Faculty

Institution

Unit

Venue

Vadim Gaponenko

Professor

University of Illinois Chicago

Affiliations

College of Medicine

Department of Biochemistry and Molecular Genetics

Vadim Gaponenko is currently serving as a College Of Medicine Professor at University of Illinois Chicago.

Honors

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Experiences

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Education

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Vadim Gaponenko

University of Illinois Chicago

Professor

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pharmacology molecular biology structural biology biochemistry protein science cell biology gene expression tumor biology medicinal research membrane biology cancer biology protein structure cell signaling receptors signal transduction c-x-c motif biological chemistry molecular cancer redox biology enzyme inhibition receptor (biochemistry) cancer treatment vascular biology molecular regulation hypervariable region structural molecular biology oncogenes molecular physiology peptides protein function clinical immunology cellular therapy tumor targeting protein chemistry anti-cancer agents drug allergy clinical allergy unique mechanism cellular biochemistry biomolecular interactions signaling pathways protein structure prediction pharmacokinetics functional modification host specificity oncogenic mutations high-affinity interaction c-terminal domain vascular smooth muscle membrane binding ras active site developmental cell developmental science clinical chemistry inhibitory activity drug targeting lead identification drug targets rational drug design experimental biophysics remedial action therapeutic efficacy intermediate host protein phosphorylation host response cellular immune responses adaptive immune system innate immune system cell culture proteasome inhibitors virus spread hcmv assembly compartment dynamic golgi-derived mtoc nuclear rotation gtp binding effector binding site biomolecular structure nuclear magnetic resonance spectroscopy protein nmr nuclear magnetic resonance

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 3323: Novel Pan-Ras Inhibitor Adt-007: A Unique Mechanism of Antitumor Selectivity in Pancreatic and Colorectal Carcinoma Models. Cancer Research (2024)

Junwei WangAdam B. KeetonSindhu RameshPeyton JohnsonYulia Y. MaxuitenkoJeremy B. FooteChung-Hui HuangKristy L. BerryKhalda FadlallaBandi D. ReddyGanji P. NagarajuElmar NurmemmedovIvan BabicVadim GaponenkoXi ChenBassel F. El-RayesDonald J. BuchsbaumGary A. Piazza

medicinal chemistrypancreatic cancercancer careunique mechanismmolecular canceranti-cancer agentscolorectal cancercancer biologyantitumor selectivitycancer researchtherapeutic targetscancer treatmentenzyme inhibitionpharmacologyradiation oncologycolorectal carcinoma modelsgeneticsoncologyclinical researchmedicinal researchcellular therapy

A Pan-Ras Inhibitor With a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer. Cancer Research (2024)

Jeremy B. FooteTyler E. MattoxAdam B. KeetonXi ChenForrest T. SmithKristy BerryThomas W. HolmesJunwei WangChung-hui HuangAntonio WardAMIT K. MitraVeronica Ramirez-AlcantaraCherlene HardyKarianne G. FletenKjersti FlatmarkKarina J. YoonSujith SarveshGanji P. NagarajuDhana Sekhar Reddy BandiYulia Y. MaxuitenkoJacaob ValiyaveettilJulienne L. CarstensDonald J. BuchsbaumJennifer YangGang ZhouElmar NurmemmedovIvan BabicVadim GaponekoHazem AbdelkarimMichael R. BoydGreg GormanUpender ManneSejong BaeBassel F. El-RayesGary A. Piazza

gastrointestinal cancertumor targetingunique mechanismcancer immunosurveillanceanti-cancer agentstumor microenvironmentcancer biologycancer researchcancer immunotherapypan-ras inhibitorcancer treatmenttumor biologyimmunotherapyimmunologypharmacologyradiation oncologycancer discoveryoncogenescancer cellsmedicinal researchcellular therapy

Ethanol Promotes Protease Activated Receptor 1: Chemokine (C-X-C Motif) Receptor 4 Heteromerization and Enhances Thrombin-Induced Impairment of Human Lung Endothelial Cell Barrier Function. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2024)

Michelle Y McGeeGarrett A EntenSadia N BoshraOlolade OgunsinaVadim GaponenkoXianlong GaoMatthias Majetschak

protein functionreceptor (biochemistry)thrombin-induced impairmentliver physiologyendocrinologyvascular biologyprotein sciencemembrane biologyinflammationc-x-c motifmolecular physiologyimmunologyreceptorspulmonary pharmacologypharmacologyredox biologyendothelial dysfunctiondisease physiologysignal transductionneuroscience

Abstract 1658: Adt-007 Binds Ras and Inhibits Ras Signaling. Cancer Research (2023)

Adam B. KeetonXi ChenJacob ValiyaveettilChung-Hui HuangTyler E. MattoxKhalda FadlallaJeremy B. FooteDonald J. BuchsbaumKristy L. BerryElmar NurmemmedovIvan BabicVadim GaponenkoGregory GormanLori CowardYulia Y. MaxuitenkoForrest T. SmithGary A. Piazza

pharmacologycancer geneticscancer researchcell signalingmolecular cancermolecular biologyoncologymedicinal researchcancer biologyhealth sciences

A Novel Pan-Ras Inhibitor With a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of Gi Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jeremy B. FooteTyler E. MattoxAdam B. KeetonXi ChenForrest SmithKristy L. BerryThomas HolmesJunwei WangChung-Hui HuangAntonio B. WardAmit K. MitraVeronica Ramirez-AlcantaraCherlene HardyKarrianne G. FletenKjersti FlatmarkKarina J. YoonSujith SarveshGanji Purnachandra NagarajuDhana Sekhar Reddy BandiYulia Y. MaxuitenkoJacob ValiyaveettilJulienne L. CarstensDonald J. BuchsbaumJennifer YangGang ZhouElmar NurmemmedovIvan BabicVadim GaponenkoHazem AbdelkarimMichael R. BoydGregory S. GormanUpender ManneSejong BaeBassel F. El-RayesGary A. Piazza

novel therapiescell biologyin vitro toxicologytumor targetingunique mechanismmolecular cancercancer genomicscancer biologymouse modelsgi cancercancer researchcancer immunotherapynovel pan-ras inhibitorcancer treatmenttumor biologyenzyme inhibitionpharmacologygliomasradiation oncologyoncologymedicinal researchcellular therapy

Development of Tolerance to Chemokine Receptor Antagonists: Current Paradigms and the Need for Further Investigation. Frontiers in Immunology (2023)

Patrick GrudzienHenry NeufeldMbasogo Ebe EyengaVadim Gaponenko

immunologymedicinepharmacologyfurther investigationtolerance inductiondrug intolerancecurrent paradigms

Dorzolamide Suppresses Pkcδ -Tirap-P38 Mapk Signaling Axis to Dampen the Inflammatory Response. Future Medicinal Chemistry (2023)

Sajjan RajpootAshutosh KumarVadim GaponenkoTeresa LM ThurstonDolly MehtaSyed M FaisalKam YJ ZhangHem C JhaGajanan N DarwhekarMirza S Baig

immunologymedicinal chemistrymedicinepharmacologyfuture medicinal chemistrypharmacotherapyinflammatory responsedrug discoveryinflammation

End Binding-3 Inhibitor Activates Regenerative Program in Age-Related Macular Degeneration. Cell Reports Medicine (2023)

Quinn LeeWan Ching ChanXinyan QuYing SunHazem AbdelkarimJonathan LeUzma SaqibMitchell Y. SunKevin KruseAvik BanerjeeBen HitchinsonMelissa GeyerFei HuangVictor GuaiquilAmelia A. MutsoMartin SandersMark I. RosenblattMark Maienschein-ClineMatthew S. LawrenceVadim GaponenkoAsrar B. MalikYulia A. Komarova

medicinepharmacologyage-related macular degenerationophthalmologycell signaling

Abstract 2918: Comprehensive Survey of Kras4B Membrane Interaction and Orientation. Cancer Research (2022)

Hyunbum JangMingzhen ZhangVadim GaponenkoRuth Nussinov

pharmacologyradiation oncologycancer researchcancer imagingoncologymedicinal researchcancer biologytumor biologyhealth sciences

Conformational Dynamics Allows Sampling of an “Active-Like” State by Oncogenic K-Ras-Gdp. Journal of Molecular Biology (2022)

Patrick GrudzienHyunbum JangNicholas LeschinskyRuth NussinovVadim Gaponenko

gene expressiononcogenic k-ras-gdpgeneticsmolecular biologyconformational dynamics

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Vadim Gaponenko

Professor

University of Illinois Chicago

Affiliations

College of Medicine

Department of Biochemistry and Molecular Genetics

Vadim Gaponenko is currently serving as a College Of Medicine Professor at University of Illinois Chicago.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Vadim Gaponenko

University of Illinois Chicago

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 3323: Novel Pan-Ras Inhibitor Adt-007: A Unique Mechanism of Antitumor Selectivity in Pancreatic and Colorectal Carcinoma Models. Cancer Research (2024)

A Pan-Ras Inhibitor With a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer. Cancer Research (2024)

Michelle Y McGeeGarrett A EntenSadia N BoshraOlolade OgunsinaVadim GaponenkoXianlong GaoMatthias Majetschak

Abstract 1658: Adt-007 Binds Ras and Inhibits Ras Signaling. Cancer Research (2023)

pharmacologycancer geneticscancer researchcell signalingmolecular cancermolecular biologyoncologymedicinal researchcancer biologyhealth sciences

A Novel Pan-Ras Inhibitor With a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of Gi Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Development of Tolerance to Chemokine Receptor Antagonists: Current Paradigms and the Need for Further Investigation. Frontiers in Immunology (2023)

Patrick GrudzienHenry NeufeldMbasogo Ebe EyengaVadim Gaponenko

immunologymedicinepharmacologyfurther investigationtolerance inductiondrug intolerancecurrent paradigms

Dorzolamide Suppresses Pkcδ -Tirap-P38 Mapk Signaling Axis to Dampen the Inflammatory Response. Future Medicinal Chemistry (2023)

Sajjan RajpootAshutosh KumarVadim GaponenkoTeresa LM ThurstonDolly MehtaSyed M FaisalKam YJ ZhangHem C JhaGajanan N DarwhekarMirza S Baig

immunologymedicinal chemistrymedicinepharmacologyfuture medicinal chemistrypharmacotherapyinflammatory responsedrug discoveryinflammation

End Binding-3 Inhibitor Activates Regenerative Program in Age-Related Macular Degeneration. Cell Reports Medicine (2023)

medicinepharmacologyage-related macular degenerationophthalmologycell signaling

Abstract 2918: Comprehensive Survey of Kras4B Membrane Interaction and Orientation. Cancer Research (2022)

Hyunbum JangMingzhen ZhangVadim GaponenkoRuth Nussinov

pharmacologyradiation oncologycancer researchcancer imagingoncologymedicinal researchcancer biologytumor biologyhealth sciences

Conformational Dynamics Allows Sampling of an “Active-Like” State by Oncogenic K-Ras-Gdp. Journal of Molecular Biology (2022)

Patrick GrudzienHyunbum JangNicholas LeschinskyRuth NussinovVadim Gaponenko

gene expressiononcogenic k-ras-gdpgeneticsmolecular biologyconformational dynamics

1
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5
9
10 / page

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