Faculty

Institution

Unit

Venue

Jetze Tepe

Professor and Director of Drug Discovery

University of Virginia

Affiliations

College and Graduate School of Arts and Sciences

Department of Chemistry

Jetze Tepe is currently serving as a College And Graduate School Of Arts And Sciences Professor and Director of Drug Discovery at University of Virginia.

Honors

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Experiences

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Education

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Jetze Tepe

University of Virginia

Professor and Director of Drug Discovery

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pharmacology chemical synthesis organic synthesis organic chemistry biochemistry organic process research medicinal chemistry synthetic chemistry biomolecular engineering therapeutic targets enzyme inhibition medicinal research organic chemistry frontier drug discovery natural product research natural product synthesis molecular biology heterocycle chemistry pharmaceutical chemistry protein science enantioselective synthesis natural products stereoselective synthesis molecular cancer proteome research anti-cancer agents cancer cells heterocyclic oncogenes chemical sciences protein function neurodegenerative diseases molecular neurodegeneration cell death biological chemistry protein misfolding inhibitory activity cancer treatment total synthesis drug development degenerative pathology diversity oriented synthesis anti-inflammatory cancer biology cancer discovery pharmacognosy proteasome enhancement rational drug design asymmetric catalysis pharmaceutical sciences synthesis methods oligonucleotides mechanisms of action proteasome activity imidazoline scaffolds proteasome inhibition nucleic acid chemistry neuroprotection inflammatory diseases apoptosis proteasome activation enol ethers multiple myeloma reductive activation protein mass spectrometry oncogenic agent cell culture inflammatory rheumatic disease chemoprevention strategies dna cross-linking tumor growth cell cycle arrest one-pot synthesis solid phase enrichment stereoselective syntheses declined proteasome activity

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1776: Investigation Into the Enhancement of 20S Proteasome-Mediated Proteolysis as a Therapeutic for Hpv-Associated Cervical Cancer. Cancer Research (2025)

Shannon M. CartwrightLinh LeKate HartnettJetze J. Tepe

cancer researchproteasome-mediated proteolysiscancer biologycancer treatmenthpv-associated cervical cancermolecular biologycervical cancer

A Tetrazine‐Based Synthesis for Accessing Underutilized Aza‐Indole Analogues. Chemistry - A European Journal (2025)

Jetze J TepeEvan J SavelsonKatarina Selewski

underutilized aza-indole analoguessynthetic chemistrytetrazine-based synthesisstructural chemistrychemical synthesischemical engineeringmedicinal chemistrycombinatorial chemistryorganometallic chemistryfuture medicinal chemistrycatalytic synthesisnatural product synthesisenantioselective synthesissustainable chemistrychemistrybiomolecular engineeringmolecular scienceorganic synthesistransition metal chemistrycatalysis

Investigation Into the Enhancement of 20S Proteasome Proteolysis as a Therapeutic for Hpv-Mediated Cervical Cancer (Abstract Id: 161603). Journal of Pharmacology and Experimental Therapeutics (2025)

Shannon CartwrightKate HartnettLinh LeJetze J. Tepe

tumor biologyproteome researchtherapeutic efficacygynecologic cancersoncologybiomolecular engineeringmolecular cancermedicinal researchhpv-mediated cervical canceroncogenesproteasome proteolysisviral oncologypharmacologytherapeutic targetsmolecular biologyclinical proteomicscervical cancertumor heterogeneity

Recent Advancements in 20S Proteasome Enhancement: Degradation of Undruggable Targets. ACS Medicinal Chemistry Letters (2025)

biochemical sciencesproteome researchenzymeschemical biologytranslational proteomicsprotein scienceproteasome enhancementprotein engineeringprotein foldingbiochemistryproteomicsbiological chemistrytherapeutic targetsprotein functionmolecular biologyenzyme inhibitionclinical proteomicsproteomic technologies

Short and High-Yielding Synthesis of a Minimalist Diazirine–Alkyne Photo-Cross-Linker and Photoaffinity Labeling Derivatives. ACS Omega (2025)

Dare E. GeorgeMiracle O. OlatundeJetze J. Tepe

high-yielding synthesischemistryoptical propertiesphotoaffinity labeling derivativesorganic synthesisminimalist diazirine-alkyne photo-cross-linkertransition metal chemistrysynthetic photochemistry

Tungsten-Enabled Diels–Alder Cycloaddition and Cycloreversion of Arenes and Alkynes: Divergent Synthesis of Highly Functionalized Barrelenes and Arenes. Journal of the American Chemical Society (2025)

Jeremy M. BlochEvan SavelsonAlvin Q. MengMegan N. EricsonIshaan U. PatelDiane A. DickieJetze J. TepeW. Dean Harman

organic process researchheterocycle chemistrychemistryorganic chemistryhighly functionalized barreleneschemical synthesisintact barrelenesorganometallic chemistrytungsten-enabled diels–alder cycloadditionorganic synthesisorganometallic catalysisalkene metathesiscoordination chemistrytransition metal chemistrychemical engineering

20S Proteasome Enhancers Prevent Cytotoxic Tubulin Polymerization-Promoting Protein Induced α-Synuclein Aggregation. iScience (2024)

Sophia D StaerzCharles AnamoahJetze J Tepe

proteasome enhancersa-synuclein aggregationprotein scienceproteomicsmolecular biology

Advances in the Total Synthesis of Bis- and Tris-Indole Alkaloids Containing N-Heterocyclic Linker Moieties. Natural Product Reports (2024)

Kyra R. DvorakJetze J. Tepe

chemistryn-heterocyclic linker moietiesnatural productstotal synthesisnatural product researchnatural product synthesis

Design, Synthesis, and Biological Evaluation of Substituted Hydroxyquinolinone Compounds as 20S Proteasome Enhancers. Journal of Pharmacology and Experimental Therapeutics (2024)

Sydney G. CobbEvan D. SavelsonJetze Tepe

biological evaluationproteome researchproteasome enhancersbiomolecular engineeringpharmacological researchbioactive compoundsmedicinal chemistryprotein sciencemedicinal researchexperimental pharmacologybiochemistrypharmacologyfunctional modificationtherapeutic targetsdrug discoverydrug deliverysubstituted hydroxyquinolinone

Development of N-Acyl Fluspirilene 20S Proteasome Enhancers for the Treatment of Neurodegenerative Diseases. Journal of Pharmacology and Experimental Therapeutics (2024)

Daniel J. Colombani-GarayJetze Tepe

proteome researchpeptide engineeringproteasome enhancersbiomolecular engineeringneurodegenerative diseasesneuropharmacologymedicinal chemistryneuroprotectionremedial actionbiochemistrypharmacologyproteomicstherapeutic targetsmolecular neurodegenerationpeptide sciencepeptidesmedicinal research

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Jetze Tepe

Professor and Director of Drug Discovery

University of Virginia

Affiliations

College and Graduate School of Arts and Sciences

Department of Chemistry

Jetze Tepe is currently serving as a College And Graduate School Of Arts And Sciences Professor and Director of Drug Discovery at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jetze Tepe

University of Virginia

Professor and Director of Drug Discovery

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1776: Investigation Into the Enhancement of 20S Proteasome-Mediated Proteolysis as a Therapeutic for Hpv-Associated Cervical Cancer. Cancer Research (2025)

Shannon M. CartwrightLinh LeKate HartnettJetze J. Tepe

cancer researchproteasome-mediated proteolysiscancer biologycancer treatmenthpv-associated cervical cancermolecular biologycervical cancer

A Tetrazine‐Based Synthesis for Accessing Underutilized Aza‐Indole Analogues. Chemistry - A European Journal (2025)

Jetze J TepeEvan J SavelsonKatarina Selewski

Shannon CartwrightKate HartnettLinh LeJetze J. Tepe

Recent Advancements in 20S Proteasome Enhancement: Degradation of Undruggable Targets. ACS Medicinal Chemistry Letters (2025)

Short and High-Yielding Synthesis of a Minimalist Diazirine–Alkyne Photo-Cross-Linker and Photoaffinity Labeling Derivatives. ACS Omega (2025)

Dare E. GeorgeMiracle O. OlatundeJetze J. Tepe

high-yielding synthesischemistryoptical propertiesphotoaffinity labeling derivativesorganic synthesisminimalist diazirine-alkyne photo-cross-linkertransition metal chemistrysynthetic photochemistry

Jeremy M. BlochEvan SavelsonAlvin Q. MengMegan N. EricsonIshaan U. PatelDiane A. DickieJetze J. TepeW. Dean Harman

20S Proteasome Enhancers Prevent Cytotoxic Tubulin Polymerization-Promoting Protein Induced α-Synuclein Aggregation. iScience (2024)

Sophia D StaerzCharles AnamoahJetze J Tepe

proteasome enhancersa-synuclein aggregationprotein scienceproteomicsmolecular biology

Advances in the Total Synthesis of Bis- and Tris-Indole Alkaloids Containing N-Heterocyclic Linker Moieties. Natural Product Reports (2024)

Kyra R. DvorakJetze J. Tepe

chemistryn-heterocyclic linker moietiesnatural productstotal synthesisnatural product researchnatural product synthesis

Design, Synthesis, and Biological Evaluation of Substituted Hydroxyquinolinone Compounds as 20S Proteasome Enhancers. Journal of Pharmacology and Experimental Therapeutics (2024)

Sydney G. CobbEvan D. SavelsonJetze Tepe

Development of N-Acyl Fluspirilene 20S Proteasome Enhancers for the Treatment of Neurodegenerative Diseases. Journal of Pharmacology and Experimental Therapeutics (2024)

Daniel J. Colombani-GarayJetze Tepe

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Institution

University of South Florida

biomolecular engineering

drug development

Daniel Romo

Institution

Baylor University

organic synthesis

chemistry

Paul R. Carlier

Institution

University of Illinois Chicago

infectious diseases (medical specialty)

malaria

Danith Ly

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Carnegie Mellon University

general chemistry

molecular and cellular biology

John Porco

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Boston University

complex synthesis

complex chemical libraries

Gordon Wayne Gribble

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Dartmouth College

synthetic chemistry

natural product

Charles E. McKenna

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future medicinal chemistry

medicinal chemistry

Robin Polt

Institution

University of Arizona

lipid chemistry

biomolecular engineering

Eugene A. Mash

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environmental chemistry

general chemistry

Jianfeng Cai

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University of South Florida

protein-protein interactions

biomolecular engineering