Faculty

Institution

Unit

Venue

Craig A. Townsend

Alsoph H Corwin Professor

Johns Hopkins University

Affiliations

Natural Sciences

Chemistry-Biology Interface Program

Department of Biology

Department of Biophysics

Department of Chemistry

Program in Cell, Molecular, Development Biology, and Biophysics

Program in Molecular Biophysics

Krieger School of Arts and Sciences

Natural Sciences

School of Medicine

Pharmacology & Molecular Sciences

Craig A. Townsend is currently serving as a Chemistry-Biology Interface Program Alsoph H Corwin Professor at Johns Hopkins University.

Honors

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Experiences

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Education

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Craig A. Townsend

Johns Hopkins University

Alsoph H Corwin Professor

You can click a keyword to filter the displayed items

biochemistry molecular biology enzymes pharmacology biosynthesis chemistry protein science biological chemistry chemical biology medicinal chemistry organic synthesis biotechnology redox biology biochemical sciences synthetic biology natural product biosynthesis biocatalysis membrane biology enzyme catalysis molecular science aflatoxin biosynthesis enzyme inhibition chemical sciences protein biosynthesis structural molecular biology protein synthesis protein chemistry natural product research clinical microbiology chemical biotechnology transition metal chemistry biological inorganic chemistry clavaminate synthase free radical biology fungal biology pharmaceutical chemistry biomolecular structure microbial genetics synthetic chemistry applied microbiology coordination chemistry structure-function enzyme kinetics bacteriology molecular microbiology protein expression natural product synthesis b-lactam synthetase clavulanic acid clavulanic acid biosynthesis molecular catalysis catalytic synthesis functional modification phytochemistry medical microbiology enzyme specificity carbapenem biosynthesis molecular physiology molecular substrates asymmetric catalysis applied chemistry cancer biology aspergillus parasiticus carbapenam synthetase biomolecular structure prediction industrial mycology microbial physiology radical (chemistry) biochemical genetics food intake streptomyces clavuligerus b-lactam formation polyketide synthase dna cleavage fatty acid synthase body weight non-ribosomal peptide synthetase

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Dababc Operon is a Marker of C4-Alkylated Monobactam Biosynthesis and Responsible for (2S,3R)-Diaminobutyrate Production. iScience (2024)

Rongfeng LiMichael S. LichstrahlTrevor A. ZandiLukas KahlertCraig A. Townsend

dababc operonbiochemistrymolecular biologypharmacologybiosynthesis

The Structure of the Monobactam-Producing Thioesterase Domain of Sulm Forms a Unique Complex With the Upstream Carrier Protein Domain. Journal of Biological Chemistry (2024)

Ketan D. PatelRyan A. OliverMichael S. LichstrahlRongfeng LiCraig A. TownsendAndrew M. Gulick

biophysicsenzymesprotein chemistryprotein sciencebiomolecular structurebiochemistrymolecular biologybiological chemistryprotein structuremonobactam-producing thioesterase domainstructural biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicscrystal structurescrystal researchdeposited datasetstructural chemistryccdc 2157502crystal engineeringcrystallographystructure determinationstructure elucidationchemistrychemical structurecrystal diffraction study

Dynemicin a Derivatives as Potential Cancer Chemotherapeutics by Mutasynthesis. Helvetica Chimica Acta (2023)

Paramita PalJamie R. AlleyDouglas R. CohenCraig A. Townsend

medicinal chemistrychemical derivativepharmacologymolecular biologymedicinederivative (chemistry)oncology

Examining Heterodimerization by Aryl C–N Coupling in Dynemicin Biosynthesis. ACS Chemical Biology (2023)

Paramita PalJamie R. AlleyCraig A. Townsend

dynemicin biosynthesisbiochemistrychemical biologychemistrymolecular biologybiological chemistryaryl c-n couplingbiosynthesis

Normal and Aberrant Methyltransferase Activities Give Insights Into the Final Steps of Dynemicin a Biosynthesis. Journal of the American Chemical Society (2023)

Paramita PalSerena M. L. WesselyCraig A. Townsend

molecular and cellular biologynatural product biosynthesisstructural molecular biologybiosynthesisenzymescell biologymolecular sciencechemical biologyprotein synthesismolecular biologyprotein biosynthesisbiocatalysisbiochemistryenzyme specificityaberrant methyltransferase activitiesprotein sciencemembrane biologybiochemical sciencesredox biology

Synthesis of Functionalized 2,3-Diaminopropionates and Their Potential for Directed Monobactam Biosynthesis. Chemical Science (2023)

Michael S. LichstrahlLukas KahlertRongfeng LiTrevor A. ZandiJerry YangCraig. A. Townsend

chemical scienceschemical engineeringsynthetic biologypeptide synthesismedicinal chemistrychemical synthesischemistrynatural product synthesisdrug discoverydirected monobactam biosynthesischemical biotechnologylipid synthesisbiomolecular engineeringorganic synthesis

Targeted Discovery of Cryptic Enediyne Natural Products via Fret-Coupled High-Throughput Elicitor Screening. ACS Chemical Biology (2023)

Esther J. HanSeoung Rak LeeCraig A. TownsendMohammad R. Seyedsayamdost

elicitation techniquehigh-throughput screeningnatural product researchtechnologysynthetic biologymedicinal chemistrychemical biologymolecular biologydrug discoverybiomolecular engineering

Accurate Substrate-Like Probes for Trapping Late-Stage Intermediates in Nonribosomal Peptide Synthetase Condensation Domains. ACS Chemical Biology (2022)

Michael J. WheadonCraig A. Townsend

biological engineeringaccurate substrate-like probeslate-stage intermediatesmolecular biologybiomolecular engineeringstructural biology

Colorimetric Determination of Adenylation Domain Activity in Nonribosomal Peptide Synthetases by Using Chrome Azurol S. ChemBioChem (2022)

Lukas KahlertMichael S. LichstrahlCraig A. Townsend

biological engineeringenzymescolorimetric determinationadenylation domain activitypharmacologynonribosomal peptide synthetasesbiomolecular engineering

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Craig A. Townsend

Alsoph H Corwin Professor

Johns Hopkins University

Affiliations

Natural Sciences

Chemistry-Biology Interface Program

Department of Biology

Department of Biophysics

Department of Chemistry

Program in Cell, Molecular, Development Biology, and Biophysics

Program in Molecular Biophysics

Krieger School of Arts and Sciences

Natural Sciences

School of Medicine

Pharmacology & Molecular Sciences

Craig A. Townsend is currently serving as a Chemistry-Biology Interface Program Alsoph H Corwin Professor at Johns Hopkins University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Craig A. Townsend

Johns Hopkins University

Alsoph H Corwin Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Dababc Operon is a Marker of C4-Alkylated Monobactam Biosynthesis and Responsible for (2S,3R)-Diaminobutyrate Production. iScience (2024)

Rongfeng LiMichael S. LichstrahlTrevor A. ZandiLukas KahlertCraig A. Townsend

dababc operonbiochemistrymolecular biologypharmacologybiosynthesis

The Structure of the Monobactam-Producing Thioesterase Domain of Sulm Forms a Unique Complex With the Upstream Carrier Protein Domain. Journal of Biological Chemistry (2024)

Ketan D. PatelRyan A. OliverMichael S. LichstrahlRongfeng LiCraig A. TownsendAndrew M. Gulick

biophysicsenzymesprotein chemistryprotein sciencebiomolecular structurebiochemistrymolecular biologybiological chemistryprotein structuremonobactam-producing thioesterase domainstructural biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Dynemicin a Derivatives as Potential Cancer Chemotherapeutics by Mutasynthesis. Helvetica Chimica Acta (2023)

Paramita PalJamie R. AlleyDouglas R. CohenCraig A. Townsend

medicinal chemistrychemical derivativepharmacologymolecular biologymedicinederivative (chemistry)oncology

Examining Heterodimerization by Aryl C–N Coupling in Dynemicin Biosynthesis. ACS Chemical Biology (2023)

Paramita PalJamie R. AlleyCraig A. Townsend

dynemicin biosynthesisbiochemistrychemical biologychemistrymolecular biologybiological chemistryaryl c-n couplingbiosynthesis

Normal and Aberrant Methyltransferase Activities Give Insights Into the Final Steps of Dynemicin a Biosynthesis. Journal of the American Chemical Society (2023)

Paramita PalSerena M. L. WesselyCraig A. Townsend

Synthesis of Functionalized 2,3-Diaminopropionates and Their Potential for Directed Monobactam Biosynthesis. Chemical Science (2023)

Michael S. LichstrahlLukas KahlertRongfeng LiTrevor A. ZandiJerry YangCraig. A. Townsend

Targeted Discovery of Cryptic Enediyne Natural Products via Fret-Coupled High-Throughput Elicitor Screening. ACS Chemical Biology (2023)

Esther J. HanSeoung Rak LeeCraig A. TownsendMohammad R. Seyedsayamdost

elicitation techniquehigh-throughput screeningnatural product researchtechnologysynthetic biologymedicinal chemistrychemical biologymolecular biologydrug discoverybiomolecular engineering

Accurate Substrate-Like Probes for Trapping Late-Stage Intermediates in Nonribosomal Peptide Synthetase Condensation Domains. ACS Chemical Biology (2022)

Michael J. WheadonCraig A. Townsend

biological engineeringaccurate substrate-like probeslate-stage intermediatesmolecular biologybiomolecular engineeringstructural biology

Colorimetric Determination of Adenylation Domain Activity in Nonribosomal Peptide Synthetases by Using Chrome Azurol S. ChemBioChem (2022)

Lukas KahlertMichael S. LichstrahlCraig A. Townsend

biological engineeringenzymescolorimetric determinationadenylation domain activitypharmacologynonribosomal peptide synthetasesbiomolecular engineering

1
2
3
4
5
28
10 / page