Faculty

Institution

Unit

Venue

Dennis Wright

Professor

University of Connecticut

Affiliations

College of Liberal Arts and Sciences

Chemistry

Dennis Wright is currently serving as a Chemistry Professor at University of Connecticut.

Honors

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Experiences

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Education

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Dennis Wright

University of Connecticut

Professor

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pharmacology organic synthesis medicinal chemistry drug discovery organic chemistry medicine immunology enzyme inhibition biochemistry enzymes structural biology clinical microbiology medicinal research propargyl-linked antifolates drug resistance protein structure biological chemistry structural molecular biology pharmaceutical chemistry protein science pharmacotherapy drug development functional modification structure-function enzyme kinetics dihydrofolate reductase infection control cell death clinical chemistry cellular therapy apoptosis cancer treatment cancer biology natural product synthesis respiratory medicine applied microbiology medical mycology structural chemistry drug targeting clinical pharmacology pharmaceutical sciences rational drug design pharmacokinetics gram-negative pathogens antiproliferative effects mammalian biology receptor tyrosine kinases enzyme catalysis drug targets cellular biology antimicrobial susceptibility antibiotic resistance inhibitory activity clinical mycology clinical therapeutics pharmaceutical research tumor targeting cell regulation catalyst activation combinatorial chemistry active site candida albicans cyathane type diterpenes potent inhibitors multiple myeloma cells protein function applied chemistry host specificity secondary metabolites mechanisms of action caspase-like sites selective inhibitor chymotrypsin-like sites specific inhibition chemotherapeutic agent lead-like natural products pregnane x receptor future medicinal chemistry complex natural products small-molecule therapeutics small molecule library therapeutic development biomolecular engineering

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

crystal diffraction studycrystal researchchemical structurebiophysicscrystal structuresccdc 2157502structural chemistrystructure determinationcrystal engineeringcrystallographystructure elucidationdeposited datasetchemistry

Hmgb2 is a Potential Diagnostic Marker and Therapeutic Target for Liver Fibrosis and Cirrhosis. Hepatology Communications (2023)

Yi HuangSuthat LiangpunsakulSwetha RudraiahJing MaSantosh K. KeshipeddyDennis WrightAntonio CostaDiane BurgessYuxia ZhangNazmul HudaLi WangZhihong Yang

hepatologypharmacologypathologypotential diagnostic markerhealth sciencesmolecular diagnosticsoncologyliver fibrosishematology

Incorporation of 53Bp1 Into Phase-Separated Bodies in Cancer Cells During Aberrant Mitosis. Journal of Cell Science (2023)

Marina BleilerAiyana CyrDennis L. WrightCharles Giardina

geneticscancer biologyaberrant mitosisstructural biologyphase-separated bodiescell biology

Chiral Evasion and Stereospecific Antifolate Resistance in Staphylococcus Aureus. PLoS Computational Biology (2022)

Siyu WangStephanie M. ReeveGraham T. HoltAdegoke A. OjewoleMarcel S. FrenkelPablo GainzaSantosh KeshipeddyVance G. FowlerDennis L. WrightBruce R. Donald

pharmacologymicrobiologystaphylococcus aureuscomputational biologyimmunologystereospecific antifolate resistancechiral evasionclinical microbiology

Structure-Guided Functional Studies of Plasmid-Encoded Dihydrofolate Reductases Reveal a Common Mechanism of Trimethoprim Resistance in Gram-Negative Pathogens. Communications Biology (2022)

Jolanta KrucinskaMichael N. LombardoHeidi ErlandsenAlexavier EstradaDebjani SiKishore ViswanathanDennis L. Wright

gram-negative pathogenspharmacologystructural biologytrimethoprim resistancestructure-guided functional studiesmolecular biologypathway analysisimmunologyplasmid-encoded dihydrofolate reductasesclinical microbiology

Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses. mBio (2022)

Katherine A. DiScipioSavithri WeerasooriyaRenata SzczepaniakAkram HazeenLee R. WrightDennis L. WrightSandra K. Weller

pharmacologyvirologyhuman herpesvirusestwo-metal ion-dependent enzymesimmunologyepidemiology

Viral Nucleases From Herpesviruses and Coronavirus in Recombination and Proofreading: Potential Targets for Antiviral Drug Discovery. Viruses (2022)

Lee R. WrightDennis L. WrightSandra K. Weller

viral nucleasesantiviral drug discoverymedicinevirologyepidemiology

Novel Guanidine Compounds Inhibit Platelet‐Derived Growth Factor Receptor Alpha Transcription and Oligodendrocyte Precursor Cell Proliferation. Glia (2020)

Jelena MedvedWilliam M. WoodMichael D. van HeystAmin SherafatJu‐Young SongSagune SakyaDennis L. WrightAkiko Nishiyama

hepatologyneurologypharmacologymembrane biologygene expressionfunctional modificationnovel guanidine compoundsneurosciencecellular physiologycell regulationtumor biologycell signalingcatalyst activationinhibitory activity

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry. EMBO Molecular Medicine (2020)

Zdeněk DvořákFelix KoppCait M CostelloJazmin S KempHao LiAneta VrzalováMartina ŠtěpánkováIveta BartoňkováEva JiskrováKarolína PoulíkováBarbora VyhlídalováLars U NordstroemChamini V KarunaratneHarmit S RanhotraKyu Shik MunAnjaparavanda P NarenIain A MurrayGary H PerdewJulius BrtkoLucia ToporovaArne SchönBret D WallaceWilliam G WaltonMatthew R RedinboKatherine SunAmanda BeckSandhya KortagereMichelle C NearyAneesh ChandranSaraswathi VishveshwaraMaria M CavalluzziGiovanni LentiniJulia Yue CuiHaiwei GuJohn C MarchShirshendu ChatterjeeAdam MatsonDennis WrightKyle L FlanniganSimon A HirotaRyan Balfour SartorSridhar Mani

pharmacologypregnane x receptorczech republic searchdrug discoverydrug targetsbiological chemistrymechanisms of actionenzyme inhibitionbiochemistrydrug metabolismin vitro toxicologysecondary metabolitesmedicinal researchmolecular pharmacologychemical biologytherapeutic targets

Drugging the Folate Pathway in Mycobacterium Tuberculosis: The Role of Multi-Targeting Agents. Cell chemical biology (2019)

Behnoush HajianEric ScoccheraCarolyn ShoenJolanta KrucinskaKishore ViswanathanNarendran G-DayanandanHeidi ErlandsenAlexavier EstradaKatarína MikušováJana KordulákováMichael CynamonDennis Wright

mycobacterium tuberculosismedicinedrug targetingclinical researchcell biologybiomolecular interactionsmolecular and cellular biologymulti-targeting agentscell researchdrug developmentcellular biochemistrybiological targetspharmacologymedicinal chemistrymolecular cell biologyfolate pathwaybiological chemistrychemical biologycellular biologycell and molecular biologyclinical biochemistry

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Dennis Wright

Professor

University of Connecticut

Affiliations

College of Liberal Arts and Sciences

Chemistry

Dennis Wright is currently serving as a Chemistry Professor at University of Connecticut.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Dennis Wright

University of Connecticut

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Hmgb2 is a Potential Diagnostic Marker and Therapeutic Target for Liver Fibrosis and Cirrhosis. Hepatology Communications (2023)

Yi HuangSuthat LiangpunsakulSwetha RudraiahJing MaSantosh K. KeshipeddyDennis WrightAntonio CostaDiane BurgessYuxia ZhangNazmul HudaLi WangZhihong Yang

hepatologypharmacologypathologypotential diagnostic markerhealth sciencesmolecular diagnosticsoncologyliver fibrosishematology

Incorporation of 53Bp1 Into Phase-Separated Bodies in Cancer Cells During Aberrant Mitosis. Journal of Cell Science (2023)

Marina BleilerAiyana CyrDennis L. WrightCharles Giardina

geneticscancer biologyaberrant mitosisstructural biologyphase-separated bodiescell biology

Chiral Evasion and Stereospecific Antifolate Resistance in Staphylococcus Aureus. PLoS Computational Biology (2022)

Siyu WangStephanie M. ReeveGraham T. HoltAdegoke A. OjewoleMarcel S. FrenkelPablo GainzaSantosh KeshipeddyVance G. FowlerDennis L. WrightBruce R. Donald

pharmacologymicrobiologystaphylococcus aureuscomputational biologyimmunologystereospecific antifolate resistancechiral evasionclinical microbiology

Structure-Guided Functional Studies of Plasmid-Encoded Dihydrofolate Reductases Reveal a Common Mechanism of Trimethoprim Resistance in Gram-Negative Pathogens. Communications Biology (2022)

Jolanta KrucinskaMichael N. LombardoHeidi ErlandsenAlexavier EstradaDebjani SiKishore ViswanathanDennis L. Wright

Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses. mBio (2022)

Katherine A. DiScipioSavithri WeerasooriyaRenata SzczepaniakAkram HazeenLee R. WrightDennis L. WrightSandra K. Weller

pharmacologyvirologyhuman herpesvirusestwo-metal ion-dependent enzymesimmunologyepidemiology

Viral Nucleases From Herpesviruses and Coronavirus in Recombination and Proofreading: Potential Targets for Antiviral Drug Discovery. Viruses (2022)

Lee R. WrightDennis L. WrightSandra K. Weller

viral nucleasesantiviral drug discoverymedicinevirologyepidemiology

Novel Guanidine Compounds Inhibit Platelet‐Derived Growth Factor Receptor Alpha Transcription and Oligodendrocyte Precursor Cell Proliferation. Glia (2020)

Jelena MedvedWilliam M. WoodMichael D. van HeystAmin SherafatJu‐Young SongSagune SakyaDennis L. WrightAkiko Nishiyama

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry. EMBO Molecular Medicine (2020)

Drugging the Folate Pathway in Mycobacterium Tuberculosis: The Role of Multi-Targeting Agents. Cell chemical biology (2019)

Behnoush HajianEric ScoccheraCarolyn ShoenJolanta KrucinskaKishore ViswanathanNarendran G-DayanandanHeidi ErlandsenAlexavier EstradaKatarína MikušováJana KordulákováMichael CynamonDennis Wright

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future medicinal chemistry

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