Faculty

Institution

Unit

Venue

Andrew Hinck

Professor

University of Pittsburgh

Affiliations

Medicine

Structural Biology

Andrew Hinck is currently serving as a Medicine Professor at University of Pittsburgh.

Honors

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Experiences

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Education

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Andrew Hinck

University of Pittsburgh

Professor

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molecular biology structural biology biochemistry protein science pharmacology protein structure genetics medicinal research cell signaling structural molecular biology receptors membrane biology cancer biology gene expression receptor (biochemistry) signal transduction enzymes molecular cell biology biological chemistry molecular physiology biomolecular interactions biomolecular structure cancer treatment vascular biology protein assembly signaling pathways staphylococcal nuclease rna biology tumor targeting mammalian biology molecular regulation protein chemistry cancer genomics cellular biochemistry leukemia molecular science signal recognition cell regulation protein nmr angiogenesis genome biology biochemical sciences structure-function enzyme kinetics adaptive immune system t-regulatory cell host specificity molecular research solution structure veterinary parasitology redox biology protein evolution host response functional modification enzyme catalysis molecular evidence protein expression g protein-coupled receptor pharmaceutical chemistry enzyme specificity disease progression sequence analysis structural basis tgf-b superfamily three-dimensional structure polycomb group sterile alpha motif receptor specificity structural characterization regulatory domain two-dimensional nmr studies tgf-b signaling phenylalanine hydroxylase sequential resonance assignments conformational heterogeneity molecular neurobiology tgf-b family nmr spectroscopy biophysics isothermal titration calorimetry downstream effectors nuclear magnetic resonance spectroscopy biomolecular analysis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Molecular Basis of Interchain Disulfide Bond Formation in Bmp-9 and Bmp-10. Journal of Molecular Biology (2025)

Tristin A SchwartzeStefanie A MoroskyTeresa L RosatoAmy HenricksonGuowu LinCynthia S HinckAlexander B TaylorShaun K OlsenGuillermo CaleroBorries DemelerBeth L RomanAndrew P Hinck

protein structuremolecular sciencemolecular biologybiochemistry

Betaglycan Sustains Hgf/Met Signaling in Lung Cancer and Endothelial Cells Promoting Cell Migration and Tumor Growth. Heliyon (2024)

Rodolfo Daniel Cervantes-VillagranaValentín MendozaCynthia S. HinckRosa Luz de la Fuente-LeónAndrew P. HinckGuadalupe Reyes-CruzJosé Vázquez-PradoFernando López-Casillas

cell signalingtherapeutic efficacycancer carevascular biologymolecular cancercancer biologydermatologycancer researchcancer growthhepatologycancer treatmentlung cancertumor growthimmunologysignaling pathwayspharmacologythoracic oncologyoncologyendothelial cellsmedicinal research

Design of High Affinity Binders to Convex Protein Target Sites. bioRxiv (Cold Spring Harbor Laboratory) (2024)

David BakerWei YangDerrick R HicksAgnidipta GhoshTristin A SchwartzeBrian CoventryInna GoreshnikAza AllenSamer HalabiyaChanJohng KimCynthia S HinckDavid S LeeAsim BeraZhe LiYujia WangThomas SchlichthaerleLongxing CaoBuwei HuangSarah GarrettStacey R GerbenStephen RettiePiper HeineNatasha EdmanAnalisa N MurrayLauren P CarterLance StewartSteven AlmoAndrew P Hinck

protein target sitesbiophysicstumor biologybiomolecular engineeringhigh affinity bindersstructural biologyprotein designprotein engineeringbiological engineering

Ficolin-3 Induces Apoptosis and Suppresses Malignant Property of Hepatocellular Carcinoma Cells via the Complement Pathway. Life Sciences (2024)

Guixi ZhengLianqiu WuHakim BouamarMatyas CserhatiYu-Chiao ChiuCinthia S HinckŁukasz WieteskaCarla R Zeballos TorrezRuolei HuAcarizia EasleyYidong ChenAndrew P HinckFrancisco G CigarroaLu-Zhe Sun

cell deathmetastasisinhibitory activityapoptosispathologyautophagycell biologycomplement pathwaycancer biologyfibroblast growth factorstherapeutic targetscancer immunotherapytumor biologysuppresses malignant propertycarcinogenesisliver cancermolecular biologyhepatocellular carcinoma cellsoncogenescancer cellsmedicinal research

Immunocompetent Murine Model of Ewing Sarcoma Reveals Role for Tgfβ Inhibition to Enhance Immune Infiltrates in Ewing Tumors During Radiation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jessica D. DaleyElina MukherjeeA Carolina TufinoNathanael BaileyShanthi BhaskarNivitha PeriyapatnaIan MacFawnSheryl KunningCynthia HinckTullia BrunoAdam C. OlsonLinda M. McAllister-LucasAndrew P. HinckKristine CooperRiyue BaoAnthony R. CilloKelly M. Bailey

host responseimmunocompetent murine modelvascular biologytgfb inhibitionimmunoeditingtumor microenvironmentcancer biologydermatologyimmune infiltratessurgical oncologyimmunity (medicine)tumor biologyimmunologythoracic oncologyradiation oncologyradiation biologyoncologymedicinal researchimmunomodulationradiationcellular therapy

Improved Protein Binder Design Using ꞵ-Pairing Targeted Rfdiffusion. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Isaac SappingtonMartin ToulDavid S. LeeStephanie A. RobinsonInna GoreshnikClara McCurdyTung Ching ChanNic BuchholzBuwei HuangDionne VafeadosMariana Garcia-SanchezNicole RoullierMatthias GlöglChristopher J. KimJoseph L. WatsonSusana Vázquez TorresKoen H. G. VerschuerenKenneth VerstraeteCynthia S. HinckMelisa Benard-ValleBrian CoventryJeremiah Nelson SimsGreen AhnXinru WangAndrew P. HinckTimothy P. JenkinsHannele Ruohola-BakerSteven M. BanikSavvas N. SavvidesDavid Baker

protein assemblybiomedical engineeringprotein structureprotein binder designbiomolecular engineeringmolecular biologyprotein designprotein scienceprotein engineeringmolecular design

Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate Alk1 Signaling in Endothelial Cells. Cells (2024)

Ya-Wen ChengAnthony R. AnzellStefanie A. MoroskyTristin A. SchwartzeCynthia S. HinckAndrew P. HinckBeth L. RomanLance A. Davidson

osmoregulationcell signalingligand synergizeliver physiologysub-femtomolar levelscell biologyshear stressvascular biologycell physiologymembrane biologyinflammationcellular physiologysignaling pathwaysreceptorsgene expressionpharmacologyenzyme inhibitionangiogenesisgeneticsendothelial cellsmedicinal research

Structures of Tgf-β With Betaglycan and the Signaling Receptors Reveal the Mechanism Whereby Betaglycan Potentiates Receptor Complex Assembly and Signaling. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Łukasz WieteskaAlexander B. TaylorEmma PunchJonathan A. ColemanIsabella O. ConwayYeu-Farn LinChang-Hyeock ByeonCynthia S. HinckTroy KrzysiakRieko IshimaFernando López-CasillasPeter CherepanovDaniel J. BernardCaroline S. HillAndrew P. Hinck

pharmacologycell signalingprotein structuregeneticsstructural molecular biologymembrane biologystructural biologyneuroscience

The Tgf-β Mimic Tgm4 Achieves Cell Specificity Through Combinatorial Surface Co-Receptor Binding. EMBO Reports (2024)

Shashi P SinghDanielle J SmythKyle T CunninghamAnanya MukundanChang-Hyeock ByeonCynthia S HinckMadeleine P J WhiteClaire CianciaNatalia WąsowskaAnna SandersRegina JinRuby F WhiteSergio LillaSara ZanivanChristina SchoenherrGareth J InmanMaarten van DintherPeter Ten DijkeAndrew P HinckRick M Maizels

immunologyreceptorscellular immune responsescell signalingmolecular cell biologymolecular biologyimmune responsescell biology

An Oncolytic Virus–Delivered Tgfβ Inhibitor Overcomes the Immunosuppressive Tumor Microenvironment. The Journal of Experimental Medicine (2023)

Kristin DePeauxDayana B. RivadeneiraKonstantinos LontosVictoria G. DeanWilliam G. GunnMcLane J. WatsonTianhong YaoDrew WilfahrtCynthia HinckLukasz WieteskaStephen H. ThorneAndrew P. HinckGreg M. Delgoffe

immunologyvirus researchmedicineantiviral researchpharmacologyimmunosuppressive therapyvirus-host interactionscancer researchvirologyexperimental therapeuticsoncologyclinical researchmedicinal researchtumor microenvironmentcancer treatmentimmunosuppressive tumor microenvironmentexperimental medicineviral oncology

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Andrew Hinck

Professor

University of Pittsburgh

Affiliations

Medicine

Structural Biology

Andrew Hinck is currently serving as a Medicine Professor at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Andrew Hinck

University of Pittsburgh

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Molecular Basis of Interchain Disulfide Bond Formation in Bmp-9 and Bmp-10. Journal of Molecular Biology (2025)

Tristin A SchwartzeStefanie A MoroskyTeresa L RosatoAmy HenricksonGuowu LinCynthia S HinckAlexander B TaylorShaun K OlsenGuillermo CaleroBorries DemelerBeth L RomanAndrew P Hinck

protein structuremolecular sciencemolecular biologybiochemistry

Betaglycan Sustains Hgf/Met Signaling in Lung Cancer and Endothelial Cells Promoting Cell Migration and Tumor Growth. Heliyon (2024)

Rodolfo Daniel Cervantes-VillagranaValentín MendozaCynthia S. HinckRosa Luz de la Fuente-LeónAndrew P. HinckGuadalupe Reyes-CruzJosé Vázquez-PradoFernando López-Casillas

Design of High Affinity Binders to Convex Protein Target Sites. bioRxiv (Cold Spring Harbor Laboratory) (2024)

protein target sitesbiophysicstumor biologybiomolecular engineeringhigh affinity bindersstructural biologyprotein designprotein engineeringbiological engineering

Ficolin-3 Induces Apoptosis and Suppresses Malignant Property of Hepatocellular Carcinoma Cells via the Complement Pathway. Life Sciences (2024)

Guixi ZhengLianqiu WuHakim BouamarMatyas CserhatiYu-Chiao ChiuCinthia S HinckŁukasz WieteskaCarla R Zeballos TorrezRuolei HuAcarizia EasleyYidong ChenAndrew P HinckFrancisco G CigarroaLu-Zhe Sun

Immunocompetent Murine Model of Ewing Sarcoma Reveals Role for Tgfβ Inhibition to Enhance Immune Infiltrates in Ewing Tumors During Radiation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Improved Protein Binder Design Using ꞵ-Pairing Targeted Rfdiffusion. bioRxiv (Cold Spring Harbor Laboratory) (2024)

protein assemblybiomedical engineeringprotein structureprotein binder designbiomolecular engineeringmolecular biologyprotein designprotein scienceprotein engineeringmolecular design

Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate Alk1 Signaling in Endothelial Cells. Cells (2024)

Ya-Wen ChengAnthony R. AnzellStefanie A. MoroskyTristin A. SchwartzeCynthia S. HinckAndrew P. HinckBeth L. RomanLance A. Davidson

pharmacologycell signalingprotein structuregeneticsstructural molecular biologymembrane biologystructural biologyneuroscience

The Tgf-β Mimic Tgm4 Achieves Cell Specificity Through Combinatorial Surface Co-Receptor Binding. EMBO Reports (2024)

immunologyreceptorscellular immune responsescell signalingmolecular cell biologymolecular biologyimmune responsescell biology

An Oncolytic Virus–Delivered Tgfβ Inhibitor Overcomes the Immunosuppressive Tumor Microenvironment. The Journal of Experimental Medicine (2023)

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