Faculty

Institution

Unit

Venue

Stephen G Sligar

Swanlund Endowed Chair Emeritus Professor

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Biochemistry

Stephen G Sligar is currently serving as a College Of Liberal Arts & Sciences Swanlund Endowed Chair Emeritus Professor at University of Illinois Urbana-Champaign.

Honors

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Experiences

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Education

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Stephen G Sligar

University of Illinois Urbana-Champaign

Swanlund Endowed Chair Emeritus Professor

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biochemistry molecular biology biophysical chemistry biophysics biological chemistry enzymes protein science molecular metabolism chemical biology redox biology protein structure structural molecular biology drug metabolism biochemical sciences molecular biophysics biomolecular structure membrane proteins biological macromolecules membrane biology proteinlipid interaction biomolecular engineering heme degradation enzyme inhibition nanodisc biomolecules structure-function enzyme kinetics altmetric attention score biochemical genetics cell metabolism redox chemistry protein chemistry heme transport membrane science enzyme catalysis biochemical interaction vibrational spectroscopy cytochrome p450 heme signaling molecular science molecular structure transition metal chemistry biomolecular interactions biomolecular analysis heme homeostasis lipid chemistry cytochrome p450cam membrane systems reactive oxygen species protein assembly biocatalysis cytochrome p-450cam biological inorganic chemistry molecular spectroscopy cellular enzymology single molecule biophysics carbonyl metabolism spectroelectrochemistry membrane structure steroid metabolism lipid movement cytochrome p-450 molecular recognition nanobiotechnology protein x-ray crystallography bioelectrochemistry donut icon escherichia coli cytochrome p450 3a4 active site osmotic pressure resonance raman resonance raman spectroscopy carbon monoxide scaffold protein cytochrome p450s spin state biological pathways nanoparticle research therapeutic nanomaterials

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Lb010: C5f2-Hexyl-(Cuban-1-Yl-Methyl)-Biguanide (C5F2-Hcb) Overcomes an Immune Excluded Tumor Microenvironment (Tme) and Suppresses Tumor Growth in the Ovarian Dependent Er+Her2- Ssm2Ucd Mammary Carcinoma Allograft Model. Cancer Research (2025)

Zhijun GuoJianxun LeiJoshua McCarraQing CaoMichael J. PryzbillaBrenda KoniarBeverly NorrisRobert J. SchumacherSwaathi JayaramanJohn R. HawseAntonino B. D'AssoroIlia G. DenisovStephen G. SligarKathryn L. SchwertfegerMichael A. FarrarDipak PanigrahyHammock D. BruceElizabeth A. AmbroseGunda I. GeorgGoetz P. MatthewDavid A. Potter

breast oncologycell biologymolecular canceranti-cancer agentsbreast cancertumor microenvironmentcancer biologycell metabolismcancer researchtherapeutic targetscancer growthtumor biologytumor growthepoxy fatty acidpharmacologycancer discoveryoncogenescancer cellsmedicinal researcheets biosynthesis

Nanodisc Single-Molecule Pulldown to Study Lipid-Protein Interactions. Journal of Lipid Research (2025)

Adriana Reyes-OrdoñezShweta ShreeNilmani SinghStephen G SligarJie Chen

biological macromoleculesmolecular biophysicsbiophysicslipid movementlipid nanodiscsproteinlipid interactionsingle-molecule detectionlipidsnanodisc single-molecule pulldownlipid-protein interactionsfluorescencecellular biochemistrymembrane proteinsmembrane sciencenanodiscmembrane biologylipid chemistrybiochemistry

A Broadly Protective Vaccine Against Swine Influenza a Virus Based on the Matrix Protein 2 (M2). AASV Annual Meeting (2024)

F. A. ZuckermannY. GrionkovaR. J. HusmannM. Pires-AlvezS. StormsS. G. Sligar

immunologyvaccinesvirus researchantiviral researchinfection controlmedical virologyvaccine developmentgeneral virologymatrix protein 2virologyinfluenza vaccinevaccinationinfectious diseasesinfluenzavaccine designswine virusprotective vaccine

An Effective Vaccine Against Influenza a Virus Based on the Matrix Protein 2 (M2). Veterinary Microbiology (2024)

Federico A ZuckermannYelena V GrinkovaRobert J HusmannMelissa Pires-AlvesSuzanna StormsWei-Yu ChenStephen G Sligar

immunologyvaccinesvirus researchantiviral researchmedical virologyvaccine developmentinfluenza a virusmatrix protein 2virologyinfluenza vaccinevaccinationinfectious diseasesinfluenzavaccine designeffective vaccine

Cryoradiolysis of Oxygenated Cytochrome P450 17A1 With Lyase Substrates Generates Expected Products. Journal of Inorganic Biochemistry (2024)

Remigio UsaiIlia G. DenisovStephen G. SligarJames R. Kincaid

biochemical engineeringdrug metabolismaldehyde dehydrogenaseredox biologylyase substrates generateschemical biologyenzymesmolecular metabolismalcohol dehydrogenasesmolecular biologybiological chemistrycellular enzymologybiochemical sciencesbiochemistry

Kras4B–Calmodulin Interaction With Membrane Surfaces: Role of Headgroup, Acyl Chain, and Electrostatics. Biochemistry (2024)

Shweta ShreeMark A. McLeanAndrew G. StephenStephen G. Sligar

biophysical chemistrybiophysicsbiological macromoleculeslipid movementmembrane transportproteinlipid interactionprotein sciencechain lengthintracellular traffickingprotein transportkras4b dissociationdissociation kineticscellular biochemistrymembrane proteinssignal transductionmolecular physiologymembrane biologybiochemistry

Nanodiscs for the Study of Membrane Proteins. Current Opinion in Structural Biology (2024)

Ilia G. DenisovStephen G. Sligar

biological macromoleculesbiophysicsmembrane systemsmembrane proteinsmembrane sciencenanodiscbiomoleculesmembrane biology

Optical Annealing of Peroxo-Ferric Intermediates in Cyp17A1 and Product Formation.. Journal of Inorganic Biochemistry (2024)

Ilia G DenisovYelena V GrinkovaStephen G Sligar

material chemistrychemical engineeringperovskite moduleoptical materialsphotochemistrylead-free perovskitescrystal growthchemistryoptical annealingtransition metal chemistry

Selective α-Hydroxyketone Formation and Subsequent C–C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes. ACS Catalysis (2024)

Joel H. Z. LeeTom ColemanMark A. McleanMatthew N. PodgorskiEva F. HayballIsobella S. J. StoneJohn B. BruningFiona WhelanJames J. De VossStephen G. SligarStephen G. Bell

md simulationsprocess biochemistryenzyme inhibitionbiomolecular engineeringenzymesmolecular metabolismbiocatalysisenzyme catalysiscytochrome p450benzoic acidbiochemistrybiosynthesis

Engineering C–C Bond Cleavage Activity Into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society (2023)

Justin C. MillerJoel H. Z. LeeMark A. McleanRebecca R. ChaoIsobella S. J. StoneTara L. PukalaJohn B. BruningJames J. De VossMary A. SchulerStephen G. SligarStephen G. Bell

process biochemistryp450 monooxygenase enzymecarbonyl metabolismbiomolecular engineeringenzymesmolecular metabolismmolecular biologyalcohol dehydrogenasesbiocatalysiscytochrome p450metabolic engineeringbiochemical scienceshuman p450 cyp17a1biochemistrybiosynthesis

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Stephen G Sligar

Swanlund Endowed Chair Emeritus Professor

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Biochemistry

Stephen G Sligar is currently serving as a College Of Liberal Arts & Sciences Swanlund Endowed Chair Emeritus Professor at University of Illinois Urbana-Champaign.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Stephen G Sligar

University of Illinois Urbana-Champaign

Swanlund Endowed Chair Emeritus Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Nanodisc Single-Molecule Pulldown to Study Lipid-Protein Interactions. Journal of Lipid Research (2025)

Adriana Reyes-OrdoñezShweta ShreeNilmani SinghStephen G SligarJie Chen

A Broadly Protective Vaccine Against Swine Influenza a Virus Based on the Matrix Protein 2 (M2). AASV Annual Meeting (2024)

F. A. ZuckermannY. GrionkovaR. J. HusmannM. Pires-AlvezS. StormsS. G. Sligar

An Effective Vaccine Against Influenza a Virus Based on the Matrix Protein 2 (M2). Veterinary Microbiology (2024)

Federico A ZuckermannYelena V GrinkovaRobert J HusmannMelissa Pires-AlvesSuzanna StormsWei-Yu ChenStephen G Sligar

Cryoradiolysis of Oxygenated Cytochrome P450 17A1 With Lyase Substrates Generates Expected Products. Journal of Inorganic Biochemistry (2024)

Remigio UsaiIlia G. DenisovStephen G. SligarJames R. Kincaid

Kras4B–Calmodulin Interaction With Membrane Surfaces: Role of Headgroup, Acyl Chain, and Electrostatics. Biochemistry (2024)

Shweta ShreeMark A. McLeanAndrew G. StephenStephen G. Sligar

Nanodiscs for the Study of Membrane Proteins. Current Opinion in Structural Biology (2024)

Ilia G. DenisovStephen G. Sligar

biological macromoleculesbiophysicsmembrane systemsmembrane proteinsmembrane sciencenanodiscbiomoleculesmembrane biology

Optical Annealing of Peroxo-Ferric Intermediates in Cyp17A1 and Product Formation.. Journal of Inorganic Biochemistry (2024)

Ilia G DenisovYelena V GrinkovaStephen G Sligar

material chemistrychemical engineeringperovskite moduleoptical materialsphotochemistrylead-free perovskitescrystal growthchemistryoptical annealingtransition metal chemistry

Selective α-Hydroxyketone Formation and Subsequent C–C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes. ACS Catalysis (2024)

Joel H. Z. LeeTom ColemanMark A. McleanMatthew N. PodgorskiEva F. HayballIsobella S. J. StoneJohn B. BruningFiona WhelanJames J. De VossStephen G. SligarStephen G. Bell

md simulationsprocess biochemistryenzyme inhibitionbiomolecular engineeringenzymesmolecular metabolismbiocatalysisenzyme catalysiscytochrome p450benzoic acidbiochemistrybiosynthesis

Engineering C–C Bond Cleavage Activity Into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society (2023)

Justin C. MillerJoel H. Z. LeeMark A. McleanRebecca R. ChaoIsobella S. J. StoneTara L. PukalaJohn B. BruningJames J. De VossMary A. SchulerStephen G. SligarStephen G. Bell

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