Faculty

Institution

Unit

Venue

JoAnne Stubbe

Professor Emerita

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Chemistry

Joanne Stubbe is currently serving as a Biology Professor Emerita at Massachusetts Institute of Technology.

Honors

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Experiences

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Education

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JoAnne Stubbe

Massachusetts Institute of Technology

Professor Emerita

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biochemistry molecular biology enzymes protein science structural biology redox biology biological chemistry protein structure biophysics structural molecular biology enzyme inhibition chemical biology enzyme catalysis membrane biology genetics free radical biology ribonucleotide reductase radical (chemistry) protein chemistry structure-function enzyme kinetics nucleic acids biomolecular structure biocatalysis biochemical sciences medicinal chemistry rna biology biological inorganic chemistry protein synthesis coordination chemistry protein engineering catalysis transition metal chemistry redox chemistry escherichia coli molecular substrates nucleic acid chemistry bacteriology applied microbiology molecular microbiology chemical sciences protein assembly protein biosynthesis microbial genetics structural chemistry molecular science functional modification proton-coupled electron transfer ribonucleotide reductases genome biology molecular catalysis oligonucleotides enzymatic modification aldo-keto reductase tyrosyl radicals bacillus subtilis molecular biotechnology x-ray crystallography subunit interface protein genetics host specificity sequence assembly radical transport ribonucleotide reduction altmetric attention score ribonucleoside diphosphate reductase ribonucleoside triphosphate reductase molecular evidence yeast catalyst activation biomolecular interactions nucleic acid amplification phap phasin mechanistic studies polyhydroxybutyrate synthase purine biosynthetic pathway lactobacillus leichmannii

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Mono-Fluorotryptophans as Probes of Proton-Coupled Electron Transfer in Biology. Journal of Inorganic Biochemistry (2025)

chemical probesbiophysical chemistrybiophysicsproton-coupled electron transferbiological chemistrychemistryproton transferbiochemistry

2.6-Å Resolution Cryo-Em Structure of a Class Ia Ribonucleotide Reductase Trapped With Mechanism-Based Inhibitor N 3 Cdp. Proceedings of the National Academy of Sciences (2024)

Dana E. WestmorelandPatricia R. FelicianoGyunghoon KangChang CuiAlbert KimJoAnne StubbeDaniel G. NoceraCatherine L. Drennan

class ia rnrsbiophysical chemistrymolecular biophysicsenzyme inhibitionaldo-keto reductasenucleic acid chemistrystructure-function enzyme kineticsprotein structurebiomolecular structureenzymesmolecular biologybiological chemistrystructural molecular biologycryogenic electron microscopystructural biologylong distanceprotein sciencebiochemistry

Protein Engineering a Photornr Chimera Based on a Unifying Evolutionary Apparatus Among the Natural Classes of Ribonucleotide Reductases. Proceedings of the National Academy of Sciences (2024)

David Y. SongJoAnne StubbeDaniel G. Nocera

photornr chimeranatural classesribonucleotide reductasesbiomolecular engineeringprotein engineeringbiological engineeringevolutionary biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicsstructure elucidationcrystal researchcrystal diffraction studystructure determinationstructural chemistryccdc 2157502chemistrydeposited datasetcrystal engineeringchemical structurecrystal structurescrystallography

Disulfide Radical Anion as a Super-Reductant in Biology and Photoredox Chemistry. Chemical Science (2023)

Qilei ZhuCyrille CostentinJoAnne StubbeDaniel G. Nocera

chemical biologychemical sciencesphotoredox chemistrychemistrybiochemistry

Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2023)

Chang CuiDavid Y. SongCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

aldo-keto reductaseradical transport facilitatedstructure-function enzyme kineticsprotein structurebiomolecular structureenzymesproton transfer networkmolecular biologystructural molecular biologystructural biologysubunit interfacebiochemistry

Decision Letter: Comprehensive Phylogenetic Analysis of the Ribonucleotide Reductase Family Reveals an Ancestral Clade. (2022)

Nir Ben-TalJoAnne StubbeAnders Hofer

phylogeneticscomprehensive phylogenetic analysisrna biologyancestral claderibonucleotide reductase familydecision letterevolutionary biology

Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. DSpace@MIT (Massachusetts Institute of Technology) (2022)

Jana NarasimhanSuzanne LetinskiStephen P JungAleksey GerasyutoJiashi WangMichael ArnoldGuangming ChenJean HedrickMelissa DumbleKanchana RavichandranTalya LevitzChang CuiCatherine L DrennanJoAnne StubbeGary KarpArthur Branstrom

antimicrobial agentsantimicrobial resistance genesantimicrobial resistanceenzyme inhibitionantibiotic resistancenovel drug targetclinical microbiologytherapeutic targetsdrug resistanceantibioticsdrug discoveryng mapinfectious diseasesribonucleotide reductasemicrobiologyantimicrobial chemotherapy

19 F Electron-Nuclear Double Resonance Reveals Interaction Between Redox-Active Tyrosines Across the α/β Interface of E. Coli Ribonucleotide Reductase. Journal of the American Chemical Society (2022)

Andreas MeyerAnnemarie KehlChang CuiFehmke A. K. ReichardtFabian HeckerLisa-Marie FunkManas K. GhoshKuan-Ting PanHenning UrlaubKai TittmannJoAnne StubbeMarina Bennati

colinear pcetα/β interfacenucleic acid chemistrystructure-function enzyme kineticsstructural biologyprotein structureredox biologyredox chemistryenzymesmolecular biologystructural molecular biologyenzyme catalysisdna replicationbiochemistrynucleic acids

Author Response: Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. (2021)

author responseenzyme inhibitionpharmacologydrug resistancedrug discoverymicrobiologynucleic acids

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JoAnne Stubbe

Professor Emerita

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Chemistry

Joanne Stubbe is currently serving as a Biology Professor Emerita at Massachusetts Institute of Technology.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

JoAnne Stubbe

Massachusetts Institute of Technology

Professor Emerita

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Mono-Fluorotryptophans as Probes of Proton-Coupled Electron Transfer in Biology. Journal of Inorganic Biochemistry (2025)

chemical probesbiophysical chemistrybiophysicsproton-coupled electron transferbiological chemistrychemistryproton transferbiochemistry

2.6-Å Resolution Cryo-Em Structure of a Class Ia Ribonucleotide Reductase Trapped With Mechanism-Based Inhibitor N 3 Cdp. Proceedings of the National Academy of Sciences (2024)

Dana E. WestmorelandPatricia R. FelicianoGyunghoon KangChang CuiAlbert KimJoAnne StubbeDaniel G. NoceraCatherine L. Drennan

Protein Engineering a Photornr Chimera Based on a Unifying Evolutionary Apparatus Among the Natural Classes of Ribonucleotide Reductases. Proceedings of the National Academy of Sciences (2024)

David Y. SongJoAnne StubbeDaniel G. Nocera

photornr chimeranatural classesribonucleotide reductasesbiomolecular engineeringprotein engineeringbiological engineeringevolutionary biology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Disulfide Radical Anion as a Super-Reductant in Biology and Photoredox Chemistry. Chemical Science (2023)

Qilei ZhuCyrille CostentinJoAnne StubbeDaniel G. Nocera

chemical biologychemical sciencesphotoredox chemistrychemistrybiochemistry

Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase. Journal of the American Chemical Society (2023)

Chang CuiDavid Y. SongCatherine L. DrennanJoAnne StubbeDaniel G. Nocera

Decision Letter: Comprehensive Phylogenetic Analysis of the Ribonucleotide Reductase Family Reveals an Ancestral Clade. (2022)

Nir Ben-TalJoAnne StubbeAnders Hofer

phylogeneticscomprehensive phylogenetic analysisrna biologyancestral claderibonucleotide reductase familydecision letterevolutionary biology

Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. DSpace@MIT (Massachusetts Institute of Technology) (2022)

Andreas MeyerAnnemarie KehlChang CuiFehmke A. K. ReichardtFabian HeckerLisa-Marie FunkManas K. GhoshKuan-Ting PanHenning UrlaubKai TittmannJoAnne StubbeMarina Bennati

Author Response: Ribonucleotide Reductase, a Novel Drug Target for Gonorrhea. (2021)

author responseenzyme inhibitionpharmacologydrug resistancedrug discoverymicrobiologynucleic acids

1
2
3
4
5
35
10 / page

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