Faculty

Institution

Unit

Venue

Lawrence J. Marnett

Professor of Biochemistry Chemistry and Pharmacology

Vanderbilt University

Affiliations

College of Arts and Science

Chemistry

Graduate School

Chemistry

School of Medicine

Department of Biochemistry

Department of Pharmacology

Lawrence J. Marnett is currently serving as a Chemistry Professor of Biochemistry Chemistry and Pharmacology at Vanderbilt University.

Honors

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Experiences

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Education

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Lawrence J. Marnett

Vanderbilt University

Professor of Biochemistry Chemistry and Pharmacology

You can click a keyword to filter the displayed items

pharmacology biochemistry molecular biology enzymes enzyme inhibition redox biology medicinal chemistry biological chemistry membrane biology genetics oncology toxicology protein science drug discovery chemical biology free radical biology tumor biology medicinal research cancer biology biochemical sciences enzyme catalysis mutagenesis biocatalysis tumor targeting mammalian biology clinical chemistry pharmacotherapy structural molecular biology redox chemistry lipid peroxidation functional modification cancer treatment pharmaceutical chemistry anti-inflammatory liver physiology cancer genetics nucleic acids biological inorganic chemistry pharmacokinetics apoptosis catalyst activation lipid chemistry lipid science cancer prevention clinical biochemistry molecular science prostaglandin biosynthesis prostaglandin endoperoxide synthase food science food toxicology rna biology drug targeting dna analysis enzyme specificity redox signaling inhibitory activity anti-cancer agents molecular substrates colorectal cancer cancer growth therapeutic efficacy biomolecular interactions nitric oxide fema gras assessment flavor ingredients arachidonic acid protein modification malondialdehyde adducts tumor initiation cyclooxygenase active site cyclooxygenase inhibitors malondialdehyde-deoxyguanosine adduct total synthesis two-base deletion dna damage endocannabinoid oxygenation cell death cell signaling protein structure cell biology in vitro toxicology inflammation cell metabolism experimental toxicology anti-inflammatory agent toxicological mechanism oxidative stress

Notable Scholarly Works

Notable Federal Grants

Collaborators

Chiral Me-2-Arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates With Stability to Cox-2. ACS Medicinal Chemistry Letters (2024)

Spyros P. NikasLipin JiYingpeng LiuMarkos-Orestis GeorgiadisAmey DopeshwarkarAlex StraikerShalley KudalkarAnastasiia V. SadybekovMichaela DvorakovaVsevolod KatritchKen MackieLawrence MarnettAlexandros Makriyannis

drug discoverypharmacologymedicinal chemistry

Polymeric Micellar Nanoparticles Enable Image-Guided Drug Delivery in Solid Tumors. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jashim UddinConnor G. OltmanJustin Han-Je LoMukesh K. GuptaThomas A. WerfelMohammed MohyuddinFarhana NazminSaidur RahmanBrenda C. CrewsPhilip J. KingsleyLawrence J. MarnettCraig L. DuvallRebecca S. Cook

nanomaterialsdrug deliverytissue engineeringnanomedicinenanotechnologybiomedical imagingbiomedical engineeringsolid tumorspharmacologynanobiotechnologymaterials science

Post-Transcriptional Modifications on Trna Fragments Confer Functional Changes to High-Density Lipoproteins in Atherosclerosis. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Elizabeth M SemlerDanielle L MichellPhilip J KingsleyClark MassickMarisol A RamirezMark A CastleberryAmanda C DoranJohn J CarrLawrence J MarnettQuanhu ShengMacRae F LintonKasey C Vickers

high-density lipoproteinsatherosclerosisfunctional changesmolecular biologytrna fragmentspost-transcriptional modifications

Temporal Dissociation of Cox-2-Dependent Arachidonic Acid and 2-Arachidonoylglycerol Metabolism in Raw264.7 Macrophages. Journal of Lipid Research (2024)

Ansari M. AleemMichelle M. MitchenerPhilip J. KingsleyCarol A. RouzerLawrence J. Marnett

lipidscarbonyl metabolismbiosynthesismetabolic syndromemolecular biologydrug metabolismreactive oxygen speciesbiochemistrycell metabolisminflammationmetabolismtemporal dissociationmolecular metabolismlipoprotein metabolismlipid peroxidationsecondary metabolismfree radical biologyredox biologybiomolecular engineering

The Oncometabolite D-2-Hydroxyglutarate Promotes Dna Hypermethylation at Lineage-Specific Enhancers Controlling Microglial Activation in Idh Mut Gliomas. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Alice LaurengePietro PuglieseQuentin RichardBertrand MathonStéphanie JouannetYvette HayatSarah ScuderiLaurent CapellePauline MarijonKarim LabrecheAgustí AlentornMaïté VerreaultAhmed IdbaihCristina BirzuEmmanuelle HuillardNina PottierAurore DesmonsInès FayacheGarrett A. KaasPhilip J. KingsleyLawrence J. MarnettEric DuplusElias El-HabrLucas A. SalasKarima MokhtariSuzanne TranMehdi TouatFranck BielleMario L. SuvàAntonio IavaroneMichele CeccarelliMichel MallatMarc SansonLuis Jaime Castro-Vega

gliomasmicroglial activationbiochemistrymolecular biologylineage-specific enhancersgenetics

Base-Displaced Intercalated Structure of the 3-(2-Deoxy-β-D-Erythropentofuranosyl)-Pyrimido[1,2- F ]Purine-6,10(3 H,5 H )-Dione (6-Oxo-M 1 Dg) Lesion in Dna. Chemical Research in Toxicology (2023)

Yizhi FuPlamen P. ChristovPhilip J. KingsleyRobyn M. Richie-JannettaLawrence J. MarnettMichael P. Stone

heterocyclicstructural chemistrychemistrybase-displaced intercalated structurestructural biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicscrystal structurescrystal researchdeposited datasetstructural chemistryccdc 2157502crystal engineeringcrystallographystructure determinationstructure elucidationchemistrychemical structurecrystal diffraction study

Development of Pluoronic Nanoparticles of Fluorocoxib a for Endoscopic Fluorescence Imaging of Colonic Adenomas. Journal of Biomedical Optics (2023)

Md. Jashim UddinHiroaki NiitsuRobert J. CoffeyLawrence J. Marnett

nanomaterialspluoronic nanoparticlesgastrointestinal oncologyphotomedicineendoscopic fluorescence imagingnanomedicinemedical imagingnanotechnologycancer imagingbiomedical engineeringpharmacologycolonic adenomashealth sciencesnanobiotechnologybiomedical imaging

Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages. ACS Chemical Biology (2023)

Ansari M. AleemWeixi KangShuyang LinMatthew MiladPhilip J. KingsleyBrenda C. CrewsMd. Jashim UddinCarol A. RouzerLawrence J. Marnett

ferroptosis inhibitorsinflammationimmunologymedicinal researchdermatologymedicinal chemistrylipopolysaccharide-stimulated macrophagesclinical chemistrychemical biologyprostaglandin synthesispharmacologydrug discovery

Jedi‐1/Megf12‐Mediated Phagocytosis Controls the Pro‐Neurogenic Properties of Microglia in the Ventricular‐Subventricular Zone. Alzheimer s & Dementia (2023)

Vivianne E MorrisonMatthew G HoupertJonathan B TrapaniAsa A BrockmanPhilip J KingsleyKetaki A. KatdareHillary M LaydenScott W HiebertGabriela Nguena‐JonesAlexandra J TrevisanKathleen A Maguire‐ZeissLawrence J MarnettGregory J BixRebecca A IhrieBruce D Carter

neurologyinflammationalzheimer's diseasepro-neurogenic propertiessystems neuroscienceneuropharmacologyneuroscienceneuroinflammationventricular-subventricular zonemedicineclinical neurosciencedementiabrain-immune interaction

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Lawrence J. Marnett

Professor of Biochemistry Chemistry and Pharmacology

Vanderbilt University

Affiliations

College of Arts and Science

Chemistry

Graduate School

Chemistry

School of Medicine

Department of Biochemistry

Department of Pharmacology

Lawrence J. Marnett is currently serving as a Chemistry Professor of Biochemistry Chemistry and Pharmacology at Vanderbilt University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Lawrence J. Marnett

Vanderbilt University

Professor of Biochemistry Chemistry and Pharmacology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Chiral Me-2-Arachidonoyl Glycerols: The First Potent Endocannabinoid Glyceride Templates With Stability to Cox-2. ACS Medicinal Chemistry Letters (2024)

drug discoverypharmacologymedicinal chemistry

Polymeric Micellar Nanoparticles Enable Image-Guided Drug Delivery in Solid Tumors. bioRxiv (Cold Spring Harbor Laboratory) (2024)

nanomaterialsdrug deliverytissue engineeringnanomedicinenanotechnologybiomedical imagingbiomedical engineeringsolid tumorspharmacologynanobiotechnologymaterials science

Post-Transcriptional Modifications on Trna Fragments Confer Functional Changes to High-Density Lipoproteins in Atherosclerosis. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Elizabeth M SemlerDanielle L MichellPhilip J KingsleyClark MassickMarisol A RamirezMark A CastleberryAmanda C DoranJohn J CarrLawrence J MarnettQuanhu ShengMacRae F LintonKasey C Vickers

high-density lipoproteinsatherosclerosisfunctional changesmolecular biologytrna fragmentspost-transcriptional modifications

Temporal Dissociation of Cox-2-Dependent Arachidonic Acid and 2-Arachidonoylglycerol Metabolism in Raw264.7 Macrophages. Journal of Lipid Research (2024)

Ansari M. AleemMichelle M. MitchenerPhilip J. KingsleyCarol A. RouzerLawrence J. Marnett

gliomasmicroglial activationbiochemistrymolecular biologylineage-specific enhancersgenetics

Base-Displaced Intercalated Structure of the 3-(2-Deoxy-β-D-Erythropentofuranosyl)-Pyrimido[1,2- F ]Purine-6,10(3 H,5 H )-Dione (6-Oxo-M 1 Dg) Lesion in Dna. Chemical Research in Toxicology (2023)

Yizhi FuPlamen P. ChristovPhilip J. KingsleyRobyn M. Richie-JannettaLawrence J. MarnettMichael P. Stone

heterocyclicstructural chemistrychemistrybase-displaced intercalated structurestructural biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Development of Pluoronic Nanoparticles of Fluorocoxib a for Endoscopic Fluorescence Imaging of Colonic Adenomas. Journal of Biomedical Optics (2023)

Md. Jashim UddinHiroaki NiitsuRobert J. CoffeyLawrence J. Marnett

Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages. ACS Chemical Biology (2023)

Ansari M. AleemWeixi KangShuyang LinMatthew MiladPhilip J. KingsleyBrenda C. CrewsMd. Jashim UddinCarol A. RouzerLawrence J. Marnett

Jedi‐1/Megf12‐Mediated Phagocytosis Controls the Pro‐Neurogenic Properties of Microglia in the Ventricular‐Subventricular Zone. Alzheimer s & Dementia (2023)

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