Faculty

Institution

Unit

Venue

Joshua J. Ziarek

Medical College of Wisconsin

Affiliations

Medical College of Wisconsin, Research

NoneJoshua J. Ziarek is currently serving as a Medical College Of Wisconsin, Research faculty at Medical College of Wisconsin.

Honors

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Experiences

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Education

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Joshua J. Ziarek

Medical College of Wisconsin

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pharmacology structural biology molecular biology protein science receptors protein structure neuroscience biochemistry nuclear magnetic resonance cell signaling drug discovery structural molecular biology medicinal chemistry tumor biology medicinal research solution structure enzyme inhibition molecular physiology peptides cancer biology g protein-coupled receptor daphnia pulicaria molecular cancer redox biology cancer cells avian biology peptide science thoracic oncology structural chemistry drug targeting host specificity host-guest chemistry relaxation process signaling pathways cell regulation tumor targeting structure determination single-molecule detection molecular neurobiology functional selectivity neurochemistry structure-based ligand discovery protein-ligand complexes oncogenes neurodevelopmental disorders scientometrics tumor suppressors molecular immunology host response cytokines protein function peptide synthesis protein chemistry interface chemistry immune checkpoint inhibitors bronchial neoplasm medical genetics genetic disorders fragmentation effect charge transport protein purification hydrobiology marine ecology neurotransmitters protein-protein interface two-site model chemokine recognition receptor activation structural basis monomeric structure dimerization interface cxc motif heparin oligosaccharides structure-based drug design sulfopeptide probes chemokine allostery

Notable Scholarly Works

Notable Federal Grants

Collaborators

Stabilization Versus Flexibility: Detergent-Dependent Trade-Offs in Neurotensin Receptor 1 Gpcr Ensembles. bioRxiv (Cold Spring Harbor Laboratory) (2025)

biophysicsgpcr ensemblesstabilization versus flexibilityprotein sciencebiophysical chemistryfunctional selectivityreceptor (biochemistry)molecular biophysicsmolecular physiologypeptidespharmacologyg protein-coupled receptormolecular pharmacologyneurotensin receptor 1signal transductionreceptors

A Multi-Iron Enzyme Installs Copper-Binding Oxazolone/Thioamide Pairs on a Nontypeable Haemophilus Influenzae Virulence Factor. Proceedings of the National Academy of Sciences (2024)

Olivia M. ManleyTucker J. ShriverTian XuIsaac A. MelendrezPhilip PalaciosScott A. RobsonYisong GuoNeil L. KelleherJoshua J. ZiarekAmy C. Rosenzweig

host-guest chemistrypathologyenzymesbioactive metalvirus-host interactionsredox biologycoordination chemistrybiochemistrymicrobiologymedicinal chemistrytransition metal chemistryvirulence factorsprotein engineeringbiological inorganic chemistrygeneral virologygene expressionenzyme inhibitionmicrobial pathogenesis

Characterizing the Monomer–Dimer Equilibrium of Ubch8/Ube2L6: A Combined Saxs and Nmr Study. ACS Omega (2024)

Kerem KahramanScott A. RobsonOktay GöcenlerCansu M. YeniciCansu D. Tozkoparan CeylanJennifer M. KleinVolker DötschEmine Sonay ElginArthur L. HaasJoshua J. ZiarekÇağdaş Dağ

biophysicsnmr studybiochemistrymolecular biologymonomer-dimer equilibriumnuclear magnetic resonancestructural biologycombined saxs

Insights on the Gpcr Helix 8 Solution Structure and Orientation Using a Neurotensin Receptor 1 Peptide. bioRxiv (Cold Spring Harbor Laboratory) (2024)

James B BowerScott Anthony RobsonJoshua J Ziarek

biophysicssolution structurecell biologyneuroscienceprotein structurestructural biology

Insights on the G Protein‐Coupled Receptor Helix 8 Solution Structure and Orientation Using a Neurotensin Receptor 1 Peptide. Protein Science (2024)

James B. BowerScott A. RobsonJoshua J. Ziarek

protein sciencesolution structureneurosciencepeptidespharmacologyprotein structurereceptorsstructural biology

Data From a Locked, Dimeric Cxcl12 Variant Effectively Inhibits Pulmonary Metastasis of Cxcr4-Expressing Melanoma Cells Due to Enhanced Serum Stability. (2023)

Tomonori TakekoshiJoshua J. ZiarekBrian F. VolkmanSam T. Hwang

pharmacologytherapeutic targetsthoracic oncologygeneticstumor biologyserum stabilitymelanomacancer researchmolecular biologycancer cellsmedicinal researchmolecular cancercellular therapypulmonary metastasiscancer biologytumor targetingoncologyclinical researchcancer genomicstherapeutic efficacy

Ligands Selectively Tune the Local and Global Motions of Neurotensin Receptor 1 (Nts1). Cell Reports (2023)

Fabian BumbakMiquel PonsAsuka InoueJuan Carlos PaniaguaFei YanHongwei WuScott A. RobsonRoss A.D. BathgateDaniel J. ScottPaul R. GooleyJoshua J. Ziarek

cell signalingcell biologyfunctional selectivityneurosciencemolecular neurobiologypharmacologymolecular neurosciencereceptorsglobal motions

Stabilization of Pre-Existing Neurotensin Receptor Conformational States by β-Arrestin-1 and the Biased Allosteric Modulator Ml314. Nature Communications (2023)

Fabian BumbakJames B. BowerSkylar C. ZemmerAsuka InoueMiquel PonsJuan Carlos PaniaguaFei YanJames FordHongwei WuScott A. RobsonRoss A. D. BathgateDaniel J. ScottPaul R. GooleyJoshua J. Ziarek

neuropharmacologyneurosciencepharmacologystabilityreceptors

A Method for Selective 19 F ‐Labeling Absent of Probe Sequestration ( Slaps ). Protein Science (2022)

Austin D. DixonScott A. RobsonJonathan C. TrinidadJoshua J. Ziarek

selective separationprotein sciencebioinformaticsimmunologydetection techniqueprotein modelingprotein engineeringpharmacologyprotein bioinformaticsprotein structurestructural biologygenetics

A Method for Selective 19 F-Labeling Absent of Probe Sequestration (Slaps). bioRxiv (Cold Spring Harbor Laboratory) (2022)

Austin D. DixonJonathan C. TrinidadJoshua J. Ziarek

molecular biologymedicineneurosciencesampling

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Joshua J. Ziarek

Medical College of Wisconsin

Affiliations

Medical College of Wisconsin, Research

NoneJoshua J. Ziarek is currently serving as a Medical College Of Wisconsin, Research faculty at Medical College of Wisconsin.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Joshua J. Ziarek

Medical College of Wisconsin

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Stabilization Versus Flexibility: Detergent-Dependent Trade-Offs in Neurotensin Receptor 1 Gpcr Ensembles. bioRxiv (Cold Spring Harbor Laboratory) (2025)

A Multi-Iron Enzyme Installs Copper-Binding Oxazolone/Thioamide Pairs on a Nontypeable Haemophilus Influenzae Virulence Factor. Proceedings of the National Academy of Sciences (2024)

Olivia M. ManleyTucker J. ShriverTian XuIsaac A. MelendrezPhilip PalaciosScott A. RobsonYisong GuoNeil L. KelleherJoshua J. ZiarekAmy C. Rosenzweig

Characterizing the Monomer–Dimer Equilibrium of Ubch8/Ube2L6: A Combined Saxs and Nmr Study. ACS Omega (2024)

Kerem KahramanScott A. RobsonOktay GöcenlerCansu M. YeniciCansu D. Tozkoparan CeylanJennifer M. KleinVolker DötschEmine Sonay ElginArthur L. HaasJoshua J. ZiarekÇağdaş Dağ

biophysicsnmr studybiochemistrymolecular biologymonomer-dimer equilibriumnuclear magnetic resonancestructural biologycombined saxs

Insights on the Gpcr Helix 8 Solution Structure and Orientation Using a Neurotensin Receptor 1 Peptide. bioRxiv (Cold Spring Harbor Laboratory) (2024)

James B BowerScott Anthony RobsonJoshua J Ziarek

biophysicssolution structurecell biologyneuroscienceprotein structurestructural biology

Insights on the G Protein‐Coupled Receptor Helix 8 Solution Structure and Orientation Using a Neurotensin Receptor 1 Peptide. Protein Science (2024)

James B. BowerScott A. RobsonJoshua J. Ziarek

protein sciencesolution structureneurosciencepeptidespharmacologyprotein structurereceptorsstructural biology

Data From a Locked, Dimeric Cxcl12 Variant Effectively Inhibits Pulmonary Metastasis of Cxcr4-Expressing Melanoma Cells Due to Enhanced Serum Stability. (2023)

Tomonori TakekoshiJoshua J. ZiarekBrian F. VolkmanSam T. Hwang

Ligands Selectively Tune the Local and Global Motions of Neurotensin Receptor 1 (Nts1). Cell Reports (2023)

Fabian BumbakMiquel PonsAsuka InoueJuan Carlos PaniaguaFei YanHongwei WuScott A. RobsonRoss A.D. BathgateDaniel J. ScottPaul R. GooleyJoshua J. Ziarek

cell signalingcell biologyfunctional selectivityneurosciencemolecular neurobiologypharmacologymolecular neurosciencereceptorsglobal motions

Stabilization of Pre-Existing Neurotensin Receptor Conformational States by β-Arrestin-1 and the Biased Allosteric Modulator Ml314. Nature Communications (2023)

Fabian BumbakJames B. BowerSkylar C. ZemmerAsuka InoueMiquel PonsJuan Carlos PaniaguaFei YanJames FordHongwei WuScott A. RobsonRoss A. D. BathgateDaniel J. ScottPaul R. GooleyJoshua J. Ziarek

neuropharmacologyneurosciencepharmacologystabilityreceptors

A Method for Selective 19 F ‐Labeling Absent of Probe Sequestration ( Slaps ). Protein Science (2022)

Austin D. DixonScott A. RobsonJonathan C. TrinidadJoshua J. Ziarek

selective separationprotein sciencebioinformaticsimmunologydetection techniqueprotein modelingprotein engineeringpharmacologyprotein bioinformaticsprotein structurestructural biologygenetics

A Method for Selective 19 F-Labeling Absent of Probe Sequestration (Slaps). bioRxiv (Cold Spring Harbor Laboratory) (2022)

Austin D. DixonJonathan C. TrinidadJoshua J. Ziarek

molecular biologymedicineneurosciencesampling

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