Faculty

Institution

Unit

Venue

Douglas Kojetin

Associate Professor

Vanderbilt University

Affiliations

School of Medicine

Department of Biochemistry

Douglas Kojetin is currently serving as a Biochemistry Associate Professor at Vanderbilt University.

Honors

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Experiences

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Education

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Douglas Kojetin

Vanderbilt University

Associate Professor

You can click a keyword to filter the displayed items

pharmacology molecular biology structural biology biochemistry neuroscience protein science structural molecular biology cell signaling protein structure medicinal chemistry drug discovery endocrinology chemical biology medicinal research membrane biology receptor (biochemistry) biological chemistry molecular cell biology biomolecular interactions biomolecular structure molecular regulation transcription regulation molecular structure structural mechanism molecular physiology gene regulation enzyme inhibition drug targeting pharmaceutical chemistry g protein-coupled receptor bacillus subtilis response regulators mammalian biology clinical chemistry redox biology cellular physiology cancer biology nuclear magnetic resonance spectroscopy pharmaceutical sciences functional selectivity structural basis liver physiology vascular biology plo biology chronobiology structural genomics antiviral therapy conformational studies endocrine research functional regulation protein expression functional modification structural composition transcriptional repression nmr spectroscopy repressive states ligand efficacy cryptochromes metabolic regulation gene characterization lead identification host specificity viral replication cellular immune responses host response protein transport adaptive immune system molecular adaptation synthetic rev-erb agonists ror nuclear receptors nuclear receptors interaction surfaces intact vdr-rxr complex alternate binding site pparg ligands synthetic antagonist biophysical chemistry biophysics biochemical assays transcription (biology) protein nmr cellular assays nuclear magnetic resonance

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ligand Efficacy Shifts a Nuclear Receptor Conformational Ensemble Between Transcriptionally Active and Repressive States. Nature Communications (2025)

repressive statesreceptorsreceptor (biochemistry)biomolecular interactionsnuclear organizationcell biologytranscription (biology)molecular cell biologyprotein sciencetranscription factorsprotein foldingsignal transductionligand efficacymolecular biology

Structural Basis of Pparγ-Mediated Transcriptional Repression by the Covalent Inverse Agonist Fx-909. bioRxiv (Cold Spring Harbor Laboratory) (2025)

receptorsgene expressionreceptor (biochemistry)pparγ-mediated transcriptional repressiongene regulationmolecular cell biologytranscription (biology)structural molecular biologytranscription factorssystems biologybiological chemistrymolecular regulationstructural basistranscription regulationmolecular biology

A Tethering Mechanism Underlies Pin1-Catalyzed Proline Cis-Trans Isomerization at a Noncanonical Site. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Christopher C WilliamsJonathan ChuckPaola Munoz-TelloDouglas J Kojetin

biophysicsenzymesprotein scienceenzyme catalysisbiochemistrynoncanonical sitemolecular biologytethering mechanism

Jagged2 Targeting in Lung Cancer Activates Anti-Tumor Immunity via Notch-Induced Functional Reprogramming of Tumor-Associated Macrophages. Immunity (2024)

Jay K. MandulaRosa A. Sierra-MondragonRachel V. JimenezDarwin ChangEslam MohamedShiun ChangJulio A. Vazquez-MartinezYu CaoCarmen M. AnadonSae Bom LeeSatyajit DasLéo Rocha-MungubaVincent M. PhamRoger LiAhmad A. TarhiniMuhammad FurqanWilliam DaltonMichelle ChurchmanCarlos M. Moran-SeguraJonathan NguyenBradford PerezDouglas J. KojetinAlyssa ObermayerXiaoqing YuAnn ChenTimothy I. ShawJose R. Conejo-GarciaPaulo C. Rodriguez

lung cancercancer immunotherapymedicinecancer biologytumor suppressorspharmacologyrespiratory medicinetumor-associated macrophagestumor biologycellular therapycancer researchcancer carecancer treatmentanti-tumor immunitynotch-induced functional reprogrammingimmune responsesimmunologytumor targetingmedicinal researchviral oncologythoracic oncology

Ligand Efficacy Shifts a Nuclear Receptor Conformational Ensemble Between Transcriptionally Active and Repressive States. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Brian MacTavishDi ZhuJinsai ShangQianzhen ShaoZhongyue J YangTheodore M KameneckaDouglas J Kojetin

repressive statesfunctional genomicsneurosciencepharmacologyconformational studiestranscription regulationmolecular biologyligand efficacy

Structural Insights Into Imp2 Dimerization and Rna Binding. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Stephen ZorcPaola Munoz-TelloTimothy O'LearyXiaoyu YuMithun NagAlthea Hansel-HarrisStefano ForliPatrick R. GriffinDouglas J. KojetinRaktim N. RoyMichalina Janiszewska

geneticsgene expressionstructural molecular biologybiochemistryrna biologymolecular biologyrna bindingstructural biology

The Endocannabinoid Anandamide Mediates Anti‐Inflammatory Effects Through Activation of Nr4A Nuclear Receptors. British Journal of Pharmacology (2024)

Tom TeichmannBeatrice Pflüger‐MüllerVirna Margarita Martín GiménezFiona SailerHenrik DirksSimonida ZehrTimothy WarwickFelix BrettnerPaola Munoz‐TelloAndreas ZimmerIrmgard TegederDominique ThomasRobert GurkeStefan GüntherJan HeeringEwgenij ProschakGerd GeisslingerIris‐S. BibliDagmar Meyer zu HeringdorfWalter ManuchaMaike WindbergsStefan KnappAndreas WeigertMatthias S. LeisegangDouglas KojetinRalf P. Brandes

receptorshivdiabetesendocannabinoid anandamidetherapeutic targetsinhibitory activitycardiovascular diseasemulti-scale studiestherapeutic efficacyepidemiologytreatment optionsimmunologyvascular biologymedicinal researchclinical lipidologydermatologycanadian studiesretrospective cohort studiesanti-inflammatory effectsenzyme inhibition

Unanticipated Mechanisms of Covalent Inhibitor and Synthetic Ligand Cobinding to Ppargamma. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jinsai ShangDouglas J. Kojetin

biophysicsbiomolecular interactionsmedicinal chemistryprotein scienceneurosciencecovalent inhibitorsynthetic ligandpharmacologymolecular pharmacologyunanticipated mechanismsdrug discovery

Unanticipated Mechanisms of Covalent Inhibitor and Synthetic Ligand Cobinding to Pparγ. eLife (2024)

Jinsai ShangDouglas J Kojetin

chemistrymechanisms of actionsynthetic ligandcovalent inhibitorunanticipated mechanisms

Unanticipated Mechanisms of Covalent Inhibitor and Synthetic Ligand Cobinding to Pparγ. eLife (2024)

receptorsreceptor (biochemistry)pharmacological researchchemical biologymechanisms of actioncell signalingbiological chemistrybiochemistrypharmacologysynthetic ligandtherapeutic targetscovalent inhibitormolecular pharmacologynon-peptide ligandenzyme inhibitiondrug discovery

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Douglas Kojetin

Associate Professor

Vanderbilt University

Affiliations

School of Medicine

Department of Biochemistry

Douglas Kojetin is currently serving as a Biochemistry Associate Professor at Vanderbilt University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Douglas Kojetin

Vanderbilt University

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ligand Efficacy Shifts a Nuclear Receptor Conformational Ensemble Between Transcriptionally Active and Repressive States. Nature Communications (2025)

Structural Basis of Pparγ-Mediated Transcriptional Repression by the Covalent Inverse Agonist Fx-909. bioRxiv (Cold Spring Harbor Laboratory) (2025)

A Tethering Mechanism Underlies Pin1-Catalyzed Proline Cis-Trans Isomerization at a Noncanonical Site. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Christopher C WilliamsJonathan ChuckPaola Munoz-TelloDouglas J Kojetin

biophysicsenzymesprotein scienceenzyme catalysisbiochemistrynoncanonical sitemolecular biologytethering mechanism

Jagged2 Targeting in Lung Cancer Activates Anti-Tumor Immunity via Notch-Induced Functional Reprogramming of Tumor-Associated Macrophages. Immunity (2024)

Ligand Efficacy Shifts a Nuclear Receptor Conformational Ensemble Between Transcriptionally Active and Repressive States. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Brian MacTavishDi ZhuJinsai ShangQianzhen ShaoZhongyue J YangTheodore M KameneckaDouglas J Kojetin

repressive statesfunctional genomicsneurosciencepharmacologyconformational studiestranscription regulationmolecular biologyligand efficacy

Structural Insights Into Imp2 Dimerization and Rna Binding. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Stephen ZorcPaola Munoz-TelloTimothy O'LearyXiaoyu YuMithun NagAlthea Hansel-HarrisStefano ForliPatrick R. GriffinDouglas J. KojetinRaktim N. RoyMichalina Janiszewska

geneticsgene expressionstructural molecular biologybiochemistryrna biologymolecular biologyrna bindingstructural biology

The Endocannabinoid Anandamide Mediates Anti‐Inflammatory Effects Through Activation of Nr4A Nuclear Receptors. British Journal of Pharmacology (2024)

Unanticipated Mechanisms of Covalent Inhibitor and Synthetic Ligand Cobinding to Ppargamma. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jinsai ShangDouglas J. Kojetin

biophysicsbiomolecular interactionsmedicinal chemistryprotein scienceneurosciencecovalent inhibitorsynthetic ligandpharmacologymolecular pharmacologyunanticipated mechanismsdrug discovery

Unanticipated Mechanisms of Covalent Inhibitor and Synthetic Ligand Cobinding to Pparγ. eLife (2024)

Jinsai ShangDouglas J Kojetin

chemistrymechanisms of actionsynthetic ligandcovalent inhibitorunanticipated mechanisms

Unanticipated Mechanisms of Covalent Inhibitor and Synthetic Ligand Cobinding to Pparγ. eLife (2024)

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4
5
12
10 / page

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photoreceptor cell

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