Faculty

Institution

Unit

Venue

Michael Forgac

Professor of Developmental Molecular and Chemical Biology Emeritus

Tufts University

Affiliations

Graduate School of Biomedical Sciences

Genetics, Molecular and Cellular Biology

Pharmacology & Drug Development

Michael Forgac is currently serving as a Genetics, Molecular And Cellular Biology Professor of Developmental Molecular and Chemical Biology Emeritus at Tufts University.

Honors

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Experiences

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Education

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Michael Forgac

Tufts University

Professor of Developmental Molecular and Chemical Biology Emeritus

You can click a keyword to filter the displayed items

biochemistry molecular biology enzymes protein science membrane biology biological chemistry structural biology cell biology protein structure biophysics molecular physiology redox biology yeast biochemical sciences molecular regulation signal transduction structural molecular biology protein transport cancer biology cell signaling gene expression enzyme inhibition cellular enzymology yeast v-atpase cell and molecular biology cellular physiology mammalian biology bioenergetics biological inorganic chemistry protein secretion protein chemistry protein function cell regulation molecular cell biology vacuolar atpase biomolecular structure liver physiology protein assembly biochemical genetics cancer cells biomolecular interactions enzyme catalysis protein expression breast oncology structure-function enzyme kinetics coated vesicle clinical biochemistry animal physiology mammalian physiology enzyme specificity cancer genetics clathrin-coated vesicles atp hydrolysis physiological research protein biosynthesis enzymatic modification functional modification mutagenesis cell physiology redox signaling coated vesicle v-atpase plasma membrane adenosine triphosphatase vacuolar atpases subunit isoforms medical biophysics disease physiology proton transfer proteinlipid interaction electron microscopy atp-dependent proton pump proton transport proton translocation subunit interactions clathrin-coated vesicle three-dimensional structure energy metabolism molecular neurodegeneration molecular metabolism cell metabolism molecular neuroscience

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Nanobody Against the V-Atpase C Subunit Inhibits Metastasis of 4T1-12B Breast Tumor Cells to Lung in Mice. Oncotarget (2024)

Zhen LiMohammed A. AlshagawiRebecca A. OotMariam K. AlamoudiKevin SuWenhui LiMichael P. CollinsStephan WilkensMichael Forgac

metastasiscancer researchbreast cancercancer biologycell biology

Isoform A4 of the Vacuolar Atpase a Subunit Promotes 4T1-12B Breast Cancer Cell–Dependent Tumor Growth and Metastasis in Vivo. Journal of Biological Chemistry (2022)

Kevin SuMichael P. CollinsChristina M. McGuireMohammed A. AlshagawiMariam K. AlamoudiZhen LiMichael Forgac

metastasiscancer geneticsbiological chemistrybiochemistrybreast oncologycell biologycancer genomicsbreast cancercancer biologycancer researchcancer growthvacuolar atpasetumor biologyenzyme inhibitionredox biologymolecular biologyoncologycancer cellsmedicinal research

Knockout of the A4 Isoform of the V‐Atpase Subunit a Reduces Tumor Growth and Metastasis in Vivo. The FASEB Journal (2022)

Mohammed AlshagawiKevin SuMichael CollinsChristina McGuireMichael Forgac

immunologyenzyme inhibitionmetastasispharmacologycancer researchmolecular cancerpeptide sciencegeneticsredox biologyenzyme specificitycancer growthenzymeshost specificityin vivo systemsoncologyv-atpase subunitcancer biologytumor biology

Akt Ser/Thr Kinase Increases V-Atpase–Dependent Lysosomal Acidification in Response to Amino Acid Starvation in Mammalian Cells. Journal of Biological Chemistry (2020)

Michael P. CollinsLaura A. StranskyMichael Forgac

cell deathprotein functioncell signalingmolecular regulationbiological chemistrycell and molecular biologybiochemistrycell biologyprotein transportenzymescellular enzymologymembrane biologycell metabolismprotein secretioncellular physiologyv-atpase-dependent lysosomal acidificationmolecular physiologyphysiologysignal transductionmammalian cells

Regulation and Function of V-Atpases in Physiology and Disease. Biochimica et Biophysica Acta (BBA) - Biomembranes (2020)

Michael P. CollinsMichael Forgac

physiologycell signalingmolecular regulationdisease physiologyprotein science

Isoform-Specific Gene Disruptions Reveal a Role for the V-Atpase Subunit A4 Isoform in the Invasiveness of 4T1-12B Breast Cancer Cells. Journal of Biological Chemistry (2019)

Christina M. McGuireMichael P. CollinsGeHong Sun-WadaYoh WadaMichael Forgac

cancer geneticsgene functionbiological chemistrybiochemistrybreast oncologycell biologyclinical biochemistrybiological functionbreast cancercancer biologymembrane biologycancer researchmolecular physiologytumor biologygene expressionredox biologymolecular biologycancer cellsisoform-specific gene disruptions

A New Twist to V-Atpases and Cancer. Oncotarget (2018)

Michael Forgac

cancer discoverymolecular biologyoncologyoncogenescancer biologytumor biology

Glucose Starvation Increases V-Atpase Assembly and Activity in Mammalian Cells Through Amp Kinase and Phosphatidylinositide 3-Kinase/Akt Signaling. Journal of Biological Chemistry (2018)

Christina M. McGuireMichael Forgac

mammalian physiologycell signalingmammalian biologycell physiologyenzymesfunctional regulationv-atpase assemblymolecular biologybiological chemistrymammalian cellsamp kinasesignal transductionglucose starvationbiochemistrycell biology

Regulation of V-Atpase Assembly in Nutrient Sensing and Function of V-Atpases in Breast Cancer Metastasis. Frontiers in Physiology (2018)

Michael P. CollinsMichael Forgac

molecular regulationcell biologyphysiological researchcell physiologyv-atpase assemblybreast cancernutrient sensingcancer biologymembrane biologybreast cancer metastasiscellular physiologymammalian biologymolecular physiologycell regulationtumor biologyphysiologyapplied physiologyredox biologysignal transductionneuroscienceneurophysiology

Abstract 27: Understanding Mechanisms of Nutrient Homeostasis: Amino Acid Availability and Regulation of V-Atpase Activity. Cancer Research (2016)

Laura A. StranskyMichael Forgac

pharmacologycancer researchamino acid availabilityredox biologynutrient homeostasismolecular biologyoncologyclinical researchmembrane biologymedicinal researchunderstanding mechanismscancer biologyprotein sciencetumor biologyhealth sciencesv-atpase activity

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Michael Forgac

Professor of Developmental Molecular and Chemical Biology Emeritus

Tufts University

Affiliations

Graduate School of Biomedical Sciences

Genetics, Molecular and Cellular Biology

Pharmacology & Drug Development

Michael Forgac is currently serving as a Genetics, Molecular And Cellular Biology Professor of Developmental Molecular and Chemical Biology Emeritus at Tufts University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael Forgac

Tufts University

Professor of Developmental Molecular and Chemical Biology Emeritus

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Nanobody Against the V-Atpase C Subunit Inhibits Metastasis of 4T1-12B Breast Tumor Cells to Lung in Mice. Oncotarget (2024)

Zhen LiMohammed A. AlshagawiRebecca A. OotMariam K. AlamoudiKevin SuWenhui LiMichael P. CollinsStephan WilkensMichael Forgac

metastasiscancer researchbreast cancercancer biologycell biology

Isoform A4 of the Vacuolar Atpase a Subunit Promotes 4T1-12B Breast Cancer Cell–Dependent Tumor Growth and Metastasis in Vivo. Journal of Biological Chemistry (2022)

Kevin SuMichael P. CollinsChristina M. McGuireMohammed A. AlshagawiMariam K. AlamoudiZhen LiMichael Forgac

Knockout of the A4 Isoform of the V‐Atpase Subunit a Reduces Tumor Growth and Metastasis in Vivo. The FASEB Journal (2022)

Mohammed AlshagawiKevin SuMichael CollinsChristina McGuireMichael Forgac

Akt Ser/Thr Kinase Increases V-Atpase–Dependent Lysosomal Acidification in Response to Amino Acid Starvation in Mammalian Cells. Journal of Biological Chemistry (2020)

Michael P. CollinsLaura A. StranskyMichael Forgac

Regulation and Function of V-Atpases in Physiology and Disease. Biochimica et Biophysica Acta (BBA) - Biomembranes (2020)

Michael P. CollinsMichael Forgac

physiologycell signalingmolecular regulationdisease physiologyprotein science

Isoform-Specific Gene Disruptions Reveal a Role for the V-Atpase Subunit A4 Isoform in the Invasiveness of 4T1-12B Breast Cancer Cells. Journal of Biological Chemistry (2019)

Christina M. McGuireMichael P. CollinsGeHong Sun-WadaYoh WadaMichael Forgac

A New Twist to V-Atpases and Cancer. Oncotarget (2018)

Michael Forgac

cancer discoverymolecular biologyoncologyoncogenescancer biologytumor biology

Glucose Starvation Increases V-Atpase Assembly and Activity in Mammalian Cells Through Amp Kinase and Phosphatidylinositide 3-Kinase/Akt Signaling. Journal of Biological Chemistry (2018)

Christina M. McGuireMichael Forgac

Regulation of V-Atpase Assembly in Nutrient Sensing and Function of V-Atpases in Breast Cancer Metastasis. Frontiers in Physiology (2018)

Michael P. CollinsMichael Forgac

Abstract 27: Understanding Mechanisms of Nutrient Homeostasis: Amino Acid Availability and Regulation of V-Atpase Activity. Cancer Research (2016)

Laura A. StranskyMichael Forgac

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Ian G. Macara

Institution

Vanderbilt University

breast cancer

cancer initiation

Kelley Moremen

Institution

University of Georgia

glycan trimming enzymes

glycosylation

Alan Brash

Institution

Vanderbilt University

lipid resource

biomolecular engineering

Rafael Fridman

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Wayne State University

proteases

cancer biology

Kermit Carraway

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University of California, Davis

pharmacological research

toxicological mechanism

Ralph Bradshaw

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University of California, Irvine

theoretical biology

molecular and cellular biology

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laboratory investigation

fungal genetics

Leslie Wilson

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University of California, Santa Barbara

microtubule dynamics

cell division

Jack Kaplan

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molecular biology

membrane protein

Palmer Taylor

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medicinal chemistry

chemistry