Faculty

Institution

Unit

Venue

Christina R. Bourne

Associate Professor

University of Oklahoma

Affiliations

Dodge Family College of Arts and Sciences

Chemistry and Biochemistry

NORMAN CAMPUS COLLEGES

Dodge Family College of Arts and Sciences

Christina R. Bourne is currently serving as a Chemistry And Biochemistry Associate Professor at University of Oklahoma.

Honors

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Experiences

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Education

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Christina R. Bourne

University of Oklahoma

Associate Professor

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pharmacology microbiology biochemistry structural biology medicinal chemistry enzyme inhibition drug discovery enzymes infectious diseases toxicology applied microbiology clinical microbiology virology protein science structural molecular biology drug resistance antimicrobial resistance clinical chemistry infection control toxins toxinology antimicrobial agents medicinal research molecular microbiology bacteriology bacillus anthracis environmental microbiology biomolecular structure biological chemistry viral hepatitis antibiotic resistance antimicrobial chemotherapy structure-function enzyme kinetics pharmaceutical chemistry molecular recognition x-ray crystallography crystal structures inhibitory activity protein chemistry microbial toxins dihydrofolate reductase yoeb toxin toxin-antitoxin modules virus research molecular diagnostics organic chemistry frontier molecular virology viral genetics viral evolution functional selectivity specific resistance lead identification diagnostic microbiology enzyme catalysis biocatalysis structure determination antimicrobial compounds high-throughput screening rna biology derivative (chemistry) pharmaceutical sciences pharmaceutical biotechnology pharmaceutical research clinical pharmacology global structural changes small-molecule effectors virus life cycle multiple protease pathways pliable switches icosahedral capsid antimicrobial discovery biosynthetic folate pathway virus capsid assembly igm cryoglobulin glycosylated fab natural proteolytic antibody bacteria

Notable Scholarly Works

Notable Federal Grants

Collaborators

Broken Beyond Repair: Ta System Pare Toxins Mediate Effective Gyrase Inhibition Without Driving Resistance. Journal of Bacteriology (2025)

drug discoverymechanisms of actionta system pareenzyme inhibitionbiochemistrybiomolecular engineeringtoxinsglycobiologymolecular pharmacologyinhibitory activity

Fuzzy Interactions Maintain Cognate Pairings in Ta Systems. Structural Dynamics (2025)

fuzzy setsintelligent systemsfuzzy systemsfuzzy interactionsfuzzy logicsystems engineeringfuzzy modeling

Osbpl11 is an African-Specific Locus Associated With 25-Hydroxyvitamin D Concentrations and Cardiometabolic Health. medRxiv (2025)

Reagan M. MogireJohn Muthii MuriukiRuth Fiona BayimenyeAlexander J MentzerAmanda ChongMateus H GouveiaAmy R. BentleyGavin BandPauline KingoriRuth MitchellEmily L WebbDhriti SenguptaLynette EkunweFrancis M NdunguAlireza MorovatAlex W MachariaClare L. CutlandGibran HemaniSodiomon B SirimaMichele RamsayCamila A. FigueiredoAndrew M. PrenticeShabir A MadhiLaura M. RaffieldManjinder S. SandhuPhilip BejonGeorge Davey SmithAlison M ElliottThomas N WilliamsCharles RotimiChristina R. BourneAnthony BurgettAdebowale AdeyemoSarah H Atkinson

geneticsafrican-specific locuspublic healthcardiometabolic health

Abstract 1943 Strategies for New Anti-Folate Development Targeting the Dihydroneopterin Aldolase Enzyme. Journal of Biological Chemistry (2024)

Christina BourneAmy Tan

membrane biologydrug discoverysynthetic biologyprotein engineeringprotein expressionbiological chemistrydihydroneopterin aldolase enzymeenzyme inhibitionbiochemistrybiomolecular engineeringenzymesprotein sciencebiological engineering

Abstract 5778: Determining the Structure and Function Relationship of the Oxysterol-Binding Protein (Osbp) to Guide Drug Development. Cancer Research (2024)

Ruth Fiona BayimenyeJorge L. Berrios-RiveraSusan NimmoChristina R. BourneAnthony W. Burgett

structural chemistrybiochemistryprotein sciencecancer biologymembrane biologycancer researchfunction relationshipvascular biologyoxysterolpharmacologycancer treatmentstructural biologyoncologyprotein structurestructural molecular biologyprotein chemistrymolecular biologyprotein functionmedicinal researchoxysterol-binding protein

Friend or Foe: Protein Inhibitors of Dna Gyrase. Biology (2024)

Shengfeng RuanChih-Han TuChristina R. Bourne

pharmacologybiologymedicinal chemistrystructural biologyenzyme inhibitionmolecular biologyprotein inhibitorsprotein sciencedna gyrase

Escherichia Coli Cells Evade Inducible Pare Toxin Expression by Reducing Plasmid Copy Number. Microbiology Spectrum (2024)

Shengfeng RuanChristina R. Bourne

pathogenic bacteriapathogenspathogen detectioninfection controlbacteriologymicrobiologymicrobial pathogenesisinfectious diseasesplasmid copy numberapplied microbiologymolecular microbiologymicrobial geneticsenvironmental microbiologybacteriaimmunologymicrobial ecologymedical microbiologyclinical microbiology

Structure–Activity Relationships of Ligand Binding to Oxysterol-Binding Protein (Osbp) and Osbp-Related Protein 4. Journal of Medicinal Chemistry (2023)

Zachary C. SeveranceJuan I. NuñezAnh T. Le-McClainCori A. MalinkyRyan C. BensenRobert S. FogleGianni W. ManginelliSophia H. SakersEmily C. FalconRichard Hoang BuiKevin J. SneadChristina R. BourneAnthony W. G. Burgett

medicinal chemistrypharmacologystructural biologystructure-activity relationshipsoxysterol-binding protein

Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of Their Antibacterial Structure–Activity Relationships and Mechanism of Action. ACS Omega (2022)

Zachary W. BoyerHannah KesslerHannah BrosmanKirsten J. RuudAlan F. FalkowskiConstance ViolletChristina R. BourneMatthew C. O’Reilly

medicinal chemistrypharmacologyantibacterial structure-activity relationshipsorganic chemistryorganic synthesisfunctionalized amino dihydropyrimidineschemical synthesischemistry

Using Alphafold2 to Model Ta System Protein–Protein Interactions: A Case Study With Parde Complexes. Acta Crystallographica Section A Foundations and Advances (2022)

Christina BourneChih-Han TuRichard Van

biophysicsstructural biologymolecular biologystructural molecular biologysystems biologyprotein modelingcrystallographyparde complexesx-ray crystallography

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Christina R. Bourne

Associate Professor

University of Oklahoma

Affiliations

Dodge Family College of Arts and Sciences

Chemistry and Biochemistry

NORMAN CAMPUS COLLEGES

Dodge Family College of Arts and Sciences

Christina R. Bourne is currently serving as a Chemistry And Biochemistry Associate Professor at University of Oklahoma.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Christina R. Bourne

University of Oklahoma

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Broken Beyond Repair: Ta System Pare Toxins Mediate Effective Gyrase Inhibition Without Driving Resistance. Journal of Bacteriology (2025)

drug discoverymechanisms of actionta system pareenzyme inhibitionbiochemistrybiomolecular engineeringtoxinsglycobiologymolecular pharmacologyinhibitory activity

Fuzzy Interactions Maintain Cognate Pairings in Ta Systems. Structural Dynamics (2025)

fuzzy setsintelligent systemsfuzzy systemsfuzzy interactionsfuzzy logicsystems engineeringfuzzy modeling

Osbpl11 is an African-Specific Locus Associated With 25-Hydroxyvitamin D Concentrations and Cardiometabolic Health. medRxiv (2025)

geneticsafrican-specific locuspublic healthcardiometabolic health

Abstract 1943 Strategies for New Anti-Folate Development Targeting the Dihydroneopterin Aldolase Enzyme. Journal of Biological Chemistry (2024)

Christina BourneAmy Tan

Abstract 5778: Determining the Structure and Function Relationship of the Oxysterol-Binding Protein (Osbp) to Guide Drug Development. Cancer Research (2024)

Ruth Fiona BayimenyeJorge L. Berrios-RiveraSusan NimmoChristina R. BourneAnthony W. Burgett

Friend or Foe: Protein Inhibitors of Dna Gyrase. Biology (2024)

Shengfeng RuanChih-Han TuChristina R. Bourne

pharmacologybiologymedicinal chemistrystructural biologyenzyme inhibitionmolecular biologyprotein inhibitorsprotein sciencedna gyrase

Escherichia Coli Cells Evade Inducible Pare Toxin Expression by Reducing Plasmid Copy Number. Microbiology Spectrum (2024)

Shengfeng RuanChristina R. Bourne

Structure–Activity Relationships of Ligand Binding to Oxysterol-Binding Protein (Osbp) and Osbp-Related Protein 4. Journal of Medicinal Chemistry (2023)

medicinal chemistrypharmacologystructural biologystructure-activity relationshipsoxysterol-binding protein

Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of Their Antibacterial Structure–Activity Relationships and Mechanism of Action. ACS Omega (2022)

Zachary W. BoyerHannah KesslerHannah BrosmanKirsten J. RuudAlan F. FalkowskiConstance ViolletChristina R. BourneMatthew C. O’Reilly

medicinal chemistrypharmacologyantibacterial structure-activity relationshipsorganic chemistryorganic synthesisfunctionalized amino dihydropyrimidineschemical synthesischemistry

Using Alphafold2 to Model Ta System Protein–Protein Interactions: A Case Study With Parde Complexes. Acta Crystallographica Section A Foundations and Advances (2022)

Christina BourneChih-Han TuRichard Van

biophysicsstructural biologymolecular biologystructural molecular biologysystems biologyprotein modelingcrystallographyparde complexesx-ray crystallography

1
2
3
4
5
6
10 / page

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Similar Faculty Members

Herman Sintim

Institution

Purdue University

antibiotic adjuvant

bio-orthogonal chemistry

Donald Ronning

Institution

University of Toledo

chemical technology

organic chemistry

Dean Crick

Institution

Colorado State University

microbial cell factory

m. tuberculosis enzymes

Timothy Wencewicz

Institution

Washington University in St. Louis

biological chemistry

biomolecular engineering

Robert H. Cichewicz

Institution

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natural product

infectious diseases

Christian Melander

Institution

University of Notre Dame

applied microbiology

biofilm

Peter J. Tonge

Institution

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biological data

biomedical informatics

Erkang Fan

Institution

University of Washington

future medicinal chemistry

mechanisms of action

Nicholas J. Mantis

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University at Albany, SUNY

microbial pathogenesis

pathogen

Delphi Chatterjee

Institution

Colorado State University

microbiology

clinical microbiology