Faculty

Institution

Unit

Venue

Peter J. Tonge

Distinguished Professor

Stony Brook University

Affiliations

College of Arts & Sciences

Chemistry

Peter J. Tonge is currently serving as a Chemistry Distinguished Professor at Stony Brook University.

Honors

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Experiences

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Education

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Peter J. Tonge

Stony Brook University

Distinguished Professor

You can click a keyword to filter the displayed items

pharmacology biochemistry molecular biology enzymes protein science drug discovery medicinal chemistry biophysics enzyme inhibition structural biology biological chemistry spectroscopy tuberculosis enzyme catalysis chemical biology structural molecular biology clinical microbiology physical chemistry vibrational spectroscopy pharmaceutical chemistry protein chemistry biochemical sciences mycobacterium tuberculosis rational drug design biomolecular structure clinical chemistry molecular science molecular structure drug targeting molecular substrates green fluorescent protein chemical sciences pharmacotherapy raman spectroscopy plant science drug development protein synthesis infrared spectroscopy biological inorganic chemistry positron emission tomography enoyl-acp reductase clinical biochemistry pharmacokinetics microbial physiology enoyl-coa hydratase experimental biophysics pharmaceutical sciences structure-function enzyme kinetics photobiology inhibitory activity active site biological evaluation drug targets antimicrobial chemotherapy antibacterial agents enzyme specificity biocatalysis substrate recognition residence time natural product biosynthesis drug-target residence time enoyl reductase chemical biotechnology molecular docking genetically modified organisms biomolecular interactions molecular microbiology electronic excited states molecular catalysis bacteriology ultrafast vibrational spectroscopy slow-onset inhibition enzyme drug target drug-target kinetics structural basis excited-state proton transfer computational biology biomedical informatics pet imaging biological data molecular informatics system pharmacology systems biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Live Cell Bret Probe to Quantify Prmt5-Mta Uncompetitive Target Engagement. ChemRxiv (2025)

Elisabeth RothweilerAni MichaudJakub StefaniakUsha SinghJames VastaMichael BeckJennifer WardCatherine RogersEsra BalıkçıJeppe Tranberg-JensenJesper HansenPeter LoppnauPaul BrennanPeter TongeMatthew RobersKilian Huber

signal transductionlive cellmolecular biologytarget predictionbiomedical engineering

Biological Evaluation of D -[ 18 F]Fluoroalanine and D -[ 18 F]Fluoroalanine- D 3 as Positron Emission Tomography Imaging Tracers for Bacterial Infection. Journal of Medicinal Chemistry (2024)

Kaixuan LiJinnette Tolentino ColladoJocelyn A. MardenAlyssa C. PollardShuwen GuoPeter J. TongeWenchao Qu

biochemistrybiomolecular engineeringtoxinsprimary metabolitepharmacological researchmedicinal chemistrypharmacologytoxicologybiological evaluationexperimental pharmacologychemical biologyapplied pharmacologydrug discoverypharmaceutical chemistryenzyme inhibitionbioassay-guided isolationmedicinal researchtherapeutic targetsenzyme specificity

Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor Ytva: From Photoactivation to Downstream Regulation. ACS Chemical Biology (2024)

YongLe HeJinnette Tolentino ColladoJames N. IulianoHelena A. WoronieckaChristopher R. HallAgnieszka A. GilSergey P. LaptenokGregory M. GreethamBoris IllarionovAdelbert BacherMarkus FischerJarrod B. FrenchAndras LukacsStephen R. MeechPeter J. Tonge

pharmacologysignal transductionbiophysicssignal transduction mechanismmolecular biologyphotochemistryblue-light-regulated photoreceptor ytvachemical biology

Enhancing Proton-Coupled Electron Transfer in Blue Light Using Fad Photoreceptor Appa Bluf. Journal of the American Chemical Society (2024)

YongLe HeAgnieszka A. GilSergey P. LaptenokAnam FatimaJinnette Tolentino ColladoJames N. IulianoHelena A. WoronieckaRichard BrustAya SabbahMichael TowrieGregory M. GreethamIgor V. SazanovichJarrod B. FrenchAndras LukacsStephen R. MeechPeter J. Tonge

nanoparticle researchproton-coupled electron transferproton transferbiophysicsluminescencephotomedicineoptoelectronicsphotoreceptor cellslight absorptionmolecular biologybiomolecular engineeringphotonicsphotochemistrylight sciencebiophotonicsoptical propertiesexcitation energy transferblue light

Preclinical Positron Emission Tomography (Pet) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[ 18 F]F- P -Aminobenzoic Acid ([ 18 F]F-Paba). ACS Infectious Diseases (2024)

Alyssa C. Pollard-KerningKaixuan LiYong LiShin Hye AhnMingqian WangMelike AkogluEduardo BravoFrancesca DelloRussoHari K. AkulaWenchao QuLabros MeimetisDavid J. SchlyerDavid E. KomatsuPeter J. Tonge

molecular imagingorthopaedic researchmedical imagingneuroradiologyprosthetic joint infectionprosthesisclinical infectionpositron emission tomographypharmacologyspinal cord injurytransplant infectious diseasesinfectious diseasesbiomedical imagingbiological imagingjoint replacementlower extremity woundsbiomedical engineeringmedical optical imagingnuclear medicine

Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled L -Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection. Journal of Medicinal Chemistry (2024)

Kaixuan LiAlexa L. GilbertiJocelyn A. MardenHari K. AkulaAlyssa C. PollardShuwen GuoBao HuPeter J. TongeWenchao Qu

medicinal chemistrypharmacologymolecular imagingbiological evaluationmedicinedrug discoverymolecular diagnosticspharmaceutical chemistrypharmaceutical sciencespositron emission tomographybiomedical imagingmedical imagingimaging agentdrug analysisanalytical chemistrychemistry

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

crystal diffraction studycrystal researchchemical structurebiophysicscrystal structuresccdc 2157502structural chemistrystructure determinationcrystal engineeringcrystallographystructure elucidationdeposited datasetchemistry

Discovery of Novel Bruton’s Tyrosine Kinase Protacs With Enhanced Selectivity and Cellular Efficacy. Journal of Medicinal Chemistry (2023)

Yi-Qian LiWilliam G. LanniganShabnam DavoodiFereidoon DaryaeeAna CorrioneroPatricia AlfonsoJose A. Rodriguez-SantamariaNan WangJohn D. HaleyPeter J. Tonge

medicinal chemistrypharmacologymedicinedrug discoverytyrosine kinase protacspharmaceutical chemistrypharmaceutical sciencesenzyme inhibitioncellular efficacytranslational medicinenovel brutonenhanced selectivity

Elucidating Signal Transduction Pathway in Light-Activated Adenylyl Cyclase Using Unnatural Amino Acid Mutagenesis. Biophysical Journal (2023)

Samruddhi S. JewlikarJinnette TolentinoMadeeha AliPeter J. Tonge

biophysical chemistrymembrane biologysignal transductionbiophysicsneurosciencebiochemistrysignal transduction pathwaylight-activated adenylyl cyclaseenzymesprotein sciencemolecular biophysics

Evaluating the Impact of the Tyr158 P K a on the Mechanism and Inhibition of Inha, the Enoyl-Acp Reductase From Mycobacterium Tuberculosis. Biochemistry (2023)

Shabnam DavoodiFereidoon DaryaeeJames N. IulianoJinnette Tolentino ColladoYongLe HeAlyssa C. PollardAgnieszka A. GilJames M. AraminiPeter J. Tonge

enzymatic modificationbiochemistryprotein scienceinhibitory activitymicrobiologystructure-function enzyme kineticsbacteriaenoyl-acp reductasepharmacologytuberculosisreceptorsmicrobial pathogenesisbiological chemistryredox biologyenzymesantibacterial agentsapplied microbiologyenzyme inhibitionenzyme specificity

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Peter J. Tonge

Distinguished Professor

Stony Brook University

Affiliations

College of Arts & Sciences

Chemistry

Peter J. Tonge is currently serving as a Chemistry Distinguished Professor at Stony Brook University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Peter J. Tonge

Stony Brook University

Distinguished Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Live Cell Bret Probe to Quantify Prmt5-Mta Uncompetitive Target Engagement. ChemRxiv (2025)

signal transductionlive cellmolecular biologytarget predictionbiomedical engineering

Biological Evaluation of D -[ 18 F]Fluoroalanine and D -[ 18 F]Fluoroalanine- D 3 as Positron Emission Tomography Imaging Tracers for Bacterial Infection. Journal of Medicinal Chemistry (2024)

Kaixuan LiJinnette Tolentino ColladoJocelyn A. MardenAlyssa C. PollardShuwen GuoPeter J. TongeWenchao Qu

Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor Ytva: From Photoactivation to Downstream Regulation. ACS Chemical Biology (2024)

pharmacologysignal transductionbiophysicssignal transduction mechanismmolecular biologyphotochemistryblue-light-regulated photoreceptor ytvachemical biology

Enhancing Proton-Coupled Electron Transfer in Blue Light Using Fad Photoreceptor Appa Bluf. Journal of the American Chemical Society (2024)

Preclinical Positron Emission Tomography (Pet) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[ 18 F]F- P -Aminobenzoic Acid ([ 18 F]F-Paba). ACS Infectious Diseases (2024)

Alyssa C. Pollard-KerningKaixuan LiYong LiShin Hye AhnMingqian WangMelike AkogluEduardo BravoFrancesca DelloRussoHari K. AkulaWenchao QuLabros MeimetisDavid J. SchlyerDavid E. KomatsuPeter J. Tonge

Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled L -Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection. Journal of Medicinal Chemistry (2024)

Kaixuan LiAlexa L. GilbertiJocelyn A. MardenHari K. AkulaAlyssa C. PollardShuwen GuoBao HuPeter J. TongeWenchao Qu

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Discovery of Novel Bruton’s Tyrosine Kinase Protacs With Enhanced Selectivity and Cellular Efficacy. Journal of Medicinal Chemistry (2023)

Yi-Qian LiWilliam G. LanniganShabnam DavoodiFereidoon DaryaeeAna CorrioneroPatricia AlfonsoJose A. Rodriguez-SantamariaNan WangJohn D. HaleyPeter J. Tonge

Elucidating Signal Transduction Pathway in Light-Activated Adenylyl Cyclase Using Unnatural Amino Acid Mutagenesis. Biophysical Journal (2023)

Samruddhi S. JewlikarJinnette TolentinoMadeeha AliPeter J. Tonge

biophysical chemistrymembrane biologysignal transductionbiophysicsneurosciencebiochemistrysignal transduction pathwaylight-activated adenylyl cyclaseenzymesprotein sciencemolecular biophysics

Evaluating the Impact of the Tyr158 P K a on the Mechanism and Inhibition of Inha, the Enoyl-Acp Reductase From Mycobacterium Tuberculosis. Biochemistry (2023)

Shabnam DavoodiFereidoon DaryaeeJames N. IulianoJinnette Tolentino ColladoYongLe HeAlyssa C. PollardAgnieszka A. GilJames M. AraminiPeter J. Tonge

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