution

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organic chemistry

medicinal chemistry

Scott G. Franzblau

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antibiotic

tuberculosis

Paul Hergenrother

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University of Illinois Urbana-Champaign

enzyme inhibitors

antibacterial compounds

Colleen M. Niswender

Institution

Vanderbilt University

neurogenetics

molecular biology

Chang-Guo Zhan

Institution

University of Kentucky

future medicinal chemistry

molecular docking

Carrie K. Jones, Ph.D.

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psychiatry

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