Faculty

Institution

Unit

Venue

Peter B. Dervan

Bren Professor of Chemistry Emeritus

California Institute of Technology

Affiliations

Division of Chemistry and Chemical Engineering

Peter B. Dervan is currently serving as a Division Of Chemistry And Chemical Engineering Bren Professor of Chemistry Emeritus at California Institute of Technology.

Honors

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Experiences

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Education

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Peter B. Dervan

California Institute of Technology

Bren Professor of Chemistry Emeritus

You can click a keyword to filter the displayed items

molecular biology genetics biochemistry structural biology biomolecular engineering nucleic acids molecular genetics dna analysis molecular science protein science minor groove medicinal chemistry chemical biology molecular recognition gene recognition structural molecular biology genome biology gene expression biological chemistry bioinformatics nucleic acid chemistry biomolecular structure genomics oligonucleotides rna biology membrane biology molecular structure pyrrole-imidazole polyamides dna sequencing transcription regulation enzyme inhibition protein chemistry sequence analysis sequence-specific recognition sequence motif cancer biology triple helix formation gene regulation structural chemistry medicinal research molecular regulation dna nanotechnology dna minor groove double-helical dna affinity cleaving pyrrole-imidazole polyamide molecular design triple-helix formation base pairs gene function epigenomics anti-cancer agents double helical dna biochemical sciences molecular substrates protein synthesis biological inorganic chemistry fragmentation effect molecular chemistry signal recognition hairpin polyamides structural basis peptides coordination chemistry virus research chromosome biology genome structure pharmaceutical chemistry oligonucleotide-directed triple-helix formation py-im polyamides sequence-specific cleavage redox biology molecular basis molecular evidence peptide engineering cytogenetics organic chemistry physical organic chemistry chemistry

Notable Scholarly Works

Notable Federal Grants

Collaborators

Data From Small Molecules Targeting Histone H4 as Potential Therapeutics for Chronic Myelogenous Leukemia. (2023)

C. James ChouMichelle E. FarkasSherry M. TsaiDavid AlvarezPeter B. DervanJoel M. Gottesfeld

epigenomicspharmacologychronic myelogenous leukemiageneticspersonalized medicinecancer immunotherapypotential therapeuticsoncologymedicinal researchcancer treatmenttherapeutic efficacycancer biologyhealth sciences

Figure S4 From a Pyrrole-Imidazole Polyamide is Active Against Enzalutamide-Resistant Prostate Cancer. (2023)

Alexis A. KurmisFei YangTimothy R. WelchNicholas G. NickolsPeter B. Dervan

medicinal chemistryneurologyenzalutamide-resistant prostate cancerpharmacologypyrrole-imidazole polyamideurologyneuropharmacologyanti-cancer agentsoncologydrug targetingcancer treatmentprostate cancer

Supplementary Figures and Table Legends From Small Molecules Targeting Histone H4 as Potential Therapeutics for Chronic Myelogenous Leukemia. (2023)

C. James ChouMichelle E. FarkasSherry M. TsaiDavid AlvarezPeter B. DervanJoel M. Gottesfeld

therapeutic efficacyproteomicschronic myelogenous leukemiamolecular cancercancer genomicspotential therapeuticscancer biologytable legendsepigenomicscancer researchcancer treatmentsupplementary figuresmedical mycologypharmacologygeneticsmolecular biologyoncologymedicinal researchepigeneticsmolecular medicine

Rna Polymerase II Trapped on a Molecular Treadmill: Structural Basis of Persistent Transcriptional Arrest by a Minor Groove Dna Binder. Proceedings of the National Academy of Sciences (2022)

Juntaek OhTiezheng JiaJun XuJenny ChongPeter B. DervanDong Wang

genome biologymolecular sciencekey siteenzymesrna polymerase iistructural biologyprotein sciencemembrane biologymolecular biophysicsscientometricstranscription (biology)structural basismolecular treadmillbiophysicstranscription regulationgeneticsmolecular biologystructural molecular biologymolecular basisstructural compositionrna biology

Repression of the Transcriptional Activity of Errα With Sequence-Specific Dna-Binding Polyamides. Medicinal Chemistry Research (2020)

Chien-yu ChenYang LiTiezheng JiaLina HeAlissa A. HareAmanda SilbersteinJohn GallagherThomas F. MartinezJoseph W. StilesBogdan OlenyukPeter B. DervanBangyan L. Stiles

medicinal chemistryepigenetic changesbiochemistrygenome biologyenzymessequence-specific dna-binding polyamidesprotein sciencemembrane biologymolecular evidencenucleic acidsmolecular substratesfunctional modificationgene expressionenzyme inhibitiontranscription regulationgeneticsmolecular biologysignal transductiontranscriptional activity

Single Position Substitution of Hairpin Pyrrole-Imidazole Polyamides Imparts Distinct Dna-Binding Profiles Across the Human Genome. PLoS ONE (2020)

Paul B. FinnDevesh BhimsariaAsfa AliAsuka EguchiAseem Z. AnsariPeter B. Dervan

genomicsgenome biologysingle position substitutionepigenomicshuman genomefunctional genomicsgeneticsgenome analysisbiomolecular engineeringmolecular biologyepigeneticsgenetic engineeringhuman genetics

A Personal Perspective on Chemical Biology: Before the Beginning. Israel Journal of Chemistry (2019)

Peter B. Dervan

chemistrybiochemistrychemical biology

Sequence Specific Suppression of Androgen Receptor–Dna Binding in Vivo by a Py-Im Polyamide. Nucleic Acids Research (2019)

Alexis A KurmisPeter B Dervan

molecular pharmacologyreceptor (biochemistry)in vivo systemsandrogen receptor-dna bindingdrug targetsgenome biologypy-im polyamideprotein sciencemembrane biologynucleic acidsnucleic acid amplificationmammalian biologyreceptorsgene expressionpharmacologysequence specific suppressionredox biologygeneticsdrug discoverymolecular biologyrna biology

Interference With Dna Repair After Ionizing Radiation by a Pyrrole-Imidazole Polyamide. PLoS ONE (2018)

Silvia Diaz-PerezNathanael KaneAlexis A. KurmisFei YangNicolas T. KummerPeter B. DervanNicholas G. Nickols

pharmacologyradiation chemistryradiation oncologyradiation biologyplo biologypyrrole-imidazole polyamidemolecular biologydna repairradiation

J. D. Roberts Special Issue. Journal of Physical Organic Chemistry (2018)

K. N. HoukMarjorie C. CaserioGeorge M. WhitesidesDavid I. SchusterPeter B. DervanDennis A. Dougherty

special issuephysical chemistrychemistryphysical organic chemistry

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Peter B. Dervan

Bren Professor of Chemistry Emeritus

California Institute of Technology

Affiliations

Division of Chemistry and Chemical Engineering

Peter B. Dervan is currently serving as a Division Of Chemistry And Chemical Engineering Bren Professor of Chemistry Emeritus at California Institute of Technology.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Peter B. Dervan

California Institute of Technology

Bren Professor of Chemistry Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Data From Small Molecules Targeting Histone H4 as Potential Therapeutics for Chronic Myelogenous Leukemia. (2023)

C. James ChouMichelle E. FarkasSherry M. TsaiDavid AlvarezPeter B. DervanJoel M. Gottesfeld

Figure S4 From a Pyrrole-Imidazole Polyamide is Active Against Enzalutamide-Resistant Prostate Cancer. (2023)

Alexis A. KurmisFei YangTimothy R. WelchNicholas G. NickolsPeter B. Dervan

Supplementary Figures and Table Legends From Small Molecules Targeting Histone H4 as Potential Therapeutics for Chronic Myelogenous Leukemia. (2023)

C. James ChouMichelle E. FarkasSherry M. TsaiDavid AlvarezPeter B. DervanJoel M. Gottesfeld

Rna Polymerase II Trapped on a Molecular Treadmill: Structural Basis of Persistent Transcriptional Arrest by a Minor Groove Dna Binder. Proceedings of the National Academy of Sciences (2022)

Juntaek OhTiezheng JiaJun XuJenny ChongPeter B. DervanDong Wang

Repression of the Transcriptional Activity of Errα With Sequence-Specific Dna-Binding Polyamides. Medicinal Chemistry Research (2020)

Chien-yu ChenYang LiTiezheng JiaLina HeAlissa A. HareAmanda SilbersteinJohn GallagherThomas F. MartinezJoseph W. StilesBogdan OlenyukPeter B. DervanBangyan L. Stiles

Single Position Substitution of Hairpin Pyrrole-Imidazole Polyamides Imparts Distinct Dna-Binding Profiles Across the Human Genome. PLoS ONE (2020)

Paul B. FinnDevesh BhimsariaAsfa AliAsuka EguchiAseem Z. AnsariPeter B. Dervan

A Personal Perspective on Chemical Biology: Before the Beginning. Israel Journal of Chemistry (2019)

Peter B. Dervan

chemistrybiochemistrychemical biology

Sequence Specific Suppression of Androgen Receptor–Dna Binding in Vivo by a Py-Im Polyamide. Nucleic Acids Research (2019)

Alexis A KurmisPeter B Dervan

Interference With Dna Repair After Ionizing Radiation by a Pyrrole-Imidazole Polyamide. PLoS ONE (2018)

Silvia Diaz-PerezNathanael KaneAlexis A. KurmisFei YangNicolas T. KummerPeter B. DervanNicholas G. Nickols

pharmacologyradiation chemistryradiation oncologyradiation biologyplo biologypyrrole-imidazole polyamidemolecular biologydna repairradiation

J. D. Roberts Special Issue. Journal of Physical Organic Chemistry (2018)

K. N. HoukMarjorie C. CaserioGeorge M. WhitesidesDavid I. SchusterPeter B. DervanDennis A. Dougherty

special issuephysical chemistrychemistryphysical organic chemistry

1
2
3
4
5
34
10 / page

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Similar Faculty Members

Tom Muir

Institution

Princeton University

peptide

chemical biotechnology

Jacqueline K. Barton

Institution

California Institute of Technology

nucleic acid chemistry

chemistry

Ronald T. Raines

Institution

Massachusetts Institute of Technology

biochemistry

molecular biology

Dieter Söll

Institution

Yale University

molecular biology

genetics

Gregory Verdine

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Harvard University

therapeutic modalities

peptide

Amos Smith

Institution

University of Pennsylvania

protein folding

bioorganic chemistry

Stephen J. Benkovic

Institution

Pennsylvania State University

biosynthesis

cellular enzymology

Laurence Hurley

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University of Arizona

oncogene

cancer biology

Philip A. Cole

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Johns Hopkins University

molecular biology

biochemistry

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Washington University in St. Louis

biological chemistry

proteomics