Faculty

Institution

Unit

Venue

Roland E. Dolle

Professor

Washington University in St. Louis

Affiliations

School of Medicine

Department of Biochemistry and Molecular Biophysics

Roland E. Dolle is currently serving as a Biochemistry And Molecular Biophysics Professor at Washington University In St. Louis.

Honors

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Experiences

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Education

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Roland E. Dolle

Washington University in St. Louis

Professor

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pharmacology medicinal chemistry biochemistry chemistry chemical synthesis drug discovery organic synthesis medicinal research enzyme inhibition therapeutic targets pharmaceutical chemistry pharmacological research chemical biology biomolecular engineering pharmacotherapy bioorganic chemistry peptide science chemical sciences combinatorial chemistry synthetic chemistry enzymes transition metal chemistry cheminformatics peptides enantioselective synthesis inhibitory activity opioid use disorder non-peptide ligand receptor (biochemistry) rational drug design total synthesis protein science pain medicine experimental pharmacology molecular science coordination chemistry future medicinal chemistry drug development cytokines anti-inflammatory molecular informatics receptor tyrosine kinases peptide therapeutics solid-phase synthesis clinical pharmacology functional modification algorithmic library chemical libraries methyl ketones atp-citrate lyase hypolipidemic intervention research library small molecule library peptide synthesis pain therapy combinatorial library synthesis pharmaceutical research molecular docking pharmaceutical sciences opioid epidemic molecular diversity novel class comprehensive survey piperidine class algorithmic composition combinatory analysis peptide library protein chemistry enzyme specificity novel therapies enzyme inhibitors glycosyl fluorides cysteine proteases conformational analysis partial synthesis practical synthesis pharmacognosy high-throughput screening

Notable Scholarly Works

Notable Federal Grants

Collaborators

Pyrimethamine and a Potent Analogue Inhibit Nrf2 by Suppressing One-Carbon Metabolism. Journal of Biological Chemistry (2025)

metabolismmolecular metabolismreactive oxygen speciesone-carbon metabolismredox signalingbiochemistrymedicinal chemistryenzyme inhibitioncell metabolismpharmacologyoxidative stressmolecular pharmacologycarbonyl metabolismpharmacological researchredox biology

Selective Inhibition of Ero1α With M6766, a Novel Small-Molecule Inhibitor, Prevents Arterial Thrombosis and Ischemic Stroke in Mice. Molecular Therapy (2025)

neurologyvascular biologycardiovascular researchischemic syndromethrombosisvascular pharmacologycerebral blood flowarterial thrombosispharmacologytherapeutic targetsischemic strokepharmacotherapynovel small-molecule inhibitorstroke

Targeting Hepatocyte-Specific Slc2A8 Blocks Hepatic Steatosis and Dissociates Tca Cycle Flux Inhibition From Glutamine Anaplerosis. Hepatology Communications (2025)

pathologyglutamine anaplerosisliver physiologydrug-induced liver injuryimmunologyhepatologymolecular physiologypharmacologytherapeutic targetshepatotoxicity

An Orally Available Compound Suppresses Glucagon Hypersecretion and Normalizes Hyperglycemia in Type 1 Diabetes. JCI Insight (2024)

Farzad AsadiSubhadra C GunawardanaRoland E DolleDavid W Piston

insulin managementnutraceutical ingredientglucagon hypersecretionsymptom managementhematologydiabetes managementavailable compounddiabetic medicinepharmacologyhealth sciencesdiabetesdiabetes therapies

Dietary Fructose Enhances Tumour Growth Indirectly via Interorgan Lipid Transfer. Nature (2024)

Ronald Fowle-GriderJoe L. RowlesIsabel ShenYahui WangMichaela Schwaiger-HaberAlden J. DunhamKay JayachandranMatthew InkmanMichael ZahnerFuad J. NaserMadelyn M. JackstadtJonathan L. SpaldingSarah ChiangKyle S. McCommisRoland E. DolleEva T. KramerSarah M. ZimmermanGeorge P. SouroullasBrian N. FinckLeah P. ShriverCharles K. KaufmanJulie K. SchwarzJin ZhangGary J. Patti

lipidscarcinogenesiscancer discoveryinterorgan lipid transfertumor biologylipid sciencecancer researchmolecular biologycancer cellsoncogenesmolecular cancerbiochemistrydietary fructose enhancesmetabolismnutritional biochemistrysecondary metabolismlipid nutritioncancer growthlipid synthesisbiomolecular engineering

A Novel Dual Nlrp1 and Nlrp3 Inflammasome Inhibitor for the Treatment of Inflammatory Diseases.. Clin. Transl. Immunology (2023)

inflammatory diseasesinflammationpathologyarthritisrheumatologyanti-inflammatorycell deathchronic inflammationimmunologymedicinal researchnovel dual nlrp1immunotherapyimmune responsesexperimental medicinetherapeutic targetsautoinflammatory disease

A Novel Dual Nlrp1 and Nlrp3 Inflammasome Inhibitor for the Treatment of Inflammatory Diseases. Clinical & Translational Immunology (2023)

Callum AH DochertyAnuruddika J FernandoSarah RosliMaggie LamRoland E DolleManuel A NaviaRonald FarquharDanny La FranceMichelle D TateChristopher K MurphyAdriano G RossiAshley Mansell

immunologic diseasesinflammationinflammatory diseasesanti-inflammatorytranslational researchimmunologymedicinal researchimmunotherapyimmune responsestherapeutic targetsimmunologic mechanismsclinical immunology

Development of Ads051, an Oral, Gut‐Restricted, Small Molecule Neutrophil Modulator for the Treatment of Neutrophil‐Mediated Inflammatory Diseases. FEBS Open Bio (2023)

Christopher K. MurphyBharat DixitFrederick B. OlesonRoland E. DolleRonald FarquharBeth A. McCormick

molecular immunologyinflammationinflammatory diseasesanti-inflammatorybiomedical researchimmunologymedicinal researchnovel therapiesbiochemistryimmune responsestherapeutic targetsneutrophil-mediated inflammatory diseases

Longitudinal Modeling of Human Neuronal Aging Identifies Rcan1-Tfeb Pathway Contributing to Neurodegeneration of Huntington’s Disease. Research Square (Research Square) (2023)

Andrew YooSeong Won LeeYoung Mi OhMatheus VictorIlya StrunilinShawei ChenSonika DahiyaRoland DolleStephen PakGary SilvermanDavid Perlmutter

huntington's diseaseneurosciencelongitudinal modeling

Longitudinal Modeling of Human Neuronal Aging Reveals the Contribution of the Rcan1–Tfeb Pathway to Huntington’s Disease Neurodegeneration. Nature Aging (2023)

Seong Won LeeYoung Mi OhMatheus B. VictorYan YangShawei ChenIlya StrunilinSonika DahiyaRoland E. DolleStephen C. PakGary A. SilvermanDavid H. PerlmutterAndrew S. Yoo

huntington's diseasehuman neuronal agingneurosciencelongitudinal modeling

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Roland E. Dolle

Professor

Washington University in St. Louis

Affiliations

School of Medicine

Department of Biochemistry and Molecular Biophysics

Roland E. Dolle is currently serving as a Biochemistry And Molecular Biophysics Professor at Washington University In St. Louis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Roland E. Dolle

Washington University in St. Louis

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Pyrimethamine and a Potent Analogue Inhibit Nrf2 by Suppressing One-Carbon Metabolism. Journal of Biological Chemistry (2025)

Selective Inhibition of Ero1α With M6766, a Novel Small-Molecule Inhibitor, Prevents Arterial Thrombosis and Ischemic Stroke in Mice. Molecular Therapy (2025)

Targeting Hepatocyte-Specific Slc2A8 Blocks Hepatic Steatosis and Dissociates Tca Cycle Flux Inhibition From Glutamine Anaplerosis. Hepatology Communications (2025)

pathologyglutamine anaplerosisliver physiologydrug-induced liver injuryimmunologyhepatologymolecular physiologypharmacologytherapeutic targetshepatotoxicity

An Orally Available Compound Suppresses Glucagon Hypersecretion and Normalizes Hyperglycemia in Type 1 Diabetes. JCI Insight (2024)

Farzad AsadiSubhadra C GunawardanaRoland E DolleDavid W Piston

Dietary Fructose Enhances Tumour Growth Indirectly via Interorgan Lipid Transfer. Nature (2024)

A Novel Dual Nlrp1 and Nlrp3 Inflammasome Inhibitor for the Treatment of Inflammatory Diseases.. Clin. Transl. Immunology (2023)

A Novel Dual Nlrp1 and Nlrp3 Inflammasome Inhibitor for the Treatment of Inflammatory Diseases. Clinical & Translational Immunology (2023)

Callum AH DochertyAnuruddika J FernandoSarah RosliMaggie LamRoland E DolleManuel A NaviaRonald FarquharDanny La FranceMichelle D TateChristopher K MurphyAdriano G RossiAshley Mansell

Development of Ads051, an Oral, Gut‐Restricted, Small Molecule Neutrophil Modulator for the Treatment of Neutrophil‐Mediated Inflammatory Diseases. FEBS Open Bio (2023)

Christopher K. MurphyBharat DixitFrederick B. OlesonRoland E. DolleRonald FarquharBeth A. McCormick

Longitudinal Modeling of Human Neuronal Aging Identifies Rcan1-Tfeb Pathway Contributing to Neurodegeneration of Huntington’s Disease. Research Square (Research Square) (2023)

Andrew YooSeong Won LeeYoung Mi OhMatheus VictorIlya StrunilinShawei ChenSonika DahiyaRoland DolleStephen PakGary SilvermanDavid Perlmutter

huntington's diseaseneurosciencelongitudinal modeling

Longitudinal Modeling of Human Neuronal Aging Reveals the Contribution of the Rcan1–Tfeb Pathway to Huntington’s Disease Neurodegeneration. Nature Aging (2023)

Seong Won LeeYoung Mi OhMatheus B. VictorYan YangShawei ChenIlya StrunilinSonika DahiyaRoland E. DolleStephen C. PakGary A. SilvermanDavid H. PerlmutterAndrew S. Yoo

huntington's diseasehuman neuronal agingneurosciencelongitudinal modeling

1
2
3
4
5
27
10 / page

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Institution

University of Illinois Urbana-Champaign

synthesis method

chemical synthesis

Richard B. Silverman

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Northwestern University

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medicinal chemistry

Robin Polt

Institution

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lipid chemistry

biomolecular engineering

Jetze Tepe

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pharmacology

organic synthesis

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high resolution nmr

biomolecular engineering

Wei Wang

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drug discovery

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medicinal chemistry

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antibacterial compounds

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