Faculty

Institution

Unit

Venue

Joseph M. Chalovich

Distinguished Professor & Emeritus

East Carolina University

Affiliations

Brody School of Medicine

Biochemistry and Molecular Biology

Joseph M. Chalovich is currently serving as a Biochemistry And Molecular Biology Distinguished Professor & Emeritus at East Carolina University.

Honors

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Experiences

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Education

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Joseph M. Chalovich

East Carolina University

Distinguished Professor & Emeritus

You can click a keyword to filter the displayed items

biophysics pharmacology biochemistry protein science molecular biology structural biology membrane biology molecular biophysics biophysical chemistry skeletal muscle enzymes cellular physiology biomechanics muscle function experimental biophysics biological chemistry mammalian biology animal physiology applied physiology cell motility protein structure cardiology molecular physiology enzyme inhibition biochemical sciences biophysical review vascular biology biophysical modeling cell biomechanics medical biophysics human physiology molecular regulation musculoskeletal research actuation musculoskeletal science orthopedic biomechanics cardiomyopathy protein transport active state bioenergetics experimental medicine biomolecular interactions experimental biology atpase activity muscle contraction thin filament activation regulated actin molecular science animal science biochemical interaction functional modification protein function actomyosin atpase activity heavy meromyosin inactive state orthopaedic research musculoskeletal interaction cell biophysics cell physiology mammalian physiology biological inorganic chemistry experimental pharmacology veterinary physiology fragmentation effect relaxed muscle cross-bridge attachment shutdown state active force relaxed fiber stiffness parallel inhibition caldesmon fragments synaptopodin family human sciences mechanisms of action musculoskeletal function protein evolution cytoskeleton muscle biology actin polymerization

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Steric Blocking Upside Down: A Different Way of Thinking About the Competition Between Myosin and Tropomyosin. Frontiers in Physics (2024)

Joseph M. Chalovich

membrane biologymolecular cell biologygene expressionbiophysicscell motilitymechanobiologymolecular biologycellular physiologysystems biologymyositisvascular biologymolecular and cellular biologymycelial interaction

Dual Thick and Thin Filament Linked Regulation of Stretch- and L-Name-Induced Tone in Young and Senescent Murine Basilar Artery. Frontiers in Physiology (2023)

Lubomir T. LubomirovMechthild M. SchroeterVeronika HasseMarina FrohnDoris MetzlerMaria BustGalyna PryymachukJürgen HeschelerOlaf GriskJoseph M. ChalovichNeil R. SmythGabriele PfitzerSymeon Papadopoulos

liver physiologyanatomycellular physiologycell biologyneurophysiologymembrane biologyapplied physiologyneurosciencephysiological researchvascular biologyl-name-induced tonegene expressionveterinary physiologyanimal physiologythin filamentdual thickfragmentation effecthuman biologycell physiologyhuman physiologyphysiology

Negative Charges Introduced Near the It Helix of Cardiac Troponin T Stabilize the Active State of Actin Filaments. Biochemistry (2023)

Li ZhuMaicon Landim-VieiraMichelle Rodriguez GarciaJose R. PintoJoseph M. Chalovich

negative chargesactin filamentsbiophysicsstructural biologyprotein structureactive statebiochemistrycell biologyprotein science

C-Terminal Basic Region of Troponin T Alters the Ca 2+ -Dependent Changes in Troponin I Interactions. Biochemistry (2022)

Li ZhuDylan JohnsonJoseph M. Chalovich

pharmacologypath dependencesignal transductionc-terminal basic regionbiochemical interactionbiochemistryimmunology

Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation. Frontiers in Physiology (2022)

J. M. ChalovichL. ZhuD. Johnson

geneticsstriated muscle regulationcardiologyneurosciencemolecular physiologyhypertrophic cardiomyopathy mutationscardiomyopathyhuman physiologyphysiology

Phosphomimetic Mutations in the C-Terminal Basic Region of Troponin T Increases Actin Filament Activity. Biophysical Journal (2022)

Li ZhuMaicon Landim-VieiraMichelle C. Rodriguez GarciaJ. Renato D. PintoJoseph M. Chalovich

geneticsactin filament activitybiophysicsstructural biologyc-terminal basic regionmolecular biologyphosphomimetic mutationsprotein sciencemolecular biophysics

Caldesmon Ablation in Mice Causes Umbilical Herniation and Alters Contractility of Fetal Urinary Bladder Smooth Muscle. The Journal of General Physiology (2021)

Sandra PützLisa Sophie BarthelMarina FrohnDoris MetzlerMohammed BarhamGalyna PryymachukOliver TrunschkeLubomir T. LubomirovJürgen HeschelerJoseph M. ChalovichWolfram F. NeissManuel KochMechthild M. SchroeterGabriele Pfitzer

neurologyurologyanimal physiologyapplied physiologymammalian physiologycaldesmon ablationcardiologyfetal medicinehuman physiologyveterinary medicineclinical physiologyveterinary physiologymammalian biologyanimal scienceelectrophysiologyphysiology

C-Terminal Basic Residues of Troponin T Facilitate Troponin I Transitions During Activation. Biophysical Journal (2021)

Li ZhuDylan JohnsonJoseph M. Chalovich

c-terminal basic residuespharmacologycell signalingbiophysics

Structure of the Shutdown State of Myosin-2. Biophysical Journal (2021)

Charlotte A. ScarffGlenn CarringtonDavid E. Casas-MaoJoseph M. ChalovichPeter J. KnightNeil A. RansonMichelle Peckham

biophysicsstructural biologyprotein structureshutdown statecell biologyphysiology

A High Ala Mutant of the C-Terminal Region of Human Cardiac Tnt Has a Large Impact on Regulation. Biophysical Journal (2020)

Dylan JohnsonLi ZhuMaicon Landim VieiraJ. Renato D. PintoJoseph M. Chalovich

biophysical chemistrybiophysical reviewmedical biophysicsbioenergeticshigh ala mutantprotein sciencebiophysical modelinglarge impactmorphological impactmolecular physiologymolecular biophysicsc-terminal regionstructural biologycardiologybiophysical aspecthuman cardiac tntmammalian biologybiophysicssignal transductionmolecular biologyexperimental biophysicsphysiology

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Joseph M. Chalovich

Distinguished Professor & Emeritus

East Carolina University

Affiliations

Brody School of Medicine

Biochemistry and Molecular Biology

Joseph M. Chalovich is currently serving as a Biochemistry And Molecular Biology Distinguished Professor & Emeritus at East Carolina University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Joseph M. Chalovich

East Carolina University

Distinguished Professor & Emeritus

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Steric Blocking Upside Down: A Different Way of Thinking About the Competition Between Myosin and Tropomyosin. Frontiers in Physics (2024)

Joseph M. Chalovich

Dual Thick and Thin Filament Linked Regulation of Stretch- and L-Name-Induced Tone in Young and Senescent Murine Basilar Artery. Frontiers in Physiology (2023)

Negative Charges Introduced Near the It Helix of Cardiac Troponin T Stabilize the Active State of Actin Filaments. Biochemistry (2023)

Li ZhuMaicon Landim-VieiraMichelle Rodriguez GarciaJose R. PintoJoseph M. Chalovich

negative chargesactin filamentsbiophysicsstructural biologyprotein structureactive statebiochemistrycell biologyprotein science

C-Terminal Basic Region of Troponin T Alters the Ca 2+ -Dependent Changes in Troponin I Interactions. Biochemistry (2022)

Li ZhuDylan JohnsonJoseph M. Chalovich

pharmacologypath dependencesignal transductionc-terminal basic regionbiochemical interactionbiochemistryimmunology

Hypertrophic Cardiomyopathy Mutations of Troponin Reveal Details of Striated Muscle Regulation. Frontiers in Physiology (2022)

J. M. ChalovichL. ZhuD. Johnson

geneticsstriated muscle regulationcardiologyneurosciencemolecular physiologyhypertrophic cardiomyopathy mutationscardiomyopathyhuman physiologyphysiology

Phosphomimetic Mutations in the C-Terminal Basic Region of Troponin T Increases Actin Filament Activity. Biophysical Journal (2022)

Li ZhuMaicon Landim-VieiraMichelle C. Rodriguez GarciaJ. Renato D. PintoJoseph M. Chalovich

geneticsactin filament activitybiophysicsstructural biologyc-terminal basic regionmolecular biologyphosphomimetic mutationsprotein sciencemolecular biophysics

Caldesmon Ablation in Mice Causes Umbilical Herniation and Alters Contractility of Fetal Urinary Bladder Smooth Muscle. The Journal of General Physiology (2021)

C-Terminal Basic Residues of Troponin T Facilitate Troponin I Transitions During Activation. Biophysical Journal (2021)

Li ZhuDylan JohnsonJoseph M. Chalovich

c-terminal basic residuespharmacologycell signalingbiophysics

Structure of the Shutdown State of Myosin-2. Biophysical Journal (2021)

Charlotte A. ScarffGlenn CarringtonDavid E. Casas-MaoJoseph M. ChalovichPeter J. KnightNeil A. RansonMichelle Peckham

biophysicsstructural biologyprotein structureshutdown statecell biologyphysiology

A High Ala Mutant of the C-Terminal Region of Human Cardiac Tnt Has a Large Impact on Regulation. Biophysical Journal (2020)

Dylan JohnsonLi ZhuMaicon Landim VieiraJ. Renato D. PintoJoseph M. Chalovich

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Similar Faculty Members

Earl Homsher

Institution

University of California, Los Angeles

molecular motor

non-muscle myosin iib

Christopher Yengo

Institution

Pennsylvania State University

molecular motor

mechanotransduction

Aldrin V. Gomes

Institution

University of California, Davis

protein homeostasis

metabolism

Jeffrey Moore

Institution

University of Massachusetts Lowell

muscle contraction

cellular motility

Sanford Bernstein

Institution

San Diego State University

human genetics

skeletal muscle

Jian-Ping Jin

Institution

Wayne State University

mechanical tension regulation

protein structure-function relationships

Carol C. Gregorio

Institution

University of Arizona

cardiac muscle

cellular physiology

James Spudich

Institution

Stanford University

molecular biology

cell biology

Clara Franzini-Armstrong

Institution

University of Pennsylvania

physiology

neuroscience

Jack Kaplan

Institution

University of Illinois Chicago

molecular biology

membrane protein