Faculty

Institution

Unit

Venue

Dale F. Mierke

Professor Frank R Mori Professor

Dartmouth College

Affiliations

Faculty of Arts and Sciences

Department of Chemistry

Dale F. Mierke is currently serving as a Chemistry Professor Frank R Mori Professor at Dartmouth College.

Honors

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Experiences

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Education

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Dale F. Mierke

Dartmouth College

Professor Frank R Mori Professor

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pharmacology biochemistry molecular biology structural biology receptors biophysics protein science protein structure endocrinology peptides parathyroid hormone cell signaling receptor (biochemistry) peptide science structural molecular biology membrane biology nuclear magnetic resonance molecular physiology conformational studies medicinal chemistry biomolecular structure biological chemistry structural chemistry g protein-coupled receptor medicinal research enzyme inhibition structural characterization cellular biochemistry cellular physiology peptide synthesis molecular cell biology signaling pathways protein chemistry peptide engineering structure determination molecular dynamics conformational analysis nuclear magnetic resonance spectroscopy structure elucidation biomolecular interactions liver physiology pharmaceutical chemistry molecular regulation protein function non-peptide ligand computer simulations virus research viral genetics gene regulation transcription regulation redox biology pharmaceutical sciences receptor tyrosine kinases drug targeting dimethyl sulfoxide molecular dynamics simulations distance geometry parathyroid hormone-related protein receptor activation pharmaceutical research cell regulation micelles protein modeling functional regulation supramolecular assemblies molecular modeling studies intermolecular interactions second intracellular loop template structures surface reactivity host specificity conformity bone homeostasis cyclic pentaalanine peptides nmr spectroscopy third extracellular loop peptide library biophysical chemistry protein nmr biomolecular engineering high resolution nmr

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Structure of a Nemo Construct Engineered for Screening Reveals Novel Determinants of Inhibition. (2024)

Amy E. KennedyAdam H. BarczewskiChristina R. ArnoldyJ. Pepper PenningtonKelly A. TiernanMaria Beatriz HidalgoCaroline C. ReillyMichael J. RagusaGevorg GrigoryanDale F. MierkeMaria M. Pellegrini

public healthnemo constructstructural biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicsstructure elucidationcrystal researchcrystal diffraction studystructure determinationstructural chemistryccdc 2157502chemistrydeposited datasetcrystal engineeringchemical structurecrystal structurescrystallography

An Engineered Construct of Cflip Provides Insight Into Ded1 Structure and Interactions. Structure (2021)

Alexandra E PanaitiuTamar BasiashviliDale F MierkeMaria Pellegrini

structural biologyengineered constructmolecular biology

Dynamic Enzymatic Synthesis of γ-Cyclodextrin Using a Photoremovable Hydrazone Template. Chem (2021)

Sirun YangDennis LarsenMaria PellegriniSebastian MeierDale F. MierkeSophie R. BeerenIvan Aprahamian

materials sciencedynamic enzymatic synthesisorganic synthesischemistryphotoremovable hydrazone template

Production, Crystallization, and Structure Determination of the Ikk-Binding Domain of Nemo. Journal of Visualized Experiments (2019)

Adam H. BarczewskiMichael J. RagusaDale F. MierkeMaria Pellegrini

visual sciencebiophysicsscientific visualizationprotein structurestructure determinationmolecular biologyvisualizationprotein scienceneuroscienceikk-binding domain

The Ikk-Binding Domain of Nemo is an Irregular Coiled Coil With a Dynamic Binding Interface. Scientific Reports (2019)

Adam H. BarczewskiMichael J. RagusaDale F. MierkeMaria Pellegrini

immunologyfunctional modificationreceptorspharmacologyprotein structuremolecular and cellular biologymammalian biologyhost specificityin vivo systemsikk-binding domaindynamic binding interfaceprotein scienceneuroanatomyneuroscienceneurophysiology

Identification of a Small Molecule Activator for Aphb, a Lysr-Type Virulence Transcriptional Regulator in Vibrio Cholerae. Biochemistry (2017)

Britney R. PrivettMaria PellegriniGabriela KovacikovaRonald K. TaylorKaren SkorupskiDale MierkeF. Jon Kull

immunologygene expressiontranscription regulationtranscription factorsviral geneticsgene functionmolecular biologyvirulence factorssmall molecule activatorinsect molecular biologybiochemistry

The Peach Rgf/Glv Signaling Peptide Pctg134 is Involved in a Regulatory Circuit That Sustains Auxin and Ethylene Actions. Frontiers in Plant Science (2017)

Nicola BusattoUmberto SalvagninFrancesca ResentiniSilvia QuaresiminLorella NavazioOriano MarinMaria PellegriniFabrizio CostaDale F. MierkeLivio Trainotti

peptidesplant biologycell signalingplant physiologybiochemistryplant biotechnologyplant hormonesplant sciencebotanymembrane biologyregulatory circuitexperimental botanyplant molecular biologyplant biochemistrysignaling pathwaysgene expressionpharmacologygeneticssignal transductionethylene actions

A Novel Caspase 8 Selective Small Molecule Potentiates Trail-Induced Cell Death. Scientific Reports (2015)

Octavian BucurGabriel GaidosAchani YatawaraBodvael PennarunChamila RupasingheJérémie RouxStefan AndreiBingqian GuoAlexandra PanaitiuMaria PellegriniDale F. MierkeRoya Khosravi-Far

immunologycell deathselective small moleculeapoptosissignal transductiontrail-induced cell death

Assembly and Turnover of Short Actin Filaments by the Formin Inf2 and Profilin. Journal of Biological Chemistry (2015)

Pinar S. GurelMu ABingqian GuoRui ShuDale F. MierkeHenry N. Higgs

supramolecular assembliesprotein assemblybiologybiological chemistryshort actin filamentsstructural biologyprotein sciencebiochemistrycell biology

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Dale F. Mierke

Professor Frank R Mori Professor

Dartmouth College

Affiliations

Faculty of Arts and Sciences

Department of Chemistry

Dale F. Mierke is currently serving as a Chemistry Professor Frank R Mori Professor at Dartmouth College.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Dale F. Mierke

Dartmouth College

Professor Frank R Mori Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Structure of a Nemo Construct Engineered for Screening Reveals Novel Determinants of Inhibition. (2024)

Amy E. KennedyAdam H. BarczewskiChristina R. ArnoldyJ. Pepper PenningtonKelly A. TiernanMaria Beatriz HidalgoCaroline C. ReillyMichael J. RagusaGevorg GrigoryanDale F. MierkeMaria M. Pellegrini

public healthnemo constructstructural biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

An Engineered Construct of Cflip Provides Insight Into Ded1 Structure and Interactions. Structure (2021)

Alexandra E PanaitiuTamar BasiashviliDale F MierkeMaria Pellegrini

structural biologyengineered constructmolecular biology

Dynamic Enzymatic Synthesis of γ-Cyclodextrin Using a Photoremovable Hydrazone Template. Chem (2021)

Sirun YangDennis LarsenMaria PellegriniSebastian MeierDale F. MierkeSophie R. BeerenIvan Aprahamian

materials sciencedynamic enzymatic synthesisorganic synthesischemistryphotoremovable hydrazone template

Production, Crystallization, and Structure Determination of the Ikk-Binding Domain of Nemo. Journal of Visualized Experiments (2019)

Adam H. BarczewskiMichael J. RagusaDale F. MierkeMaria Pellegrini

visual sciencebiophysicsscientific visualizationprotein structurestructure determinationmolecular biologyvisualizationprotein scienceneuroscienceikk-binding domain

The Ikk-Binding Domain of Nemo is an Irregular Coiled Coil With a Dynamic Binding Interface. Scientific Reports (2019)

Adam H. BarczewskiMichael J. RagusaDale F. MierkeMaria Pellegrini

Identification of a Small Molecule Activator for Aphb, a Lysr-Type Virulence Transcriptional Regulator in Vibrio Cholerae. Biochemistry (2017)

Britney R. PrivettMaria PellegriniGabriela KovacikovaRonald K. TaylorKaren SkorupskiDale MierkeF. Jon Kull

immunologygene expressiontranscription regulationtranscription factorsviral geneticsgene functionmolecular biologyvirulence factorssmall molecule activatorinsect molecular biologybiochemistry

The Peach Rgf/Glv Signaling Peptide Pctg134 is Involved in a Regulatory Circuit That Sustains Auxin and Ethylene Actions. Frontiers in Plant Science (2017)

Nicola BusattoUmberto SalvagninFrancesca ResentiniSilvia QuaresiminLorella NavazioOriano MarinMaria PellegriniFabrizio CostaDale F. MierkeLivio Trainotti

A Novel Caspase 8 Selective Small Molecule Potentiates Trail-Induced Cell Death. Scientific Reports (2015)

Octavian BucurGabriel GaidosAchani YatawaraBodvael PennarunChamila RupasingheJérémie RouxStefan AndreiBingqian GuoAlexandra PanaitiuMaria PellegriniDale F. MierkeRoya Khosravi-Far

immunologycell deathselective small moleculeapoptosissignal transductiontrail-induced cell death

Assembly and Turnover of Short Actin Filaments by the Formin Inf2 and Profilin. Journal of Biological Chemistry (2015)

Pinar S. GurelMu ABingqian GuoRui ShuDale F. MierkeHenry N. Higgs

supramolecular assembliesprotein assemblybiologybiological chemistryshort actin filamentsstructural biologyprotein sciencebiochemistrycell biology

1
2
3
4
5
33
10 / page

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Charles E. McKenna

Institution

University of Southern California

future medicinal chemistry

medicinal chemistry

Vadim Cherezov

Institution

University of Southern California

membrane protein

proteinlipid interaction

Jens Meiler

Institution

Vanderbilt University

molecular informatics

biomolecular engineering

Shahriar Mobashery

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University of Notre Dame

pharmacology

biochemistry

Amos Smith

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protein folding

bioorganic chemistry

Nikolay Dokholyan

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University of North Carolina at Chapel Hill

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biomolecular structure

theoretical biology

Philip A. Cole

Institution

Johns Hopkins University

molecular biology

biochemistry

Nicholas Geacintov

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molecular biology

mutagenesis

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future medicinal chemistry

molecular docking