Faculty

Institution

Unit

Venue

Neil Osheroff

Professor

Vanderbilt University

Affiliations

School of Medicine

Department of Biochemistry

Neil Osheroff is currently serving as a Biochemistry Professor at Vanderbilt University.

Honors

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Experiences

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Education

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Neil Osheroff

Vanderbilt University

Professor

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molecular biology biochemistry pharmacology enzyme inhibition enzymes biological chemistry nucleic acids genetics drug discovery structural biology medicinal chemistry structural molecular biology protein science medicinal research molecular cell biology topoisomerase ii epigenetics oncology cancer research human topoisomerase iia molecular cancer dna cleavage nucleic acid chemistry tumor biology genome biology anti-cancer agents redox biology cancer biology biochemical sciences leukemia pharmacological research clinical microbiology cancer treatment hematological malignancies eukaryotic topoisomerase ii enzyme specificity experimental toxicology topoisomerase iv pharmacotherapy drug targeting cancer genetics dna topoisomerase ii insect molecular biology cancer genomics biomolecular interactions molecular microbiology pharmaceutical chemistry enzyme catalysis protein phosphorylation yeast biological inorganic chemistry molecular regulation biochemical genetics tumor targeting viral genetics mechanisms of action rna biology biocatalysis apoptosis drug development cell regulation enzyme-mediated dna cleavage dna topoisomerases dna cleavage reaction type ii cytogenetics inhibitory activity topoisomerase iia quinolone action casein kinase ii antineoplastic drugs water-metal ion bridge molecular evidence nucleic acid amplification functional modification eukaryotic topoisomerases cancer letter dna sequencing dna replication dna repair molecular diversity chromatin dna topology

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Anti-Mycobacterial Activity of Bacterial Topoisomerase Inhibitors With Dioxygenated Linkers. ACS Infectious Diseases (2025)

MJ Mitton-FryJE CummingsY LuJF ArmeniaJAW BylAA Oviatt...

antimicrobial agentsinfectious diseasesanti-mycobacterial activitybacterial topoisomerase inhibitorspathogenic bacteriamicrobiologyantimicrobial compoundsdioxygenated linkers

Bacterial Type II Topoisomerases Cleave Dna in a Species-Specific Manner. bioRxiv (Cold Spring Harbor Laboratory) (2025)

environmental dnamolecular microbiologymicroorganismsnucleic acidsmicrobiologybacteriamicrobial geneticsmolecular biologybacteriologybacterial type ii

Abstract 1657 Interactions of Established and Novel Antibacterials With Acinetobacter Baumannii Gyrase and Topoisomerase IV. Journal of Biological Chemistry (2024)

Samika JoshiJo Ann BylNeil Osheroff

clinical microbiologybacteriologyenzymesbiomolecular interactionsacinetobacter baumannii gyrasemicrobiologytopoisomerase ivmedicinepharmacologydrug discoveryherb-drug interactions

Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening. ACS Medicinal Chemistry Letters (2024)

Joshua W. PowellChelsea A. MannPaul D. TothSheri NolanAnja SteinertClarissa OveJustin T. SeffernickDaniel J. WozniakRazieh KebriaeiSteffen LindertNeil OsheroffJack C. YalowichMark J. Mitton-Fry

drug discoverycomputational screeningpharmacologymedicinal chemistry

Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance. ACS Infectious Diseases (2024)

Jessica A. CollinsNeil Osheroff

clinical microbiologydrug deliveryinfectious diseasesdrug targetingold targetsfluoroquinolone resistancemedicinal chemistrydrug resistanceclinical researchmedicinepharmacologydrug discoveryenzyme inhibitioninfection control

Interactions Between Gepotidacin and Escherichia Coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting. ACS Infectious Diseases (2024)

Alexandria A. OviattElizabeth G. GibsonJianzhong HuangKaren MatternKeir C. NeumanPan F. ChanNeil Osheroff

geneticsclinical microbiologyenzymesinfectious diseasesdisease transmissiongenomicsemerging infectious diseaseswell-balanced dual-targetinggene expressioninfection controlvirologybiochemical evidencebiochemistrytopoisomerase ivclinical infectionclinical infectious diseaseprotein sciencebiotechnologyenzyme inhibitionmolecular evidence

Interactions Between Zoliflodacin and Neisseria Gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting. ACS Infectious Diseases (2024)

Jessica A. CollinsGregory S. BasarabKelly ChibaleNeil Osheroff

intracellular traffickingbacteriaclinical microbiologyinfectious diseasesdisease transmissionpathogenesisenzymological basiscell biologypathogensemerging infectious diseasesinfection controltropical medicinecellular targetingpathogenic bacteriamicrobiologytopoisomerase ivcellular enzymologymicrobial pathogenesisenzymatic modificationantiviral researchenzyme inhibition

Target-Mediated Fluoroquinolone Resistance in Neisseria Gonorrhoeae: Actions of Ciprofloxacin Against Gyrase and Topoisomerase IV. ACS Infectious Diseases (2024)

Jessica A. CollinsAlexandria A. OviattPan F. ChanNeil Osheroff

clinical microbiologyclinical infectious diseasepathologyinfectious diseasesdrug resistanceemerging infectious diseasestopoisomerase ivpharmacologyclinical infectiontarget-mediated fluoroquinolone resistanceinfection controlmicrobial pathogenesis

Actions of a Novel Bacterial Topoisomerase Inhibitor Against Neisseria Gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded Dna Breaks. International Journal of Molecular Sciences (2023)

Soziema E. DaudaJessica A. CollinsJo Ann W. BylYanran LuJack C. YalowichMark J. Mitton-FryNeil Osheroff

clinical microbiologygenome editingvirologymolecular microbiologyimmunologymolecular medicineenzyme inhibitiondouble-stranded dna breakstopoisomerase ivpharmacologymolecular biologydna repairneisseria gonorrhoeae gyrase

A Series of Spiropyrimidinetriones That Enhances Dna Cleavage Mediated by Mycobacterium Tuberculosis Gyrase. ACS Infectious Diseases (2023)

Jo Ann W. BylRudolf MuellerBen BaxGregory S. BasarabKelly ChibaleNeil Osheroff

enzymatic modificationclinical microbiologyenzyme specificitystructural molecular biologyenzymesinfectious diseasestuberculosisdisease transmissionmolecular microbiologynucleic acid amplificationmicrobiologypharmacologygene expressionenzyme inhibitiondna cleavageinfection controlmicrobial pathogenesis

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Neil Osheroff

Professor

Vanderbilt University

Affiliations

School of Medicine

Department of Biochemistry

Neil Osheroff is currently serving as a Biochemistry Professor at Vanderbilt University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Neil Osheroff

Vanderbilt University

Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Anti-Mycobacterial Activity of Bacterial Topoisomerase Inhibitors With Dioxygenated Linkers. ACS Infectious Diseases (2025)

MJ Mitton-FryJE CummingsY LuJF ArmeniaJAW BylAA Oviatt...

antimicrobial agentsinfectious diseasesanti-mycobacterial activitybacterial topoisomerase inhibitorspathogenic bacteriamicrobiologyantimicrobial compoundsdioxygenated linkers

Bacterial Type II Topoisomerases Cleave Dna in a Species-Specific Manner. bioRxiv (Cold Spring Harbor Laboratory) (2025)

environmental dnamolecular microbiologymicroorganismsnucleic acidsmicrobiologybacteriamicrobial geneticsmolecular biologybacteriologybacterial type ii

Abstract 1657 Interactions of Established and Novel Antibacterials With Acinetobacter Baumannii Gyrase and Topoisomerase IV. Journal of Biological Chemistry (2024)

Samika JoshiJo Ann BylNeil Osheroff

clinical microbiologybacteriologyenzymesbiomolecular interactionsacinetobacter baumannii gyrasemicrobiologytopoisomerase ivmedicinepharmacologydrug discoveryherb-drug interactions

Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening. ACS Medicinal Chemistry Letters (2024)

Joshua W. PowellChelsea A. MannPaul D. TothSheri NolanAnja SteinertClarissa OveJustin T. SeffernickDaniel J. WozniakRazieh KebriaeiSteffen LindertNeil OsheroffJack C. YalowichMark J. Mitton-Fry

drug discoverycomputational screeningpharmacologymedicinal chemistry

Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance. ACS Infectious Diseases (2024)

Jessica A. CollinsNeil Osheroff

Interactions Between Gepotidacin and Escherichia Coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting. ACS Infectious Diseases (2024)

Alexandria A. OviattElizabeth G. GibsonJianzhong HuangKaren MatternKeir C. NeumanPan F. ChanNeil Osheroff

Interactions Between Zoliflodacin and Neisseria Gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting. ACS Infectious Diseases (2024)

Jessica A. CollinsGregory S. BasarabKelly ChibaleNeil Osheroff

Target-Mediated Fluoroquinolone Resistance in Neisseria Gonorrhoeae: Actions of Ciprofloxacin Against Gyrase and Topoisomerase IV. ACS Infectious Diseases (2024)

Jessica A. CollinsAlexandria A. OviattPan F. ChanNeil Osheroff

Soziema E. DaudaJessica A. CollinsJo Ann W. BylYanran LuJack C. YalowichMark J. Mitton-FryNeil Osheroff

A Series of Spiropyrimidinetriones That Enhances Dna Cleavage Mediated by Mycobacterium Tuberculosis Gyrase. ACS Infectious Diseases (2023)

Jo Ann W. BylRudolf MuellerBen BaxGregory S. BasarabKelly ChibaleNeil Osheroff

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