Faculty

Institution

Unit

Venue

Dr. James Leahy

Professor & Chair

University of South Florida

Affiliations

College of Arts and Sciences

School of Natural Sciences and Mathematics

Department of Chemistry

Dr. James Leahy is currently serving as a College Of Arts And Sciences Professor & Chair at University of South Florida.

Honors

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Experiences

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Education

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Dr. James Leahy

University of South Florida

Professor & Chair

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pharmacology organic synthesis chemical synthesis medicinal chemistry drug discovery chemistry natural product research enzyme inhibition natural product synthesis medicinal research organic chemistry pharmacological research synthetic chemistry pharmaceutical chemistry molecular biology chemical biology pharmaceutics drug development protein science chemical sciences enzymes total synthesis medicine synthetic biology insect biochemistry anti-cancer agents rational drug design peptide science enantioselective total synthesis rapamycin synthetic studies clinical microbiology peptoids pulmonary pharmacology drug targeting asymmetric baylis-hillman reaction clinical chemistry immunomodulation peptide synthesis steroid metabolism insecticides ab-initio methods cancer biology heterocyclic unified total synthesis bioactive conformation peptide ligands first design analogue development novel scaffold peptidomimetic employing versatile steroid nucleus relevant treatments waste management poultry science energy research thermal engineering energy conversion protein synthesis energy engineering gasification biological inorganic chemistry translational pharmacology sensory science experimental pharmacology clinical pharmacology quantum theory disease transmission emerging infectious diseases phytochemistry nucleic acid chemistry tumor suppressors apoptosis integrative biology fluidized bed reactor poultry litter gasification limestone addition future medicinal chemistry pharmacotherapy drug candidates biomolecular engineering

Notable Scholarly Works

Notable Federal Grants

Collaborators

Pkc-ι Regulates an Oncogenic Positive Feedback Loop Between the Mapk/Jnk Signaling Pathway, C-Jun/Ap-1 and Tnf-α in Breast Cancer. (2025)

signaling pathwaysmapk/jnk signaling pathwaycancer biologysystems biologycell signalingbreast canceroncogenescancer cellssignal transductiontumor biologycell biology

Proteasome Inhibitor Mg-132 and Pkc-ι-Specific Inhibitor Ica-1S Degrade Mutant P53 and Induce Apoptosis in Ovarian Cancer Cell Lines. International Journal of Molecular Sciences (2025)

proteasome inhibitor mg-132cell deathgynecologic oncologytumor suppressorsanti-cancer agentsapoptosiscancer cellsinduce apoptosiscancer biologypathologytumor biologyovarian cancercell biology

Abstract 1050 Protein Identification and Characterization via Binding Based Proteomic Profiling (Bbpp) of Fatty Acid Amides in Drosophila Melanogaster. Journal of Biological Chemistry (2024)

Imani McCallaSuzeeta BhandariRobert FeeneyJames LeahyDavid Merkler

insect biochemistryfatty acid amidesproteomicsprotein sciencebiologyproteomic profilinganimal sciencemolecular biologyinsect scienceprotein identificationinsect molecular biologydrosophila melanogasterstructural biologybotanymembrane biologybiochemistry

Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human Sting Receptor. (2024)

Robert SparksWilliam LawlessAnna KharitonovaRainer MetcalfJamie NunziataGrace BinderSauradip ChaudhuryChristine GambinoMichelle WildeLinette HardingJaret CrewsMansi GopuEmilia DalamangusSarah LawlessMark EschenfelderRobert GreenElizabeth NompleggiTimothy TranKathy YangDonna TraskPaul ThompsonNiketa PatelRekha PatelWesley BrooksGuy BradleyMildred Acevedo-DuncanAlan MullenJames LeahyKenyon DanielWayne Guida

peptidesreceptor (biochemistry)insect sting allergybiochemistryplatelet antagonistpain medicineendocrinologyvascular biologysub-femtomolar modulatorpheromone biochemistrypeptide sciencetherapeutic targetshuman sting receptorimmunologyreceptorspharmacologydrug discoveryvenomicsmedicinal researchsignal transduction

Selective Targeting of Plasmodium Falciparum Hsp90 Disrupts the 26S Proteasome. Cell chemical biology (2024)

Christopher R. MansfieldBaiyi QuanMichael E. ChirgwinBenjamin EdufulPhilip F. HughesGaëlle NeveuKayla SylvesterDaniel H. RyanBjörn F.C. KafsackTimothy A.J. HaysteadJames W. LeahyMichael C. FitzgeraldEmily R. Derbyshire

molecular biologyselective targetinginfectious diseasesmalariacell biology

Abstract 1380: Binding Based Proteomic Profiling (Bbpp) of Fatty Acid Amide Binding Protein in Drosophila Melanogaster. Journal of Biological Chemistry (2023)

Suzeeta BhandariRobert FeeneyImani McCallaJames LeahyDavid Merkler

insect biochemistryintegrative biologyproteomicsprotein scienceprotein structurebiologyproteomic profilingentomologyanimal sciencemolecular biologyinsect sciencedrosophila melanogasterstructural biologyinsect molecular biologymembrane biologybiochemistry

Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation. ACS Chemical Biology (2023)

Shannon E. HillDavid Beaulieu-AbdelahadAndrea LemusJack M. WebsterSantiago Rodriguez OspinaApril L. DarlingMackenzie D. MartinShreya PatelLiznair BridenstineRonald SwongerSteven PaulRoy BlackburnLaurent CalculChad A. DickeyJames W. LeahyLaura J. Blair

medicinal chemistrydermatologypharmacologyhematologyclinical chemistrychemical biologybioactive compoundsdrug discoverymolecular biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicsstructure elucidationcrystal researchcrystal diffraction studystructure determinationstructural chemistryccdc 2157502chemistrydeposited datasetcrystal engineeringchemical structurecrystal structurescrystallography

Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors Against Pathogenic Free-Living Amoeba Glucokinases. ACS Infectious Diseases (2023)

Mintesinot KassuPrakash T. ParvatkarJillian MilanesNeil P. MonaghanChungsik KimMatthew DowgialloYingzhao ZhaoAmi H. AsakawaLili HuangAlicia WagnerBrandon MillerKarissa CarterKayleigh F. BarrettLogan M. TilleryLynn K. BarrettIsabelle Q. PhanSandhya SubramanianPeter J. MylerWesley C. Van VoorhisJames W. LeahyChristopher A. RiceDennis E. KyleJames MorrisRoman Manetsch

medicinal chemistryclinical microbiologyinfectious diseasesdrug developmentmedicinerational drug designenzymesmicrobial pathogenesissmall-molecule inhibitorsdrug targetingsynthetic biologydisease transmissionenzyme inhibitionpharmacologyinfection controlcancer discoverydrug discoverymedicinal researchemerging infectious diseases

Alkyne Modified Purines for Assessment of Activation of Plasmodium Vivax Hypnozoites and Growth of Pre-Erythrocytic and Erythrocytic Stages in Plasmodium Spp.. International Journal for Parasitology (2022)

Alona BotnarGrant LawrenceSteven P. MaherAmélie VantauxBenoît WitkowskiJustine C. ShiauEmilio F. MerinoDavid De VoreChristian YangCameron MurrayMaria B. CasseraJames W. LeahyDennis E. Kyle

plasmodium vivax hypnozoitespharmacologyparasitologyplasmodium sppmalariaerythrocytic stages

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Dr. James Leahy

Professor & Chair

University of South Florida

Affiliations

College of Arts and Sciences

School of Natural Sciences and Mathematics

Department of Chemistry

Dr. James Leahy is currently serving as a College Of Arts And Sciences Professor & Chair at University of South Florida.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Dr. James Leahy

University of South Florida

Professor & Chair

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Pkc-ι Regulates an Oncogenic Positive Feedback Loop Between the Mapk/Jnk Signaling Pathway, C-Jun/Ap-1 and Tnf-α in Breast Cancer. (2025)

signaling pathwaysmapk/jnk signaling pathwaycancer biologysystems biologycell signalingbreast canceroncogenescancer cellssignal transductiontumor biologycell biology

Proteasome Inhibitor Mg-132 and Pkc-ι-Specific Inhibitor Ica-1S Degrade Mutant P53 and Induce Apoptosis in Ovarian Cancer Cell Lines. International Journal of Molecular Sciences (2025)

proteasome inhibitor mg-132cell deathgynecologic oncologytumor suppressorsanti-cancer agentsapoptosiscancer cellsinduce apoptosiscancer biologypathologytumor biologyovarian cancercell biology

Abstract 1050 Protein Identification and Characterization via Binding Based Proteomic Profiling (Bbpp) of Fatty Acid Amides in Drosophila Melanogaster. Journal of Biological Chemistry (2024)

Imani McCallaSuzeeta BhandariRobert FeeneyJames LeahyDavid Merkler

Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human Sting Receptor. (2024)

Selective Targeting of Plasmodium Falciparum Hsp90 Disrupts the 26S Proteasome. Cell chemical biology (2024)

molecular biologyselective targetinginfectious diseasesmalariacell biology

Abstract 1380: Binding Based Proteomic Profiling (Bbpp) of Fatty Acid Amide Binding Protein in Drosophila Melanogaster. Journal of Biological Chemistry (2023)

Suzeeta BhandariRobert FeeneyImani McCallaJames LeahyDavid Merkler

Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation. ACS Chemical Biology (2023)

medicinal chemistrydermatologypharmacologyhematologyclinical chemistrychemical biologybioactive compoundsdrug discoverymolecular biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors Against Pathogenic Free-Living Amoeba Glucokinases. ACS Infectious Diseases (2023)

Alona BotnarGrant LawrenceSteven P. MaherAmélie VantauxBenoît WitkowskiJustine C. ShiauEmilio F. MerinoDavid De VoreChristian YangCameron MurrayMaria B. CasseraJames W. LeahyDennis E. Kyle

plasmodium vivax hypnozoitespharmacologyparasitologyplasmodium sppmalariaerythrocytic stages

1
2
3
4
5
16
10 / page

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