Faculty

Institution

Unit

Venue

Carol Fierke

Jerome and Isabella Karle Distinguished University Professor Emerita of Chemistry College of LSA; Professor Emerita of Biological Chemistry Medical School

University of Michigan

Affiliations

College of Literature, Science, and The Arts

Department of Chemistry

Carol Fierke is currently serving as a College Of Literature, Science, And The Arts Jerome and Isabella Karle Distinguished University Professor Emerita of Chemistry College of LSA; Professor Emerita of Biological Chemistry Medical School at University of Michigan.

Honors

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Experiences

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Education

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Carol Fierke

University of Michigan

Jerome and Isabella Karle Distinguished University Professor Emerita of Chemistry College of LSA; Professor Emerita of Biological Chemistry Medical School

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biochemistry molecular biology enzymes protein science structural biology biomolecular engineering structural molecular biology protein structure enzyme inhibition biophysics enzyme catalysis chemical biology biosensors gene expression protein chemistry rna biology catalysis biological chemistry protein engineering transition metal chemistry biocatalysis protein biosynthesis redox biology biomolecular structure structure-function enzyme kinetics biological inorganic chemistry biochemical sciences enzyme specificity protein farnesyltransferase carbonic anhydrase coordination chemistry structural chemistry peptides nucleic acids inhibitory activity bacillus subtilis molecular structure enzymatic modification molecular catalysis biomolecules protein phosphorylation molecular substrates rna processing protein synthesis anion sensing dihydrofolate reductase carbonic anhydrase ii biological macromolecules molecular science metalloproteins mutagenesis nuclear magnetic resonance spectroscopy mitochondrial function molecular recognition escherichia coli protein evolution drug targeting protein x-ray crystallography biomolecular analysis structural bioinformatics glycosylation key site biomolecular interactions biomedical photonics catalytic activity protein prenyltransferases reperfusion injury hydrogen bond nmr studies protein component hydrophobic pocket altmetric attention score kinetic mechanism extracellular free zinc catalytic efficiency biochemical characterization

Notable Scholarly Works

Notable Federal Grants

Collaborators

Brd4354 is a Potent Covalent Inhibitor Against the Sars-Cov-2 Main Protease. Biochemistry (2024)

Yan J. ShengSyuan-Ting A. KuoTingyuan YangHanyuan E. ZhangDavid H. RussellXin YanShiqing XuWenshe R. LiuCarol A. Fierke

infectious diseasesbiochemistrysars-cov-2pharmacologypotent covalent inhibitorvirus research

Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors. ACS Central Science (2024)

Peng-Hsun Chase ChenXuejiao Shirley GuoHanyuan Eric ZhangGopal K. DubeyZhi Zachary GengCarol A. FierkeShiqing XuJ. Trae HamptonWenshe Ray Liu

drug targetingepigeneticsmedicinal researchphage biologynovel pathwaymolecular biologypharmacologydrug discoverymolecular regulation

A Novel Y-Shaped, S–O–N–O–S-Bridged Cross-Link Between Three Residues C22, C44, and K61 is Frequently Observed in the Sars-Cov-2 Main Protease. ACS Chemical Biology (2023)

Kai S. YangLauren R. BlankenshipSyuan-Ting Alex KuoYan J. ShengPingwei LiCarol A. FierkeDavid H. RussellXin YanShiqing XuWenshe Ray Liu

enzymesprotein chemistryprotein sciencebiochemistrysars-cov-2chemical biologychemistrymolecular biologybiological chemistryprotein structurestructural molecular biologystructural biologybiological inorganic chemistry

Phage-Assisted, Active Site-Directed Ligand Evolution With a Genetically Encoded N ε -Butyryl-L-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the Enl Yeats Domain as an Anti-Leukemia Agent. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Peng-Hsun Chase ChenXuejiao Shirley GuoHanyuan Eric ZhangZhi Zachary GengGopal K. DubeyCarol A. FierkeShiqing XuWenshe Ray Liu

selective inhibitorcellularly potentphage biologymammalian biologypathway analysismolecular biologypharmacologymolecular pharmacologydrug discoverygene expressionenzyme inhibitiongenetics

A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink Between Three Residues C22, C44, and K61 is a Redox Switch of the Sars-Cov-2 Main Protease. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Kai S. YangSyuan-Ting Alex KuoLauren R. BlankenshipYan J. ShengBanumathi SankaranPingwei LiCarol A. FierkeDavid H. RussellXin YanShiqing XuWenshe Ray Liu

enzymesprotein chemistryprotein scienceredox switchbiochemistrysars-cov-2protein engineeringmolecular biologyprotein structureenzyme inhibitionstructural biologygenetics

Gambogic Acid and Juglone Inhibit Rnase P Through Distinct Mechanisms. Journal of Biological Chemistry (2022)

Nancy Wu MeyersAgnes KarasikKipchumba KaitanyCarol A. FierkeMarkos Koutmos

molecular and cellular biologyimmunologypharmacologyenzymesclinical biochemistryenzyme inhibitionreceptorsprotein biosynthesisgambogic acidmorphological evidencebiochemistrybiological chemistrydistinct mechanismsrna biologyfunctional modificationprotein sciencemembrane biologymolecular pharmacologyspecific resistanceredox biology

Mode of Inhibition of Rnase P by Gambogic Acid and Juglone. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Nancy Wu MeyersAgnes KarasikKipchumba KaitanyCarol A. FierkeMarkos Koutmos

enzymesprotein sciencegambogic acidimmunologycell biologymembrane biologypharmacologymammalian biologyenzyme inhibitionrna biology

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Jared S. MorseYan J. ShengJ. Trae HamptonLauralee D. SylvainSukant DasYugendar R. AlugubelliPeng-Hsun Chase ChenKai S. YangShiqing XuCarol A. FierkeWenshe Ray Liu

enzymestumor biologyphage biologybiochemistrymedicinal chemistrymembrane biologymolecular biologypharmacologydrug discoveryenzyme inhibition

Ratiometric Zinc Biosensor Based on Bioluminescence Resonance Energy Transfer: Trace Metal Ion Determination With Tunable Response. International Journal of Molecular Sciences (2022)

Evgenia G. MatveevaAndrea K. StoddardHui-Hui ZengGraham FrankeLeslie BourneCarol A. FierkeRichard B. Thompson

biophysicstrace metalstunable responseanalytical chemistrybiochemistrymolecular scienceratiometric zinc biosensorbiosensorsmolecular biology

Phage‐Assisted, Active Site‐Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor. Protein Science (2022)

Jared S. MorseYan J. ShengJoshua Trae HamptonLauralee D. SylvainSukant DasYugendar R. AlugubelliPeng‐Hsun Chase ChenKai S. YangShiqing XuCarol A. FierkeWenshe Ray Liu

enzymesprotein chemistryprotein scienceenzyme catalysisdrug targetingphage biologybiochemistrymedicinal chemistryprotein engineeringmolecular biologypharmacologymolecular pharmacologydrug discoveryenzyme inhibitionprotein evolution

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Carol Fierke

Jerome and Isabella Karle Distinguished University Professor Emerita of Chemistry College of LSA; Professor Emerita of Biological Chemistry Medical School

University of Michigan

Affiliations

College of Literature, Science, and The Arts

Department of Chemistry

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Carol Fierke

University of Michigan

Jerome and Isabella Karle Distinguished University Professor Emerita of Chemistry College of LSA; Professor Emerita of Biological Chemistry Medical School

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Brd4354 is a Potent Covalent Inhibitor Against the Sars-Cov-2 Main Protease. Biochemistry (2024)

Yan J. ShengSyuan-Ting A. KuoTingyuan YangHanyuan E. ZhangDavid H. RussellXin YanShiqing XuWenshe R. LiuCarol A. Fierke

infectious diseasesbiochemistrysars-cov-2pharmacologypotent covalent inhibitorvirus research

Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors. ACS Central Science (2024)

Peng-Hsun Chase ChenXuejiao Shirley GuoHanyuan Eric ZhangGopal K. DubeyZhi Zachary GengCarol A. FierkeShiqing XuJ. Trae HamptonWenshe Ray Liu

drug targetingepigeneticsmedicinal researchphage biologynovel pathwaymolecular biologypharmacologydrug discoverymolecular regulation

A Novel Y-Shaped, S–O–N–O–S-Bridged Cross-Link Between Three Residues C22, C44, and K61 is Frequently Observed in the Sars-Cov-2 Main Protease. ACS Chemical Biology (2023)

Kai S. YangLauren R. BlankenshipSyuan-Ting Alex KuoYan J. ShengPingwei LiCarol A. FierkeDavid H. RussellXin YanShiqing XuWenshe Ray Liu

Peng-Hsun Chase ChenXuejiao Shirley GuoHanyuan Eric ZhangZhi Zachary GengGopal K. DubeyCarol A. FierkeShiqing XuWenshe Ray Liu

selective inhibitorcellularly potentphage biologymammalian biologypathway analysismolecular biologypharmacologymolecular pharmacologydrug discoverygene expressionenzyme inhibitiongenetics

A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink Between Three Residues C22, C44, and K61 is a Redox Switch of the Sars-Cov-2 Main Protease. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Kai S. YangSyuan-Ting Alex KuoLauren R. BlankenshipYan J. ShengBanumathi SankaranPingwei LiCarol A. FierkeDavid H. RussellXin YanShiqing XuWenshe Ray Liu

enzymesprotein chemistryprotein scienceredox switchbiochemistrysars-cov-2protein engineeringmolecular biologyprotein structureenzyme inhibitionstructural biologygenetics

Gambogic Acid and Juglone Inhibit Rnase P Through Distinct Mechanisms. Journal of Biological Chemistry (2022)

Nancy Wu MeyersAgnes KarasikKipchumba KaitanyCarol A. FierkeMarkos Koutmos

Mode of Inhibition of Rnase P by Gambogic Acid and Juglone. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Nancy Wu MeyersAgnes KarasikKipchumba KaitanyCarol A. FierkeMarkos Koutmos

enzymesprotein sciencegambogic acidimmunologycell biologymembrane biologypharmacologymammalian biologyenzyme inhibitionrna biology

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Jared S. MorseYan J. ShengJ. Trae HamptonLauralee D. SylvainSukant DasYugendar R. AlugubelliPeng-Hsun Chase ChenKai S. YangShiqing XuCarol A. FierkeWenshe Ray Liu

enzymestumor biologyphage biologybiochemistrymedicinal chemistrymembrane biologymolecular biologypharmacologydrug discoveryenzyme inhibition

Ratiometric Zinc Biosensor Based on Bioluminescence Resonance Energy Transfer: Trace Metal Ion Determination With Tunable Response. International Journal of Molecular Sciences (2022)

Evgenia G. MatveevaAndrea K. StoddardHui-Hui ZengGraham FrankeLeslie BourneCarol A. FierkeRichard B. Thompson

biophysicstrace metalstunable responseanalytical chemistrybiochemistrymolecular scienceratiometric zinc biosensorbiosensorsmolecular biology

Phage‐Assisted, Active Site‐Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor. Protein Science (2022)

Jared S. MorseYan J. ShengJoshua Trae HamptonLauralee D. SylvainSukant DasYugendar R. AlugubelliPeng‐Hsun Chase ChenKai S. YangShiqing XuCarol A. FierkeWenshe Ray Liu

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Vern Schramm

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Albert Einstein College of Medicine

protein modeling

protein structure

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Institution

Brandeis University

biochemistry

molecular biology

David W. Christianson

Institution

University of Pennsylvania

molecular biology

enzyme catalysis

Stephen J. Benkovic

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Pennsylvania State University

biosynthesis

cellular enzymology

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structural basis

biomolecular structure

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Brandeis University

biomolecular structure

protein structure

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nucleic acid

biotechnology

Liang Tong

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Columbia University

molecular biology

structural biology

Robert J. Fletterick

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molecular biology

biochemistry

Ruma Banerjee

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biochemistry

molecular biology