Faculty

Institution

Unit

Venue

Antje Schaefer

Assistant Professor

Medical College of Wisconsin

Affiliations

Departments of Pharmacology and Toxicology

Antje Schaefer is currently serving as a Departments Of Pharmacology And Toxicology Assistant Professor at Medical College of Wisconsin.

Honors

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Experiences

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Education

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Antje Schaefer

Medical College of Wisconsin

Assistant Professor

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cancer research cell biology cancer biology oncology tumor biology oncogenes molecular biology immunology pharmacology molecular cancer medicinal research cancer genetics cancer growth gene expression cancer genomics carcinogenesis vascular biology cell signaling diffuse gastric cancer cancer cells signal transduction cell research enzyme inhibition tumor suppressors cell adhesion therapeutic targets cellular therapy cellular physiology signaling pathways cell migration cancer treatment cell regulation cancer care plant physiology plant science biochemical sciences liver physiology anti-cancer agents colorectal cancer histocompatibility pancreatic cancer mutagenesis oncogenic agent neutrophil transmigration cancer discovery cell death cancer risk tumor targeting mechanotransduction apoptosis enzyme specificity plant biology angiogenesis cell interactions cellular biology functional regulation biochemical genetics cancer disparities cancer prevention neck oncology immune dysregulation molecular immunology leukocyte transendothelial migration raf-mek-erk cascade low-dose vertical inhibition kras mutant cancers apoptotic death local activation rhogtpase specificity cytoskeletal dynamics rho proteins functional cycle endothelial junctions trio-based signaling local ve-cadherin actin-binding proteins ras gtpases pathology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract B083: Defining a Molecular Basis and Therapeutic Approach for Keap1-Nrf2 Mediated Resistance to Kras Inhibition in Kras-Mutant Pancreatic Ductal Adenocarcinoma. Cancer Research (2025)

cancer biologymolecular cancercancer cellsmolecular basisoncogenesmolecular medicinecancer researchabstract b083systems biologycarcinogenesiscell biologykras inhibitionpancreatic cancer

Rap1-Rho Small Gtpase Cross-Talk Mediates Integrin-Dependent and -Independent Platelet Procoagulant Response. bioRxiv (Cold Spring Harbor Laboratory) (2025)

pathologyblood plateletthrombosishemostasiscell signalingblood vesselsvascular biologycell biologyhematology

Determining the Erk-Regulated Phosphoproteome Driving Kras-Mutant Cancer. UNC Libraries (2024)

Klomp, Jennifer EDiehl, J NathanielKlomp, Jeffrey AEdwards, A ColeYang, RunyingMorales, Alexis JTaylor, Khalilah EDrizyte-Miller, KristinaBryant, Kirsten LSchaefer, AntjeJohnson, Jared LHuntsman, Emily MYaron, Tomer MPierobon, MariaelenaBaldelli, ElisaPrevatte, Alex WBarker, Natalie KHerring, Laura EPetricoin, Emanuel FGraves, Lee MCantley, Lewis CCox, Adrienne DDer, Channing JStalnecker, Clint A

cell regulationgeneticscancer biologymembrane biologymolecular cancercancer researchcancer genomicstumor biologypharmacologykras-mutant cancergene expressiononcologyclinical proteomicscancer geneticsoncogenesenzyme inhibitionmolecular biologymedicinal researchcancer growth

Recurrent Rhogap Gene Fusion Cldn18-Arhgap26 Promotes Rhoa Activation and Focal Adhesion Kinase and Yap-Tead Signalling in Diffuse Gastric Cancer. Gut (2024)

Feifei ZhangVarun SahuKe PengYichen WangTianxia LiPratyusha BalaDaulet AitymbayevPranshu SahgalAntje SchaeferChanning J DerSandra RyeomSam YoonNilay SethiAdam J BassHaisheng Zhang

geneticspharmacologyhepatologycancer biologyfocal adhesion kinasegene therapyyap-tead signallingcancer researchhost factorsoncologycancer genomicsmolecular biologycancer geneticstumor biologymedicinal researchmolecular regulationdiffuse gastric cancer

Rhoa Drives the Development of Diffuse Gastric Cancer Through Igf1R-Pak1-Yap1 Signaling. Sci Signal (2024)

gastrointestinal oncologypathologycancer biologytumor suppressorscancer cellsoncogenesigf1r-pak1-yap1 signalingcancer researchoncologymolecular gastroenterologytumor biologycarcinogenesiscell biologydiffuse gastric cancercancer growth

Data From Aberrant Expression and Subcellular Localization of Ect2 Drives Colorectal Cancer Progression and Growth. (2023)

Danielle R. CookMelissa KangTimothy D. MartinJoseph A. GalankoGabriela H. LoezaDimitri G. TrembathVerline JustilienKaren A. PickeringDavid F. VincentArmin JaroschPhilipp JurmeisterAndrew M. WatersPriya S. HibshmanAndrew D. CampbellCatriona A. FordTemitope O. KekuJen Jen YehMichael S. LeeAdrienne D. CoxAlan P. FieldsRobert S. SandlerOwen J. SansomChristine SersAntje SchaeferChanning J. Der

geneticsurologyhepatologycancer biologyaberrant expressiongene expressiononcogenesgenitourinary cancerscancer researchcolorectal canceroncologysubcellular localizationcancer geneticsdermatologycarcinogenesisvascular biologycancer growth

Data From Concurrent Inhibition of Erk and Farnesyltransferase Suppresses the Growth of Hras Mutant Head and Neck Squamous Cell Carcinoma. (2023)

Sehrish JavaidAntje SchaeferCraig M. GoodwinVictoria V. NguyenFrances L. MasseyMariaelena PierobonDa'Jhnae Gambrell-SandersAndrew M. WatersKathryn N. LambertJ. Nathaniel DiehlG. Aaron HobbsKris C. WoodEmanuel F. PetricoinChanning J. DerAdrienne D. Cox

anti-cancer agentscell biologymolecular cancercancer researchtumor biologypharmacologytumor suppressorscancer treatmentoncogenic agentoncologycellular therapycancer immunotherapyoncogenesconcurrent inhibitionenzyme inhibitionradiation oncologyhras mutant headmedicinal researchtherapeutic targetscancer growth

Data From Gain-Of-Function I Rhoa /I Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer. (2023)

Haisheng ZhangAntje SchaeferYichen WangRichard G. HodgeDevon R. BlakeJ. Nathaniel DiehlAlex G. PapageorgeMatthew D. StachlerJennifer LiaoJin ZhouZhong WuFahire G. AkarcaLeonie K. de KlerkSarah DerksMariaelena PierobonKatherine A. HoadleyTimothy C. WangGeorge ChurchKwok-Kin WongEmanuel F. PetricoinAdrienne D. CoxDouglas R. LowyChanning J. DerAdam J. Bass

pathologycancer biologymolecular cancercancer researchcancer genomicstumor biologypharmacologymolecular cell biologygene expressioncell adhesiononcologycancer geneticsdiffuse gastric cancercancer immunotherapyoncogenesenzyme inhibitionmolecular biologymedicinal researchcancer growth

Functional and Biological Heterogeneity of Kras Mutations. Sci Signal (2023)

geneticsmolecular cell biologymutagenesismolecular geneticsgenomicsgenome biologygene evolutionkras mutationsmutagenesis (molecular biology technique)

Rhoa L57V Drives the Development of Diffuse Gastric Cancer Through Igf1R-Pak1-Yap1 Signaling. Science Signaling (2023)

Antje SchaeferRichard G. HodgeHaisheng ZhangG. Aaron HobbsJulien DillyMinh V. HuynhCraig M. GoodwinFeifei ZhangJ. Nathaniel DiehlMariaelena PierobonElisa BaldelliSehrish JavaidKarson GuthrieNaim U. RashidEmanuel F. PetricoinAdrienne D. CoxWilliam C. HahnAndrew J. AguirreAdam J. BassChanning J. Der

geneticspharmacologybiologycancer biologygene expressionsignal transductiononcogenescancer researchoncologycancer genomicscell regulationcell signalingsignaling pathwaysmedicinal researchexperimental medicinediffuse gastric cancercancer growth

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Antje Schaefer

Assistant Professor

Medical College of Wisconsin

Affiliations

Departments of Pharmacology and Toxicology

Antje Schaefer is currently serving as a Departments Of Pharmacology And Toxicology Assistant Professor at Medical College of Wisconsin.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Antje Schaefer

Medical College of Wisconsin

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract B083: Defining a Molecular Basis and Therapeutic Approach for Keap1-Nrf2 Mediated Resistance to Kras Inhibition in Kras-Mutant Pancreatic Ductal Adenocarcinoma. Cancer Research (2025)

cancer biologymolecular cancercancer cellsmolecular basisoncogenesmolecular medicinecancer researchabstract b083systems biologycarcinogenesiscell biologykras inhibitionpancreatic cancer

Rap1-Rho Small Gtpase Cross-Talk Mediates Integrin-Dependent and -Independent Platelet Procoagulant Response. bioRxiv (Cold Spring Harbor Laboratory) (2025)

pathologyblood plateletthrombosishemostasiscell signalingblood vesselsvascular biologycell biologyhematology

Determining the Erk-Regulated Phosphoproteome Driving Kras-Mutant Cancer. UNC Libraries (2024)

Recurrent Rhogap Gene Fusion Cldn18-Arhgap26 Promotes Rhoa Activation and Focal Adhesion Kinase and Yap-Tead Signalling in Diffuse Gastric Cancer. Gut (2024)

Feifei ZhangVarun SahuKe PengYichen WangTianxia LiPratyusha BalaDaulet AitymbayevPranshu SahgalAntje SchaeferChanning J DerSandra RyeomSam YoonNilay SethiAdam J BassHaisheng Zhang

Rhoa Drives the Development of Diffuse Gastric Cancer Through Igf1R-Pak1-Yap1 Signaling. Sci Signal (2024)

Data From Aberrant Expression and Subcellular Localization of Ect2 Drives Colorectal Cancer Progression and Growth. (2023)

Data From Concurrent Inhibition of Erk and Farnesyltransferase Suppresses the Growth of Hras Mutant Head and Neck Squamous Cell Carcinoma. (2023)

Data From Gain-Of-Function I Rhoa /I Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer. (2023)

Functional and Biological Heterogeneity of Kras Mutations. Sci Signal (2023)

geneticsmolecular cell biologymutagenesismolecular geneticsgenomicsgenome biologygene evolutionkras mutationsmutagenesis (molecular biology technique)

Rhoa L57V Drives the Development of Diffuse Gastric Cancer Through Igf1R-Pak1-Yap1 Signaling. Science Signaling (2023)

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cardiovascular disease

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cancer letter

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University of North Carolina at Chapel Hill

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