Faculty

Institution

Unit

Venue

Stephen Sprang

Professor Emeritus

University of Montana

Affiliations

College of Humanities and Sciences

Biochemistry

Biological Sciences

Stephen Sprang is currently serving as a Biochemistry Professor Emeritus at University of Montana.

Honors

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Experiences

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Education

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Stephen Sprang

University of Montana

Professor Emeritus

You can click a keyword to filter the displayed items

structural biology molecular biology biochemistry protein science protein structure pharmacology enzymes structural molecular biology genetics biological chemistry membrane biology crystallography catalysis receptors enzyme catalysis biomolecular structure gene expression enzyme inhibition protein chemistry biocatalysis g protein-coupled receptor structural basis molecular structure molecular regulation crystal structures adenylyl cyclase biomolecular interactions molecular catalysis glycogen phosphorylase mammalian adenylyl cyclase biochemical sciences molecular substrates redox biology pharmacological research mammalian biology medicinal research structural chemistry biological inorganic chemistry protein x-ray crystallography conformational studies gtp hydrolysis catalytic site rgrgs domain catalytic domains peptides oncogenes virus research molecular science structural bioinformatics protein function enzyme specificity catalyst activation protein genetics protein modeling structural composition molecular diversity signaling pathways biochemical genetics extracellular domain catalytic mechanism ga-catalyzed gtp hydrolysis kinetic isotope effects cellular structure cellular biology cytokines surface functionalization charge transport molecular basis inhibitory process inhibitory activity mitochondrial function receptor (biochemistry) transition state two-metal-ion catalysis quaternary structural changes cytokine structural taxonomy protein expression signal transduction proteome research biological function cell signaling

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Neuronal Calcium Sensor Ncs-1 Regulates the Phosphorylation State and Activity of the Gα Chaperone and Gef Ric-8a. eLife (2023)

Daniel Muñoz-ReyesLevi J McClellandSandra Arroyo-UreaSonia Sánchez-YepesJuan SabínSara Pérez-SuárezMargarita MenendezAlicia MansillaJavier García-NafríaStephen SprangMaria Jose Sanchez-Barrena

neurologypharmacologyelectrophysiologyphosphorylation statecell signalingneurochemistryneuropharmacologyga chaperonesignal transductionneuroscienceneurophysiologyneuronal calcium sensor

Application of Sulfur Sad to Small Crystals With a Large Asymmetric Unit and Anomalous Substructure. Acta Crystallographica Section D Structural Biology (2022)

Tung-Chung MouBaisen ZengTzanko I. DoukovStephen R. Sprang

materials sciencesmall crystalscryogenicsanomalous substructurestructural biologycrystal structurescrystallography

The Structure of the Cysteine-Rich Region From Human Histone-Lysine N-Methyltransferase Ehmt2 (G9A). Journal of Structural Biology X (2021)

Keshia M. KerchnerTung-Chung MouYizhi SunDomniţa-Valeria RusnacStephen R. SprangKlára Briknarová

protein structuregeneticsmammalian biologybiomolecular structureenzymesstructural molecular biologycysteine-rich regionstructural biology

Cryo-Em Structure of Mammalian Ric-8A: Galpha(I): Nanobody Complex. (2020)

T.C. MouK. ZhangJ.D. JohnstonW. ChiuS.R. Sprang

structural biologycryo-em structuremolecular biologygenetics

Crystal and Cryo-Em Structures of the Cytosolic G Protein Alpha Chaperone and Guanine Nucleotide Exchange Factor Ric-8A Bound to Gαi1. bioRxiv (Cold Spring Harbor Laboratory) (2020)

Levi J. McClellandKaiming ZhangTung-Chung MouJake JohnstonCindee Yates-HansenShanshan LiCelestine J. ThomasTzanko I. DoukovSarah TriestAlexandre WohlkonigGregory G. TallJan SteyaertWah ChiuStephen R. Sprang

protein structuregeneticscryo-em structuresmolecular biologystructural biologycrystallographycell biology

Ric8A-Gα, a Complex Structure of a Guanine Nucleotide Exchange Factor. Biophysical Journal (2020)

Levi J. McClellandKaiming ZhangTung-Chung MouJake JohnstonCindee Yates-HansenJan SteyaertWah ChiuStephen Sprang

biophysical chemistrymolecular biophysicsbiophysicsprotein structuregeneticsmolecular biologycomplex structurestructural biologyprotein science

Structure of the G Protein Chaperone and Guanine Nucleotide Exchange Factor Ric-8A Bound to Gαi1. Nature Communications (2020)

protein structuregeneticsmolecular biologystructural biologybiochemistry

Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8a. Structure (2019)

Baisen ZengTung-Chung MouTzanko I. DoukovAndrea SteinerWenxi YuMakaia Papasergi-ScottGregory G. TallFranz HagnStephen R. Sprang

biophysicsprotein structuregeneticsbiologystructural mechanicsbiomolecular structuremolecular structurestructural molecular biologystructural biology

The Structure of the Complex of the Cytoplasmic Guanine Nucleotide Exchange Factor Ric-8A Bound to Gαi1. Acta Crystallographica Section A Foundations and Advances (2019)

Stephen SprangLevi McClellandJake JohnstonCindee Yates-HansenTung-Chung MouKaiming Zhang

cytoplasmic guanineprotein structuregeneticsmolecular structuremolecular biologystructural molecular biologystructural chemistrymolecular complexesstructural biologycrystal structuresx-ray crystallographycrystallographybiochemistry

Crystal Structure of the Major Quadruplex Formed in the Promoter Region of the Human C-Myc Oncogene. PLoS ONE (2018)

Sascha StumpTung-Chung MouStephen R. SprangNicholas R. NataleHoward D. Beall

genomicsgenome biologymajor quadruplexhuman c-myc oncogeneprotein structuregeneticsplo biologyprotein geneticspromoter regionmolecular biologymolecular geneticsoncogenesstructural molecular biologystructural biologyprotein sciencetumor biologycell biology

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Stephen Sprang

Professor Emeritus

University of Montana

Affiliations

College of Humanities and Sciences

Biochemistry

Biological Sciences

Stephen Sprang is currently serving as a Biochemistry Professor Emeritus at University of Montana.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Stephen Sprang

University of Montana

Professor Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Neuronal Calcium Sensor Ncs-1 Regulates the Phosphorylation State and Activity of the Gα Chaperone and Gef Ric-8a. eLife (2023)

Daniel Muñoz-ReyesLevi J McClellandSandra Arroyo-UreaSonia Sánchez-YepesJuan SabínSara Pérez-SuárezMargarita MenendezAlicia MansillaJavier García-NafríaStephen SprangMaria Jose Sanchez-Barrena

neurologypharmacologyelectrophysiologyphosphorylation statecell signalingneurochemistryneuropharmacologyga chaperonesignal transductionneuroscienceneurophysiologyneuronal calcium sensor

Application of Sulfur Sad to Small Crystals With a Large Asymmetric Unit and Anomalous Substructure. Acta Crystallographica Section D Structural Biology (2022)

Tung-Chung MouBaisen ZengTzanko I. DoukovStephen R. Sprang

materials sciencesmall crystalscryogenicsanomalous substructurestructural biologycrystal structurescrystallography

The Structure of the Cysteine-Rich Region From Human Histone-Lysine N-Methyltransferase Ehmt2 (G9A). Journal of Structural Biology X (2021)

Keshia M. KerchnerTung-Chung MouYizhi SunDomniţa-Valeria RusnacStephen R. SprangKlára Briknarová

protein structuregeneticsmammalian biologybiomolecular structureenzymesstructural molecular biologycysteine-rich regionstructural biology

Cryo-Em Structure of Mammalian Ric-8A: Galpha(I): Nanobody Complex. (2020)

T.C. MouK. ZhangJ.D. JohnstonW. ChiuS.R. Sprang

structural biologycryo-em structuremolecular biologygenetics

Crystal and Cryo-Em Structures of the Cytosolic G Protein Alpha Chaperone and Guanine Nucleotide Exchange Factor Ric-8A Bound to Gαi1. bioRxiv (Cold Spring Harbor Laboratory) (2020)

protein structuregeneticscryo-em structuresmolecular biologystructural biologycrystallographycell biology

Ric8A-Gα, a Complex Structure of a Guanine Nucleotide Exchange Factor. Biophysical Journal (2020)

Levi J. McClellandKaiming ZhangTung-Chung MouJake JohnstonCindee Yates-HansenJan SteyaertWah ChiuStephen Sprang

biophysical chemistrymolecular biophysicsbiophysicsprotein structuregeneticsmolecular biologycomplex structurestructural biologyprotein science

Structure of the G Protein Chaperone and Guanine Nucleotide Exchange Factor Ric-8A Bound to Gαi1. Nature Communications (2020)

protein structuregeneticsmolecular biologystructural biologybiochemistry

Structure, Function, and Dynamics of the Gα Binding Domain of Ric-8a. Structure (2019)

Baisen ZengTung-Chung MouTzanko I. DoukovAndrea SteinerWenxi YuMakaia Papasergi-ScottGregory G. TallFranz HagnStephen R. Sprang

biophysicsprotein structuregeneticsbiologystructural mechanicsbiomolecular structuremolecular structurestructural molecular biologystructural biology

The Structure of the Complex of the Cytoplasmic Guanine Nucleotide Exchange Factor Ric-8A Bound to Gαi1. Acta Crystallographica Section A Foundations and Advances (2019)

Stephen SprangLevi McClellandJake JohnstonCindee Yates-HansenTung-Chung MouKaiming Zhang

Crystal Structure of the Major Quadruplex Formed in the Promoter Region of the Human C-Myc Oncogene. PLoS ONE (2018)

Sascha StumpTung-Chung MouStephen R. SprangNicholas R. NataleHoward D. Beall

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