Faculty

Institution

Unit

Venue

Denis Rousseau

Professor

Albert Einstein College of Medicine

Affiliations

Department of Biochemistry

Denis Rousseau is currently serving as a Biochemistry Professor at Albert Einstein College of Medicine.

Honors

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Experiences

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Education

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Denis Rousseau

Albert Einstein College of Medicine

Professor

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biochemistry molecular biology enzymes biophysics structural biology redox biology protein science chemical biology biological chemistry protein structure biophysical chemistry heme transport structural molecular biology membrane biology heme homeostasis heme signaling raman spectroscopy biomolecular engineering transition metal chemistry biomolecular structure oxidative stress structure-function enzyme kinetics spectroscopy enzyme inhibition biological inorganic chemistry vascular biology heme trafficking vibrational spectroscopy coordination chemistry heme degradation enzyme catalysis redox signaling molecular structure biochemical sciences bioenergetics biological macromolecules protein chemistry redox chemistry membrane science molecular spectroscopy cytochrome c oxidase surface reactivity oxygen reduction reaction reactive oxygen species biocatalysis inhibitory activity structure elucidation resonance raman resonance raman spectroscopy photophysical properties catalyst activation proton transfer intermediate host bioelectrochemistry reaction intermediates biochemical interaction inducible nitric-oxide synthase raman difference spectroscopy resonance raman spectra proton translocation selective separation absorption spectroscopy biomolecular interactions metalloproteins x-ray spectroscopy x-ray crystallography charge transport resonance raman scattering hydrogen bonding structural characterization altmetric attention score heme oxygenase molecular iodine neuronal nitric-oxide synthase heme environment ligand exchange cryogenic electron microscopy catalytic intermediates catalysis chemistry

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structural and Functional Mechanisms of Cytochrome C Oxidase. Journal of Inorganic Biochemistry (2024)

Denis L RousseauIzumi IshigamiSyun-Ru Yeh

protein scienceprotein structurefree radical biologystructure-function enzyme kineticsfunctional modificationinhibitory activityenzymesoxidative stresschemical biologyfunctional mechanismsbiological inorganic chemistryredox biologybiochemistryredox signalingstructural biologybiophysicsstructural molecular biologymolecular biologyenzyme inhibition

Detection of a Geminate Photoproduct of Bovine Cytochrome C Oxidase by Time-Resolved Serial Femtosecond Crystallography. Journal of the American Chemical Society (2023)

Izumi IshigamiSergio CarbajoNadia ZatsepinMasahide HikitaChelsie E. ConradGarrett NelsonJesse CoeShibom BasuThomas GrantMatthew H. SeabergRaymond G. SierraMark S. HunterPetra FrommeRaimund FrommeDenis L. RousseauSyun-Ru Yeh

biochemical engineeringchemical sciencesbiophotonicsenvironmental sciencephotoelectrochemistrybiogeochemistrychemical ecologyspectroelectrochemistrybiological chemistrybiochemical scienceschemical biologyenvironmental chemistryredox biologybiochemistrybioelectrochemistrybiophysicssustainable chemistrychemistrybiomolecular engineeringbiological engineeringprocess biochemistrymolecular biologychemical engineering

Structural Basis for Functional Properties of Cytochrome C Oxidase. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Izumi IshigamiRaymond G. SierraZhen SuAriana PeckCong WangFrederic PoitevinStella LisovaBrandon HayesFrank R. MossSébastien BoutetRobert E. SublettChun Hong YoonSyun-Ru YehDenis L. Rousseau

enzymesmolecular structureprotein sciencebiomolecular structureprotein structurebiochemistrystructural basisstructure elucidationmolecular biologystructural biology

Structural Insights Into Functional Properties of the Oxidized Form of Cytochrome C Oxidase. Nature Communications (2023)

Izumi IshigamiRaymond G. SierraZhen SuAriana PeckCong WangFrederic PoitevinStella LisovaBrandon HayesFrank R. MossSébastien BoutetRobert E. SublettChun Hong YoonSyun-Ru YehDenis L. Rousseau

enzymesoxidative stressoxidized formbiomolecular structureprotein structureredox biologybiochemistrystructural insightsmolecular biologystructural biology

Temperature-Dependent Structural Transition Following X-Ray-Induced Metal Center Reduction in Oxidized Cytochrome C Oxidase. Journal of Biological Chemistry (2022)

Izumi IshigamiSilvia RussiAina CohenSyun-Ru YehDenis L. Rousseau

x-ray spectroscopyprotein sciencetemperature-dependent structural transitionfree radical biologyenzymesoxidative stressx-ray crystallographybiological chemistrystructure elucidationchemical biologymolecular structurebiochemistryprotein x-ray crystallographybiophysical chemistrystructural biologybiophysicsstructural integritymolecular biologytransition metal chemistry

Snapshot of an Oxygen Intermediate in the Catalytic Reaction of Cytochrome C Oxidase. Proceedings of the National Academy of Sciences (2019)

Izumi IshigamiAriel Lewis-BallesterAustin EchelmeierGerrit BrehmNadia A. ZatsepinThomas D. GrantJesse D. CoeStella LisovaGarrett NelsonShangji ZhangZachary F. DobsonSébastien BoutetRaymond G. SierraAlexander BatyukPetra FrommeRaimund FrommeJohn C. H. SpenceAlexandra RosSyun-Ru YehDenis L. Rousseau

science and technology studiesscientific communicationchemical sciencesbiologyscience studiesscholarly communicationenvironmental sciencehistory of science

Crystal Structure of Co-Bound Cytochrome C Oxidase Determined by Serial Femtosecond X-Ray Crystallography at Room Temperature. Proceedings of the National Academy of Sciences (2017)

Izumi IshigamiNadia A. ZatsepinMasahide HikitaChelsie E. ConradGarrett NelsonJesse D. CoeShibom BasuThomas D. GrantMatthew H. SeabergRaymond G. SierraMark S. HunterPetra FrommeRaimund FrommeSyun-Ru YehDenis L. Rousseau

x-ray spectroscopychemical sciencesstructure-function enzyme kineticsenvironmental sciencescience and technology studiesx-ray crystallographymolecular biologybiological chemistrystructure elucidationexperimental petrologymolecular structureroom temperatureredox biologybiochemistryphysicsstructural biologybiophysical chemistrybiophysicsbiomolecular engineeringcrystallographymolecular sciencescientific communicationchemical structurescholarly communication

Raman Scattering. IUPAC Standards Online (2016)

Masahide TerazimaNoboru HirotaSilvia E. BraslavskyAndreas MandelisStephen E. BialkowskiGerald J. DieboldR. J. D. MillerDanièle FournierRichard A. PalmerAndy Tam

optical propertiesoptical spectrometerlight scattering spectroscopytransient gratingphotochemistryultrafast laser spectroscopyraman scatteringlight sciencespectroscopyphotothermal effectsphysicsspectroscopic methodsphotothermal phenomenachemistrysurface-enhanced raman scatteringoptical materialsvibrational spectroscopyapplied physicsraman spectroscopyatomic spectroscopyoptical spectroscopy

Three-Dimensional-Printed Gas Dynamic Virtual Nozzles for X-Ray Laser Sample Delivery. Optics Express (2016)

Garrett NelsonRichard A. KirianUwe WeierstallNadia A. ZatsepinTomáš FaragóTilo BaumbachFabian WildeFabian B. P. NieslerBenjamin ZimmerIzumi IshigamiMasahide HikitaSaša BajtSyun-Ru YehDenis L. RousseauHenry N. ChapmanJohn C. H. SpenceMichael Heymann

laser-assisted depositionmechanical engineeringprecision engineeringadditive manufacturingtechnologyprinted electronicsbiomedical engineering3d printingrapid prototypingmanufacturing technology

Heme Stabilization of α-Synuclein Oligomers During Amyloid Fibril Formation. Biochemistry (2015)

Eric Y. HaydenPrerna KaurThomas L. WilliamsHiroshi MatsuiSyun-Ru YehDenis L. Rousseau

geneticsa-synuclein oligomersneurodegenerative diseasesprotein scienceheme homeostasisbiochemistryamyloid fibril formationphysiologymolecular neurodegenerationheme stabilization

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Denis Rousseau

Professor

Albert Einstein College of Medicine

Affiliations

Department of Biochemistry

Denis Rousseau is currently serving as a Biochemistry Professor at Albert Einstein College of Medicine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Denis Rousseau

Albert Einstein College of Medicine

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structural and Functional Mechanisms of Cytochrome C Oxidase. Journal of Inorganic Biochemistry (2024)

Denis L RousseauIzumi IshigamiSyun-Ru Yeh

Detection of a Geminate Photoproduct of Bovine Cytochrome C Oxidase by Time-Resolved Serial Femtosecond Crystallography. Journal of the American Chemical Society (2023)

Structural Basis for Functional Properties of Cytochrome C Oxidase. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Izumi IshigamiRaymond G. SierraZhen SuAriana PeckCong WangFrederic PoitevinStella LisovaBrandon HayesFrank R. MossSébastien BoutetRobert E. SublettChun Hong YoonSyun-Ru YehDenis L. Rousseau

enzymesmolecular structureprotein sciencebiomolecular structureprotein structurebiochemistrystructural basisstructure elucidationmolecular biologystructural biology

Structural Insights Into Functional Properties of the Oxidized Form of Cytochrome C Oxidase. Nature Communications (2023)

Izumi IshigamiRaymond G. SierraZhen SuAriana PeckCong WangFrederic PoitevinStella LisovaBrandon HayesFrank R. MossSébastien BoutetRobert E. SublettChun Hong YoonSyun-Ru YehDenis L. Rousseau

enzymesoxidative stressoxidized formbiomolecular structureprotein structureredox biologybiochemistrystructural insightsmolecular biologystructural biology

Temperature-Dependent Structural Transition Following X-Ray-Induced Metal Center Reduction in Oxidized Cytochrome C Oxidase. Journal of Biological Chemistry (2022)

Izumi IshigamiSilvia RussiAina CohenSyun-Ru YehDenis L. Rousseau

Snapshot of an Oxygen Intermediate in the Catalytic Reaction of Cytochrome C Oxidase. Proceedings of the National Academy of Sciences (2019)

science and technology studiesscientific communicationchemical sciencesbiologyscience studiesscholarly communicationenvironmental sciencehistory of science

Crystal Structure of Co-Bound Cytochrome C Oxidase Determined by Serial Femtosecond X-Ray Crystallography at Room Temperature. Proceedings of the National Academy of Sciences (2017)

Raman Scattering. IUPAC Standards Online (2016)

Masahide TerazimaNoboru HirotaSilvia E. BraslavskyAndreas MandelisStephen E. BialkowskiGerald J. DieboldR. J. D. MillerDanièle FournierRichard A. PalmerAndy Tam

Three-Dimensional-Printed Gas Dynamic Virtual Nozzles for X-Ray Laser Sample Delivery. Optics Express (2016)

laser-assisted depositionmechanical engineeringprecision engineeringadditive manufacturingtechnologyprinted electronicsbiomedical engineering3d printingrapid prototypingmanufacturing technology

Heme Stabilization of α-Synuclein Oligomers During Amyloid Fibril Formation. Biochemistry (2015)

Eric Y. HaydenPrerna KaurThomas L. WilliamsHiroshi MatsuiSyun-Ru YehDenis L. Rousseau

geneticsa-synuclein oligomersneurodegenerative diseasesprotein scienceheme homeostasisbiochemistryamyloid fibril formationphysiologymolecular neurodegenerationheme stabilization

1
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10 / page

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