Faculty

Institution

Unit

Venue

Laurence Hurley

Professor Emeritus Pharmacology and Toxicology

University of Arizona

Affiliations

College of Science

Chemistry and Biochemistry

College of Pharmacy

Department of Pharmacology and Toxicology

Laurence Hurley is currently serving as a Chemistry And Biochemistry Professor Emeritus Pharmacology and Toxicology at University of Arizona.

Honors

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Experiences

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Education

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Laurence Hurley

University of Arizona

Professor Emeritus Pharmacology and Toxicology

You can click a keyword to filter the displayed items

molecular biology pharmacology genetics oncology biochemistry tumor biology cancer research medicinal research structural biology gene expression medicinal chemistry cancer treatment cancer biology molecular cancer protein science drug discovery transcription regulation tumor targeting cancer genomics molecular science cancer genetics oncogenes cancer care enzymes nucleic acids enzyme inhibition gene regulation structural molecular biology cellular therapy anti-cancer agents biomolecular structure drug targeting pharmacotherapy molecular regulation biological chemistry gene function genome biology sequence motif rna biology cell regulation molecular structure redox biology protein expression c-myc promoter pharmaceutical chemistry biomolecular interactions cancer management dna analysis gene structure nucleic acid chemistry pharmaceutical sciences g-quadruplex structures gene vector functional modification gene regulatory networks i-motif structures cationic porphyrins molecular basis molecular chemistry rational drug design dna nanotechnology structure determination molecular design molecular research telomerase inhibition human telomerase quadruplex dna telomerase inhibitors dynamic character g-quadruplex dna nmr-based model proximal promoter region hnrnp ll g-quadruplex-interactive agents molecular targets g-quadruplex silencer element cell biology antitumor agents

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Synthetic Lethal Approach to Drug Targeting of G-Quadruplexes Based on CX-5461. Bioorganic & Medicinal Chemistry Letters (2023)

Meiyu JinLaurence H. HurleyHong Xu

medicinal chemistrypharmacologymedicinedrug discoverysynthetic biologydrug targetingdrug deliverybioorganic chemistry

Data From Ua62784, a Novel Inhibitor of Centromere Protein E Kinesin-Like Protein. (2023)

Meredith C. HendersonYeng-Jeng Y. ShawHong WangHaiyong HanLaurence H. HurleyGary FlynnRobert T. DorrDaniel D. Von Hoff

pharmacologymedicinal chemistrynovel inhibitorproteomicsneurosciencecell biologyprotein science

A First-In-Class Clinical G-Quadruplex-Targeting Drug. the Bench-To-Bedside Translation of the Fluoroquinolone Qq58 to CX-5461 (Pidnarulex). Bioorganic & Medicinal Chemistry Letters (2022)

Hong XuLaurence H Hurley

medicinal chemistrypharmacologymedicinedrug discoveryclinical chemistrydrug targetingdrug deliveryclinical pharmacologytranslational medicinerational drug designbench-to-bedside translation

Quindoline-Derivatives Display Potent G-Quadruplex-Mediated Antiviral Activity Against Herpes Simplex Virus 1. Antiviral Research (2022)

Ilaria FrassonPaola SoldàMatteo NadaiMartina TassinariMatteo ScalabrinVijay GokhaleLaurence H. HurleySara N. Richter

pharmacologyimmunologyantiviral researchvirology

The Role of G-Quadruplex Dna in Paraspeckle Formation in Cancer. Biochimie (2021)

Uditi BhattAmy L. KretzmannAurore GuédinArnold OuSimon KobelkeCharles S. BondCameron W. EvansLaurence H. HurleyJean-Louis MergnyK. Swaminathan IyerArcha H. FoxNicole M. Smith

geneticscancer biologybiologycancer researchparaspeckle formationmolecular biologyg-quadruplex dna

Abstract 5822: Targeting an Immortalization Mutation to Control Glioblastoma. Cancer Research (2020)

Jayashree S. IyerNanyun TangShayesteh R. FerdosiVijay GokhaleLaurence H. HurleyHarshil D. DhruvMichael E. Berens

tumor targetingmedicineclinical researchgeneticscancer biologycancer researchneuro-oncologycancer genomicsimmortalization mutationtumor biologyvascular biologyneurologycancer treatmentoncologybrain tumor researchcellular therapycancer geneticscancer caremedicinal research

CORRECTION: Nucleolin Represses Transcription of the Androgen Receptor Gene Through a G-Quadruplex. Oncotarget (2020)

Cindy K. MirantiSara MooreYongeun KimVenkateshwar Reddy ChappetaKui WuBiswanath DeVijay GokhaleLaurence H. HurleyElsa M. Reyes-Reyes

geneticspharmacologyhuman geneticsreceptorsgene functiongene expressionreceptor (biochemistry)gene regulatory networksmolecular biologyepigeneticstranscription regulationtranscription (biology)androgen receptor gene

Dna G-Quadruplex and I-Motif Structure Formation is Interdependent in Human Cells. Journal of the American Chemical Society (2020)

Jessica J. KingKelly L. IrvingCameron W. EvansRupesh V. ChikhaleRouven BeckerChristopher J. MorrisCristian D. Peña MartinezPeter SchofieldDaniel ChristLaurence H. HurleyZoë A. E. WallerK. Swaminathan IyerNicole M. Smith

geneticsi-motif structure formationstructural biologymolecular biologycell biology

Scavenging of Labile Heme by Hemopexin is a Key Check-Point in Cancer Growth and Metastases. SSRN Electronic Journal (2020)

pathologyheme traffickingcancer growthlabile hemetumor microenvironmentcancer researchheme homeostasiscancer discoveryradiation oncologyheme signalingmetastasisheme degradationtumor biologykey check-pointclinical biochemistrycancer cellsheme transport

Scavenging of Labile Heme by Hemopexin is a Key Checkpoint in Cancer Growth and Metastases. Cell Reports (2020)

Giacomo CanesinAnnalisa Di RuscioMailin LiSimone UmmarinoAndreas HedblomReeham ChoudhuryAgnieszka KrzyzanowskaEva CsizmadiaMacarena PalominosAnna StiehmAlexander EbralidzeShao-Yong ChenMahmoud A. BassalPing ZhaoEmanuela TolosanoLaurence HurleyAnders BjartellDaniel G. TenenBarbara Wegiel

tumor targetinglabile hemekey checkpointanti-cancer agentscell biologycancer biologycancer researchmetastasistumor biologycell researchcell deathpharmacologycancer treatmentoncologycellular therapycancer immunotherapyenzyme inhibitionradiation oncologymedicinal researchcancer growth

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Laurence Hurley

Professor Emeritus Pharmacology and Toxicology

University of Arizona

Affiliations

College of Science

Chemistry and Biochemistry

College of Pharmacy

Department of Pharmacology and Toxicology

Laurence Hurley is currently serving as a Chemistry And Biochemistry Professor Emeritus Pharmacology and Toxicology at University of Arizona.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Laurence Hurley

University of Arizona

Professor Emeritus Pharmacology and Toxicology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Synthetic Lethal Approach to Drug Targeting of G-Quadruplexes Based on CX-5461. Bioorganic & Medicinal Chemistry Letters (2023)

Meiyu JinLaurence H. HurleyHong Xu

medicinal chemistrypharmacologymedicinedrug discoverysynthetic biologydrug targetingdrug deliverybioorganic chemistry

Data From Ua62784, a Novel Inhibitor of Centromere Protein E Kinesin-Like Protein. (2023)

Meredith C. HendersonYeng-Jeng Y. ShawHong WangHaiyong HanLaurence H. HurleyGary FlynnRobert T. DorrDaniel D. Von Hoff

pharmacologymedicinal chemistrynovel inhibitorproteomicsneurosciencecell biologyprotein science

A First-In-Class Clinical G-Quadruplex-Targeting Drug. the Bench-To-Bedside Translation of the Fluoroquinolone Qq58 to CX-5461 (Pidnarulex). Bioorganic & Medicinal Chemistry Letters (2022)

Hong XuLaurence H Hurley

medicinal chemistrypharmacologymedicinedrug discoveryclinical chemistrydrug targetingdrug deliveryclinical pharmacologytranslational medicinerational drug designbench-to-bedside translation

Quindoline-Derivatives Display Potent G-Quadruplex-Mediated Antiviral Activity Against Herpes Simplex Virus 1. Antiviral Research (2022)

Ilaria FrassonPaola SoldàMatteo NadaiMartina TassinariMatteo ScalabrinVijay GokhaleLaurence H. HurleySara N. Richter

pharmacologyimmunologyantiviral researchvirology

The Role of G-Quadruplex Dna in Paraspeckle Formation in Cancer. Biochimie (2021)

Uditi BhattAmy L. KretzmannAurore GuédinArnold OuSimon KobelkeCharles S. BondCameron W. EvansLaurence H. HurleyJean-Louis MergnyK. Swaminathan IyerArcha H. FoxNicole M. Smith

geneticscancer biologybiologycancer researchparaspeckle formationmolecular biologyg-quadruplex dna

Abstract 5822: Targeting an Immortalization Mutation to Control Glioblastoma. Cancer Research (2020)

Jayashree S. IyerNanyun TangShayesteh R. FerdosiVijay GokhaleLaurence H. HurleyHarshil D. DhruvMichael E. Berens

CORRECTION: Nucleolin Represses Transcription of the Androgen Receptor Gene Through a G-Quadruplex. Oncotarget (2020)

Cindy K. MirantiSara MooreYongeun KimVenkateshwar Reddy ChappetaKui WuBiswanath DeVijay GokhaleLaurence H. HurleyElsa M. Reyes-Reyes

Dna G-Quadruplex and I-Motif Structure Formation is Interdependent in Human Cells. Journal of the American Chemical Society (2020)

geneticsi-motif structure formationstructural biologymolecular biologycell biology

Scavenging of Labile Heme by Hemopexin is a Key Check-Point in Cancer Growth and Metastases. SSRN Electronic Journal (2020)

Scavenging of Labile Heme by Hemopexin is a Key Checkpoint in Cancer Growth and Metastases. Cell Reports (2020)

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5
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10 / page

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