Faculty

Institution

Unit

Venue

Brad Nolen

Associate professor Chemistry and Biochemistry

University of Oregon

Affiliations

College of Arts and Sciences

Biochemistry

Chemistry and Biochemistry

Brad Nolen is currently serving as a Biochemistry Associate professor Chemistry and Biochemistry at University of Oregon.

Honors

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Experiences

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Education

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Brad Nolen

University of Oregon

Associate professor Chemistry and Biochemistry

You can click a keyword to filter the displayed items

molecular biology structural biology biophysics protein structure protein science biochemistry cell biology membrane biology structural molecular biology biomolecular structure cell signaling biological chemistry gene expression molecular cell biology yeast protein assembly cytoskeleton protein function signal transduction molecular regulation multi-protein assembly nucleation cell and molecular biology molecular structure enzyme inhibition biomolecular interactions crystal structures protein chemistry actin filaments actin cytoskeleton redox biology nucleic acids molecular physiology molecular docking catalyst activation protein x-ray crystallography biochemical interaction biological inorganic chemistry conformational studies functional modification molecular dynamics simulations small molecule inhibitors medicinal research cellular biochemistry biochemical sciences stem cell research cellular physiology heredity cell regulation protein phosphorylation functional regulation protein expression mechanisms of action molecular complexes structural bioinformatics x-ray crystallography supramolecular assemblies structure-function enzyme kinetics receptor tyrosine kinases signaling pathways receptor (biochemistry) cell fate determination neural stem cells coordination complex protein kinases activating conformational change biochemical characterization nucleation-promoting factor wasp-vca synergistic activation processive phosphorylation structural basis actin family proteins novel mechanism constitutive activity single-particle cryo-electron microscopy nucleation-competent state

Notable Scholarly Works

Notable Federal Grants

Collaborators

Arp2/3 Involvement in Intercellular Bridge Membrane Fluctuations and Constriction During Neural Stem Cell Divisions. iScience (2026)

stem cell researchcellular physiologycell fate determinationcell signalingneural stem cellsmolecular cell biologysignal transductioncellular differentiationneuroscienceneuronscell biology

Direct Actin Monomer Delivery is a Wasp-Specific Requirement for Arp2/3 Complex Activation. Journal of Molecular Biology (2026)

protein functioncytoskeletonmolecular cell biologystructural molecular biologymolecular biologyprotein science

Activation of Arp2/3 Complex by a Spin90 Dimer in Linear Actin-Filament Nucleation. Nature Structural & Molecular Biology (2025)

biophysicscytoskeletonprotein structurebiomolecular structuremolecular biologystructural molecular biologystructural biologymulti-protein assemblybiochemistry

Both Las17-Binding Sites on Arp2/3 Complex Are Important for Branching Nucleation and Assembly of Functional Endocytic Actin Networks in S. Cerevisiae. Journal of Biological Chemistry (2024)

arp2/3 complexlas17-binding sitesprotein assemblyprotein functioncytoskeletonprotein structuremolecular and cellular biologymolecular cell biologymolecular biologys. cerevisiaecell and molecular biologyprotein sciencemulti-protein assemblyprotein foldingcell biology

Abstract 1750: The C. Elegans Pvd Dendrite Branching Receptor Hpo-30 Regulates Actin Polymerization Through Two Distinct Mechanisms. Journal of Biological Chemistry (2023)

Daniel KramerHeidy Narvaez-OrtizRebecca ShiKang ShenJulien RocheBrad Nolen

functional modificationreceptorsgene expressionsignaling pathwaysbiomolecular interactionsdistinct mechanismscell signalinggeneticsmolecular regulationreceptor (biochemistry)molecular biologybiological chemistrysignal transductionprotein sciencemembrane biologymolecular physiologybiochemistry

Improved Analysis of Cross-Linking Mass Spectrometry Data With Kojak 2.0, Advanced by Integration Into the Trans-Proteomic Pipeline. Journal of Proteome Research (2023)

Michael R. HoopmannDavid D. ShteynbergAlex ZelterMichael RiffleAndrew S. LyonDavid A. AgardQing LuanBrad J. NolenMichael J. MacCossTrisha N. DavisRobert L. Moritz

proteomicsdata integrationtrans-proteomic pipelinedata sciencemass spectrometry

Molecular Dynamics Simulations Support a Multistep Pathway for Activation of Branched Actin Filament Nucleation by Arp2/3 Complex. Journal of Biological Chemistry (2023)

Yuvraj SinghGlen M. HockyBrad J. Nolen

multistep pathwaymolecular dynamics simulationsbiophysicsmolecular biologystructural biologycell biology

The Intrinsically Disordered Cytoplasmic Tail of a Dendrite Branching Receptor Uses Two Distinct Mechanisms to Regulate the Actin Cytoskeleton. eLife (2023)

Daniel A KramerHeidy Y Narvaez-OrtizUrval PatelRebecca ShiKang ShenBrad J NolenJulien RocheBaoyu Chen

actin cytoskeletondistinct mechanismsgeneticsdisordered cytoplasmic taildendrite branching receptormembrane biologystructural biologyprotein scienceneuroscienceneuroanatomycell biology

Analysis of Functional Surfaces on the Actin Nucleation Promoting Factor Dip1 Required for Arp2/3 Complex Activation and Endocytic Actin Network Assembly. Journal of Biological Chemistry (2022)

Su-Ling LiuHeidy Y. Narvaez-OrtizMatt MinerJack KiemelNicholas OberhelmanApril WattAndrew R. WagnerQing LuanLuke A. HelgesonBrad J. Nolen

biophysical chemistryprotein assemblyprotein chemistryprotein functionredox biologybiological inorganic chemistrymolecular biologybiological chemistrycell and molecular biologyactin nucleationstructural biologyprotein sciencemembrane biologybiochemistrycell biology

Structure of Arp2/3 Complex at a Branched Actin Filament Junction Resolved by Single-Particle Cryo-Electron Microscopy. Proceedings of the National Academy of Sciences (2022)

Bojian DingHeidy Y. Narvaez-OrtizYuvraj SinghGlen M. HockySaikat ChowdhuryBrad J. Nolen

biophysicsprotein structuremolecular structurebiomolecular structuresingle-particle cryo-electron microscopymolecular biologymicroscopystructural biologycrystallographycell biology

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Brad Nolen

Associate professor Chemistry and Biochemistry

University of Oregon

Affiliations

College of Arts and Sciences

Biochemistry

Chemistry and Biochemistry

Brad Nolen is currently serving as a Biochemistry Associate professor Chemistry and Biochemistry at University of Oregon.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Brad Nolen

University of Oregon

Associate professor Chemistry and Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Arp2/3 Involvement in Intercellular Bridge Membrane Fluctuations and Constriction During Neural Stem Cell Divisions. iScience (2026)

stem cell researchcellular physiologycell fate determinationcell signalingneural stem cellsmolecular cell biologysignal transductioncellular differentiationneuroscienceneuronscell biology

Direct Actin Monomer Delivery is a Wasp-Specific Requirement for Arp2/3 Complex Activation. Journal of Molecular Biology (2026)

protein functioncytoskeletonmolecular cell biologystructural molecular biologymolecular biologyprotein science

Activation of Arp2/3 Complex by a Spin90 Dimer in Linear Actin-Filament Nucleation. Nature Structural & Molecular Biology (2025)

biophysicscytoskeletonprotein structurebiomolecular structuremolecular biologystructural molecular biologystructural biologymulti-protein assemblybiochemistry

Both Las17-Binding Sites on Arp2/3 Complex Are Important for Branching Nucleation and Assembly of Functional Endocytic Actin Networks in S. Cerevisiae. Journal of Biological Chemistry (2024)

Abstract 1750: The C. Elegans Pvd Dendrite Branching Receptor Hpo-30 Regulates Actin Polymerization Through Two Distinct Mechanisms. Journal of Biological Chemistry (2023)

Daniel KramerHeidy Narvaez-OrtizRebecca ShiKang ShenJulien RocheBrad Nolen

Improved Analysis of Cross-Linking Mass Spectrometry Data With Kojak 2.0, Advanced by Integration Into the Trans-Proteomic Pipeline. Journal of Proteome Research (2023)

Michael R. HoopmannDavid D. ShteynbergAlex ZelterMichael RiffleAndrew S. LyonDavid A. AgardQing LuanBrad J. NolenMichael J. MacCossTrisha N. DavisRobert L. Moritz

proteomicsdata integrationtrans-proteomic pipelinedata sciencemass spectrometry

Molecular Dynamics Simulations Support a Multistep Pathway for Activation of Branched Actin Filament Nucleation by Arp2/3 Complex. Journal of Biological Chemistry (2023)

Yuvraj SinghGlen M. HockyBrad J. Nolen

multistep pathwaymolecular dynamics simulationsbiophysicsmolecular biologystructural biologycell biology

The Intrinsically Disordered Cytoplasmic Tail of a Dendrite Branching Receptor Uses Two Distinct Mechanisms to Regulate the Actin Cytoskeleton. eLife (2023)

Daniel A KramerHeidy Y Narvaez-OrtizUrval PatelRebecca ShiKang ShenBrad J NolenJulien RocheBaoyu Chen

actin cytoskeletondistinct mechanismsgeneticsdisordered cytoplasmic taildendrite branching receptormembrane biologystructural biologyprotein scienceneuroscienceneuroanatomycell biology

Analysis of Functional Surfaces on the Actin Nucleation Promoting Factor Dip1 Required for Arp2/3 Complex Activation and Endocytic Actin Network Assembly. Journal of Biological Chemistry (2022)

Su-Ling LiuHeidy Y. Narvaez-OrtizMatt MinerJack KiemelNicholas OberhelmanApril WattAndrew R. WagnerQing LuanLuke A. HelgesonBrad J. Nolen

Structure of Arp2/3 Complex at a Branched Actin Filament Junction Resolved by Single-Particle Cryo-Electron Microscopy. Proceedings of the National Academy of Sciences (2022)

Bojian DingHeidy Y. Narvaez-OrtizYuvraj SinghGlen M. HockySaikat ChowdhuryBrad J. Nolen

biophysicsprotein structuremolecular structurebiomolecular structuresingle-particle cryo-electron microscopymolecular biologymicroscopystructural biologycrystallographycell biology

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actin binding proteins

protein structure

Emil Reisler

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University of California, Los Angeles

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structural biology

Elisar J. Barbar

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molecular biology

nuclear magnetic resonance spectroscopy

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