Faculty

Institution

Unit

Venue

Thomas Poulos

Distinguished Professor of Biochemistry Chemistry and Pharmaceutical Sciences

University of California, Irvine

Affiliations

School of Biological Sciences

Department of Molecular Biology and Biochemistry

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

Thomas Poulos is currently serving as a Molecular Biology And Biochemistry Distinguished Professor of Biochemistry Chemistry and Pharmaceutical Sciences at University of California, Irvine.

Honors

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Experiences

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Education

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Thomas Poulos

University of California, Irvine

Distinguished Professor of Biochemistry Chemistry and Pharmaceutical Sciences

You can click a keyword to filter the displayed items

biochemistry enzymes molecular biology structural biology pharmacology protein science protein structure redox biology enzyme inhibition biophysics structural molecular biology crystallography medicinal chemistry drug discovery biological chemistry biological inorganic chemistry membrane biology protein chemistry chemical biology pharmaceutical chemistry biomolecular structure crystal structures enzyme catalysis biochemical sciences neurochemistry protein x-ray crystallography structural chemistry medicinal research rational drug design heme signaling heme homeostasis molecular structure molecular metabolism drug development structure-function enzyme kinetics structural basis biochemical genetics enzyme specificity biomolecular interactions drug targeting biochemical interaction nitric oxide synthase coordination chemistry peptide science protein synthesis protein function structural composition ascorbate peroxidase synthase inhibitors molecular physiology biocatalysis molecular substrates mutagenesis heme trafficking inhibitory activity heme transport electron transfer chemical sciences protein modeling conformational studies manganese peroxidase selective inhibitors molecular dynamics plant science catalyst activation mechanisms of action active site preliminary crystallographic analysis putidaredoxin reductase molecular biotechnology functional modification phanerochaete chrysosporium nitric oxide synthases oxygen activation heme domain synthase inhibition

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Assessment of the Cytochrome P450 2-Hydroxyisoflavanone Synthase (2-His) Crystal Structure. Communications Biology (2026)

enzymeschemistrymolecular metabolismchemical biologyalcohol dehydrogenasesenzyme catalysiscytochrome p450 2-hydroxyisoflavanonebiomolecular structureprotein structurestructural molecular biologybiochemistryprotein x-ray crystallographystructure-function enzyme kineticsnatural product researchmolecular biologycrystal structurestructural biology

Enhancement of Potency and Selectivity of 2-Aminoquinoline-Based Human Neuronal Nitric Oxide Synthase Inhibitors. Journal of Medicinal Chemistry (2026)

inhibitory activityneuropharmacologypharmacological researchreactive nitrogen speciesdrug developmentneurosciencebiochemistrypharmacologyenzyme inhibitiondrug discoveryneuropsychopharmacology

New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. Journal of Medicinal Chemistry (2026)

new inhibitorsneuropharmacologynitrosative stressreactive nitrogen speciespharmacologyfuture medicinal chemistrytherapeutic targetsmelanomadrug discovery

Potent, Selective, and Brain Penetrant Ether-Linked 2-Aminopyridine Inhibitors of Human Neuronal Nitric Oxide Synthase With Excellent Oral Bioavailability. Journal of Medicinal Chemistry (2026)

neuropharmacologypharmacological researchreactive nitrogen speciesdrug developmentmechanisms of actionexcellent oral bioavailabilityneurosciencebiochemistrypharmacologymolecular pharmacologyenzyme inhibitiondrug discoveryneuropsychopharmacology

A Tetrahydrobiopterin-Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor With an Unprecedented Binding Mode. ACS Medicinal Chemistry Letters (2025)

Pathum M. WeerawarnaHuiying LiAthri D. RathnayakeChristine D. HardyThomas L. PoulosRichard B. Silverman

neurochemistryunprecedented binding modepharmaceutical chemistryneuropharmacologyneuronsnitrosative stressmedicinal chemistrymedicinal researchneuroscienceneuropeptidesbiochemistrysynthase inhibitormolecular biologyenzyme inhibitiondrug discoverynervous system

Crystal Structure of Cytochrome P450 Nysl and the Structural Basis for Stereo- and Regio-Selective Oxidation of Antifungal Macrolides. Journal of Biological Chemistry (2025)

cytochrome p450 nyslbiomolecular engineeringchemical biologyantimicrobial compoundsmedicinal chemistrybioorganic chemistryantifungal agentsbiochemistryantimicrobial agentsenzyme inhibitionregio-selective oxidationcrystal structure

Structural and Dynamic Regulation of Reactive Intermediates in Cytochrome P450s. Structural Dynamics (2025)

reactive intermediatesdrug metabolismenzymesmolecular and cellular biologybiomolecular interactionsstructural molecular biologyprotein structureredox biologybiochemistrybiological chemistrystructure-function enzyme kineticsmolecular biologyenzyme inhibition

Truncated Pyridinylbenzylamines: Potent, Selective, and Highly Membrane Permeable Inhibitors of Human Neuronal Nitric Oxide Synthase. Bioorganic & Medicinal Chemistry (2025)

Dhananjayan VasuHa T DoHuiying LiChristine D HardyThomas L PoulosRichard B Silverman

bioorganic chemistryneuroscienceneuropeptidespharmacologypeptide sciencemembrane permeable inhibitorsmedicinal chemistrymolecular neurodegenerationdrug discoveryneuropharmacologychemical biologybiochemistryenzyme specificitynatural product researchmedicinal researchneurochemistrypharmaceutical chemistrynitrosative stressenzyme inhibition

Application of the Linear Interaction Energy Method to Nitric Oxide Synthase Structure-Based Inhibitor Design. Journal of Chemical Information and Modeling (2024)

Alec H. FollmerThomas L. Poulos

enzymesbiomolecular engineeringchemical biologyenzyme catalysisprotein designstructural molecular biologybiochemistrystructure-function enzyme kineticsrational drug designenzyme inhibitionmolecular modellingstructural biologychemical engineering

Biosynthesis of a New Skyllamycin in Streptomyces Nodosus: A Cytochrome P450 Forms an Epoxide in the Cinnamoyl Chain. Organic & Biomolecular Chemistry (2024)

Yuhao SongJose A. AmayaVidhi C. MurarkaHugo MendezMark HoganJimmy MuldoonPaul EvansYannick OrtinSteven L. KellyDavid C. LambThomas L. PoulosPatrick Caffrey

redox biologybiosynthesisbiologybiochemistrymolecular biologycinnamoyl chain

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Thomas Poulos

Distinguished Professor of Biochemistry Chemistry and Pharmaceutical Sciences

University of California, Irvine

Affiliations

School of Biological Sciences

Department of Molecular Biology and Biochemistry

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

Thomas Poulos is currently serving as a Molecular Biology And Biochemistry Distinguished Professor of Biochemistry Chemistry and Pharmaceutical Sciences at University of California, Irvine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Thomas Poulos

University of California, Irvine

Distinguished Professor of Biochemistry Chemistry and Pharmaceutical Sciences

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Assessment of the Cytochrome P450 2-Hydroxyisoflavanone Synthase (2-His) Crystal Structure. Communications Biology (2026)

Enhancement of Potency and Selectivity of 2-Aminoquinoline-Based Human Neuronal Nitric Oxide Synthase Inhibitors. Journal of Medicinal Chemistry (2026)

inhibitory activityneuropharmacologypharmacological researchreactive nitrogen speciesdrug developmentneurosciencebiochemistrypharmacologyenzyme inhibitiondrug discoveryneuropsychopharmacology

New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. Journal of Medicinal Chemistry (2026)

new inhibitorsneuropharmacologynitrosative stressreactive nitrogen speciespharmacologyfuture medicinal chemistrytherapeutic targetsmelanomadrug discovery

Potent, Selective, and Brain Penetrant Ether-Linked 2-Aminopyridine Inhibitors of Human Neuronal Nitric Oxide Synthase With Excellent Oral Bioavailability. Journal of Medicinal Chemistry (2026)

A Tetrahydrobiopterin-Displacing Potent Neuronal Nitric Oxide Synthase Inhibitor With an Unprecedented Binding Mode. ACS Medicinal Chemistry Letters (2025)

Pathum M. WeerawarnaHuiying LiAthri D. RathnayakeChristine D. HardyThomas L. PoulosRichard B. Silverman

Crystal Structure of Cytochrome P450 Nysl and the Structural Basis for Stereo- and Regio-Selective Oxidation of Antifungal Macrolides. Journal of Biological Chemistry (2025)

Structural and Dynamic Regulation of Reactive Intermediates in Cytochrome P450s. Structural Dynamics (2025)

Truncated Pyridinylbenzylamines: Potent, Selective, and Highly Membrane Permeable Inhibitors of Human Neuronal Nitric Oxide Synthase. Bioorganic & Medicinal Chemistry (2025)

Dhananjayan VasuHa T DoHuiying LiChristine D HardyThomas L PoulosRichard B Silverman

Application of the Linear Interaction Energy Method to Nitric Oxide Synthase Structure-Based Inhibitor Design. Journal of Chemical Information and Modeling (2024)

Alec H. FollmerThomas L. Poulos

Biosynthesis of a New Skyllamycin in Streptomyces Nodosus: A Cytochrome P450 Forms an Epoxide in the Cinnamoyl Chain. Organic & Biomolecular Chemistry (2024)

Yuhao SongJose A. AmayaVidhi C. MurarkaHugo MendezMark HoganJimmy MuldoonPaul EvansYannick OrtinSteven L. KellyDavid C. LambThomas L. PoulosPatrick Caffrey

redox biologybiosynthesisbiologybiochemistrymolecular biologycinnamoyl chain

1
2
3
4
5
39
10 / page

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biomolecular structure

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molecular biology

enzyme catalysis

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