Faculty

Institution

Unit

Venue

John Bushweller

Professor Molecular Physiology and Biological Physics

University of Virginia

Affiliations

School of Medicine

Department of Molecular Physiology and Biological Physics

John Bushweller is currently serving as a Molecular Physiology And Biological Physics Professor Molecular Physiology and Biological Physics at University of Virginia.

Honors

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Experiences

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Education

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John Bushweller

University of Virginia

Professor Molecular Physiology and Biological Physics

You can click a keyword to filter the displayed items

molecular biology cell biology structural molecular biology protein structure biomolecular structure molecular cell biology biochemistry structural biology oncogenes protein science leukemia cancer cells tumor biology transcription factors hematological malignancies systems biology cancer biology cell signaling protein nmr therapeutic targets protein function nucleic acids molecular cancer membrane proteins chromatin myeloid neoplasia biological chemistry molecular regulation protein assembly biological macromolecules biomolecular interactions proteinlipid interaction cell regulation cancer genetics anti-cancer agents enzyme inhibition transcription regulation structure-function enzyme kinetics chromatin remodeling mixed-phenotype acute leukemia cancer growth structural bioinformatics gene regulation acute myeloid leukemia molecular structure molecular basis cellular biochemistry peptides gene function biomolecular analysis multi-protein assembly malignant blood disorders genome biology signaling pathways myelopoiesis membrane structure protein structure prediction dna analysis mixed disulfide dna binding virus structure viral structural protein molecular microbiology altmetric attention score nmr solution structure coupled folding dna methylation human glutaredoxin jigsaw algorithm noesy jigsaw residual dipolar couplings cbf alpha solution structure membrane fusion mixed lineage leukemia familial thrombocytopenia

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Backbone 1H, 15N Chemical Shift Assignments of Human Mllt3 Yeats Domain in Presence of Sl4 of 7Sk Ncrna. Open MIND (2026)

human mllt3 yeatsnon-coding rnabackbone 1hprotein sciencenucleic acidsbiochemistrychemical shift assignmentstranscription (biology)molecular biologyprotein structurerna biologystructural biology

Backbone 1H, 15N Chemical Shift Assignments of Human Mllt3 Yeats Domain (K63Ek67E Double Mutant). Open MIND (2026)

protein geneticsbackbone 1hprotein sciencebiochemistrystructural bioinformaticsmolecular basischemical shift assignmentsmolecular biologyprotein structurestructural molecular biologystructural biology

Backbone 1H, 15N Chemical Shift Assignments of Human Mllt3 Yeats Domain (K63Ek67E Double Mutant) in Presence of Sl4 of 7Sk Ncrna. Open MIND (2026)

molecular and cellular biologynon-coding rnabackbone 1hnucleic acidschemical shift assignmentsmolecular biologysystems biologygene expressionstructural molecular biologyrna biology

Chemical Shift Assignments of Human Mllt3 Yeats Domain. Open MIND (2026)

biochemistrychemical shift assignmentssignal recognitionmolecular biologyprotein structurebiological chemistry

Abstract 5739: Small Molecule Modulation of Autoinhibition to Inhibit Dna Binding of Erg and Fli1 - Therapeutic for Ewing Sarcoma, Prostate Cancer, and All. Cancer Research (2025)

John H. BushwellerKiran Srimath TirumalaAshish KabraAdam BoultonKarla RubioMichael BondAnglea SuMiguel RiveraKim Stegmaier

dna bindingsmall molecule modulationprostate cancercancer researchmolecular biologycancer treatment

The Mllt3 Yeats Domain is a Dual Reader of Histone Marks (H3K9/18/27Ac/Cr) and Ncrna (7Sk), Linking Epigenetic and Rna Signaling to Regulate Hematopoiesis. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Adam BoultonAshish KabraNicholas AchilleEmmalee R AdelmanDimitrios G AnastasakisFelipe BeckedorffPradeepkumar CingaramYing ZhangBenjamin LeachRamin ShiekhattarAkihiko YokoyamaMarkus HafnerMaria FigueroaNancy Zeleznik-LeJohn Bushweller

non-coding rnanucleic acidscell biologyepigeneticsgenome biologymolecular cell biologyepigenomicstranscription (biology)n-terminal yeats domainchromatingene expressionleukemiarna biologyyeats domaingeneticsmllt3 yeats domain

Abstract 1092: Runx2 Inhibition Alters Pax3:: Foxo1 Driven Fusion-Positive Rhabdomyosarcoma Cell State and Growth. Cancer Research (2024)

Elizabeth A. MendesAudrey L. ChambersSamantha J. WeitzelMichael DeelAanandi MunshiChristopher M. CounterSeth ZimmermanJohn BushwellerCorinne M. Linardic

oncogenesradiation oncologytumor targetingtumor biologyanti-cancer agentscancer immunotherapycancer treatmentmedicinal researchcancer researchcancer growthpharmacologymedicineclinical researchcancer cellsenzyme inhibitioncancer careoncologycancer biology

N-Myc Regulates Cell Survival via Eif4G1 in Inv(16) Acute Myeloid Leukemia. Science Advances (2024)

Philomina Sona PeramangalamSridevi SurapallyAnthony J. VeltriShikan ZhengRobert BurnsNan ZhuSridhar RaoCarsten Muller-TidowJohn H. BushwellerJohn A. Pulikkan

cancer biologyn-myc regulatescell biologymedicinal researchhematologyhematological malignanciesgene regulationacute myeloid leukemiascience advancegene expressioncancer geneticsmolecular regulationgenetics

Pharmacological Inhibition of Ras Overcomes Flt3 Inhibitor Resistance in Flt3-Itd+ Aml Through Ap-1 and Runx1. iScience (2024)

Daniel J.L. ColemanPeter KeanePaulynn S. ChinLuke AmesSophie KellawayHelen BlairNaeem KhanJames GriffinElizabeth HolmesAlexander MaytumSandeep PotluriLara StrateKinga KoscielniakManoj RaghavanJohn BushwellerOlaf HeidenreichTerry RabbittsPeter N. CockerillConstanze Bonifer

pharmacological inhibitionras overcomesdrug resistancepharmacologyinhibitor resistance

Recombinant Expression and Purification of Human Ep300-Kix87 Domain From #160;Escherichia Coli. BIO-PROTOCOL (2024)

John H. BushwellerKwon-Sik ParkAshish Kabra

cell biologyprotein purificationescherichia colimolecular biologyrecombinant expressionbioinformatics

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John Bushweller

Professor Molecular Physiology and Biological Physics

University of Virginia

Affiliations

School of Medicine

Department of Molecular Physiology and Biological Physics

John Bushweller is currently serving as a Molecular Physiology And Biological Physics Professor Molecular Physiology and Biological Physics at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

John Bushweller

University of Virginia

Professor Molecular Physiology and Biological Physics

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Backbone 1H, 15N Chemical Shift Assignments of Human Mllt3 Yeats Domain in Presence of Sl4 of 7Sk Ncrna. Open MIND (2026)

human mllt3 yeatsnon-coding rnabackbone 1hprotein sciencenucleic acidsbiochemistrychemical shift assignmentstranscription (biology)molecular biologyprotein structurerna biologystructural biology

Backbone 1H, 15N Chemical Shift Assignments of Human Mllt3 Yeats Domain (K63Ek67E Double Mutant). Open MIND (2026)

Backbone 1H, 15N Chemical Shift Assignments of Human Mllt3 Yeats Domain (K63Ek67E Double Mutant) in Presence of Sl4 of 7Sk Ncrna. Open MIND (2026)

molecular and cellular biologynon-coding rnabackbone 1hnucleic acidschemical shift assignmentsmolecular biologysystems biologygene expressionstructural molecular biologyrna biology

Chemical Shift Assignments of Human Mllt3 Yeats Domain. Open MIND (2026)

biochemistrychemical shift assignmentssignal recognitionmolecular biologyprotein structurebiological chemistry

Abstract 5739: Small Molecule Modulation of Autoinhibition to Inhibit Dna Binding of Erg and Fli1 - Therapeutic for Ewing Sarcoma, Prostate Cancer, and All. Cancer Research (2025)

John H. BushwellerKiran Srimath TirumalaAshish KabraAdam BoultonKarla RubioMichael BondAnglea SuMiguel RiveraKim Stegmaier

dna bindingsmall molecule modulationprostate cancercancer researchmolecular biologycancer treatment

Abstract 1092: Runx2 Inhibition Alters Pax3:: Foxo1 Driven Fusion-Positive Rhabdomyosarcoma Cell State and Growth. Cancer Research (2024)

Elizabeth A. MendesAudrey L. ChambersSamantha J. WeitzelMichael DeelAanandi MunshiChristopher M. CounterSeth ZimmermanJohn BushwellerCorinne M. Linardic

N-Myc Regulates Cell Survival via Eif4G1 in Inv(16) Acute Myeloid Leukemia. Science Advances (2024)

Philomina Sona PeramangalamSridevi SurapallyAnthony J. VeltriShikan ZhengRobert BurnsNan ZhuSridhar RaoCarsten Muller-TidowJohn H. BushwellerJohn A. Pulikkan

Pharmacological Inhibition of Ras Overcomes Flt3 Inhibitor Resistance in Flt3-Itd+ Aml Through Ap-1 and Runx1. iScience (2024)

pharmacological inhibitionras overcomesdrug resistancepharmacologyinhibitor resistance

Recombinant Expression and Purification of Human Ep300-Kix87 Domain From #160;Escherichia Coli. BIO-PROTOCOL (2024)

John H. BushwellerKwon-Sik ParkAshish Kabra

cell biologyprotein purificationescherichia colimolecular biologyrecombinant expressionbioinformatics

1
2
3
4
5
16
10 / page

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oncology

cancer research

Pradip Raychaudhuri

Institution

University of Illinois Chicago

oncogene

cancer biology

Scott W. Hiebert

Institution

Vanderbilt University

nascent transcription

oncogene

Nancy Speck

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University of Pennsylvania

stem cell

haematopoiesis

Philip A. Cole

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Johns Hopkins University

molecular biology

biochemistry

Michele Pagano, MD

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New York University

cell cycle

cell cycle control

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molecular research

molecular pathway

Stephen W. Fesik

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Vanderbilt University

drug discovery

biochemistry

Wei Li

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biomedical informatics

computational biology

Ian G. Macara

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breast cancer

cancer initiation