Faculty

Institution

Unit

Venue

Timothy Wencewicz

Associate Professor of Chemistry Director of Graduate Studies in Chemistry

Washington University in St. Louis

Affiliations

Arts & Sciences

Chemistry

Timothy Wencewicz is currently serving as an Arts & Sciences Associate Professor of Chemistry Director of Graduate Studies in Chemistry at Washington University In St. Louis.

Honors

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Experiences

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Education

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Timothy Wencewicz

Washington University in St. Louis

Associate Professor of Chemistry Director of Graduate Studies in Chemistry

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pharmacology biochemistry microbiology antimicrobial agents clinical microbiology enzymes molecular biology medicinal chemistry enzyme inhibition drug discovery biosynthesis chemical biology antibiotic resistance bacteriology antimicrobial compounds applied microbiology biological chemistry protein science antimicrobial chemotherapy enzyme catalysis microbial pathogenesis structural biology pharmaceutical chemistry structural molecular biology infection control natural product research biochemical sciences molecular microbiology pathogens peptides biomolecular structure natural product biosynthesis antimicrobial resistance genes future medicinal chemistry structural basis biocatalysis natural product synthesis redox biology drug targeting drug development structure-function enzyme kinetics environmental microbiology protein chemistry tetracycline-inactivating enzymes microbial physiology mechanisms of action nonribosomal peptide synthetase human commensal tetracycline resistance enzymes structural composition catalytic synthesis disease transmission infectious disease modelling chemical biotechnology enzyme specificity molecule-centered perspective novel family broad-spectrum tetracycline resistance trihydroxamate siderophore-fluoroquinolone conjugates drug release antimicrobial activity siderophore-drug conjugates molecular science single molecule biophysics biological inorganic chemistry veterinary microbiology clinical infection emerging infectious diseases immobilized enzymes biomolecular interactions molecular diversity host specificity biosynthetic pathways versatile catalysts synthetic desferridanoxamine-antibiotic conjugates biological studies organic chemistry biomolecular engineering bioorganic chemistry organic synthesis rational drug design drug delivery diversity oriented synthesis

Notable Scholarly Works

Notable Federal Grants

Collaborators

3-Hydroxy-Beta-Lactam Inhibitors of Dihydrofolate Synthetase. ACS Bio & Med Chem Au (2025)

enzymesmolecular metabolismpharmaceutical chemistrydrug developmentmedicinal chemistrydihydrofolate synthetasebiosynthesisbiochemistrypharmacologyfuture medicinal chemistrynatural product researchenzyme inhibitiondrug discovery

C10-Benzoate Esters of Anhydrotetracycline Inhibit Tetracycline Destructases and Recover Tetracycline Antibacterial Activity. ACS Infectious Diseases (2025)

Emily E. WillifordYao-Peng XueWai Kwan TangRuihao LiKatherine V. JonesKevin S. BlakeHelen C. BlaineXiang LianChristina L. StallingsNiraj H. ToliaGautam DantasTimothy A. Wencewicz

microbiologyantibiotic resistanceantimicrobial agentsinfection controlantimicrobial compoundsinfectious diseasesdrug resistancemedicinal chemistryantimicrobial chemotherapyclinical microbiologyantibioticspharmacologyinfectious respiratory diseaseantimicrobial resistancepathogenesisinhibitory activitytetracycline antibacterial activity

Chemical Logic of Peptide Branching by Iterative Nonlinear Nonribosomal Peptide Synthetases. Biochemistry (2025)

enzymesbioconjugationchemical biologypeptide branchingpeptide synthesispeptide sciencebiochemistrychemical logicmolecular biologypeptides

Covalent Irreversible Inhibitors of Tetracycline Destructases. ACS Infectious Diseases (2025)

pharmaceutical chemistrychemical biologymedicinal chemistrycheminformaticscombinatorial chemistrytetracycline destructaseschemical sciencesbiochemistryenzyme inhibitiondrug discovery

Expanding the Landscape of Dual Action Antifolate Antibacterials Through 2,4-Diamino-1,6-Dihydro-1,3,5-Triazines. ACS Infectious Diseases (2025)

microbiologyheterocycle chemistryantimicrobial agentsantimicrobial compoundsantimicrobial chemotherapymedicinal chemistrybioorganic chemistryantibioticspharmacologyfuture medicinal chemistryantibacterial agentsantimicrobial resistanceenzyme inhibitionorganic chemistry frontier

Impact of Biocontainment on Small Animal Pet Performance Adapted for Bsl-2/3 Infectious Disease Imaging Research. EJNMMI Research (2025)

biomedical imagingveterinary diagnosticsveterinary medicinebsl-2/3 infectious diseaseinfectious diseasesbiological imagingveterinary scienceanimal bioscienceinfectious diseases (medical specialty)pet-mrismall animal internal medicinepositron emission tomographyradiologyclinical researchmedical imaging

The Tetracycline Resistome is Shaped by Selection for Specific Resistance Mechanisms by Each Antibiotic Generation. Nature Communications (2025)

microbiologyantibiotic resistancetetracycline resistomeantimicrobial agentsantimicrobial resistance genesantimicrobial chemotherapydrug resistancespecific resistance mechanismsantibiotic generationantibioticspharmacologyfuture medicinal chemistryantimicrobial resistance

Expanding the Substrate Selectivity of the Fimsbactin Biosynthetic Adenylation Domain, Fbsh. ACS Chemical Biology (2024)

Syed Fardin AhmedAdam BalutowskiJinping YangTimothy A. WencewiczAndrew M. Gulick

biosynthesischemical biologybiochemistrysubstrate selectivity

Sequence-Structure-Function Characterization of the Emerging Tetracycline Destructase Family of Antibiotic Resistance Enzymes. Communications Biology (2024)

Kevin S. BlakeHirdesh KumarAnisha LoganathanEmily E. WillifordLuke Diorio-TothYao-Peng XueWai Kwan TangTayte P. CampbellDavid D. ChongSteven AngtuacoTimothy A. WencewiczNiraj H. ToliaGautam Dantas

microbiologyantibiotic resistanceenzymesmicrobial ecologytetracycline destructase familyclinical microbiologysequence-structure-function characterizationpharmacologyantibiotic resistance enzymesmolecular biology

Siderophore-Dependent Ferrichelatases. Methods in enzymology on CD-ROM/Methods in enzymology (2024)

C E MerrickN M GulatiT A Wencewicz

geneticsenzymescellular enzymologyprotein sciencestructural biologyprotein engineeringbiochemistrymembrane biologymolecular biological methodsiderophore-dependent ferrichelatasesenzymatic modificationmolecular biologynanotechnology

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Timothy Wencewicz

Associate Professor of Chemistry Director of Graduate Studies in Chemistry

Washington University in St. Louis

Affiliations

Arts & Sciences

Chemistry

Timothy Wencewicz is currently serving as an Arts & Sciences Associate Professor of Chemistry Director of Graduate Studies in Chemistry at Washington University In St. Louis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Timothy Wencewicz

Washington University in St. Louis

Associate Professor of Chemistry Director of Graduate Studies in Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

3-Hydroxy-Beta-Lactam Inhibitors of Dihydrofolate Synthetase. ACS Bio & Med Chem Au (2025)

C10-Benzoate Esters of Anhydrotetracycline Inhibit Tetracycline Destructases and Recover Tetracycline Antibacterial Activity. ACS Infectious Diseases (2025)

Emily E. WillifordYao-Peng XueWai Kwan TangRuihao LiKatherine V. JonesKevin S. BlakeHelen C. BlaineXiang LianChristina L. StallingsNiraj H. ToliaGautam DantasTimothy A. Wencewicz

Chemical Logic of Peptide Branching by Iterative Nonlinear Nonribosomal Peptide Synthetases. Biochemistry (2025)

enzymesbioconjugationchemical biologypeptide branchingpeptide synthesispeptide sciencebiochemistrychemical logicmolecular biologypeptides

Covalent Irreversible Inhibitors of Tetracycline Destructases. ACS Infectious Diseases (2025)

pharmaceutical chemistrychemical biologymedicinal chemistrycheminformaticscombinatorial chemistrytetracycline destructaseschemical sciencesbiochemistryenzyme inhibitiondrug discovery

Expanding the Landscape of Dual Action Antifolate Antibacterials Through 2,4-Diamino-1,6-Dihydro-1,3,5-Triazines. ACS Infectious Diseases (2025)

Impact of Biocontainment on Small Animal Pet Performance Adapted for Bsl-2/3 Infectious Disease Imaging Research. EJNMMI Research (2025)

The Tetracycline Resistome is Shaped by Selection for Specific Resistance Mechanisms by Each Antibiotic Generation. Nature Communications (2025)

Expanding the Substrate Selectivity of the Fimsbactin Biosynthetic Adenylation Domain, Fbsh. ACS Chemical Biology (2024)

Syed Fardin AhmedAdam BalutowskiJinping YangTimothy A. WencewiczAndrew M. Gulick

biosynthesischemical biologybiochemistrysubstrate selectivity

Sequence-Structure-Function Characterization of the Emerging Tetracycline Destructase Family of Antibiotic Resistance Enzymes. Communications Biology (2024)

Kevin S. BlakeHirdesh KumarAnisha LoganathanEmily E. WillifordLuke Diorio-TothYao-Peng XueWai Kwan TangTayte P. CampbellDavid D. ChongSteven AngtuacoTimothy A. WencewiczNiraj H. ToliaGautam Dantas

Siderophore-Dependent Ferrichelatases. Methods in enzymology on CD-ROM/Methods in enzymology (2024)

C E MerrickN M GulatiT A Wencewicz

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10 / page

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protein structure

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