Faculty

Institution

Unit

Venue

John D. Buynak

Professor

Southern Methodist University

Affiliations

Dedman College of Humanities and Science

Chemistry

John D. Buynak is currently serving as a Chemistry Professor at Southern Methodist University.

Honors

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Experiences

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Education

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John D. Buynak

Southern Methodist University

Professor

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pharmacology chemistry organic synthesis organic chemistry medicinal chemistry chemical synthesis drug discovery biochemistry enzyme inhibition clinical microbiology medicine enzymes drug resistance b-lactamase inhibitors clinical chemistry pharmacotherapy antimicrobial resistance antimicrobial chemotherapy formal synthesis pharmaceutical chemistry biological chemistry applied microbiology protein science clinical pharmacology synthetic chemistry bacteriology cephalosporin sulfones clinical biochemistry antimicrobial agents chemical sciences infection control rational drug design protein chemistry penicillanic acid sulfone b-lactamase inhibition redox biology structural chemistry medical mycology klebsiella pneumoniae antibacterial agents respiratory infections disease transmission emerging infectious diseases clinical infection antiviral drug development heterocyclic chemical transformations catalytic synthesis b-lactamase inhibitor acinetobacter baumannii potent inhibition human leukocyte elastase migratory preference silicon-based groups thermal rearrangements respiratory medicine molecular diagnostics drug development antiviral drugs antiviral therapy biological inorganic chemistry crystal structure design therapeutic patent pathogen detection medical microbiology diagnostic microbiology chemical technology organic material chemistry host response protein assembly pharmaceutical biotechnology transformation kinetics b-lactam antibiotics useful chemistry clavulanic acid inactivation potent inhibitors

Notable Scholarly Works

Notable Federal Grants

Collaborators

Decarboxylation of the Catalytic Lysine Residue by the C5α-Methyl-Substituted Carbapenem Na-1-157 Leads to Potent Inhibition of the Oxa-58 Carbapenemase. ACS Infectious Diseases (2024)

Marta TothNichole K. StewartAiliena O. MaggioloPojun QuanMd Mahbub Kabir KhanJohn D. BuynakClyde A. SmithSergei B. Vakulenko

medicinal chemistrydrug metabolismclinical microbiologyfunctional selectivityenzyme catalysispotent inhibitioninfectious diseasesbiochemistryantiviral researchenzymespathogenic bacteriaprotein sciencemembrane biologycarbohydrate-protein interactionsprotein chemistrybiocatalysiscatalytic lysine residueenzyme inhibitionredox biologymolecular biology

Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem Na-1-157 Leads to Potent Inhibition of the Ges-5 Carbapenemase. ACS Infectious Diseases (2024)

Nichole K. StewartMarta TothPojun QuanMichael BeerJohn D. BuynakClyde A. SmithSergei B. Vakulenko

pathogensdisease transmissionpharmacologyrotational flexibilityinfection controlrespiratory infectionsclinical infectionclinical microbiologyvirologyglobal healthpotent inhibitioninfectious diseasesclinical infectious diseaseemerging infectious diseases

The C5α-Methyl-Substituted Carbapenem Na-1-157 Exhibits Potent Activity Against Klebsiella Spp. Isolates Producing Oxa-48-Type Carbapenemases. ACS Infectious Diseases (2023)

Clyde A. SmithNichole K. StewartMarta TothPojun QuanJohn D. BuynakSergei B. Vakulenko

pathogensdisease transmissionmicrobial pathogenesispharmacologyinfection controlclinical infectionrespiratory infectionsepidemiologyclinical microbiologyvirologyklebsiella pneumoniaeinfectious diseasesbacteriaemerging infectious diseases

C6 Hydroxymethyl-Substituted Carbapenem Ma-1-206 Inhibits the Major Acinetobacter Baumannii Carbapenemase Oxa-23 by Impeding Deacylation. mBio (2022)

Nichole K. StewartMarta TothMaha A. AlqurafiWeirui ChaiThu Q. NguyenPojun QuanMijoon LeeJohn D. BuynakClyde A. SmithSergei B. Vakulenko

enzyme inhibitionmicrobial pathogenesispharmacologybacteriologyclinical microbiologyantibacterial agentsglobal healthbacteriamicrobiology

Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination With the β-Lactamase Inhibitor Ln-1-255 Against Acinetobacter Spp.. Antibiotics (2021)

Cristina Lasarte-MonterrubioJuan C. Vázquez-UchaMaria ManeiroJorge Arca-SuárezIsaac AlonsoPaula Guijarro-SánchezJohn D. BuynakGermán BouConcepción González-BelloAlejandro Beceiro

medicinepharmacologyclinical microbiologydrug discoveryglobal healthacinetobacter spp

Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β-Lactamase Inhibitors. ACS Infectious Diseases (2021)

Rashmi GuptaNoora M. S. A. Al-KharjiMaha A. AlqurafiThu Q. NguyenWeirui ChaiPojun QuanRiya MalhotraBreven S. SimcoxPhil MortimerLeighanne A. Brammer BastaKyle H. RohdeJohn D. Buynak

pharmacologycarbapenem antibioticsepidemiologyinfectious diseasesantimycobacterial activityb-lactamase inhibitors

Carbapenemase-Stable Carbapenem Antibiotics With Potential to Treat Multidrug-Resistant Acinetobacter Baumannii. (2020)

Maha AlqurafiRachel SchererIan LoweSergei VakulenkoNichole StewartYasmine SamadzadaElizabeth WagnerMadeline PanCassidy JanecekTaezja PhelanAngela HeMarta TothWeirui ChaiHiren BaggaZhihan ChuSara KohLexi NewmanNjeshi NformiJohn BuynakBenjamin NwokoyeJustin PattySiddhakshi SolankiNoora Al-KharjiThu Nguyen

medicinecarbapenemase-stable carbapenem antibioticspharmacologyclinical microbiologydrug resistance

Therapeutic Efficacy of Ln-1-255 in Combination With Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter Baumannii. Antimicrobial Agents and Chemotherapy (2019)

Juan Carlos Vázquez-UchaMarta Martínez-GuitiánMaría ManeiroKelly Conde-PérezLaura Álvarez-FragaGabriel TorrensAntonio OliverJohn D. BuynakRobert A. BonomoGermán BouConcepción González-BelloMargarita PozaAlejandro Beceiro

antimicrobial resistancepharmacologyinfection controlclinical microbiologyclinical therapeuticspharmacotherapycarbapenem-resistant acinetobacter baumanniiglobal healthinfectious diseasessevere infection

Virtual Screening and Experimental Testing of B1 Metallo-β-Lactamase Inhibitors. Journal of Chemical Information and Modeling (2018)

Joon S. KangAntonia L. ZhangMohammad FaheemCharles J. ZhangNi AiJohn D. BuynakWilliam J. WelshPeter Oelschlaeger

medicinal chemistryvirtual screeningenzyme inhibitionpharmacology

Activity of the β-Lactamase Inhibitor Ln-1-255 Against Carbapenem-Hydrolyzing Class D β-Lactamases From Acinetobacter Baumannii. Antimicrobial Agents and Chemotherapy (2017)

Juan Carlos Vázquez-UchaMaría ManeiroMarta Martínez-GuitiánJohn BuynakChristopher R. BethelRobert A. BonomoGermán BouMargarita PozaConcepción González-BelloAlejandro Beceiro

medicineantimicrobial resistancepharmacologyenzyme inhibitionb-lactamase inhibitorclinical microbiologydrug discoveryinfectious diseasesacinetobacter baumanniiantimicrobial chemotherapy

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John D. Buynak

Professor

Southern Methodist University

Affiliations

Dedman College of Humanities and Science

Chemistry

John D. Buynak is currently serving as a Chemistry Professor at Southern Methodist University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

John D. Buynak

Southern Methodist University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Decarboxylation of the Catalytic Lysine Residue by the C5α-Methyl-Substituted Carbapenem Na-1-157 Leads to Potent Inhibition of the Oxa-58 Carbapenemase. ACS Infectious Diseases (2024)

Marta TothNichole K. StewartAiliena O. MaggioloPojun QuanMd Mahbub Kabir KhanJohn D. BuynakClyde A. SmithSergei B. Vakulenko

Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem Na-1-157 Leads to Potent Inhibition of the Ges-5 Carbapenemase. ACS Infectious Diseases (2024)

Nichole K. StewartMarta TothPojun QuanMichael BeerJohn D. BuynakClyde A. SmithSergei B. Vakulenko

The C5α-Methyl-Substituted Carbapenem Na-1-157 Exhibits Potent Activity Against Klebsiella Spp. Isolates Producing Oxa-48-Type Carbapenemases. ACS Infectious Diseases (2023)

Clyde A. SmithNichole K. StewartMarta TothPojun QuanJohn D. BuynakSergei B. Vakulenko

C6 Hydroxymethyl-Substituted Carbapenem Ma-1-206 Inhibits the Major Acinetobacter Baumannii Carbapenemase Oxa-23 by Impeding Deacylation. mBio (2022)

Nichole K. StewartMarta TothMaha A. AlqurafiWeirui ChaiThu Q. NguyenPojun QuanMijoon LeeJohn D. BuynakClyde A. SmithSergei B. Vakulenko

enzyme inhibitionmicrobial pathogenesispharmacologybacteriologyclinical microbiologyantibacterial agentsglobal healthbacteriamicrobiology

Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination With the β-Lactamase Inhibitor Ln-1-255 Against Acinetobacter Spp.. Antibiotics (2021)

Cristina Lasarte-MonterrubioJuan C. Vázquez-UchaMaria ManeiroJorge Arca-SuárezIsaac AlonsoPaula Guijarro-SánchezJohn D. BuynakGermán BouConcepción González-BelloAlejandro Beceiro

medicinepharmacologyclinical microbiologydrug discoveryglobal healthacinetobacter spp

Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β-Lactamase Inhibitors. ACS Infectious Diseases (2021)

Rashmi GuptaNoora M. S. A. Al-KharjiMaha A. AlqurafiThu Q. NguyenWeirui ChaiPojun QuanRiya MalhotraBreven S. SimcoxPhil MortimerLeighanne A. Brammer BastaKyle H. RohdeJohn D. Buynak

pharmacologycarbapenem antibioticsepidemiologyinfectious diseasesantimycobacterial activityb-lactamase inhibitors

Carbapenemase-Stable Carbapenem Antibiotics With Potential to Treat Multidrug-Resistant Acinetobacter Baumannii. (2020)

medicinecarbapenemase-stable carbapenem antibioticspharmacologyclinical microbiologydrug resistance

Therapeutic Efficacy of Ln-1-255 in Combination With Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter Baumannii. Antimicrobial Agents and Chemotherapy (2019)

Virtual Screening and Experimental Testing of B1 Metallo-β-Lactamase Inhibitors. Journal of Chemical Information and Modeling (2018)

Joon S. KangAntonia L. ZhangMohammad FaheemCharles J. ZhangNi AiJohn D. BuynakWilliam J. WelshPeter Oelschlaeger

medicinal chemistryvirtual screeningenzyme inhibitionpharmacology

Activity of the β-Lactamase Inhibitor Ln-1-255 Against Carbapenem-Hydrolyzing Class D β-Lactamases From Acinetobacter Baumannii. Antimicrobial Agents and Chemotherapy (2017)

Juan Carlos Vázquez-UchaMaría ManeiroMarta Martínez-GuitiánJohn BuynakChristopher R. BethelRobert A. BonomoGermán BouMargarita PozaConcepción González-BelloAlejandro Beceiro

medicineantimicrobial resistancepharmacologyenzyme inhibitionb-lactamase inhibitorclinical microbiologydrug discoveryinfectious diseasesacinetobacter baumanniiantimicrobial chemotherapy

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pharmaceutical research

pharmacology

Dennis Wright

Institution

University of Connecticut

future medicinal chemistry

complex natural products

Mayland Chang

Institution

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pathology

cancer cell

Christian Melander

Institution

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applied microbiology

biofilm

Timothy Wencewicz

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biological chemistry

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Peter J. Tonge

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biological data

biomedical informatics

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Daniel Lim

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University of South Florida

pathogenic bacteria

infectious diseases

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antibiotic adjuvant

bio-orthogonal chemistry

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molecular biology

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