Faculty

Institution

Unit

Venue

Stephen J. Benkovic

Atherton Professor Eberly Chair in Chemistry

Pennsylvania State University

Affiliations

Eberly College of Science

Department of Chemistry

Stephen J. Benkovic is currently serving as a Chemistry Atherton Professor Eberly Chair in Chemistry at Pennsylvania State University.

Honors

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Experiences

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Education

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Stephen J. Benkovic

Pennsylvania State University

Atherton Professor Eberly Chair in Chemistry

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biochemistry molecular biology enzymes protein science structural biology pharmacology genetics enzyme catalysis medicinal chemistry biological chemistry biocatalysis catalysis structural molecular biology bacteriophages enzyme inhibition membrane biology protein structure protein engineering chemical biology biochemical sciences antibody engineering redox biology dihydrofolate reductase bacteriology protein chemistry genome biology molecular catalysis phage biology molecular microbiology virus research protein assembly biomolecular structure nucleic acids molecular science rna biology functional modification glycinamide ribonucleotide transformylase catalytic antibodies biological inorganic chemistry structure-function enzyme kinetics protein biosynthesis mutagenesis biochemical genetics chemical sciences clinical chemistry molecular substrates purine biosynthesis phenylalanine hydroxylase viral genetics microbial physiology pharmaceutical chemistry tetrahydrofolic acid liver physiology protein synthesis molecular regulation molecular biotechnology catalytic process escherichia coli biological evaluation general virology structural chemistry protein expression biomolecular interactions sequence assembly enzyme specificity metabolic regulation enzymatic modification protein-protein interactions molecular virology kinetic mechanism antibody catalysis single-stranded dna chromobacterium violaceum catalytic mechanism sulfate esters chicken liver biosynthesis enzyme molecular cell biology dna repair dna replication cellular enzymology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Enhancing Transcription–Replication Conflict Targets Ecdna-Positive Cancers. Nature (2024)

Jun TangNatasha E. WeiserGuiping WangSudhir ChowdhryEllis J. CurtisYanding ZhaoIvy Tsz-Lo WongGeorgi K. MarinovRui LiPhilip HanoianEdison TseSalvador Garcia MojicaRyan HansenJoshua PlumAuzon SteffySnezana MilutinovicS. Todd MeyerJens LuebeckYanbo WangShu ZhangNicolas AltemoseChristina CurtisWilliam J. GreenleafVineet BafnaStephen J. BenkovicAnthony B. PinkertonShailaja KasibhatlaChristian A. HassigPaul S. MischelHoward Y. Chang

cancer genomicstumor biologygene expressioncancer researchbiomolecular engineeringmolecular cancermolecular researchgenome instabilitytranscription (biology)cancer cellsoncogenessystems biologyjama oncologytranscription regulationmolecular biologygene therapycancer discoverycancer genetics

Purinosomes Spatially Co-Localize With Mitochondrial Transporters. Journal of Biological Chemistry (2024)

Zhou ShaStephen J. Benkovic

molecular biologybiological chemistrybiochemistrymitochondrial transporters

Rampant Transcription Replication Conflict Creates Therapeutic Vulnerability in Extrachromosomal Dna Containing Cancers. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jun TangNatasha Elise WeiserGuiping WangSudhir ChowdhryEllis J CurtisYanding ZhaoIvy Tsz-Lo WongGeorgi K MarinovRui LiPhilip HanoianEdison TseRyan HansenJoshua PlumAuzon SteffySnezana MilutinovicS. Todd MeyerNicolas AltemoseChristina CurtisWilliam J GreenleafVineet BafnaStephen J. BenkovicAnthony B. PinkertonShailaja KasibhatlaChristian A. HassigPaul S. MischelHoward Y Chang

therapeutic vulnerabilitycancer biologypharmacologytumor biologydna replicationcancer researchoncologyclinical microbiologycancer carecancer riskreplicationcancer genomicsgeneticsmolecular cancernovel therapiesextrachromosomal dnagenome biologymedicinal researchmolecular biologycancer genetics

Purine Synthesis Suppression Reduces the Development and Progression of Pulmonary Hypertension in Rodent Models. European Heart Journal (2023)

Q MaQ YangJ XuHG SellersZL BrownZ LiuZ BordanX ShiD Zhao...

pulmonary hypertensioncardiologyveterinary medicinerodent modelspurine synthesis suppressionpharmacologyrespiratory medicinephysiologymammalian biologyhealth sciences

Structural Basis of the T4 Bacteriophage Primosome Assembly and Primer Synthesis. Nature Communications (2023)

Xiang FengMichelle M. SpieringRuda de Luna Almeida SantosStephen J. BenkovicHuilin Li

microbiologygeneticsbacteriophagesbacteriologystructural basisgenome biologymolecular biologyprimer synthesisstructural biology

Atic-Associated De Novo Purine Synthesis is Critically Involved in Proliferative Arterial Disease. Circulation (2022)

Q MaQ YangJ XuX ZhangD KimZ LiuQ DaX MaoY ZhouY Cai...

hepatologyhematologycardiologyarterial diseasedermatologyproliferative arterial diseasepurine synthesispharmacologymembrane biologyrespiratory medicinenephrologycardiovascular researchvascular biologyhealth sciences

Purine Biosynthetic Enzymes Assemble Into Liquid-Like Condensates Dependent on the Activity of Chaperone Protein Hsp90. Journal of Biological Chemistry (2022)

Anthony M. PedleyJack P. BoylanChung Yu ChanErin L. KennedyMinjoung KyoungStephen J. Benkovic

biological engineeringliquid-like condensatesprotein engineeringbiological chemistrybiochemistrypurine biosynthetic enzymesmolecular biology

The Purinosome: A Case Study for a Mammalian Metabolon. Annual Review of Biochemistry (2022)

Anthony M. PedleyVidhi PareekStephen J. Benkovic

metabolomicsbiochemistrymammalian biologymammalian metabolon

From Bioorganic Models to Cells. Annual Review of Biochemistry (2021)

Stephen J. Benkovic

cell biologybioorganic chemistrybiological modelsbiochemistrybioorganic models

Human De Novo Purine Biosynthesis. Critical Reviews in Biochemistry and Molecular Biology (2020)

Vidhi PareekAnthony M. PedleyStephen J. Benkovic

biomolecular engineeringhuman biologybiosynthesisbiochemistrymolecular biologypurine biosynthesis

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Stephen J. Benkovic

Atherton Professor Eberly Chair in Chemistry

Pennsylvania State University

Affiliations

Eberly College of Science

Department of Chemistry

Stephen J. Benkovic is currently serving as a Chemistry Atherton Professor Eberly Chair in Chemistry at Pennsylvania State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Stephen J. Benkovic

Pennsylvania State University

Atherton Professor Eberly Chair in Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Enhancing Transcription–Replication Conflict Targets Ecdna-Positive Cancers. Nature (2024)

Purinosomes Spatially Co-Localize With Mitochondrial Transporters. Journal of Biological Chemistry (2024)

Zhou ShaStephen J. Benkovic

molecular biologybiological chemistrybiochemistrymitochondrial transporters

Rampant Transcription Replication Conflict Creates Therapeutic Vulnerability in Extrachromosomal Dna Containing Cancers. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Purine Synthesis Suppression Reduces the Development and Progression of Pulmonary Hypertension in Rodent Models. European Heart Journal (2023)

Q MaQ YangJ XuHG SellersZL BrownZ LiuZ BordanX ShiD Zhao...

pulmonary hypertensioncardiologyveterinary medicinerodent modelspurine synthesis suppressionpharmacologyrespiratory medicinephysiologymammalian biologyhealth sciences

Structural Basis of the T4 Bacteriophage Primosome Assembly and Primer Synthesis. Nature Communications (2023)

Xiang FengMichelle M. SpieringRuda de Luna Almeida SantosStephen J. BenkovicHuilin Li

microbiologygeneticsbacteriophagesbacteriologystructural basisgenome biologymolecular biologyprimer synthesisstructural biology

Atic-Associated De Novo Purine Synthesis is Critically Involved in Proliferative Arterial Disease. Circulation (2022)

Q MaQ YangJ XuX ZhangD KimZ LiuQ DaX MaoY ZhouY Cai...

Purine Biosynthetic Enzymes Assemble Into Liquid-Like Condensates Dependent on the Activity of Chaperone Protein Hsp90. Journal of Biological Chemistry (2022)

Anthony M. PedleyJack P. BoylanChung Yu ChanErin L. KennedyMinjoung KyoungStephen J. Benkovic

biological engineeringliquid-like condensatesprotein engineeringbiological chemistrybiochemistrypurine biosynthetic enzymesmolecular biology

The Purinosome: A Case Study for a Mammalian Metabolon. Annual Review of Biochemistry (2022)

Anthony M. PedleyVidhi PareekStephen J. Benkovic

metabolomicsbiochemistrymammalian biologymammalian metabolon

From Bioorganic Models to Cells. Annual Review of Biochemistry (2021)

Stephen J. Benkovic

cell biologybioorganic chemistrybiological modelsbiochemistrybioorganic models

Human De Novo Purine Biosynthesis. Critical Reviews in Biochemistry and Molecular Biology (2020)

Vidhi PareekAnthony M. PedleyStephen J. Benkovic

biomolecular engineeringhuman biologybiosynthesisbiochemistrymolecular biologypurine biosynthesis

1
2
3
4
5
60
10 / page

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Massachusetts Institute of Technology

biochemistry

molecular biology

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Institution

Yale University

molecular biology

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molecular biology

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antibody screening

clinical proteomics

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