Faculty

Institution

Unit

Venue

Ke-He Ruan

Professor of Medicinal Chemistry & Pharmacology

University of Houston

Affiliations

College of Pharmacy

Pharmacological & Pharmaceutical Sciences

Ke-he Ruan is currently serving as a College Of Pharmacy Professor of Medicinal Chemistry & Pharmacology at University of Houston.

Honors

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Experiences

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Education

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Ke-He Ruan

University of Houston

Professor of Medicinal Chemistry & Pharmacology

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pharmacology biochemistry protein science structural biology membrane biology enzymes enzyme inhibition receptors molecular biology biophysics protein structure medicinal chemistry biochemical sciences drug discovery receptor (biochemistry) protein engineering medicinal research vascular biology redox biology future medicinal chemistry pharmaceutical sciences biological chemistry respiratory medicine molecular physiology drug development enzyme catalysis solution structure cardiovascular research structural molecular biology biocatalysis protein chemistry protein biosynthesis host specificity pulmonary arterial hypertension second extracellular loop liver physiology functional modification signaling pathways protein nmr arachidonic acid prostacyclin receptor cellular biochemistry pharmacotherapy protein synthesis receptor tyrosine kinases molecular substrates prostacyclin biosynthesis human thromboxane membrane-bound prostacyclin synthase endoplasmic reticulum membrane therapeutic potential sexual medicine biological function mutagenesis catalyst activation chronic inflammation experimental biophysics g protein-coupled receptor molecular basis insulin signaling cell regulation two-phase mechanism ligand recognition intracellular loops gas protein first intracellular loop human prostacyclin receptor heart disease biomedical research pharmaceutical care pharmaceutical technology cancer biology cancer treatment anti-cancer agents lead identification pancreatic cancer signal transduction cell metabolism cell specialization endothelial cell biology natural product research cell signaling cell biology endothelial dysfunction

Notable Scholarly Works

Notable Federal Grants

Collaborators

Design, Synthesis and Characterization of Lead Compounds as Anti-Inflammatory Drugs Targeting Mpges-1 via Enzymelink Screening. Future Medicinal Chemistry (2023)

Renzhong LuHironori AkasakaKe-He Ruan

medicinal chemistrymedicinepharmacologyrational drug designfuture medicinal chemistrylead compoundsdrug discoverychemistrydrug targetinganti-inflammatorypharmaceutical sciencesanti-inflammatory drugsdrug developmentinflammation

Latest Advancements in the Study of the Relationship Between Nsaids and Three Prostaglandin E2 Synthases. Future Medicinal Chemistry (2023)

Ke-He RuanRenzhong Lu

medicinal chemistrymedicineenzyme inhibitionpharmacologypharmaceutical chemistryfuture medicinal chemistrypharmaceutical sciencespharmaceutical researchtherapeutic targetsenzymesdrug discoverylatest advancementsdrug developmentdrug deliverypharmacological researchbiochemistry

Reprogramming Megakaryocyte Gene Expression to Release Platelet-Like Particles With Opposite Biological Activities: Carrying Single-Chain Thromboxane A2 Receptor-G-Protein Complex With Therapeutic Potentials. (2023)

Renzhong LuYan LiAnna XuBridgette KingKe-He Ruan

gene therapycell signalingmegakaryocyte gene expressionreceptor (biochemistry)hematologythrombosissingle-chain thromboxaneopposite biological activitiesplatelet-like particlesgene transfermolecular physiologyhemostasisgene expressionpharmacologybiomedical engineeringmolecular biologytherapeutic potentialscellular therapymolecular medicine

Reprogramming Megakaryocytes for Controlled Release of Platelet-Like Particles Carrying a Single-Chain Thromboxane A2 Receptor-G-Protein Complex With Therapeutic Potential. Cells (2023)

Renzhong LuYan LiAnna XuBridgette KingKe-He Ruan

immunologyplatelet-like particlespharmacologybiomedical engineeringhematologysingle-chain thromboxanetherapeutic potentialhemostasis

Fusion of the β 2 ‐Adrenergic Receptor With Either GαS or βArrestin‐2 Produces Constitutive Signaling by Each Pathway and Induces Gain‐of‐Function in Beas‐2B Cells. FASEB BioAdvances (2022)

Emilio Y. Lucero‐Garcia RojasArfaxad Reyes‐AlcarazKehe RuanBradley K. McConnellRichard A. Bond

receptorspharmacologycell signalingneuropharmacologysignal transductionneuroscience

Latest Progress in the Development of Cyclooxygenase-2 Pathway Inhibitors Targeting Microsomal Prostaglandin E 2 Synthase-1. Future Medicinal Chemistry (2022)

Krista LaBordeRenzhong LuKe-He Ruan

medicinal chemistrydermatologymedicinepharmacologyenzyme inhibitionpharmaceutical chemistryfuture medicinal chemistrypharmaceutical sciencespharmaceutical researchenzymesdrug discoveryprostate cancerdrug deliverydrug developmentlatest progress

Reversing Thromboxane A2 Receptor Activity From Calcium to Camp Signaling by Shifting GαQ to GαS Covalently Linked to the Receptor. Biochemical Engineering Journal (2022)

Qun-Ying LiYan LiAsuka InoueRenzhong LuAnna XuKe-He Ruan

receptorspharmacologybiochemical engineeringcell signalingsignal transductionbiological engineeringbiochemistry

Engineering ‘Enzymelink’ for Screening Lead Compounds to Inhibit Mpges-1 While Maintaining Prostacyclin Synthase Activity. Future Medicinal Chemistry (2021)

Diana T RuanNanhong TangHironari AkasakaRenzhong LuKe-He Ruan

medicinal chemistrygene expressionpharmacologyenzyme inhibitionbiomedical engineeringprostacyclin synthase activityfuture medicinal chemistrylead compoundsbiomolecular engineeringdrug discoveryoncologydrug development

Recent Advances of Cannabidiol Studies in Medicinal Chemistry, Pharmacology and Therapeutics. Future Medicinal Chemistry (2021)

Karishma ThakkarCheng-Huai RuanKe-He Ruan

medicinal chemistrycannabidiol studiespharmacology

Redirecting Thromboxane a 2 and Prostacyclin Biosyntheses From Thrombotic to Antithrombotic Property by an Enzymelink. Future Medicinal Chemistry (2021)

Diana T RuanRenzhong LuKe-He Ruan

medicinal chemistryenzyme inhibitionantithrombotic propertytreatment developmentfuture medicinal chemistrythrombosisprostacyclin biosynthesesbiomolecular engineeringdrug discoverybiological engineeringdrug developmentbiochemistry

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Ke-He Ruan

Professor of Medicinal Chemistry & Pharmacology

University of Houston

Affiliations

College of Pharmacy

Pharmacological & Pharmaceutical Sciences

Ke-he Ruan is currently serving as a College Of Pharmacy Professor of Medicinal Chemistry & Pharmacology at University of Houston.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ke-He Ruan

University of Houston

Professor of Medicinal Chemistry & Pharmacology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Design, Synthesis and Characterization of Lead Compounds as Anti-Inflammatory Drugs Targeting Mpges-1 via Enzymelink Screening. Future Medicinal Chemistry (2023)

Renzhong LuHironori AkasakaKe-He Ruan

Latest Advancements in the Study of the Relationship Between Nsaids and Three Prostaglandin E2 Synthases. Future Medicinal Chemistry (2023)

Ke-He RuanRenzhong Lu

Renzhong LuYan LiAnna XuBridgette KingKe-He Ruan

Reprogramming Megakaryocytes for Controlled Release of Platelet-Like Particles Carrying a Single-Chain Thromboxane A2 Receptor-G-Protein Complex With Therapeutic Potential. Cells (2023)

Renzhong LuYan LiAnna XuBridgette KingKe-He Ruan

immunologyplatelet-like particlespharmacologybiomedical engineeringhematologysingle-chain thromboxanetherapeutic potentialhemostasis

Emilio Y. Lucero‐Garcia RojasArfaxad Reyes‐AlcarazKehe RuanBradley K. McConnellRichard A. Bond

receptorspharmacologycell signalingneuropharmacologysignal transductionneuroscience

Latest Progress in the Development of Cyclooxygenase-2 Pathway Inhibitors Targeting Microsomal Prostaglandin E 2 Synthase-1. Future Medicinal Chemistry (2022)

Krista LaBordeRenzhong LuKe-He Ruan

Reversing Thromboxane A2 Receptor Activity From Calcium to Camp Signaling by Shifting GαQ to GαS Covalently Linked to the Receptor. Biochemical Engineering Journal (2022)

Qun-Ying LiYan LiAsuka InoueRenzhong LuAnna XuKe-He Ruan

receptorspharmacologybiochemical engineeringcell signalingsignal transductionbiological engineeringbiochemistry

Engineering ‘Enzymelink’ for Screening Lead Compounds to Inhibit Mpges-1 While Maintaining Prostacyclin Synthase Activity. Future Medicinal Chemistry (2021)

Diana T RuanNanhong TangHironari AkasakaRenzhong LuKe-He Ruan

Recent Advances of Cannabidiol Studies in Medicinal Chemistry, Pharmacology and Therapeutics. Future Medicinal Chemistry (2021)

Karishma ThakkarCheng-Huai RuanKe-He Ruan

medicinal chemistrycannabidiol studiespharmacology

Redirecting Thromboxane a 2 and Prostacyclin Biosyntheses From Thrombotic to Antithrombotic Property by an Enzymelink. Future Medicinal Chemistry (2021)

Diana T RuanRenzhong LuKe-He Ruan

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Richard Neubig

Institution

Michigan State University

signaling pathway

molecular regulation

Shantu Amin

Institution

Pennsylvania State University

cancer letter

polycyclic aromatic hydrocarbon

Alexandros Makriyannis

Institution

Northeastern University

biological chemistry

receptor

Anthony E. Pegg

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Pennsylvania State University

cancer letter

toxicological mechanism

Harvey R. Herschman

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University of California, Los Angeles

imaging genomics

cell biology

Mark Quinn

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Montana State University

microbiology

immunology

Alan Brash

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biomolecular engineering

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University of Illinois Chicago

electrophysiology

cellular physiology

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biochemistry

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atherosclerosis

endothelial dysfunction