Faculty

Institution

Unit

Venue

Robert T. Sauer

Salvador E Luria Professor of Biology

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Robert T. Sauer is currently serving as a Biology Salvador E Luria Professor of Biology at Massachusetts Institute of Technology.

Honors

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Experiences

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Education

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Robert T. Sauer

Massachusetts Institute of Technology

Salvador E Luria Professor of Biology

You can click a keyword to filter the displayed items

molecular biology protein science structural biology biochemistry biophysics protein structure genetics enzymes structural molecular biology protein folding protein engineering gene expression biomolecular structure membrane biology biological chemistry molecular cell biology molecular microbiology bacteria enzyme inhibition bacteriophages phage biology bacteriology protein function protein chemistry molecular science molecular structure protein assembly genome biology peptides virus research nucleic acids molecular substrates protein transport biochemical sciences structural bioinformatics rna biology protein stability arc repressor applied microbiology cellular physiology protein biosynthesis parathyroid hormone clinical microbiology protein refolding mutagenesis mnt repressor protein degradation gene function enzyme specificity molecular regulation parathyroid glands protein modeling protein bioinformatics gene structure protein expression microbial genetics dna analysis key site protein misfolding gene regulation escherichia coli dna binding selective separation signal recognition host specificity protein synthesis clpxp protease sspb adaptor operator dna operator binding protein unfolding amino acid sequence ribosome rescue dna recognition protein sequences clpp peptidase

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Asymmetric Nautilus-Like Hflk/C Assembly Controls Ftsh Proteolysis of Membrane Proteins. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Alireza GhanbarpourBertina TelusmaBarrett M. PowellJia Jia ZhangIsabella BolstadCarolyn VargasSandro KellerTania BakerRobert T. SauerJoseph H. Davis

biophysicsftsh proteolysismembrane proteinsbiochemistrymembrane biologymembranesmolecular biologyprotein structureprotein assembly

A Proteolytic Aaa+ Machine Poised to Unfold Protein Substrates. Nature Communications (2024)

Alireza GhanbarpourRobert T. SauerJoseph H. Davis

protein scienceprotein foldingprotein engineeringprotein synthesisprotein structureprotein substratesprotein assemblybiomolecular engineering

How the Double-Ring Clpap Protease Motor Grips the Substrate to Unfold and Degrade Stable Proteins. Journal of Biological Chemistry (2024)

Tsai-Ting ShihRobert T SauerTania A Baker

biophysicsprotein structureprotein sciencebiochemistrystable proteinsmolecular biologybiological chemistryprotein foldingprotein biosynthesis

The Membrane-Cytoplasmic Linker Defines Activity of Ftsh Proteases in Pseudomonas Aeruginosa Clone C. Journal of Biological Chemistry (2024)

Gina D. MawlaShady M. KamalLian-Ying CaoPasi PurhonenHans HebertRobert T. SauerTania A. BakerUte Römling

ftsh proteasesbiochemistrymembrane-cytoplasmic linkermembrane biologymolecular biologygenetics

A Closed Translocation Channel in the Substrate-Free Aaa+ Clpxp Protease Diminishes Rogue Degradation. Nature Communications (2023)

Alireza GhanbarpourSteven E. CohenXue FeiLaurel F. KinmanTristan A. BellJia Jia ZhangTania A. BakerJoseph H. DavisRobert T. Sauer

biophysicsrogue degradationmembrane biologymolecular biologyclosed translocation channelgenetics

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicscrystal structurescrystal researchdeposited datasetstructural chemistryccdc 2157502crystal engineeringcrystallographystructure determinationstructure elucidationchemistrychemical structurecrystal diffraction study

Lon Degrades Stable Substrates Slowly but With Enhanced Processivity, Redefining the Attributes of a Successful Aaa+ Protease. Cell Reports (2023)

Meghann R. KasalHema Chandra KotamarthiMadeline M. JohnsonHannah M. StephensMatthew J. LangRobert T. SauerTania A. Baker

catalysiscellular biologyprotein engineeringcell researchstructural molecular biologyenhanced processivitycell physiologyenzymescell biologyprotein foldingbiological engineeringbiocatalysiscellular physiologybiochemistryprotein chemistryprotein scienceenzyme catalysiscell engineeringbiochemical sciences

Lon Protease Degrades Stable Substrates Slowly but With Enhanced Processivity, Redefining the Model of a Strong and Robust Aaa+ Protease. Biophysical Journal (2023)

Meghann KasalHema Chandra KotamarthiMadeline M. JohnsonHannah StephensMatthew J. LangRobert T. SauerTania Baker

lon proteaseprotein engineeringbiophysical modelingbiophysical chemistryenhanced processivityenzymesbiophysical reviewmolecular sciencemolecular biophysicsmolecular biologybiocatalysisbiochemistryexperimental biophysicsstructural biologybiophysicssurface reactivityprotein scienceenzyme catalysisstable substratesbiochemical sciencesenzyme inhibition

The Membrane-Cytoplasmic Linker Defines Activity of Ftsh Proteases in Pseudomonas Aeruginosa Clone C. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Gina D MawlaShady Mansour KamalLianying CaoPasi PurhonenHans HebertRobert T SauerTania A BakerUte Römling

ftsh proteasescell biologymicrobiologymembrane-cytoplasmic linkermembrane biologymolecular biology

The Sspb Adaptor Drives Structural Changes in the Aaa+ Clpxp Protease During Ssra-Tagged Substrate Delivery. Proceedings of the National Academy of Sciences (2023)

Alireza GhanbarpourXue FeiTania A. BakerJoseph H. DavisRobert T. Sauer

sspb adaptorstructural genomicsprotein transportprotein engineeringstructural molecular biologyssra-tagged substrate deliveryenzymescell biologymolecular sciencemolecular biologyprotein foldingbiochemistrysensor suiteprotein structurestructural biologyprotein sciencebiochemical sciencesstructure-function enzyme kineticsmolecular substratesenzyme inhibition

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Robert T. Sauer

Salvador E Luria Professor of Biology

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Robert T. Sauer is currently serving as a Biology Salvador E Luria Professor of Biology at Massachusetts Institute of Technology.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Robert T. Sauer

Massachusetts Institute of Technology

Salvador E Luria Professor of Biology

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Asymmetric Nautilus-Like Hflk/C Assembly Controls Ftsh Proteolysis of Membrane Proteins. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Alireza GhanbarpourBertina TelusmaBarrett M. PowellJia Jia ZhangIsabella BolstadCarolyn VargasSandro KellerTania BakerRobert T. SauerJoseph H. Davis

biophysicsftsh proteolysismembrane proteinsbiochemistrymembrane biologymembranesmolecular biologyprotein structureprotein assembly

A Proteolytic Aaa+ Machine Poised to Unfold Protein Substrates. Nature Communications (2024)

Alireza GhanbarpourRobert T. SauerJoseph H. Davis

protein scienceprotein foldingprotein engineeringprotein synthesisprotein structureprotein substratesprotein assemblybiomolecular engineering

How the Double-Ring Clpap Protease Motor Grips the Substrate to Unfold and Degrade Stable Proteins. Journal of Biological Chemistry (2024)

Tsai-Ting ShihRobert T SauerTania A Baker

biophysicsprotein structureprotein sciencebiochemistrystable proteinsmolecular biologybiological chemistryprotein foldingprotein biosynthesis

The Membrane-Cytoplasmic Linker Defines Activity of Ftsh Proteases in Pseudomonas Aeruginosa Clone C. Journal of Biological Chemistry (2024)

Gina D. MawlaShady M. KamalLian-Ying CaoPasi PurhonenHans HebertRobert T. SauerTania A. BakerUte Römling

ftsh proteasesbiochemistrymembrane-cytoplasmic linkermembrane biologymolecular biologygenetics

A Closed Translocation Channel in the Substrate-Free Aaa+ Clpxp Protease Diminishes Rogue Degradation. Nature Communications (2023)

Alireza GhanbarpourSteven E. CohenXue FeiLaurel F. KinmanTristan A. BellJia Jia ZhangTania A. BakerJoseph H. DavisRobert T. Sauer

biophysicsrogue degradationmembrane biologymolecular biologyclosed translocation channelgenetics

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Lon Degrades Stable Substrates Slowly but With Enhanced Processivity, Redefining the Attributes of a Successful Aaa+ Protease. Cell Reports (2023)

Meghann R. KasalHema Chandra KotamarthiMadeline M. JohnsonHannah M. StephensMatthew J. LangRobert T. SauerTania A. Baker

Lon Protease Degrades Stable Substrates Slowly but With Enhanced Processivity, Redefining the Model of a Strong and Robust Aaa+ Protease. Biophysical Journal (2023)

Meghann KasalHema Chandra KotamarthiMadeline M. JohnsonHannah StephensMatthew J. LangRobert T. SauerTania Baker

The Membrane-Cytoplasmic Linker Defines Activity of Ftsh Proteases in Pseudomonas Aeruginosa Clone C. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Gina D MawlaShady Mansour KamalLianying CaoPasi PurhonenHans HebertRobert T SauerTania A BakerUte Römling

ftsh proteasescell biologymicrobiologymembrane-cytoplasmic linkermembrane biologymolecular biology

The Sspb Adaptor Drives Structural Changes in the Aaa+ Clpxp Protease During Ssra-Tagged Substrate Delivery. Proceedings of the National Academy of Sciences (2023)

Alireza GhanbarpourXue FeiTania A. BakerJoseph H. DavisRobert T. Sauer

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retinal diseases

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