Faculty

Institution

Unit

Venue

Ilia G Denisov

Research Scientist

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Biochemistry

Ilia G Denisov is currently serving as a College Of Liberal Arts & Sciences Research Scientist at University of Illinois Urbana-Champaign.

Honors

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Experiences

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Education

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Ilia G Denisov

University of Illinois Urbana-Champaign

Research Scientist

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biochemistry enzymes biophysical chemistry molecular metabolism drug metabolism biological chemistry molecular biology biochemical sciences chemical biology redox biology enzyme inhibition biophysics pharmacology heme degradation molecular biophysics cell metabolism protein science membrane proteins membrane biology molecular pharmacology biological macromolecules structural molecular biology biomolecular structure nanodisc pharmacological research redox chemistry biochemical genetics biomolecules steroid metabolism biochemical interaction structure-function enzyme kinetics cytochrome p450 membrane science molecular science vibrational spectroscopy transition metal chemistry enzyme catalysis heme transport proteinlipid interaction aldehyde dehydrogenase reaction intermediates protein x-ray crystallography drug targets cellular enzymology hormonal receptor cytochrome p450 3a4 membrane structure membrane systems heme signaling reactive oxygen species heme homeostasis cytochromes p450 p450 cyp17a1 spectroelectrochemistry biological inorganic chemistry oxygen reduction reaction toxicological mechanism protein assembly aldo-keto reductase biocatalysis scaffold protein resonance raman active site monomeric cyp3a4 solvent isotope effects lipid movement membrane formation molecular communication molecular switches controlled size membrane scaffold protein membrane biochemistry nanometer scale nadph oxidation cholesterol esters membrane scaffold proteins structural biology protein structure protein biogenesis protein structure prediction

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Lb010: C5f2-Hexyl-(Cuban-1-Yl-Methyl)-Biguanide (C5F2-Hcb) Overcomes an Immune Excluded Tumor Microenvironment (Tme) and Suppresses Tumor Growth in the Ovarian Dependent Er+Her2- Ssm2Ucd Mammary Carcinoma Allograft Model. Cancer Research (2025)

Zhijun GuoJianxun LeiJoshua McCarraQing CaoMichael J. PryzbillaBrenda KoniarBeverly NorrisRobert J. SchumacherSwaathi JayaramanJohn R. HawseAntonino B. D'AssoroIlia G. DenisovStephen G. SligarKathryn L. SchwertfegerMichael A. FarrarDipak PanigrahyHammock D. BruceElizabeth A. AmbroseGunda I. GeorgGoetz P. MatthewDavid A. Potter

cancer biologycell biologybreast oncologypharmacologytherapeutic targetstumor growthtumor biologycancer researchepoxy fatty acideets biosynthesiscell metabolismcancer discoverytumor microenvironmentanti-cancer agentsmolecular cancerbreast cancermedicinal researchcancer growthcancer cellsoncogenes

Cryoradiolysis of Oxygenated Cytochrome P450 17A1 With Lyase Substrates Generates Expected Products. Journal of Inorganic Biochemistry (2024)

Remigio UsaiIlia G. DenisovStephen G. SligarJames R. Kincaid

lyase substrates generatesbiochemical sciencesdrug metabolismenzymesmolecular metabolismchemical biologyalcohol dehydrogenasescellular enzymologyaldehyde dehydrogenasebiochemical engineeringredox biologybiological chemistrybiochemistrymolecular biology

Nanodiscs for the Study of Membrane Proteins. Current Opinion in Structural Biology (2024)

Ilia G. DenisovStephen G. Sligar

biophysicsnanodiscmembrane systemsbiological macromoleculesmembrane proteinsbiomoleculesmembrane biologymembrane science

Optical Annealing of Peroxo-Ferric Intermediates in Cyp17A1 and Product Formation.. Journal of Inorganic Biochemistry (2024)

Ilia G DenisovYelena V GrinkovaStephen G Sligar

chemistryoptical annealingmaterial chemistryoptical materialslead-free perovskitesphotochemistryperovskite modulecrystal growthtransition metal chemistrychemical engineering

Solvent Isotope Effects in the Catalytic Cycle of P450 Cyp17A1: Computational Modeling of the Hydroxylation and Lyase Reactions. Journal of Inorganic Biochemistry (2023)

Ilia G. DenisovStephen G. Sligar

organic process researchchemical kineticsbiochemical sciencesenzymesmolecular metabolismbiomolecular engineeringbiocatalysischemical biologylyase reactionssolvent isotope effectsenzyme catalysisaldehyde dehydrogenasechemical reaction engineeringchemical sciencesbiochemistrystructure-function enzyme kineticscatalysisp450 cyp17a1

Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human Cyp17a1. Biochemistry (2022)

Yilin LiuIlia DenisovMichael GregoryStephen G. SligarJames R. Kincaid

drug metabolismenzymesmolecular metabolismenzyme inhibitionchemical biologysolvent isotope effectsaldehyde dehydrogenaseasparagine 202steroid metabolismbiosynthesisbiological chemistrybiochemistryaldo-keto reductaseactive site structuremolecular biologycell metabolism

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by Cyp3a4. Biomolecules (2022)

Ilia G. DenisovYelena V. GrinkovaMark A. McLeanTyler CampStephen G. Sligar

pharmaceutical sciencesdrug metabolismpharmacological researchlipid nanodiscsnew drug candidatesdrug targetsbiochemistrypharmacologyapplied pharmacologytherapeutic targetspharmacokineticsmolecular pharmacologymd simulationsdrug discoverypharmacotherapy

Abstract Lb078: Hexyl-(Cuban-1-Yl-Methyl)-Biguanide (Hcb) Inhibits Hormone Therapy Resistant Breast Cancer Cells, in Part by Inhibiting Cyp3A4 Arachidonic Acid Epoxygenase Activity. Cancer Research (2021)

Zhijun GuoJianxun LeiKwon Ho HongBeverly NorrisCraig M. FlorySwaathi JayaramanConnor McDermottElizabeth AmbroseIrina SevrioukovaTom PoulosIlia DenisovStephen SligaRobert J. SchumacherGunda I. GeorgJohn R. HawseMatthew P. GoetzDavid A. Potter

breast oncologyhcb treatmentpharmacologytherapeutic targetstumor biologymedicinal chemistryendocrine-related cancerscancer discoverydrug discoveryepoxygenase activityanti-cancer agentsmolecular cancerbioactive compoundsbiochemistrybreast cancermedicinal researchpharmaceutical chemistrypharmacological researchoncogenesenzyme inhibition

Mechanism of the Clinically Relevant E305G Mutation in Human P450 Cyp17a1. Biochemistry (2021)

Yilin LiuYelena GrinkovaMichael C. GregoryIlia G. DenisovJames R. KincaidStephen G. Sligar

drug metabolismsteroid metabolismpharmacologymolecular pharmacologymetabolic pathwaysmetabolismbiological chemistryhormonal receptorcytochrome p450scell metabolismendocrine researchbiochemical sciencesbiochemistryendocrine mechanismscytochrome p450 cyp17a1molecular metabolismendocrinologyactive siteenzyme inhibitionbiochemical genetics

Midazolam as a Probe for Drug–Drug Interactions Mediated by Cyp3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation. Biochemistry (2021)

Ilia G. DenisovYelena V. GrinkovaTyler CampMark A. McLeanStephen G. Sligar

drug metabolismmembrane surfacepharmacological researchmechanisms of actionfirst mdz moleculedrug targetsbiochemistrypharmacologyproductive sitemolecular pharmacologyenzyme inhibitiondrug discovery

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Ilia G Denisov

Research Scientist

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Biochemistry

Ilia G Denisov is currently serving as a College Of Liberal Arts & Sciences Research Scientist at University of Illinois Urbana-Champaign.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ilia G Denisov

University of Illinois Urbana-Champaign

Research Scientist

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cryoradiolysis of Oxygenated Cytochrome P450 17A1 With Lyase Substrates Generates Expected Products. Journal of Inorganic Biochemistry (2024)

Remigio UsaiIlia G. DenisovStephen G. SligarJames R. Kincaid

Nanodiscs for the Study of Membrane Proteins. Current Opinion in Structural Biology (2024)

Ilia G. DenisovStephen G. Sligar

biophysicsnanodiscmembrane systemsbiological macromoleculesmembrane proteinsbiomoleculesmembrane biologymembrane science

Optical Annealing of Peroxo-Ferric Intermediates in Cyp17A1 and Product Formation.. Journal of Inorganic Biochemistry (2024)

Ilia G DenisovYelena V GrinkovaStephen G Sligar

chemistryoptical annealingmaterial chemistryoptical materialslead-free perovskitesphotochemistryperovskite modulecrystal growthtransition metal chemistrychemical engineering

Solvent Isotope Effects in the Catalytic Cycle of P450 Cyp17A1: Computational Modeling of the Hydroxylation and Lyase Reactions. Journal of Inorganic Biochemistry (2023)

Ilia G. DenisovStephen G. Sligar

Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human Cyp17a1. Biochemistry (2022)

Yilin LiuIlia DenisovMichael GregoryStephen G. SligarJames R. Kincaid

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by Cyp3a4. Biomolecules (2022)

Ilia G. DenisovYelena V. GrinkovaMark A. McLeanTyler CampStephen G. Sligar

Mechanism of the Clinically Relevant E305G Mutation in Human P450 Cyp17a1. Biochemistry (2021)

Yilin LiuYelena GrinkovaMichael C. GregoryIlia G. DenisovJames R. KincaidStephen G. Sligar

Midazolam as a Probe for Drug–Drug Interactions Mediated by Cyp3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation. Biochemistry (2021)

Ilia G. DenisovYelena V. GrinkovaTyler CampMark A. McLeanStephen G. Sligar

drug metabolismmembrane surfacepharmacological researchmechanisms of actionfirst mdz moleculedrug targetsbiochemistrypharmacologyproductive sitemolecular pharmacologyenzyme inhibitiondrug discovery

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