Faculty

Institution

Unit

Venue

Vern Schramm

Professor

Albert Einstein College of Medicine

Affiliations

Department of Biochemistry

Marion Bessin Liver Research Center

Vern Schramm is currently serving as a Biochemistry Professor at Albert Einstein College of Medicine.

Honors

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Experiences

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Education

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Vern Schramm

Albert Einstein College of Medicine

Professor

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biochemistry molecular biology enzymes protein science enzyme inhibition chemical biology structural biology structural molecular biology enzyme catalysis biomolecular engineering biophysics biological chemistry protein structure medicinal chemistry protein phosphorylation nucleic acids biomolecular structure structure-function enzyme kinetics biophysical chemistry drug discovery membrane biology transition metal chemistry biocatalysis biological macromolecules nucleic acid chemistry redox biology enzymatic modification peptide science protein chemistry inhibitory activity pharmaceutical chemistry purine nucleoside phosphorylase biochemical sciences molecular metabolism molecular science human purine transition state analogues medicinal research transition state biomolecules cell metabolism transition state structure amp nucleosidase cellular enzymology catalyst activation protein biosynthesis molecular catalysis protein synthesis biological inorganic chemistry enzyme specificity transition states isotope effects transition-state analysis bioelectrochemistry glycosylation rna biology transition state analogue transition-state structure transition state analysis kinetic isotope effects protein assembly biomolecular analysis yeast molecular substrates biochemical interaction residual stress mechanisms of action metabolic regulation enzymatic transition states plasmodium falciparum remedial action single molecule biophysics pharmacokinetics reactive oxygen species key site transition-state analogs protein dynamics protein modeling

Notable Scholarly Works

Notable Federal Grants

Collaborators

Transition State Analogs of Human Dnph1 Reveal Two Electrophile Migration Mechanisms. Journal of Medicinal Chemistry (2025)

Andrew G. WagnerThomas B. D. LangEdward T. LedinghamAgnidipta GhoshDonovan BrooksRoozbeh EskandariKajitha SuthagarSteven C. AlmoFarah Lamiable-OulaidiPeter C. TylerVern L. Schramm

medicinal chemistryelectrophile migration mechanismssystems biologytransition state analogsmolecular biology

Transition State Analysis of Samhd1 From Primary 18 O, 33 P, and Solvent Kinetic Isotope Effects. Journal of the American Chemical Society (2025)

Ananda K. GhoshDaniel P. GroomVern L. Schramm

transition state analysischemical scienceschemistry

Isofagomine Inhibits Multiple Tcdb Variants and Protects Mice From Clostridioides Difficile -Induced Mortality. ACS Infectious Diseases (2024)

Ashleigh S. PaparellaIsabella BrewHuynh A. HongWilliam FerrieraSimon CuttingFarah Lamiable-OulaidiMichael PopadynecPeter C. TylerVern L. Schramm

public healthpathogensinfection controldrug resistanceinfectious diseasesmicrobiologyemerging infectious diseases

An Enzyme-Coupled Microplate Assay for Activity and Inhibition of Hmdump Hydrolysis by Dnph1. Analytical Biochemistry (2023)

Andrew G WagnerRoozbeh EskandariVern L Schramm

enzyme inhibitionbiochemical engineeringenzyme-coupled microplate assayenzymesanalytical chemistryinhibitory activityhmdump hydrolysisbiochemistry

Cell-Effective Transition-State Analogue of Phenylethanolamine N -Methyltransferase. Biochemistry (2023)

Niusha MahmoodiYacoba V. T. MinnowRajesh K. HarijanGabriel T. BedardVern L. Schramm

biological macromoleculesbioorganic chemistryinhibitory activitycatalyst activationcell biologymembrane biologybiosynthesiscell metabolismfunctional modificationbiological engineeringglycobiologygene expressionenzyme inhibitionfree radical biologycell-effective transition-state analogueconformational studiesmolecular biologystructural molecular biologyenzymatic modification

Combined Inhibition of Mtap and Mat2A Mimics Synthetic Lethality in Tumor Models via Prmt5 Inhibition. Journal of Biological Chemistry (2023)

Gabriel T. BedardNord GilajKarina PeregrinaIsabella BrewElena TostiKarl ShafferPeter C. TylerWinfried EdelmannLeonard H. AugenlichtVern L. Schramm

tumor modelsbiomedical engineeringinhibitory activitymolecular biologybiological chemistrytumor biologysynthetic biologybiochemistry

Decreased Transition-State Analogue Affinity in Isotopically Heavy Mtan With Increased Catalysis. Biochemistry (2023)

Morais BrownVern L. Schramm

catalysistransition-state analogue affinityheavy mtanincreased catalysisbiochemistry

Mat Gain of Activity Mutation in Helicobacter Pylori is Associated With Resistance to Mtan Transition State Analogues. ACS Infectious Diseases (2023)

Mu FengHilda Namanja-MaglianoSaranathan RajagopalanTanmay MishraRodrigo G. DucatiBrett M. HirschLibusha KellyWendy SzymczakJorge Eduardo FajardoSimone SidoliAndras FiserWilliam R. JacobsVern L. Schramm

pathogensactivity mutationantimicrobial resistancemicrobial pathogenesisdrug resistancepathogenic bacteriaresistance mutation (virology)molecular biologyinfectious diseasestransition state analoguesmicrobiology

Phosphate Binding in Pnp Alters Transition-State Analogue Affinity and Subunit Cooperativity. Biochemistry (2023)

Yacoba V. T. MinnowVern L. SchrammSteven C. AlmoAgnidipta Ghosh

protein chemistrysubunit cooperativityprotein structuremolecular biologyphosphate bindingprotein sciencebiochemistry

Phosphoinositide and Redox Dysregulation by the Anticancer Methylthioadenosine Phosphorylase Transition State Inhibitor. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (2023)

Timothy SalitaYepy H. RustamVinzenz HofferekMichael JacksonIsaac TollestrupJeffrey P. SheridanVern L. SchrammGary B. EvansGavin E. ReidAndrew B. Munkacsi

biophysicsenzyme inhibitionlipidsredox biologymolecular and cellular biologyredox dysregulationenzymesmolecular biologybiochemistry

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Vern Schramm

Professor

Albert Einstein College of Medicine

Affiliations

Department of Biochemistry

Marion Bessin Liver Research Center

Vern Schramm is currently serving as a Biochemistry Professor at Albert Einstein College of Medicine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Vern Schramm

Albert Einstein College of Medicine

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Transition State Analogs of Human Dnph1 Reveal Two Electrophile Migration Mechanisms. Journal of Medicinal Chemistry (2025)

Andrew G. WagnerThomas B. D. LangEdward T. LedinghamAgnidipta GhoshDonovan BrooksRoozbeh EskandariKajitha SuthagarSteven C. AlmoFarah Lamiable-OulaidiPeter C. TylerVern L. Schramm

medicinal chemistryelectrophile migration mechanismssystems biologytransition state analogsmolecular biology

Transition State Analysis of Samhd1 From Primary 18 O, 33 P, and Solvent Kinetic Isotope Effects. Journal of the American Chemical Society (2025)

Ananda K. GhoshDaniel P. GroomVern L. Schramm

transition state analysischemical scienceschemistry

Isofagomine Inhibits Multiple Tcdb Variants and Protects Mice From Clostridioides Difficile -Induced Mortality. ACS Infectious Diseases (2024)

Ashleigh S. PaparellaIsabella BrewHuynh A. HongWilliam FerrieraSimon CuttingFarah Lamiable-OulaidiMichael PopadynecPeter C. TylerVern L. Schramm

public healthpathogensinfection controldrug resistanceinfectious diseasesmicrobiologyemerging infectious diseases

An Enzyme-Coupled Microplate Assay for Activity and Inhibition of Hmdump Hydrolysis by Dnph1. Analytical Biochemistry (2023)

Andrew G WagnerRoozbeh EskandariVern L Schramm

enzyme inhibitionbiochemical engineeringenzyme-coupled microplate assayenzymesanalytical chemistryinhibitory activityhmdump hydrolysisbiochemistry

Cell-Effective Transition-State Analogue of Phenylethanolamine N -Methyltransferase. Biochemistry (2023)

Niusha MahmoodiYacoba V. T. MinnowRajesh K. HarijanGabriel T. BedardVern L. Schramm

Combined Inhibition of Mtap and Mat2A Mimics Synthetic Lethality in Tumor Models via Prmt5 Inhibition. Journal of Biological Chemistry (2023)

Gabriel T. BedardNord GilajKarina PeregrinaIsabella BrewElena TostiKarl ShafferPeter C. TylerWinfried EdelmannLeonard H. AugenlichtVern L. Schramm

tumor modelsbiomedical engineeringinhibitory activitymolecular biologybiological chemistrytumor biologysynthetic biologybiochemistry

Decreased Transition-State Analogue Affinity in Isotopically Heavy Mtan With Increased Catalysis. Biochemistry (2023)

Morais BrownVern L. Schramm

catalysistransition-state analogue affinityheavy mtanincreased catalysisbiochemistry

Mat Gain of Activity Mutation in Helicobacter Pylori is Associated With Resistance to Mtan Transition State Analogues. ACS Infectious Diseases (2023)

Phosphate Binding in Pnp Alters Transition-State Analogue Affinity and Subunit Cooperativity. Biochemistry (2023)

Yacoba V. T. MinnowVern L. SchrammSteven C. AlmoAgnidipta Ghosh

protein chemistrysubunit cooperativityprotein structuremolecular biologyphosphate bindingprotein sciencebiochemistry

Timothy SalitaYepy H. RustamVinzenz HofferekMichael JacksonIsaac TollestrupJeffrey P. SheridanVern L. SchrammGary B. EvansGavin E. ReidAndrew B. Munkacsi

biophysicsenzyme inhibitionlipidsredox biologymolecular and cellular biologyredox dysregulationenzymesmolecular biologybiochemistry

1
2
3
4
5
36
10 / page

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