Faculty

Institution

Unit

Venue

Carl Frieden

Professor

Washington University in St. Louis

Affiliations

School of Medicine

Department of Biochemistry and Molecular Biophysics

Carl Frieden is currently serving as a Biochemistry And Molecular Biophysics Professor at Washington University In St. Louis.

Honors

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Experiences

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Education

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Carl Frieden

Washington University in St. Louis

Professor

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biochemistry molecular biology protein science enzymes biophysics protein structure structural biology protein folding structural molecular biology biological chemistry biomolecular engineering enzyme catalysis enzyme inhibition chemical biology structure-function enzyme kinetics biomolecular structure molecular metabolism lipids nuclear magnetic resonance biochemical sciences protein chemistry membrane biology protein assembly biological macromolecules redox biology cell metabolism peptide science muscle function protein nmr protein phosphorylation proteinlipid interaction enzyme specificity enzymatic modification glutamate dehydrogenase biochemical interaction skeletal muscle nuclear magnetic resonance spectroscopy intestinal fatty acid biomolecules liver physiology vascular biology glycosylation rabbit muscle phosphofructokinase glutamic dehydrogenase molecular physiology molecular science mechanisms of action molecular substrates g protein-coupled receptor protein function conformational studies biocatalysis aldehyde dehydrogenase inhibitory activity cellular enzymology biomolecular interactions polymerization kinetics protein refolding protein modeling adenosine deaminase protein transport protein x-ray crystallography fluorescence correlation spectroscopy adenylate deaminase rabbit muscle enzyme nmr studies energy metabolism kinetics (physics) transformation kinetics enzymatic activity domain-domain interactions molecular weight computer simulation numerical integration myoadenylate deaminase deficiency actin polymerization proteome research mass spectrometry alzheimer's disease protein misfolding fluorescence methods proteomics protein mass spectrometry

Notable Scholarly Works

Notable Federal Grants

Collaborators

Apolipoprotein E4 Has Extensive Conformational Heterogeneity in Lipid-Free and Lipid-Bound Forms. Proceedings of the National Academy of Sciences (2023)

Melissa D. Stuchell-BreretonMaxwell I. ZimmermanJustin J. MillerUpasana L. MallimadugulaJ. Jeremías InciccoDebjit RoyLouis G. SmithJasmine CubukBerevan BabanGregory T. DeKosterCarl FriedenGregory R. BowmanAndrea Soranno

neurologyproteomicslipid-bound formsprotein structureconformational studiesmolecular biologymembrane biologyepigeneticsstructural biologyprotein scienceneuroscience

Single-Molecule Spectroscopy of Apolipoprotein E Reveals a Complex Conformational Ensemble. Biophysical Journal (2023)

Melissa D. Stuchell-BreretonMaxwell I. ZimmermanJustin J. MillerUpasana L. MallimadugulaJuan J. InciccoDebjit RoyLouis G. SmithJasmine CubukBerevan BabanGregory T. DeKosterCarl FriedenGregory R. BowmanAndrea Soranno

molecular biophysicsbiophysicsprotein structureconformational studiesmolecular biologysingle-molecule spectroscopystructural biologyprotein sciencecell biology

Contributors. Elsevier eBooks (2022)

Ron AltermanJeffrey E. ArleKerry BradleySergio CanaveroSteven M. FalowskiChad W. FarleyYakov GologorskyJianwen Wendy GuH. Louis JournéeJohn KastOlga KhazenJoachim K. KraussVignessh KumarMark LentRobert M. LevyAndres M. LozanoCharles MackelGeorge T. MandyburBryan L. McLaughlinDaniel R. MerrillAlon Y. MogilnerGabi MolnarGuillermo A. MonsalveRichard B. NorthYunseo Linda ParkJohn ParkerShrey PatelJulie G. PilitsisFrancisco A. PonceJason E. PopeAdolfo Ramirez-ZamoraLouis J. RasoJoshua M. RosenowJay L. ShilsPeter SingleKonstantin V. SlavinMichael D. StaudtMark M. SteckerHuy Q. Truong

Single-Molecule Fluorescence Spectroscopy of Apolipoprotein E. Biophysical Journal (2022)

Melissa D. Stuchell-BreretonMaxwell I. ZimmermanUpasana L. MallimadugulaJ. Jeremias InciccoDebjit RoyBerevan BabanGregory T. DeKosterGregory BowmanCarl FriedenAndrea Soranno

fluorescence spectroscopybiophysical chemistrymolecular biophysicsbiophysicsexperimental biophysicssingle-molecule fluorescence spectroscopyfluorescencemolecular biologyprotein sciencebiochemistry

Apoe3-Jacksonville (V236E) Variant Reduces Self-Aggregation and Risk of Dementia. Sci Transl Med. (2021)

neurologyvascular dementiaaging-associated diseasesfrontotemporal dementianeurogeneticsdementiacognitive impairmentmolecular neurodegenerationneuroscience of agingneuroscienceneurodegenerative diseases

Apoe3 -Jacksonville (V236E) Variant Reduces Self-Aggregation and Risk of Dementia. Science Translational Medicine (2021)

Chia-Chen LiuMelissa E. MurrayXia LiNa ZhaoNa WangMichael G. HeckmanFrancis ShueYuka MartensYonghe LiAna-Caroline RaulinCassandra L. RosenbergSydney V. DossJing ZhaoMelissa C. WrenLin JiaYingxue RenTadafumi C. IkezuWenyan LuYuan FuThomas CaulfieldZachary A. TrottierJoshua KnightYixing ChenCynthia LinaresXue WangAishe KurtiYan W. AsmannZbigniew K. WszolekGlenn E. SmithPrashanthi VemuriKejal KantarciDavid S. KnopmanVal J. LoweClifford R. JackJoseph E. ParisiTanis J. FermanBradley F. BoeveNeill R. Graff-RadfordRonald C. PetersenSteven G. YounkinJohn D. FryerHu WangXianlin HanCarl FriedenDennis W. DicksonOwen A. RossGuojun Bu

neurologyvariant interpretationgeneticsallelic variantdementiasomatic variantpsychiatric geneticsmedicinal researchhuman geneticsneurosciencetranslational medicine

19 F Nmr Reveals the Conformational Properties of Free Thrombin and Its Zymogen Precursor Prethrombin-2. J Biol Chem (2020)

f nmrbiophysical chemistrybiophysicsprotein structurezymogen precursor prethrombin-2biomolecular structureprotein nmrfree thrombinmolecular biologystructural molecular biologybiochemistrystructural biologynuclear magnetic resonanceprotein scienceprotein folding

19F Nmr Reveals the Conformational Properties of Free Thrombin and Its Zymogen Precursor Prethrombin-2. Journal of Biological Chemistry (2020)

Eliza A. RubenPrafull S. GandhiZhiwei ChenSarah K. KoesterGregory T. DeKosterCarl FriedenEnrico Di Cera

protein structureprotein nmrbiological chemistrybiochemistrythrombosisfree thrombinstructural biologyprotein scienceprotein foldingprotein assemblynmr revealsmolecular and cellular biologyconformational propertiesnuclear magnetic resonance spectroscopynuclear magnetic resonancebiophysicsconformational studiesmolecular biologystructural molecular biologyprotein x-ray crystallography

Bioorthogonal Chemistry Enables Single‐Molecule Fret Measurements of Catalytically Active Protein Disulfide Isomerase. ChemBioChem (2020)

Mathivanan ChinnarajDavid A. BarriosCarl FriedenTomasz HeydukRobert FlaumenhaftNicola Pozzi

single-molecule fret measurementsenzymesbiocatalysisbioorthogonal chemistrymolecular biologyenzyme catalysisbiochemistry

Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts. Analytical Chemistry (2020)

John T. PetroffAiling TongLawrence J. ChenGregory T. DekosterFarha KhanJeff AbramsonCarl FriedenWayland W. L. Cheng

charge reductionbiophysicsnative mass spectrometryanalytical chemistrymass spectrometrybiological engineering

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Carl Frieden

Professor

Washington University in St. Louis

Affiliations

School of Medicine

Department of Biochemistry and Molecular Biophysics

Carl Frieden is currently serving as a Biochemistry And Molecular Biophysics Professor at Washington University In St. Louis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Carl Frieden

Washington University in St. Louis

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Apolipoprotein E4 Has Extensive Conformational Heterogeneity in Lipid-Free and Lipid-Bound Forms. Proceedings of the National Academy of Sciences (2023)

neurologyproteomicslipid-bound formsprotein structureconformational studiesmolecular biologymembrane biologyepigeneticsstructural biologyprotein scienceneuroscience

Single-Molecule Spectroscopy of Apolipoprotein E Reveals a Complex Conformational Ensemble. Biophysical Journal (2023)

molecular biophysicsbiophysicsprotein structureconformational studiesmolecular biologysingle-molecule spectroscopystructural biologyprotein sciencecell biology

Contributors. Elsevier eBooks (2022)

Single-Molecule Fluorescence Spectroscopy of Apolipoprotein E. Biophysical Journal (2022)

Melissa D. Stuchell-BreretonMaxwell I. ZimmermanUpasana L. MallimadugulaJ. Jeremias InciccoDebjit RoyBerevan BabanGregory T. DeKosterGregory BowmanCarl FriedenAndrea Soranno

fluorescence spectroscopybiophysical chemistrymolecular biophysicsbiophysicsexperimental biophysicssingle-molecule fluorescence spectroscopyfluorescencemolecular biologyprotein sciencebiochemistry

Apoe3-Jacksonville (V236E) Variant Reduces Self-Aggregation and Risk of Dementia. Sci Transl Med. (2021)

Apoe3 -Jacksonville (V236E) Variant Reduces Self-Aggregation and Risk of Dementia. Science Translational Medicine (2021)

neurologyvariant interpretationgeneticsallelic variantdementiasomatic variantpsychiatric geneticsmedicinal researchhuman geneticsneurosciencetranslational medicine

19 F Nmr Reveals the Conformational Properties of Free Thrombin and Its Zymogen Precursor Prethrombin-2. J Biol Chem (2020)

19F Nmr Reveals the Conformational Properties of Free Thrombin and Its Zymogen Precursor Prethrombin-2. Journal of Biological Chemistry (2020)

Eliza A. RubenPrafull S. GandhiZhiwei ChenSarah K. KoesterGregory T. DeKosterCarl FriedenEnrico Di Cera

Bioorthogonal Chemistry Enables Single‐Molecule Fret Measurements of Catalytically Active Protein Disulfide Isomerase. ChemBioChem (2020)

Mathivanan ChinnarajDavid A. BarriosCarl FriedenTomasz HeydukRobert FlaumenhaftNicola Pozzi

single-molecule fret measurementsenzymesbiocatalysisbioorthogonal chemistrymolecular biologyenzyme catalysisbiochemistry

Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts. Analytical Chemistry (2020)

John T. PetroffAiling TongLawrence J. ChenGregory T. DekosterFarha KhanJeff AbramsonCarl FriedenWayland W. L. Cheng

charge reductionbiophysicsnative mass spectrometryanalytical chemistrymass spectrometrybiological engineering

1
2
3
4
5
23
10 / page

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protein structure

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