Faculty

Institution

Unit

Venue

Nikolay Dokholyan

University of North Carolina at Chapel Hill

Affiliations

the Eshelman School of Pharmacy

Chemical Biology and Medicinal Chemistry

NoneNikolay Dokholyan is currently serving as a Chemical Biology And Medicinal Chemistry faculty at University of North Carolina At Chapel Hill.

Honors

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Experiences

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Education

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Nikolay Dokholyan

University of North Carolina at Chapel Hill

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molecular biology biophysics structural biology protein science neuroscience pharmacology protein structure membrane biology protein folding medicinal research rna biology bioinformatics molecular biophysics computational biology protein engineering structural molecular biology biological chemistry amyotrophic lateral sclerosis molecular physiology protein misfolding protein modeling enzyme inhibition protein evolution protein function redox biology biomolecular structure mammalian biology biophysical modeling discrete molecular dynamics rna structure prediction skeletal muscle tumor targeting protein transport cancer biology living cells protein chemistry biomolecular interactions nucleic acids biochemical sciences cellular physiology genome biology molecular neurodegeneration nanobiotechnology receptor (biochemistry) anti-cancer agents computational biophysics cancer treatment theoretical biology molecular docking dna sequences molecular basis signaling pathways drug targeting rational design superoxide dismutase structural basis molecular science protein bioinformatics protein genetics membrane transport biological inorganic chemistry molecular regulation medical genetics medical biophysics percolation theory protein aggregation viral genetics muscle function amino acids molecular mechanisms molecular dynamics simulations allosteric communications hierarchical protein evolution backbone flexibility human erythrocytes computational design

Notable Scholarly Works

Notable Federal Grants

Collaborators

Autonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells. ACS Nano (2025)

Martin PanigajTanaya Basu RoyElizabeth SkellyMorgan R. ChandlerJian WangSrinivasan EkambaramKristin BircsakNikolay V. DokholyanKirill A. Afonin

dna computingnanotechnologysynthetic biologyliving cellsbiosensorsprotein sciencenanoparticle researchnanomedicinecell engineeringbiomolecular engineeringbiological computationautonomous nucleic acidbiological engineeringbio-inspired computationnanobiotechnologybiological computingnucleic acidsmolecular biologydna nanotechnologybiomolecules

2′3′-Cgamp Interactome Identifies 2′3′-Cgamp/Rab18/Fosb Signaling in Cell Migration Control Independent of Innate Immunity. Science Advances (2024)

Yu DengQuentin HahnLe YuZhichuan ZhuJoshua A. BoyerJian WangDeyu KongLeiah M. CareyAustin J. HepperlaJeremy M. SimonBrenda TempleZhigang ZhangYanqiong ZhangCharlene SantosJonathan E. FrankLaura E. HerringXiaodong WangNikolay V. DokholyanSharon L. CampbellAlbert S. BaldwinBlossom DamaniaQi ZhangPengda Liu

cell migrationimmune responsessignal transductioninnate immune systeminnate immunitysystems biologycell signalingimmunologysignaling pathwayscell migration controlcell biologyscience advance

500-P: Disruption of Redd1 Protein Allostery as a Therapeutic for Diabetic Retinopathy. Diabetes (2024)

MICHAEL D. DENNISSIDDHARTH SUNILKUMARWILLIAM P. MILLERCONGZHOU M. SHANIKOLAY V. DOKHOLYAN

medicinehealth sciencesdiabetes therapiesophthalmologydiabetic retinopathydiabetesretina

A Piecewise Design Approach to Engineering a Miniature Ace2 Mimic to Bind Sars-Cov-2. ACS Applied Bio Materials (2024)

Yashavantha L. VishweshwaraiahBrianna HnathJian WangMorgan ChandlerArnab MukherjeeNeela H. YennawarSquire J. BookerKirill A. AfoninNikolay V. Dokholyan

biocompatible materialsvaccinesbiomaterials designsars-cov-2virus researchmicrofabricationbiomolecular engineeringadhesiontissue engineeringbiomedical engineeringvaccine designbiological engineering

Apoe Regulates the Transport of Gm1. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Dong Yan ZhangJian WangGangtong HuangSara LangbergFeng DingNikolay V. Dokholyan

pharmacologygene expressionneurosciencecell biologyprotein transport

Application of Quantum Tensor Networks for Protein Classification. Proceedings of the Great Lakes Symposium on VLSI 2022 (2024)

Debarshi KunduArchisman GhoshSrinivasan EkambaramJian WangNikolay DokholyanSwaroop Ghosh

biophysicsstructural biologyprotein classificationprotein sciencequantum tensor networks

CANDI: A Web Server for Predicting Molecular Targets and Pathways of Cannabis-Based Therapeutics. Research Square (Research Square) (2024)

Srinivasan EkambaramJian WangNikolay V. Dokholyan

molecular evidencetarget predictionfuture medicinal chemistrymolecular medicinemolecular informaticsbiomolecular engineeringdrug intelligencepharmacological researchpharmacologymedicinal chemistrypathway analysisweb serveraddiction biologydrug discoverycannabis-based therapeuticsmolecular targetsmolecular biologymedicinal researchmolecular pharmacologycannabis usetherapeutic targets

Comprehensive Mapping of the Interaction of Levodopa and Iron Metabolism in Parkinson’s Disease. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jian WangSrinivasan EkambaramXuemei HuangRichard B. MailmanElizabeth A. ProctorNikolay V. Dokholyan

neurologyparkinson's diseaseiron metabolismneurodegenerative diseasesmetabolism

Cracking the Code: Enhancing Molecular Tools for Progress in Nanobiotechnology. ACS Applied Bio Materials (2024)

Yelixza I. AvilaLaura P. RebolledoElizabeth SkellyRenata de Freitas SaitoHui WeiDavid LilleyRobin E. StanleyYa-Ming HouHaoyun YangJoanna Sztuba-SolinskaShi-Jie ChenNikolay V. DokholyanCheemeng TanS. Kevin LiXiaoming HeXiaoting ZhangWayne MilesElisa FrancoDaniel W. BinzelPeixuan GuoKirill A. Afonin

biomolecular engineeringnanobiotechnologymolecular toolsnanotechnology

Differentiable Rotamer Sampling With Molecular Force Fields. Biophysical Journal (2024)

Congzhou M. ShaJian WangNikolay V. Dokholyan

biophysicsmolecular force fieldsapplied physicsexperimental biophysicsanimal sciencedifferentiable rotamermolecular biophysics

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Nikolay Dokholyan

University of North Carolina at Chapel Hill

Affiliations

the Eshelman School of Pharmacy

Chemical Biology and Medicinal Chemistry

NoneNikolay Dokholyan is currently serving as a Chemical Biology And Medicinal Chemistry faculty at University of North Carolina At Chapel Hill.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Nikolay Dokholyan

University of North Carolina at Chapel Hill

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Autonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells. ACS Nano (2025)

Martin PanigajTanaya Basu RoyElizabeth SkellyMorgan R. ChandlerJian WangSrinivasan EkambaramKristin BircsakNikolay V. DokholyanKirill A. Afonin

2′3′-Cgamp Interactome Identifies 2′3′-Cgamp/Rab18/Fosb Signaling in Cell Migration Control Independent of Innate Immunity. Science Advances (2024)

cell migrationimmune responsessignal transductioninnate immune systeminnate immunitysystems biologycell signalingimmunologysignaling pathwayscell migration controlcell biologyscience advance

500-P: Disruption of Redd1 Protein Allostery as a Therapeutic for Diabetic Retinopathy. Diabetes (2024)

MICHAEL D. DENNISSIDDHARTH SUNILKUMARWILLIAM P. MILLERCONGZHOU M. SHANIKOLAY V. DOKHOLYAN

medicinehealth sciencesdiabetes therapiesophthalmologydiabetic retinopathydiabetesretina

A Piecewise Design Approach to Engineering a Miniature Ace2 Mimic to Bind Sars-Cov-2. ACS Applied Bio Materials (2024)

Yashavantha L. VishweshwaraiahBrianna HnathJian WangMorgan ChandlerArnab MukherjeeNeela H. YennawarSquire J. BookerKirill A. AfoninNikolay V. Dokholyan

biocompatible materialsvaccinesbiomaterials designsars-cov-2virus researchmicrofabricationbiomolecular engineeringadhesiontissue engineeringbiomedical engineeringvaccine designbiological engineering

Apoe Regulates the Transport of Gm1. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Dong Yan ZhangJian WangGangtong HuangSara LangbergFeng DingNikolay V. Dokholyan

pharmacologygene expressionneurosciencecell biologyprotein transport

Application of Quantum Tensor Networks for Protein Classification. Proceedings of the Great Lakes Symposium on VLSI 2022 (2024)

Debarshi KunduArchisman GhoshSrinivasan EkambaramJian WangNikolay DokholyanSwaroop Ghosh

biophysicsstructural biologyprotein classificationprotein sciencequantum tensor networks

CANDI: A Web Server for Predicting Molecular Targets and Pathways of Cannabis-Based Therapeutics. Research Square (Research Square) (2024)

Srinivasan EkambaramJian WangNikolay V. Dokholyan

Comprehensive Mapping of the Interaction of Levodopa and Iron Metabolism in Parkinson’s Disease. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jian WangSrinivasan EkambaramXuemei HuangRichard B. MailmanElizabeth A. ProctorNikolay V. Dokholyan

neurologyparkinson's diseaseiron metabolismneurodegenerative diseasesmetabolism

Cracking the Code: Enhancing Molecular Tools for Progress in Nanobiotechnology. ACS Applied Bio Materials (2024)

biomolecular engineeringnanobiotechnologymolecular toolsnanotechnology

Differentiable Rotamer Sampling With Molecular Force Fields. Biophysical Journal (2024)

Congzhou M. ShaJian WangNikolay V. Dokholyan

biophysicsmolecular force fieldsapplied physicsexperimental biophysicsanimal sciencedifferentiable rotamermolecular biophysics

1
2
3
4
5
51
10 / page

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