Faculty

Institution

Unit

Venue

Sharon Campbell

Professor of Biophysics

University of North Carolina at Chapel Hill

Affiliations

School of Medicine

Biochemistry and Biophysics

Sharon Campbell is currently serving as a Biochemistry And Biophysics Professor of Biophysics at University of North Carolina At Chapel Hill.

Honors

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Experiences

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Education

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Sharon Campbell

University of North Carolina at Chapel Hill

Professor of Biophysics

You can click a keyword to filter the displayed items

molecular biology biochemistry structural biology biophysics protein science pharmacology protein structure biological chemistry cell signaling signal transduction gene expression membrane biology structural molecular biology nuclear magnetic resonance redox biology molecular and cellular biology biomolecular structure protein nmr molecular cell biology free radical biology cancer biology oncogenes medicinal research protein function molecular regulation biomolecular interactions enzyme inhibition nuclear magnetic resonance spectroscopy protein chemistry cell adhesion protein phosphorylation nucleic acids biochemical sciences molecular cancer g protein-coupled receptor signaling pathways molecular basis redox chemistry focal adhesion kinase focal adhesion molecular science structural chemistry molecular physiology gene regulation cell regulation biomolecular analysis cell migration cancer genomics nmr solution structure tail domain structural characterization ras proteins vinculin activation redox regulation rho gtpases redox signaling biological inorganic chemistry proteinlipid interaction reactive nitrogen species transcription regulation mutagenesis tumor suppressors cancer growth protein refolding cell motility molecular redox switch ras transformation rho family proteins focal adhesions solution structure ras interaction paxillin ld peptide heme signaling gene function functional modification dna analysis tumor biology cancer research cell biology carcinogenesis pathology

Notable Scholarly Works

Notable Federal Grants

Collaborators

2′3′-Cgamp Interactome Identifies 2′3′-Cgamp/Rab18/Fosb Signaling in Cell Migration Control Independent of Innate Immunity. Science Advances (2024)

Yu DengQuentin HahnLe YuZhichuan ZhuJoshua A. BoyerJian WangDeyu KongLeiah M. CareyAustin J. HepperlaJeremy M. SimonBrenda TempleZhigang ZhangYanqiong ZhangCharlene SantosJonathan E. FrankLaura E. HerringXiaodong WangNikolay V. DokholyanSharon L. CampbellAlbert S. BaldwinBlossom DamaniaQi ZhangPengda Liu

cell signalingimmunologycell biologycell migration controlsignaling pathwaysimmune responsesinnate immunityscience advancesystems biologysignal transductioninnate immune systemcell migration

Molecular and Functional Profiling of GαI as an Intracellular Ph Sensor. (2024)

Sharon CampbellAjit PrakashZijian LiVenkat ChirasaniJuhi RasquinhaNatalie ValentinGarrett HubbardGuowei YinHenrik Dohlman

sensorsmolecular and cellular biologyfunctional profilinggene expression profilingprotein scienceintracellular ph sensorimmunologymolecular informaticsmolecular physiologymembrane biologybiosensorsmolecular biologygene expressiongenetics

Catalytic Site Mutations Confer Multiple States of G Protein Activation. Science Signaling (2023)

Natalie HewittNing MaNadia ArangSarah A. MartinAjit PrakashJeffrey F. DiBertoKevin M. KnightSoumadwip GhoshReid H. J. OlsenBryan L. RothJ. Silvio GutkindNagarajan VaidehiSharon L. CampbellHenrik G. Dohlman

key siteprotein scienceenzyme catalysiscell signalingcatalytic site mutationssignaling pathwaysbiochemistrymultiple statesmolecular biologyg protein-coupled receptorprotein structuresystems biologysignal transductiongene expressionstructural molecular biology

Characterization of Kinetic and Redox Properties of Oncogenic Krasg12C Inhibitors. Free Radical Biology and Medicine (2023)

Sharon Campbell

oncogenescatalyst activationchemical kineticsbiochemistryfree radical biologyenzyme inhibitiontransition metal chemistryoncogenic agentpharmacologyoxidative stresstherapeutic targetsdrug discoveryredox chemistryredox biologyredox propertiesbiomolecular engineering

Elucidation of the Molecular Basis and Cellular Functions of Vinculin-Actin Directional Catch Bonding. Research Square (2023)

Sharon CampbellVenkat ChirasaniMohammad KhanJuilee MalavadeNikolay DokholyanBrenton Hoffman

biophysicsbiochemistrymolecular biophysicsmolecular basiscellular functionsmolecular biology

Molecular Basis and Cellular Functions of Vinculin-Actin Directional Catch Bonding. Nature Communications (2023)

Venkat R. ChirasaniMohammad Ashhar I. KhanJuilee N. MalavadeNikolay V. DokholyanBrenton D. HoffmanSharon L. Campbell

biophysicscell biologymolecular biophysicsmolecular basiscellular functionsmolecular biology

Enhanced Braf Engagement by Nras Mutants Capable of Promoting Melanoma Initiation. Nature Communications (2022)

Brandon M. MurphyElizabeth M. TerrellVenkat R. ChirasaniTirzah J. WeissRachel E. LewAndrea M. HolderbaumAastha DhakalValentina PosadaMarie FortMichael S. BodnarLeiah M. CareyMin ChenCraig J. BurdVincenzo CoppolaDeborah K. MorrisonSharon L. CampbellChristin E. Burd

braf engagementmelanoma initiationdermatologypharmacologytumor biologynaturenras mutantscancer researchtumor suppressorsmolecular biologygene expressiongene therapymedicinal researchmolecular cancercancer biologymetastasisskin cancermolecular cell biologycancer growthleukemiacancer genomics

Kinetic and Redox Characterization of Kras G12C Inhibition. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Minh V. HuynhDerek ParsonageTom E. ForshawVenkata R. ChirasaniG. Aaron HobbsHanzhi WuJingyun LeeCristina M. FurduiLeslie B. PooleSharon L. Campbell

redox characterizationchemical kineticsneurosciencebiochemistrypharmacologyredox biology

Oncogenic Kras G12C: Kinetic and Redox Characterization of Covalent Inhibition. Journal of Biological Chemistry (2022)

Minh V. HuynhDerek ParsonageTom E. ForshawVenkat R. ChirasaniG. Aaron HobbsHanzhi WuJingyun LeeCristina M. FurduiLeslie B. PooleSharon L. Campbell

oncogenestumor biologyredox characterizationmedicinal chemistrybiochemistrycovalent inhibitiononcogenic agentmolecular biologypharmacologybiological chemistryredox biology

A Universal Allosteric Mechanism for G Protein Activation. Molecular Cell (2021)

Kevin M. KnightSoumadwip GhoshSharon L. CampbellTyler J. LefevreReid H.J. OlsenAlan V. SmrckaNatalie H. ValentinGuowei YinNagarajan VaidehiHenrik G. Dohlman

protein scienceuniversal allosteric mechanismcell signalingcell biologybiochemistrymolecular cell biologymolecular biologyg protein-coupled receptor

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Sharon Campbell

Professor of Biophysics

University of North Carolina at Chapel Hill

Affiliations

School of Medicine

Biochemistry and Biophysics

Sharon Campbell is currently serving as a Biochemistry And Biophysics Professor of Biophysics at University of North Carolina At Chapel Hill.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Sharon Campbell

University of North Carolina at Chapel Hill

Professor of Biophysics

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

2′3′-Cgamp Interactome Identifies 2′3′-Cgamp/Rab18/Fosb Signaling in Cell Migration Control Independent of Innate Immunity. Science Advances (2024)

cell signalingimmunologycell biologycell migration controlsignaling pathwaysimmune responsesinnate immunityscience advancesystems biologysignal transductioninnate immune systemcell migration

Molecular and Functional Profiling of GαI as an Intracellular Ph Sensor. (2024)

Sharon CampbellAjit PrakashZijian LiVenkat ChirasaniJuhi RasquinhaNatalie ValentinGarrett HubbardGuowei YinHenrik Dohlman

Catalytic Site Mutations Confer Multiple States of G Protein Activation. Science Signaling (2023)

Characterization of Kinetic and Redox Properties of Oncogenic Krasg12C Inhibitors. Free Radical Biology and Medicine (2023)

Sharon Campbell

Elucidation of the Molecular Basis and Cellular Functions of Vinculin-Actin Directional Catch Bonding. Research Square (2023)

Sharon CampbellVenkat ChirasaniMohammad KhanJuilee MalavadeNikolay DokholyanBrenton Hoffman

biophysicsbiochemistrymolecular biophysicsmolecular basiscellular functionsmolecular biology

Molecular Basis and Cellular Functions of Vinculin-Actin Directional Catch Bonding. Nature Communications (2023)

Venkat R. ChirasaniMohammad Ashhar I. KhanJuilee N. MalavadeNikolay V. DokholyanBrenton D. HoffmanSharon L. Campbell

biophysicscell biologymolecular biophysicsmolecular basiscellular functionsmolecular biology

Enhanced Braf Engagement by Nras Mutants Capable of Promoting Melanoma Initiation. Nature Communications (2022)

Kinetic and Redox Characterization of Kras G12C Inhibition. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Minh V. HuynhDerek ParsonageTom E. ForshawVenkata R. ChirasaniG. Aaron HobbsHanzhi WuJingyun LeeCristina M. FurduiLeslie B. PooleSharon L. Campbell

redox characterizationchemical kineticsneurosciencebiochemistrypharmacologyredox biology

Oncogenic Kras G12C: Kinetic and Redox Characterization of Covalent Inhibition. Journal of Biological Chemistry (2022)

Minh V. HuynhDerek ParsonageTom E. ForshawVenkat R. ChirasaniG. Aaron HobbsHanzhi WuJingyun LeeCristina M. FurduiLeslie B. PooleSharon L. Campbell

oncogenestumor biologyredox characterizationmedicinal chemistrybiochemistrycovalent inhibitiononcogenic agentmolecular biologypharmacologybiological chemistryredox biology

A Universal Allosteric Mechanism for G Protein Activation. Molecular Cell (2021)

Kevin M. KnightSoumadwip GhoshSharon L. CampbellTyler J. LefevreReid H.J. OlsenAlan V. SmrckaNatalie H. ValentinGuowei YinNagarajan VaidehiHenrik G. Dohlman

protein scienceuniversal allosteric mechanismcell signalingcell biologybiochemistrymolecular cell biologymolecular biologyg protein-coupled receptor

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synthetic biology

cancer discovery

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molecular biology

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molecular biology

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Steven GONIAS

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protein chaperones

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protein bioinformatics

biomolecular structure