Faculty

Institution

Unit

Venue

Jack Kaplan

Professor Emeritus

University of Illinois Chicago

Affiliations

College of Medicine

Department of Biochemistry and Molecular Genetics

Jack Kaplan is currently serving as a College Of Medicine Professor Emeritus at University of Illinois Chicago.

Honors

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Experiences

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Education

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Jack Kaplan

University of Illinois Chicago

Professor Emeritus

You can click a keyword to filter the displayed items

biochemistry enzymes membrane biology physiology molecular biology biological chemistry pharmacology protein science cellular physiology redox biology molecular physiology biophysical chemistry protein structure electrophysiology membrane transport enzyme inhibition structural molecular biology protein transport structure-function enzyme kinetics vascular biology biological inorganic chemistry structural biology circulatory physiology protein chemistry chemical biology biochemical sciences signal transduction liver physiology cardiovascular physiology cell physiology metalloproteins sodium pump enzyme catalysis transition metal chemistry biochemical interaction membrane science cellular enzymology coordination chemistry angiogenesis vascular disease applied physiology renal function insect cells mammalian biology metal toxicity chemical modification renal pathophysiology biomolecular interactions protein function photolabile chelators human physiology charge carrier transport translational physiology tissue physiology angiology cellular biology copper uptake copper transport caged calcium o-linked glycosylation protein assembly mammalian cells divalent cations laser photolysis enzyme inactivation adp exchange functional modification veterinary physiology ion exchange clinical pharmacology charge transport protein secretion cell trafficking p-type atpases caged compounds human copper chaperone copper homeostasis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4142846: Endothelial Copper Uptake Transporter Ctr1 Senses Disturbed Flow to Promote Atherosclerosis Through Cuproptosis. Circulation (2024)

Sudhahar VaradarajanZhen XiaoArchita DasDipankar AshShikha YadavBarun ChatterjeeMalgorzata McMenaminStephanie KelleyJianghong RaoJack KaplanMasuko Ushio-FukaiTohru Fukai

physiologycardiovascular physiologycardiovascular researchatherosclerosisvascular biologyblood flowvascular diseaseendothelial dysfunctioncardiovascular disease

Abstract 4143778: Ros-Dependent Sumoylation of Copper Chaperone Atox1 Orchestrates Endothelial Inflammatory and Angiogenic Signaling, Promoting Neovascularization Following Ischemic Injury. Circulation (2024)

Archita DasSudhahar VaradarajanShikha YadavDavid FultonStephanie KelleyMalgorzata McMenaminJunichi AbeJack KaplanMasuko Ushio-FukaiTohru Fukai

endothelial inflammatoryangiogenic signalingvascular diseasecerebral blood flowcell biologyischemic injurythrombosisvascular biologyros-dependent sumoylationmembrane biologyinflammationredox signalingneovascularizationphysiologyangiogenesisfree radical biologyredox biologybiomolecular engineeringendothelial dysfunctionoxidative stressblood vesselscardiovascular disease

Altered Copper Transport in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction Associated With Alzheimer's Disease. Vascular Pharmacology (2024)

Md Selim HossainArchita DasAshiq M RafiqFerenc DeákZsolt BagiRashelle OutlawVaradarajan SudhaharMai YamamotoJack H KaplanMasuko Ushio-FukaiTohru Fukai

vascular cognitive disordercerebral blood flowneuroscience of agingneurologyvascular biologyneuropharmacologycopper transportneurodegenerative diseasesbrain injurymolecular neurodegenerationvascular pharmacologyneurovascular diseasesredox biologybiomolecular engineeringendothelial dysfunctiontrace metalsalzheimer's diseaseoxidative stressneuroscience

Novel Role of Copper Transport Proteins in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction and Inflammation Associated With Alzheimer’s Disease. Free Radical Biology and Medicine (2024)

Md. Selim HossainArchita DasAshiq RafiqFerenc DeákZsolt BagiRashelle OutlawSudhahar VaradarajanMai YamamotoJack H. KaplanMasuko Ushio-FukaiTohru Fukai

cerebral blood flownovel rolebiochemistryneuroinflammationvascular biologykey siteneurodegenerative diseasesmetalloproteinsbrain injurymolecular neurosciencereactive oxygen speciesmolecular neurodegenerationcopper transport proteinsfree radical biologyredox biologymolecular biologyalzheimer's diseaseoxidative stressneurosciencebrain-immune interaction

Abstract 15774: Cu Uptake Transporter Ctr1 Cys189 Oxidation Protects Against Atherosclerosis via Limiting Mitochondrial Dysfunction and Endothelial Senescence. Circulation (2023)

Archita DasSudhahar VaradarajanShikha YadavSheela NagarkotiMalgorzata McMenaminJack H KaplanMasuko Ushio-FukaiTohru Fukai

cellular senescencevascular diseasehematologyvascular biologyendothelial senescencemembrane biologyhealth sciencesinflammationcardiologyredox signalingatherosclerosisphysiologyenzyme inhibitionpharmacologycardiovascular physiologycardiovascular researchfree radical biologyredox biologymitochondrial functionmitochondrial dysfunction

Abstract 12879: Endothelial Cu Exporter Atp7A Deficiency Promotes Cu-Dependent Endothelial-To-Mesenchymal Transition and Atherosclerosis via Orchestrating Glycolysis and Ros Signaling. Circulation (2022)

Dipankar AshSeock-Won YounSudhahar VaradarajanArchita DasYali HouMalgorzata McMenaminHarriet BoatwrightBradford G HillJack H KaplanMasuko Ushio-FukaiTohru Fukai

hyperlipidemiaepidemiologyvascular diseaseglobal healthliver physiologyclinical lipidologycu-dependent endothelial-to-mesenchymal transitionhematologyvascular biologyros signalinghealth sciencescardiologyatherosclerosisnephrologyblood flowcardiovascular physiologycardiovascular researchendothelial dysfunctioncirculatory physiologycardiovascular disease

Cysteine Oxidation of Copper Transporter Ctr1 Drives Vegfr2 Signalling and Angiogenesis. Nature Cell Biology (2022)

Archita DasDipankar AshAbdelrahman Y. FoudaVaradarajan SudhaharYoung-Mee KimYali HouFarlyn Z. HudsonBrian K. StansfieldRuth B. CaldwellMalgorzata McMenaminRodney LittlejohnHuabo SuMaureen R. ReganBradley J. MerrillLeslie B. PooleJack H. KaplanTohru FukaiMasuko Ushio-Fukai

gene expressionpharmacologyangiogenesiscell signalingredox biologyvascular biologyangiologymembrane biologycatalyst activationcysteine oxidationcellular biologyneurosciencecell biology

Cysteine Oxidation of Cu Uptake Transporter Ctr1 Protects Against Atherosclerosis via Limiting Endothelial Senescence. Free Radical Biology and Medicine (2022)

Archita DasSudhahar VaradarajanShikha YadavHarriet BoatwrightMaggie McMenaminJack H. KaplanMasuko Ushio-FukaiTohru Fukai

heme homeostasisradical (chemistry)vascular adaptationcatalyst activationliver physiologymedicinevascular biologyendothelial senescencemembrane biologydermatologyregenerative medicineredox signalingatherosclerosishepatologycysteine oxidationgene expressionpharmacologyenzyme inhibitionfree radical biologyredox biology

Endothelial Cu Transporter Atp7A Deficiency Promotes Endothelial-To-Mesenchymal Transition and Atherosclerosis via Inducing Metabolic Reprogramming. Free Radical Biology and Medicine (2022)

Dipankar AshY. Seock -WonounSudhahar VaradarajanArchita DasYali HouMaggie McMenaminHarriet BoatwrightBradford HillJack H. KaplanTohru FukaiMasuko Ushio-Fukai

endothelial-to-mesenchymal transitionheme homeostasisvascular adaptationliver physiologymedicineendocrinologyvascular biologymetabolic reprogrammingmembrane biologyinflammationregenerative medicineatherosclerosisimmunologyangiogenesispharmacologyfree radical biologymitochondrial functionendothelial dysfunctionmedicinal researchcirculatory physiology

Whole-Transcriptome Sequencing Analyses of Nuclear Antixoxidant-1 in Endothelial Cells: Role in Inflammation and Atherosclerosis. Cells (2022)

Varadarajan SudhaharYang ShiJack H. KaplanMasuko Ushio-FukaiTohru Fukai

genomicsgenome biologydermatologypharmacologyproteomicsatherosclerosisvascular biologyendothelial cellswhole-transcriptome sequencing analysescell biologymembrane biologyinflammation

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Jack Kaplan

Professor Emeritus

University of Illinois Chicago

Affiliations

College of Medicine

Department of Biochemistry and Molecular Genetics

Jack Kaplan is currently serving as a College Of Medicine Professor Emeritus at University of Illinois Chicago.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jack Kaplan

University of Illinois Chicago

Professor Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4142846: Endothelial Copper Uptake Transporter Ctr1 Senses Disturbed Flow to Promote Atherosclerosis Through Cuproptosis. Circulation (2024)

Sudhahar VaradarajanZhen XiaoArchita DasDipankar AshShikha YadavBarun ChatterjeeMalgorzata McMenaminStephanie KelleyJianghong RaoJack KaplanMasuko Ushio-FukaiTohru Fukai

physiologycardiovascular physiologycardiovascular researchatherosclerosisvascular biologyblood flowvascular diseaseendothelial dysfunctioncardiovascular disease

Archita DasSudhahar VaradarajanShikha YadavDavid FultonStephanie KelleyMalgorzata McMenaminJunichi AbeJack KaplanMasuko Ushio-FukaiTohru Fukai

Altered Copper Transport in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction Associated With Alzheimer's Disease. Vascular Pharmacology (2024)

Md Selim HossainArchita DasAshiq M RafiqFerenc DeákZsolt BagiRashelle OutlawVaradarajan SudhaharMai YamamotoJack H KaplanMasuko Ushio-FukaiTohru Fukai

Md. Selim HossainArchita DasAshiq RafiqFerenc DeákZsolt BagiRashelle OutlawSudhahar VaradarajanMai YamamotoJack H. KaplanMasuko Ushio-FukaiTohru Fukai

Abstract 15774: Cu Uptake Transporter Ctr1 Cys189 Oxidation Protects Against Atherosclerosis via Limiting Mitochondrial Dysfunction and Endothelial Senescence. Circulation (2023)

Archita DasSudhahar VaradarajanShikha YadavSheela NagarkotiMalgorzata McMenaminJack H KaplanMasuko Ushio-FukaiTohru Fukai

Dipankar AshSeock-Won YounSudhahar VaradarajanArchita DasYali HouMalgorzata McMenaminHarriet BoatwrightBradford G HillJack H KaplanMasuko Ushio-FukaiTohru Fukai

Cysteine Oxidation of Copper Transporter Ctr1 Drives Vegfr2 Signalling and Angiogenesis. Nature Cell Biology (2022)

gene expressionpharmacologyangiogenesiscell signalingredox biologyvascular biologyangiologymembrane biologycatalyst activationcysteine oxidationcellular biologyneurosciencecell biology

Cysteine Oxidation of Cu Uptake Transporter Ctr1 Protects Against Atherosclerosis via Limiting Endothelial Senescence. Free Radical Biology and Medicine (2022)

Archita DasSudhahar VaradarajanShikha YadavHarriet BoatwrightMaggie McMenaminJack H. KaplanMasuko Ushio-FukaiTohru Fukai

Endothelial Cu Transporter Atp7A Deficiency Promotes Endothelial-To-Mesenchymal Transition and Atherosclerosis via Inducing Metabolic Reprogramming. Free Radical Biology and Medicine (2022)

Dipankar AshY. Seock -WonounSudhahar VaradarajanArchita DasYali HouMaggie McMenaminHarriet BoatwrightBradford HillJack H. KaplanTohru FukaiMasuko Ushio-Fukai

Whole-Transcriptome Sequencing Analyses of Nuclear Antixoxidant-1 in Endothelial Cells: Role in Inflammation and Atherosclerosis. Cells (2022)

Varadarajan SudhaharYang ShiJack H. KaplanMasuko Ushio-FukaiTohru Fukai

genomicsgenome biologydermatologypharmacologyproteomicsatherosclerosisvascular biologyendothelial cellswhole-transcriptome sequencing analysescell biologymembrane biologyinflammation

1
2
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4
5
31
10 / page

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