Faculty

Institution

Unit

Venue

Nancy Speck

John W Eckman Professor in Medical Science II

University of Pennsylvania

Affiliations

Perelman School of Medicine

Cell and Developmental Biology

Nancy Speck is currently serving as a Cell And Developmental Biology John W Eckman Professor in Medical Science II at University of Pennsylvania.

Honors

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Experiences

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Education

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Nancy Speck

University of Pennsylvania

John W Eckman Professor in Medical Science II

You can click a keyword to filter the displayed items

hematology cell biology genetics developmental biology molecular biology gene expression haematopoiesis structural biology molecular cell biology structural molecular biology vascular biology regenerative medicine stem cell research transcription factors leukemia mammalian biology protein science biomolecular structure oncogenes angiogenesis virology molecular and cellular biology transcription regulation embryonic development medicinal research viral genetics protein function hematological malignancies cancer biology gene function experimental medicine molecular regulation cell regulation cancer genetics fish biology developmental science genome biology cellular biology molecular virology biomolecular interactions viral oncology biological chemistry cytogenetics gene regulation blood cells hemostasis core-binding factor cellular physiology experimental biology myeloid neoplasia developmental genetics cell lineage hematopoietic stem cells angiology medical genetics core binding factor tissue development gene regulatory networks viral evolution molecular research multi-protein assembly protein assembly knockout mice core-binding factors endothelial cells mouse embryos inflammatory cytokine production hematopoietic progenitor cbf alpha blood cell formation acute myeloid leukemia familial thrombocytopenia acute myelogenous leukaemia haematopoietic cell transition intra-aortic hematopoietic clusters cbfβ subunit stem cell mobilization

Notable Scholarly Works

Notable Federal Grants

Collaborators

3024 – Restraint of Tgf-B Signaling by Smad7 is Necessary for Hematopoietic Stem Cell Formation in the Mouse Embryo. Experimental Hematology (2024)

Laura BennettHyun Hyung AnNancy Speck

developmental biologyhematologyembryonic developmentstem cellsreproductive biologymouse embryotgf-b signaling

Alternating High-Fat Diet Enhances Atherosclerosis by Neutrophil Reprogramming. Nature (2024)

Jean-Rémi LavillegrandRida Al-RifaiSara ThietartThéo GuyonMarie VandestienneRaphael CohenVincent DuvalXiaodan ZhongDaniel YenMumin OzturkYutaka NegishiJoanne KonkelEmmanuel PinteauxOlivia LenoirJose VilarLudivine LauransBruno EspositoMarius BredonHarry SokolMarc DiedisheimAntoine-Emmanuel SalibaAlma ZerneckeClément CochainJessica HaubAlain TedguiNancy A SpeckSoraya TalebMusa M MhlangaAndreas SchlitzerNiels P RiksenHafid Ait-Oufella

diabetesfunctional recoveryfunctional modificationchronic diseasesnucleic acid amplificationliver physiologystrokeknockout miceneutrophil reprogrammingneurologyepidemiologygeneticsdigestive diseaseshypertensionvascular biologynephrologythrombosismedicinal researchremedial action

Tropomyosin 1 Deficiency Facilitates Cell State Transitions and Enhances Hemogenic Endothelial Cell Specification During Hematopoiesis. Stem Cell Reports (2024)

Madison B WilkenGennadiy FonarRong QiuLaura BennettJoanna ToberCatriana NationsGiulia PavaniVictor TsaoJames GarifallouChayanne PetitJean Ann MaguireAlyssa GagneNkemdilim OkoliPaul GadueStella T ChouDeborah L FrenchNancy A SpeckChristopher S Thom

haematopoiesisvascular biologystem cellscell biology

Characterization of Niche Cells and Signals Regulating Stepwise Embryonic Hematopoiesis Using Slide-Seq and Merfish Spatial Transcriptomics. Blood (2023)

Xinjian MaoNing ZhangXi HeKate HallKaitlyn PetentlerAllison ScottSeth MalloyJeff HaugHua LiAnoja PereraJay UnruhBrian SlaughterNancy SpeckLinheng Li

developmental biologyhematologyniche cellshaematopoiesisbioinformaticsmerfish spatial transcriptomicscell biologymembrane biologyfish biologymolecular biologytranscriptomics technology

Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-Of-Function Mouse Model of Runx1-Fpd. HemaSphere (2023)

Martijn P. T. ErnstEline PronkClaire van DijkPaulina M. H. van StrienTim V. D. van TienhovenMichiel J. W. WeversMathijs A. SandersEric M. J. BindelsNancy A. SpeckMarc H. G. P. Raaijmakers

developmental biologyhematologyhaematopoiesisbiological engineeringcell biologymammalian biology

Runx1 is Required in Granulocyte–Monocyte Progenitors to Attenuate Inflammatory Cytokine Production by Neutrophils. Genes & Development (2023)

Alexandra U. ZezulinDaniel YenDarwin YeElizabeth D. HowellErica BrescianiJamie DiemerJian-gang RenMohd Hafiz AhmadLucio H. CastillaIvo P. TouwAndy J. MinnWei TongP. Paul LiuKai TanWenbao YuNancy A. Speck

hematologychronic inflammationgeneticsimmune responsesinflammatory cytokine productioninflammationdermatologygranulocytegranulocyte-monocyte progenitorsimmunologyinnate immune systemgene functioncytokinesgene expressionmedicinal research

Tropomyosin 1 Deficiency Facilitates Cell State Transitions to Enhance Hemogenic Endothelial Cell Specification During Hematopoiesis. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Madison B WilkenGennadiy FonarCatriana NationsGiulia PavaniVictor TsaoJames GarifallouJoanna ToberLaura BennettJean Ann MaguireAlyssa GagneNkemdilim OkoliPaul GadueStella T ChouNancy A SpeckDeborah L FrenchChristopher S Thom

hematologyhaematopoiesiscell biologyimmunologymembrane biologyvascular biologyhealth sciences

3239 – Determining the Mechanism by Which Runx1 Loss Leads to an Inflammatory Response in Hematopoietic Cells. Experimental Hematology (2022)

alexandra zezulinElizabeth HowellWenboa YuJian-gang RenWei TongKai TanNancy Speck

hematologyhematopoietic cellsinflammationcell biologyinflammatory responseimmunologyphysiologyexperimental medicine

A Pernicious Cycle Affecting Premalignant Stem Cells. New England Journal of Medicine (2022)

Nancy A. Speck

stem cellsmedicinepremalignant stem cellspernicious cycle

Endothelial Mekk3-Klf2/4 Signaling Integrates Inflammatory and Hemodynamic Signals During Definitive Hematopoiesis. Blood (2022)

Yiqing YangMelanie MumauJoanna ToberQin ZhuLaura BennettCourtney HongDerek SungThomas KellerYasin UzunPeng GaoSwapnil ShewaleMei ChenJisheng YangXiaowen ChenSteven A. ThomasKai TanNancy A. SpeckMark L. Kahn

hematologyhemodynamic signalsinflammationhaematopoiesiscell biologycell signalingimmunologyfish biologyvascular biologyangiogenesishealth sciences

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Nancy Speck

John W Eckman Professor in Medical Science II

University of Pennsylvania

Affiliations

Perelman School of Medicine

Cell and Developmental Biology

Nancy Speck is currently serving as a Cell And Developmental Biology John W Eckman Professor in Medical Science II at University of Pennsylvania.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Nancy Speck

University of Pennsylvania

John W Eckman Professor in Medical Science II

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

3024 – Restraint of Tgf-B Signaling by Smad7 is Necessary for Hematopoietic Stem Cell Formation in the Mouse Embryo. Experimental Hematology (2024)

Laura BennettHyun Hyung AnNancy Speck

developmental biologyhematologyembryonic developmentstem cellsreproductive biologymouse embryotgf-b signaling

Alternating High-Fat Diet Enhances Atherosclerosis by Neutrophil Reprogramming. Nature (2024)

Tropomyosin 1 Deficiency Facilitates Cell State Transitions and Enhances Hemogenic Endothelial Cell Specification During Hematopoiesis. Stem Cell Reports (2024)

haematopoiesisvascular biologystem cellscell biology

Characterization of Niche Cells and Signals Regulating Stepwise Embryonic Hematopoiesis Using Slide-Seq and Merfish Spatial Transcriptomics. Blood (2023)

Xinjian MaoNing ZhangXi HeKate HallKaitlyn PetentlerAllison ScottSeth MalloyJeff HaugHua LiAnoja PereraJay UnruhBrian SlaughterNancy SpeckLinheng Li

developmental biologyhematologyniche cellshaematopoiesisbioinformaticsmerfish spatial transcriptomicscell biologymembrane biologyfish biologymolecular biologytranscriptomics technology

Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-Of-Function Mouse Model of Runx1-Fpd. HemaSphere (2023)

Martijn P. T. ErnstEline PronkClaire van DijkPaulina M. H. van StrienTim V. D. van TienhovenMichiel J. W. WeversMathijs A. SandersEric M. J. BindelsNancy A. SpeckMarc H. G. P. Raaijmakers

developmental biologyhematologyhaematopoiesisbiological engineeringcell biologymammalian biology

Runx1 is Required in Granulocyte–Monocyte Progenitors to Attenuate Inflammatory Cytokine Production by Neutrophils. Genes & Development (2023)

Tropomyosin 1 Deficiency Facilitates Cell State Transitions to Enhance Hemogenic Endothelial Cell Specification During Hematopoiesis. bioRxiv (Cold Spring Harbor Laboratory) (2023)

hematologyhaematopoiesiscell biologyimmunologymembrane biologyvascular biologyhealth sciences

3239 – Determining the Mechanism by Which Runx1 Loss Leads to an Inflammatory Response in Hematopoietic Cells. Experimental Hematology (2022)

alexandra zezulinElizabeth HowellWenboa YuJian-gang RenWei TongKai TanNancy Speck

hematologyhematopoietic cellsinflammationcell biologyinflammatory responseimmunologyphysiologyexperimental medicine

A Pernicious Cycle Affecting Premalignant Stem Cells. New England Journal of Medicine (2022)

Nancy A. Speck

stem cellsmedicinepremalignant stem cellspernicious cycle

Endothelial Mekk3-Klf2/4 Signaling Integrates Inflammatory and Hemodynamic Signals During Definitive Hematopoiesis. Blood (2022)

hematologyhemodynamic signalsinflammationhaematopoiesiscell biologycell signalingimmunologyfish biologyvascular biologyangiogenesishealth sciences

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5
20
10 / page

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nascent transcription

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