Faculty

Institution

Unit

Venue

Gregory Verdine

Erving Professor of Chemistry Emeritus

Harvard University

Affiliations

Harvard Medical School

Cell Biology

Stem Cell and Regenerative Biology

Harvard Faculty of Arts and Sciences

Chemistry & Chemical Biology

Stem Cell & Regenerative Biology

Gregory Verdine is currently serving as a Cell Biology Erving Professor of Chemistry Emeritus at Harvard University.

Honors

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Experiences

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Education

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Gregory Verdine

Harvard University

Erving Professor of Chemistry Emeritus

You can click a keyword to filter the displayed items

molecular biology structural biology biochemistry genetics protein science enzymes protein structure structural molecular biology pharmacology dna repair biological chemistry molecular genetics epigenetics gene expression biomolecular structure medicinal chemistry medicinal research rna biology enzyme inhibition genome biology peptides nucleic acids molecular cancer protein genetics oligonucleotides molecular science oncogenes transcription regulation cancer genomics cancer biology structural basis enzyme catalysis protein chemistry cancer treatment drug targeting molecular structure molecular cell biology biochemical sciences peptide science peptide engineering mutagenesis protein expression peptide synthesis molecular biotechnology gene function molecular virology cell regulation gene regulation molecular regulation biomolecular interactions glycosylation dna analysis molecular microbiology biocatalysis dna binding viral genetics protein function nucleic acid chemistry remedial action genome structure crystal structures microbial genetics a-helical peptides undamaged dna dna glycosylase escherichia coli duplex dna stereodiversified library base-excision dna-repair protein ring-closing olefin metathesis dna methyltransferases base-excision dna repair bis ring-closing metathesis protein-dna complexes solution structure specific binding chemical biology molecular technology therapeutic modalities

Notable Scholarly Works

Notable Federal Grants

Collaborators

Genomic Discovery and Structure–Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors. Journal of Medicinal Chemistry (2024)

Jack R. DavisonMichalis HadjithomasStuart P. RomerilYoon Jong ChoiKeith W. BentleyJohn B. BigginsNadia ChackoM. Paola CastaldiLawrence K. ChanJared N. CummingThomas D. DownesEric L. EisenhauerFan FeiBenjamin M. FontaineVenkatesh Endalur GopinarayananSrishti GurnaniAudrey HechtChristopher J. HosfordAshraf IbrahimAnnika JagelsCamil JoubranJi-Nu KimJohn P. LisherDaniel D. LiuJames T. LylesMatteo N. MannaraGordon J. MurrayEmilia MusialMengyao NiuRoberto Olivares-AmayaMarielle PercuocoSusanne SaalauKristen SharpeAnjali V. SheahanNeroshan ThevakumaranJames E. ThompsonDawn A. ThompsonAric WiestStephen A. WykaJason YanoGregory L. Verdine

medicinal chemistrygenomicspharmaceutical chemistrygenomic discoverystructure-activity explorationdrug discoverymolecular biologystructural molecular biologynovel family

Mirror-Image Ligand Discovery Enabled by Single-Shot Fast-Flow Synthesis of D-Proteins. Nature Communications (2024)

Alex J. CallahanSatish GandhesiriTara L. TravalineRahi M. RejaLia Lozano SalazarStephanie HannaYen-Chun LeeKunhua LiOlena S. TokarevaJean-Marie SwiecickiAndrei LoasGregory L. VerdineJohn H. McGeeBradley L. Pentelute

computational imagingbiophysicspharmacologypeptide sciencesingle-shot fast-flow synthesisprotein bioinformaticsbiomolecular engineeringdrug discoverymirror-image ligand discoverybiological imagingmedicinal researchprotein sciencemachine learningsynthetic biologybioinformatics

Preclinical Evaluation of Stereopure Antisense Oligonucleotides for Allele-Selective Lowering of Mutant Htt. Molecular Therapy — Nucleic Acids (2024)

Naoki IwamotoYuanjing LiuMaria Frank-KamenetskyAbbie MaguireWei Chou TsengKristin TabornNayantara KothariAli AkhtarKeith BowmanJuili Dilip ShelkeAnthony LamattinaXiao Shelley HuHyun Gyung JangPachamuthu KandasamyFangjun LiuKen LongoRichard LoobyNone MeenaJake MettervilleQianli PanErin Purcell-EstabrookMamoru ShimizuPriyanka Shiva PrakashaStephany StandleyHansini UpadhyayHailin YangYuan YinAnderson ZhaoChristopher FrancisMike ByrneElena DaleGregory L VerdineChandra Vargeese

medicineallele-selective loweringgeneticsstereopure antisense oligonucleotidesmutant httmolecular geneticspreclinical evaluation

Recognition and Reprogramming of E3 Ubiquitin Ligase Surfaces by α-Helical Peptides. Nature Communications (2023)

Olena S. TokarevaKunhua LiTara L. TravalineTy M. ThomsonJean-Marie SwiecickiMahmoud MoussaJessica D. RamirezSean LitchmanGregory L. VerdineJohn H. McGee

biophysicspeptidesprotein chemistrysignal recognitionprotein structureenzymesmolecular biologystructural biologya-helical peptidesprotein sciencebiochemistry

Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display. ChemRxiv (2023)

Alex J. CallahanSatish GandhesiriTara L. TravalineLia Lozano SalazarStephanie HannaYen-Chun LeeKunhua LiOlena S. TokarevaJean-Marie SwiecickiAndrei LoasGregory L. VerdineJohn H. McGeeBradley L. Pentelute

computational imagingbiomedical engineeringsingle-shot flow synthesisphage biologybacteriophagesbiological imagingmirror-image phage display

De Novo Mapping of α-Helix Recognition Sites on Protein Surfaces Using Unbiased Libraries. Proceedings of the National Academy of Sciences (2022)

Kunhua LiOlena S. TokarevaTy M. ThomsonSebastian C. T. WahlTara L. TravalineJessica D. RamirezSantosh K. ChoudarySorabh AgarwalWard G. WalkupTivoli J. OlsenMatthew J. BrennanGregory L. VerdineJohn H. McGee

biophysicsmolecular biologystructural bioinformaticsunbiased librariesprotein surfacesa-helix recognition sitesstructural biologyprotein sciencebioinformatics

Targeted β‐Catenin Ubiquitination and Degradation by Multifunctional Stapled Peptides. Journal of Peptide Science (2021)

Xiaofeng WangLiuli DongJiongjia ChengGregory L. VerdineAijun LinQian Chu

pharmacologypeptidespeptide engineeringpeptide scienceb-catenin ubiquitinationtherapeutic targetsbiomolecular engineeringbiological engineering

A Stapled Pol κ Peptide Targets Rev1 to Inhibit Mutagenic Translesion Synthesis. Environmental and Molecular Mutagenesis (2020)

Nimrat ChatterjeeSanjay D'SouzaMohammad ShababCynthia A. HarrisGerard J. HilinskiGregory L. VerdineGraham C. Walker

pharmacologypeptidesmutagenesisgeneticsenvironmental scienceprotein synthesisenvironmental chemistrymutagenesis (molecular biology technique)mutagenic translesion synthesispeptide synthesis

Genomic Discovery of an Evolutionarily Programmed Modality for Small-Molecule Targeting of an Intractable Protein Surface. Proceedings of the National Academy of Sciences (2020)

Uddhav K. ShigdelSeung-Joo LeeMathew E. SowaBrian R. BowmanKeith RobisonMinyun ZhouKhian Hong PuaDylan T. StilesJoshua A. V. BlodgettDaniel W. UdwaryAndrew T. RajczewskiAlan S. MannSiavash MostafaviTara HardySukrat AryaZhigang WengMichelle StewartKyle KenyonJay P. MorgensternEnde PanDaniel C. GrayRoy M. PollockAndrew M. FryRichard D. KlausnerSharon A. TownsonGregory L. Verdine

genomicssmall-molecule targetingintractable protein surfacegenomic discoverybiomolecular engineeringmolecular biologybiological engineering

The Trajectory of Intrahelical Lesion Recognition and Extrusion by the Human 8-Oxoguanine Dna Glycosylase. Nature Communications (2020)

Uddhav K. ShigdelVictor OvchinnikovSeung-Joo LeeJenny A. ShihMartin KarplusKwangho NamGregory L. Verdine

biophysicsgeneticsmammalian biologyintrahelical lesion recognitionmolecular biologystructural biology

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Gregory Verdine

Erving Professor of Chemistry Emeritus

Harvard University

Affiliations

Harvard Medical School

Cell Biology

Stem Cell and Regenerative Biology

Harvard Faculty of Arts and Sciences

Chemistry & Chemical Biology

Stem Cell & Regenerative Biology

Gregory Verdine is currently serving as a Cell Biology Erving Professor of Chemistry Emeritus at Harvard University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gregory Verdine

Harvard University

Erving Professor of Chemistry Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Genomic Discovery and Structure–Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors. Journal of Medicinal Chemistry (2024)

medicinal chemistrygenomicspharmaceutical chemistrygenomic discoverystructure-activity explorationdrug discoverymolecular biologystructural molecular biologynovel family

Mirror-Image Ligand Discovery Enabled by Single-Shot Fast-Flow Synthesis of D-Proteins. Nature Communications (2024)

Preclinical Evaluation of Stereopure Antisense Oligonucleotides for Allele-Selective Lowering of Mutant Htt. Molecular Therapy — Nucleic Acids (2024)

medicineallele-selective loweringgeneticsstereopure antisense oligonucleotidesmutant httmolecular geneticspreclinical evaluation

Recognition and Reprogramming of E3 Ubiquitin Ligase Surfaces by α-Helical Peptides. Nature Communications (2023)

Olena S. TokarevaKunhua LiTara L. TravalineTy M. ThomsonJean-Marie SwiecickiMahmoud MoussaJessica D. RamirezSean LitchmanGregory L. VerdineJohn H. McGee

biophysicspeptidesprotein chemistrysignal recognitionprotein structureenzymesmolecular biologystructural biologya-helical peptidesprotein sciencebiochemistry

Single-Shot Flow Synthesis of D-Proteins for Mirror-Image Phage Display. ChemRxiv (2023)

computational imagingbiomedical engineeringsingle-shot flow synthesisphage biologybacteriophagesbiological imagingmirror-image phage display

De Novo Mapping of α-Helix Recognition Sites on Protein Surfaces Using Unbiased Libraries. Proceedings of the National Academy of Sciences (2022)

biophysicsmolecular biologystructural bioinformaticsunbiased librariesprotein surfacesa-helix recognition sitesstructural biologyprotein sciencebioinformatics

Targeted β‐Catenin Ubiquitination and Degradation by Multifunctional Stapled Peptides. Journal of Peptide Science (2021)

Xiaofeng WangLiuli DongJiongjia ChengGregory L. VerdineAijun LinQian Chu

pharmacologypeptidespeptide engineeringpeptide scienceb-catenin ubiquitinationtherapeutic targetsbiomolecular engineeringbiological engineering

A Stapled Pol κ Peptide Targets Rev1 to Inhibit Mutagenic Translesion Synthesis. Environmental and Molecular Mutagenesis (2020)

Nimrat ChatterjeeSanjay D'SouzaMohammad ShababCynthia A. HarrisGerard J. HilinskiGregory L. VerdineGraham C. Walker

pharmacologypeptidesmutagenesisgeneticsenvironmental scienceprotein synthesisenvironmental chemistrymutagenesis (molecular biology technique)mutagenic translesion synthesispeptide synthesis

Genomic Discovery of an Evolutionarily Programmed Modality for Small-Molecule Targeting of an Intractable Protein Surface. Proceedings of the National Academy of Sciences (2020)

genomicssmall-molecule targetingintractable protein surfacegenomic discoverybiomolecular engineeringmolecular biologybiological engineering

The Trajectory of Intrahelical Lesion Recognition and Extrusion by the Human 8-Oxoguanine Dna Glycosylase. Nature Communications (2020)

Uddhav K. ShigdelVictor OvchinnikovSeung-Joo LeeJenny A. ShihMartin KarplusKwangho NamGregory L. Verdine

biophysicsgeneticsmammalian biologyintrahelical lesion recognitionmolecular biologystructural biology

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Johns Hopkins University

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