Faculty

Institution

Unit

Venue

Robert G. Salomon

Charles Frederic Mabery Professor of Research in Chemistry

Case Western Reserve University

Affiliations

School of Medicine

Biochemistry

College of Arts and Sciences

Department of Chemistry

Robert G. Salomon is currently serving as a Biochemistry Charles Frederic Mabery Professor of Research in Chemistry at Case Western Reserve University.

Honors

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Experiences

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Education

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Robert G. Salomon

Case Western Reserve University

Charles Frederic Mabery Professor of Research in Chemistry

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chemistry pharmacology organic synthesis organic chemistry cheminform abstract ophthalmology biochemistry redox biology oxidative stress transition metal chemistry medicinal chemistry membrane biology total synthesis catalysis protein science free radical biology coordination chemistry toxicology biological chemistry inflammation vascular biology lipid chemistry age-related macular degeneration prostaglandin endoperoxides clinical chemistry lipid science olefin photoreactions liver physiology medicinal research organometallic catalysis clinical lipidology retina mammalian biology chemical sciences cardiovascular research experimental medicine protein chemistry oxidized phospholipids biochemical sciences clinical toxicology ocular disease lipid disorders experimental toxicology redox signaling molecular fragmentation lipid analysis natural product synthesis hemostasis lipid peroxidation angiogenesis experimental ophthalmology catalytic synthesis isoprostane pathway inhalation toxicology lipid synthesis biocatalysis lipoprotein metabolism immunochemistry chronic inflammation functional modification experimental biology lead identification molecular catalysis pharmacokinetics experimental pharmacology mitochondrial function heterocycle chemistry human plasma oxidant stress mouse model novel family protective role diazo compounds olefin coordination reactive g-ketoaldehydes cationic olefin complexes

Notable Scholarly Works

Notable Federal Grants

Collaborators

Radical-Induced Lipid Oxidation Produces a Torrent of Leukotriene-Like Agonists in Severe Asthma. Journal of Allergy and Clinical Immunology (2025)

lipidsasthmainflammationpulmonary pharmacologyradical-induced lipid oxidationsevere asthmaphysiologylipid peroxidationreactive oxygen speciesrespiratory medicineallergyleukotriene-like agonistspharmacologyoxidative stressfree radical biologypharmacological research

Cysteinyl Leukotriene-Like Metabolites Are Generated in Retinal Pigment Epithelial Cells Through Glutathionylation/Reduction of an Oxidatively Truncated Fragment of Arachidonate. Results in Chemistry (2023)

Mikhail LinetskyAnshula MondalSi-Yang LiuAbby M. HiteShravani EnduriYu-Shiuan ChengBeatriz FeijoGraham KangNana ArhinHong ZengOlivia R. LaniakJohn DenkerRobert G. Salomon

medicinal chemistrycysteinyl leukotriene-like metabolitesmolecular biologypharmacologyophthalmologyredox biology

References. Edward Elgar Publishing eBooks (2021)

Andrew JohnstonRobert Huggins

university knowledgeuniversity collaborationbusinessindustrial collaborationcollaboration processentrepreneurshipsocial innovationsmall business managementinter-firm coordinationtechnology transfermanagementstrategic managementinterorganizational relationships

4-Hydroxy-7-Oxo-5-Heptenoic Acid (Hoha) Lactone Induces Apoptosis in Retinal Pigment Epithelial Cells. Free Radical Biology and Medicine (2020)

Mikhail LinetskyJunhong GuoEmeka UdeigweDuoming MaAmanda S. ChamberlainAnnabelle O. YuKseniya SolovyovaElise EdgarRobert G. Salomon

apoptosiscell deathmedicinal researchfree radical biologymembrane biologymedicinepharmacologyoxidative stressophthalmology

4-Hydroxy-7-Oxo-5-Heptenoic Acid Lactone Can Induce Mitochondrial Dysfunction in Retinal Pigmented Epithelial Cells. Free Radical Biology and Medicine (2020)

Yu-Shiuan ChengMikhail LinetskyHaoting LiNaji AyyashAnthony GardellaRobert G. Salomon

mitochondrial dysfunctionregenerative medicinephysiologycellular physiologytissue physiologymolecular physiologymembrane biologypharmacologyoxidative stressfree radical biologymitochondrial functionophthalmologyredox biology

Toll-Like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration. Cell Reports (2020)

Kelly MulfaulEma OzakiNilisha FernandoKiva BrennanKathleen R. ChircoEmma ConnollyChris GreeneArvydas MaminishkisRobert G. SalomonMikhail LinetskyRiccardo NatoliRobert F. MullinsMatthew CampbellSarah L. Doyle

cell interactionscell-matrix interactionscell deathimmunologycell biologycellular biologyimmune responsescellular immune responsesoxidative stressfree radical biologyophthalmologyredox biology

4-Hydroxy-7-Oxo-5-Heptenoic Acid Lactone is a Potent Inducer of Brain Cancer Cell Invasiveness That May Contribute to the Failure of Anti-Angiogenic Therapies. Free Radical Biology and Medicine (2019)

Nicholas TomkoMark KlueverChunying WuJunqing ZhuYanming WangRobert G. Salomon

neurologyanti-angiogenic therapiesangiogenesisgliomasbrain tumor researchcancer researchmedicinepharmacologyfree radical biologypotent inducerbrain cancer celloncologycancer biology

The Adductomics of Isolevuglandins: Oxidation of Isolg Pyrrole Intermediates Generates Pyrrole–Pyrrole Crosslinks and Lactams. High-Throughput (2019)

Wenzhao BiGeeng-Fu JangLei ZhangJohn W. CrabbJames LairdMikhail LinetskyRobert G. Salomon

protein sciencemedicinal chemistrybiochemistrychemistrymolecular biologyorganic chemistrybiological chemistrypyrrole-pyrrole crosslinksisolg pyrrole intermediates

4-Hydroxy-7-Oxo-5-Heptenoic Acid Lactone is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells. Chemical Research in Toxicology (2018)

Mikhail LinetskyKarina S. BondelidSofiya LosovskiyVadym GabyakMario J. RulloThomas I. StiadleVasu MunjaparaPriyali SaxenaDuoming MaYu-Shiuan ChengAndrew M. HowesEmeka UdeigweRobert G. Salomon

immunologyredox signalingexperimental toxicologypharmacologyregulatory toxicologyclinical toxicologycell signalingclinical chemistrychemical biologydrug discoverycomplement pathwayophthalmologyepithelial cellsin vitro toxicologytoxicologyremedial actionmembrane biologypotent inducermammalian biologyredox biologymolecular regulation

Carboxyvinylpyrrole Protein Adducts: Potential Amd Biomarkers. Investigative Ophthalmology & Visual Science (2018)

Geeng-Fu JangJack Crabbbelinda WillardJoe G HollyfieldRobert SalomonJohn W Crabb

carboxyvinylpyrrole protein adductsdermatologypharmacologybiomarkersophthalmology

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Robert G. Salomon

Charles Frederic Mabery Professor of Research in Chemistry

Case Western Reserve University

Affiliations

School of Medicine

Biochemistry

College of Arts and Sciences

Department of Chemistry

Robert G. Salomon is currently serving as a Biochemistry Charles Frederic Mabery Professor of Research in Chemistry at Case Western Reserve University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Robert G. Salomon

Case Western Reserve University

Charles Frederic Mabery Professor of Research in Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Radical-Induced Lipid Oxidation Produces a Torrent of Leukotriene-Like Agonists in Severe Asthma. Journal of Allergy and Clinical Immunology (2025)

Mikhail LinetskyAnshula MondalSi-Yang LiuAbby M. HiteShravani EnduriYu-Shiuan ChengBeatriz FeijoGraham KangNana ArhinHong ZengOlivia R. LaniakJohn DenkerRobert G. Salomon

medicinal chemistrycysteinyl leukotriene-like metabolitesmolecular biologypharmacologyophthalmologyredox biology

References. Edward Elgar Publishing eBooks (2021)

Andrew JohnstonRobert Huggins

4-Hydroxy-7-Oxo-5-Heptenoic Acid (Hoha) Lactone Induces Apoptosis in Retinal Pigment Epithelial Cells. Free Radical Biology and Medicine (2020)

Mikhail LinetskyJunhong GuoEmeka UdeigweDuoming MaAmanda S. ChamberlainAnnabelle O. YuKseniya SolovyovaElise EdgarRobert G. Salomon

apoptosiscell deathmedicinal researchfree radical biologymembrane biologymedicinepharmacologyoxidative stressophthalmology

4-Hydroxy-7-Oxo-5-Heptenoic Acid Lactone Can Induce Mitochondrial Dysfunction in Retinal Pigmented Epithelial Cells. Free Radical Biology and Medicine (2020)

Yu-Shiuan ChengMikhail LinetskyHaoting LiNaji AyyashAnthony GardellaRobert G. Salomon

Toll-Like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration. Cell Reports (2020)

cell interactionscell-matrix interactionscell deathimmunologycell biologycellular biologyimmune responsescellular immune responsesoxidative stressfree radical biologyophthalmologyredox biology

Nicholas TomkoMark KlueverChunying WuJunqing ZhuYanming WangRobert G. Salomon

neurologyanti-angiogenic therapiesangiogenesisgliomasbrain tumor researchcancer researchmedicinepharmacologyfree radical biologypotent inducerbrain cancer celloncologycancer biology

The Adductomics of Isolevuglandins: Oxidation of Isolg Pyrrole Intermediates Generates Pyrrole–Pyrrole Crosslinks and Lactams. High-Throughput (2019)

Wenzhao BiGeeng-Fu JangLei ZhangJohn W. CrabbJames LairdMikhail LinetskyRobert G. Salomon

protein sciencemedicinal chemistrybiochemistrychemistrymolecular biologyorganic chemistrybiological chemistrypyrrole-pyrrole crosslinksisolg pyrrole intermediates

4-Hydroxy-7-Oxo-5-Heptenoic Acid Lactone is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells. Chemical Research in Toxicology (2018)

Mikhail LinetskyKarina S. BondelidSofiya LosovskiyVadym GabyakMario J. RulloThomas I. StiadleVasu MunjaparaPriyali SaxenaDuoming MaYu-Shiuan ChengAndrew M. HowesEmeka UdeigweRobert G. Salomon

Carboxyvinylpyrrole Protein Adducts: Potential Amd Biomarkers. Investigative Ophthalmology & Visual Science (2018)

Geeng-Fu JangJack Crabbbelinda WillardJoe G HollyfieldRobert SalomonJohn W Crabb

carboxyvinylpyrrole protein adductsdermatologypharmacologybiomarkersophthalmology

1
2
3
4
5
32
10 / page

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lipid resource

biomolecular engineering

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volatile organic compounds

free radical biology

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nanotoxicology

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toxicological mechanism

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radiology

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bioorganic chemistry

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clinical lipidology