Faculty

Institution

Unit

Venue

Biff Forbush

Professor Emeritus of Cellular And Molecular Physiology

Yale University

Affiliations

Cellular & Molecular Physiology

Biff Forbush is currently serving as a Cellular & Molecular Physiology Professor Emeritus of Cellular And Molecular Physiology at Yale University.

Honors

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Experiences

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Education

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Biff Forbush

Yale University

Professor Emeritus of Cellular And Molecular Physiology

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membrane biology molecular biology biochemistry protein science pharmacology physiology biological chemistry molecular physiology enzymes protein transport gene expression redox biology nephrology liver physiology signal transduction cellular physiology na-k-cl cotransporter cell signaling animal physiology membrane transport endocrinology vascular biology enzyme inhibition mammalian biology renal function structural biology cell physiology fish biology tissue physiology molecular regulation applied physiology cell regulation biochemical sciences protein function shark rectal gland avian biology protein phosphorylation protein chemistry cellular biology osmoregulation renal pathophysiology functional expression occluded state molecular cell biology path dependence key site biological inorganic chemistry translational physiology mammalian physiology ion transport rapid release medicinal research biochemical genetics protein biosynthesis neurochemistry charge transport membrane characterization intracellular trafficking cell trafficking neurotransmission vestibular system bumetanide-sensitive na-k-cl cotransporter molecular cloning k-cl cotransporter monoclonal antibodies na-k-cl cotransport protein renal na-k-cl cotransporter na-k-cl cotransporters bumetanide binding alternative splice variants structural basis human physiology cellular regulatory mechanism renal care translational pharmacology receptor (biochemistry) protein secretion protein structure

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structural Bases for Na+-CL− Cotransporter Inhibition by Thiazide Diuretic Drugs and Activation by Kinases. Nature Communications (2024)

Yongxiang ZhaoHeidi SchubertAlan BlakelyBiff ForbushMicholas Dean SmithJesse RinehartErhu Cao

thiazide diuretic drugsprotein sciencestructural basespeptide sciencemolecular dockingmedicinal chemistrybiochemistrymolecular biologymolecular pharmacologydrug discoveryenzyme inhibitionbiomolecular engineering

Structural Basis for Inhibition of the Cation-Chloride Cotransporter Nkcc1 by the Diuretic Drug Bumetanide. Nature Communications (2022)

Yongxiang ZhaoKasturi RoyPietro VidossichLaura CanceddaMarco De VivoBiff ForbushErhu Cao

drug deliverypharmaceutical chemistrystructural basispharmaceutical sciencesdiuretic drug bumetanidemedicinal chemistrybiochemistrymolecular biologypharmacologymolecular pharmacologydrug discoveryreceptors

The Structural Basis of Function and Regulation of Neuronal Cotransporters Nkcc1 and Kcc2. Communications Biology (2021)

Sensen ZhangJun ZhouYuebin ZhangTianya LiuPerrine FriedelWei ZhuoSuma SomasekharanKasturi RoyLaixing ZhangYang LiuXianbin MengHaiteng DengWenwen ZengGuohui LiBiff ForbushMaojun Yang

physiologyprotein sciencecell signalingredox biologyneurosciencecell traffickingintracellular traffickingmembrane biologyneurophysiologypharmacologyneuronal cotransportersstructural basisneurotransmissiongene expressionreceptorsmolecular regulationneurotransmitters

Photolysis Quantum Yield Measurements in the Near-Uv; a Critical Analysis of 1-(2-Nitrophenyl)Ethyl Photochemistry. Photochemical & Photobiological Sciences (2016)

John E. T. CorrieJack H. KaplanBiff ForbushDavid C. OgdenDavid R. Trentham

photochemistrycritical analysismaterials science

Commentary on “Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for Ultraviolet‐a‐Induced Photouncaging” by G. Gasser and Co‐Workers. ChemPhysChem (2015)

John E. T. CorrieJack H. KaplanBiff ForbushDavid C. OgdenDavid R. Trentham

caged phosphatequantum yieldsphotochemistrychemistryultraviolet-a-induced photouncagingmaterials science

Molecular Motions Involved in Na-K-CL Cotransporter-Mediated Ion Transport and Transporter Activation Revealed by Internal Cross-Linking Between Transmembrane Domains 10 and 11/12. Journal of Biological Chemistry (2014)

Michelle Y. MonetteSuma SomasekharanBiff Forbush

molecular motionsprotein sciencemembrane transportinternal cross-linkingbiochemistrymolecular biophysicsmembrane biologychemical biologymembranespharmacologymolecular biologybiological chemistryprotein transporttransporter activationredox biologystructural biologybiological inorganic chemistry

Functional Expression of Human Nkcc1 From a Synthetic Cassette-Based Cdna: Introduction of Extracellular Epitope Tags and Removal of Cysteines. PLoS ONE (2013)

Suma SomasekharanMichelle Y. MonetteBiff Forbush

inflammationextracellular epitope tagsphysiologyprotein scienceprotein functionmembrane biologytranscription (biology)molecular biologyfunctional regulationgene expressionenzyme inhibitionsynthetic cassette-based cdnageneticsfunctional expression

Loop Diuretic and Ion-Binding Residues Revealed by Scanning Mutagenesis of Transmembrane Helix 3 (Tm3) of Na-K-CL Cotransporter (Nkcc1). Journal of Biological Chemistry (2012)

Suma SomasekharanJessica TanisBiff Forbush

structural molecular biologyenzymesprotein chemistryprotein sciencecell biologymembrane proteinsna-k-cl cotransporterbiochemistrymembrane biologyprotein transportmolecular biologybiological chemistryprotein structureion-binding residuesredox biologystructural biologybiological inorganic chemistry

Regulatory Activation is Accompanied by Movements in the Cterminus of the Na‐K‐CL Cotransporter (Nkcc1). The FASEB Journal (2012)

Michelle Y MonetteBiff Forbush

physiologycell signalingregulatory activationcell biologyneurosciencemolecular physiologymembrane biologyprotein transportsignal transductioncell regulationna-k-cl cotransporter

Rare Mutations in the Human Na-K-CL Cotransporter (Nkcc2) Associated With Lower Blood Pressure Exhibit Impaired Processing and Transport Function. American Journal of Physiology-Renal Physiology (2011)

Michelle Y. MonetteJesse RinehartRichard P. LiftonBiff Forbush

liver physiologypharmacologygeneticsvascular biologytransport functionnephrologyphysiologyapplied physiologycardiovascular physiologymembrane transporttranslational medicinetranslational physiologyendocrinologycardiovascular researchrare mutationselectrophysiologymolecular physiologymembrane biologyclinical physiologyblood pressurehuman na-k-cl cotransporter

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Biff Forbush

Professor Emeritus of Cellular And Molecular Physiology

Yale University

Affiliations

Cellular & Molecular Physiology

Biff Forbush is currently serving as a Cellular & Molecular Physiology Professor Emeritus of Cellular And Molecular Physiology at Yale University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Biff Forbush

Yale University

Professor Emeritus of Cellular And Molecular Physiology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structural Bases for Na+-CL− Cotransporter Inhibition by Thiazide Diuretic Drugs and Activation by Kinases. Nature Communications (2024)

Yongxiang ZhaoHeidi SchubertAlan BlakelyBiff ForbushMicholas Dean SmithJesse RinehartErhu Cao

Structural Basis for Inhibition of the Cation-Chloride Cotransporter Nkcc1 by the Diuretic Drug Bumetanide. Nature Communications (2022)

Yongxiang ZhaoKasturi RoyPietro VidossichLaura CanceddaMarco De VivoBiff ForbushErhu Cao

The Structural Basis of Function and Regulation of Neuronal Cotransporters Nkcc1 and Kcc2. Communications Biology (2021)

Sensen ZhangJun ZhouYuebin ZhangTianya LiuPerrine FriedelWei ZhuoSuma SomasekharanKasturi RoyLaixing ZhangYang LiuXianbin MengHaiteng DengWenwen ZengGuohui LiBiff ForbushMaojun Yang

Photolysis Quantum Yield Measurements in the Near-Uv; a Critical Analysis of 1-(2-Nitrophenyl)Ethyl Photochemistry. Photochemical & Photobiological Sciences (2016)

John E. T. CorrieJack H. KaplanBiff ForbushDavid C. OgdenDavid R. Trentham

photochemistrycritical analysismaterials science

Commentary on “Caged Phosphate and the Slips and Misses in Determination of Quantum Yields for Ultraviolet‐a‐Induced Photouncaging” by G. Gasser and Co‐Workers. ChemPhysChem (2015)

John E. T. CorrieJack H. KaplanBiff ForbushDavid C. OgdenDavid R. Trentham

caged phosphatequantum yieldsphotochemistrychemistryultraviolet-a-induced photouncagingmaterials science

Michelle Y. MonetteSuma SomasekharanBiff Forbush

Functional Expression of Human Nkcc1 From a Synthetic Cassette-Based Cdna: Introduction of Extracellular Epitope Tags and Removal of Cysteines. PLoS ONE (2013)

Suma SomasekharanMichelle Y. MonetteBiff Forbush

Loop Diuretic and Ion-Binding Residues Revealed by Scanning Mutagenesis of Transmembrane Helix 3 (Tm3) of Na-K-CL Cotransporter (Nkcc1). Journal of Biological Chemistry (2012)

Suma SomasekharanJessica TanisBiff Forbush

Regulatory Activation is Accompanied by Movements in the Cterminus of the Na‐K‐CL Cotransporter (Nkcc1). The FASEB Journal (2012)

Michelle Y MonetteBiff Forbush

physiologycell signalingregulatory activationcell biologyneurosciencemolecular physiologymembrane biologyprotein transportsignal transductioncell regulationna-k-cl cotransporter

Michelle Y. MonetteJesse RinehartRichard P. LiftonBiff Forbush

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cell biology

membrane biology

Walter Boron

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Case Western Reserve University

membrane transport

gas exchange process

William Guggino

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Johns Hopkins University

membrane biology

cell biology

Eric Delpire

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neuroscience

nervous system

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molecular biology

membrane protein

Ernest Wright

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molecular metabolism

membrane transport

Mark Donowitz

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pharmacology

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membrane transport

electrophysiology

Bruce A. Stanton

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infectious diseases

clinical microbiology

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proteome research

molecular and cellular biology