Faculty

Institution

Unit

Venue

Tania A. Baker

E C Whitehead Professor of Biology; Investigator Howard Hughes Medical Institute

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Tania A. Baker is currently serving as a Biology E C Whitehead Professor of Biology; Investigator Howard Hughes Medical Institute at Massachusetts Institute of Technology.

Honors

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Experiences

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Education

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Tania A. Baker

Massachusetts Institute of Technology

E C Whitehead Professor of Biology; Investigator Howard Hughes Medical Institute

You can click a keyword to filter the displayed items

molecular biology protein science structural biology genetics biochemistry enzymes cell biology protein engineering protein folding protein structure structural molecular biology membrane biology gene expression molecular cell biology genome biology molecular microbiology biological chemistry molecular and cellular biology gene function enzyme inhibition molecular science protein transport biochemical sciences molecular substrates protein function protein assembly biomolecular structure protein chemistry mammalian biology molecular physiology enzyme catalysis cellular physiology structural bioinformatics molecular regulation bacteriology clpxp protease protein degradation molecular structure redox biology applied microbiology rna biology protein biosynthesis mu transposase clinical microbiology signal recognition functional modification chromosome biology molecular recognition biocatalysis cellular biology biological inorganic chemistry sspb adaptor mu transposition escherichia coli mitochondrial clpx protein expression microbial physiology phage biology enzyme specificity microbial genetics structure-function enzyme kinetics mu transposase tetramer substrate processing atp hydrolysis sequence assembly cytogenetics host specificity gene structure biochemical genetics molecular research clpxp degradation machine ssra-tagged substrates enzymatic replication dynamic interactions protein unfolding dna damage nucleic acid chemistry dna transposition dna sequencing dna transposons dna replication mutagenesis (molecular biology technique)

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Asymmetric Nautilus-Like Hflk/C Assembly Controls Ftsh Proteolysis of Membrane Proteins. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Alireza GhanbarpourBertina TelusmaBarrett M. PowellJia Jia ZhangIsabella BolstadCarolyn VargasSandro KellerTania BakerRobert T. SauerJoseph H. Davis

biophysicsprotein assemblymembranesprotein structureftsh proteolysismolecular biologymembrane proteinsmembrane biologybiochemistry

How the Double-Ring Clpap Protease Motor Grips the Substrate to Unfold and Degrade Stable Proteins. Journal of Biological Chemistry (2024)

Tsai-Ting ShihRobert T SauerTania A Baker

biophysicsprotein structuremolecular biologybiological chemistrybiochemistryprotein biosynthesisprotein sciencestable proteinsprotein folding

The Membrane-Cytoplasmic Linker Defines Activity of Ftsh Proteases in Pseudomonas Aeruginosa Clone C. Journal of Biological Chemistry (2024)

Gina D. MawlaShady M. KamalLian-Ying CaoPasi PurhonenHans HebertRobert T. SauerTania A. BakerUte Römling

ftsh proteasesmembrane-cytoplasmic linkergeneticsmolecular biologymembrane biologybiochemistry

A Closed Translocation Channel in the Substrate-Free Aaa+ Clpxp Protease Diminishes Rogue Degradation. Nature Communications (2023)

Alireza GhanbarpourSteven E. CohenXue FeiLaurel F. KinmanTristan A. BellJia Jia ZhangTania A. BakerJoseph H. DavisRobert T. Sauer

biophysicsgeneticsclosed translocation channelmolecular biologyrogue degradationmembrane biology

Lon Degrades Stable Substrates Slowly but With Enhanced Processivity, Redefining the Attributes of a Successful Aaa+ Protease. Cell Reports (2023)

Meghann R. KasalHema Chandra KotamarthiMadeline M. JohnsonHannah M. StephensMatthew J. LangRobert T. SauerTania A. Baker

cell researchenzyme catalysisbiochemistrycell biologycell physiologyenzymesbiochemical sciencescellular biologyprotein scienceprotein foldingprotein chemistrycellular physiologycatalysisbiocatalysisenhanced processivityprotein engineeringbiological engineeringcell engineeringstructural molecular biology

Lon Protease Degrades Stable Substrates Slowly but With Enhanced Processivity, Redefining the Model of a Strong and Robust Aaa+ Protease. Biophysical Journal (2023)

Meghann KasalHema Chandra KotamarthiMadeline M. JohnsonHannah StephensMatthew J. LangRobert T. SauerTania Baker

experimental biophysicsenzyme catalysissurface reactivitybiochemistrybiophysical chemistrybiophysical reviewmolecular scienceenzymesstable substratesstructural biologyprotein sciencebiochemical sciencesmolecular biophysicsbiocatalysisenhanced processivityprotein engineeringbiophysical modelingbiophysicsenzyme inhibitionmolecular biologylon protease

The Sspb Adaptor Drives Structural Changes in the Aaa+ Clpxp Protease During Ssra-Tagged Substrate Delivery. Proceedings of the National Academy of Sciences (2023)

Alireza GhanbarpourXue FeiTania A. BakerJoseph H. DavisRobert T. Sauer

structure-function enzyme kineticsprotein structurebiochemistrycell biologysensor suitemolecular scienceprotein transportenzymesstructural biologybiochemical sciencesprotein scienceprotein foldingssra-tagged substrate deliverymolecular substratessspb adaptorprotein engineeringstructural genomicsenzyme inhibitionmolecular biologystructural molecular biology

Aaa+ Protease-Adaptor Structures Reveal Altered Conformations and Ring Specialization. Nature Structural & Molecular Biology (2022)

Sora KimXue FeiRobert T. SauerTania A. Baker

protein structuregeneticsmolecular structurebiomolecular structureenzymesconformational studiesaltered conformationsmolecular biologystructural molecular biologystructural biologyprotein science

Ftsh Degrades Dihydrofolate Reductase by Recognizing a Partially Folded Species. Protein Science (2022)

Juhee P. MorehouseTania A. BakerRobert T. Sauer

biophysicsprotein chemistryprotein structuregeneticsfolded speciesdihydrofolate reductaseenzymesbiochemistrystructural biologyprotein scienceprotein engineeringprotein folding

Ftsh Degrades Kinetically Stable Dimers of Cyclopropane Fatty Acid Synthase via an Internal Degron. Molecular Microbiology (2022)

Sanjay B. HariJuhee P. MorehouseTania A. BakerRobert T. Sauer

gene expressionenzyme inhibitionstable dimersmetabolic remodelingmolecular microbiologystructure-function enzyme kineticsinternal degronmicrobial geneticschemical biologyenzymesmolecular metabolismbiocatalysismolecular biologybiological chemistrymembrane biologybiochemical sciencesmicrobiologybiochemistry

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Tania A. Baker

E C Whitehead Professor of Biology; Investigator Howard Hughes Medical Institute

Massachusetts Institute of Technology

Affiliations

School of Science

Biology

Tania A. Baker is currently serving as a Biology E C Whitehead Professor of Biology; Investigator Howard Hughes Medical Institute at Massachusetts Institute of Technology.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Tania A. Baker

Massachusetts Institute of Technology

E C Whitehead Professor of Biology; Investigator Howard Hughes Medical Institute

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Asymmetric Nautilus-Like Hflk/C Assembly Controls Ftsh Proteolysis of Membrane Proteins. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Alireza GhanbarpourBertina TelusmaBarrett M. PowellJia Jia ZhangIsabella BolstadCarolyn VargasSandro KellerTania BakerRobert T. SauerJoseph H. Davis

biophysicsprotein assemblymembranesprotein structureftsh proteolysismolecular biologymembrane proteinsmembrane biologybiochemistry

How the Double-Ring Clpap Protease Motor Grips the Substrate to Unfold and Degrade Stable Proteins. Journal of Biological Chemistry (2024)

Tsai-Ting ShihRobert T SauerTania A Baker

biophysicsprotein structuremolecular biologybiological chemistrybiochemistryprotein biosynthesisprotein sciencestable proteinsprotein folding

The Membrane-Cytoplasmic Linker Defines Activity of Ftsh Proteases in Pseudomonas Aeruginosa Clone C. Journal of Biological Chemistry (2024)

Gina D. MawlaShady M. KamalLian-Ying CaoPasi PurhonenHans HebertRobert T. SauerTania A. BakerUte Römling

ftsh proteasesmembrane-cytoplasmic linkergeneticsmolecular biologymembrane biologybiochemistry

A Closed Translocation Channel in the Substrate-Free Aaa+ Clpxp Protease Diminishes Rogue Degradation. Nature Communications (2023)

Alireza GhanbarpourSteven E. CohenXue FeiLaurel F. KinmanTristan A. BellJia Jia ZhangTania A. BakerJoseph H. DavisRobert T. Sauer

biophysicsgeneticsclosed translocation channelmolecular biologyrogue degradationmembrane biology

Lon Degrades Stable Substrates Slowly but With Enhanced Processivity, Redefining the Attributes of a Successful Aaa+ Protease. Cell Reports (2023)

Meghann R. KasalHema Chandra KotamarthiMadeline M. JohnsonHannah M. StephensMatthew J. LangRobert T. SauerTania A. Baker

Lon Protease Degrades Stable Substrates Slowly but With Enhanced Processivity, Redefining the Model of a Strong and Robust Aaa+ Protease. Biophysical Journal (2023)

Meghann KasalHema Chandra KotamarthiMadeline M. JohnsonHannah StephensMatthew J. LangRobert T. SauerTania Baker

The Sspb Adaptor Drives Structural Changes in the Aaa+ Clpxp Protease During Ssra-Tagged Substrate Delivery. Proceedings of the National Academy of Sciences (2023)

Alireza GhanbarpourXue FeiTania A. BakerJoseph H. DavisRobert T. Sauer

Aaa+ Protease-Adaptor Structures Reveal Altered Conformations and Ring Specialization. Nature Structural & Molecular Biology (2022)

Sora KimXue FeiRobert T. SauerTania A. Baker

protein structuregeneticsmolecular structurebiomolecular structureenzymesconformational studiesaltered conformationsmolecular biologystructural molecular biologystructural biologyprotein science

Ftsh Degrades Dihydrofolate Reductase by Recognizing a Partially Folded Species. Protein Science (2022)

Juhee P. MorehouseTania A. BakerRobert T. Sauer

biophysicsprotein chemistryprotein structuregeneticsfolded speciesdihydrofolate reductaseenzymesbiochemistrystructural biologyprotein scienceprotein engineeringprotein folding

Ftsh Degrades Kinetically Stable Dimers of Cyclopropane Fatty Acid Synthase via an Internal Degron. Molecular Microbiology (2022)

Sanjay B. HariJuhee P. MorehouseTania A. BakerRobert T. Sauer

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