Faculty

Institution

Unit

Venue

Adrienne Cox

Professor

University of North Carolina at Chapel Hill

Affiliations

School of Medicine

Pharmacology

Adrienne Cox is currently serving as a Pharmacology Professor at University of North Carolina At Chapel Hill.

Honors

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Experiences

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Education

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Adrienne Cox

University of North Carolina at Chapel Hill

Professor

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molecular biology pharmacology cancer research oncology tumor biology medicinal research cancer biology cell biology oncogenes cell signaling cancer treatment biochemistry molecular cancer enzyme inhibition cancer genetics signal transduction pancreatic cancer cancer care cancer cells gene expression protein science cell regulation cellular therapy tumor targeting cancer genomics drug discovery cancer discovery molecular and cellular biology molecular cell biology cell death pharmacotherapy signaling pathways biological chemistry cancer growth anti-cancer agents molecular physiology cancer management leukemia drug targeting radiation biology redox biology cellular biology kras-mutant pancreatic cancer farnesyltransferase inhibitors apoptosis intracellular trafficking g protein-coupled receptor protein expression molecular regulation therapeutic efficacy functional modification drug development tumor suppressors enzyme specificity protein phosphorylation redox signaling receptor tyrosine kinases cell migration malignant disease oncogenic agent hematological malignancies transforming activity oncogenic ras key site endoplasmic reticulum protein prenylation extracellular signal-regulated kinase tumor growth ras inhibitors prenylation signal sequences anti-cancer drugs mammalian cells raf inhibitor paradox undruggable ras ras history isoprenoid addition lipid modification carcinogenesis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1936: Keap1-Nrf2 Mediated Resistance Against Krasg12D Inhibitor in Pancreatic Ductal Adenocarcinoma. Cancer Research (2024)

Wen-Hsuan ChangAddison G. StameyAndrew M. WatersKirsten L. BryantAdrienne D. CoxChanning J. Der

immunologydisease progressiondermatologypancreatic ductal adenocarcinomapharmacologycancer immunotherapyenzyme inhibitioncancer researchcancer treatmentoncogenesmedicinal researchcellular therapydrug resistancecancer carecancer biologytumor targetingclinical researchcancer geneticsoncology

Abstract 4588: Combination of Mta-Cooperative Prmt5 Inhibitor and Direct Mutant-Selective Kras Inhibitors as a Novel Therapeutic Approach for Mtap-Deficient Pancreatic Cancer. Cancer Research (2024)

Kristina Drizyte-MillerWen-Hsuan ChangAndrew M. WatersClint A. StalneckerJunning WangAndrew J. AguirreAdrienne D. CoxChanning J. Der

cancer discoverypharmacologycancer researchcancer geneticspancreatic cancerdrug discoverycancer treatmentreceptorshealth sciencesradiation oncologymedicinal researchmolecular cancermedicinal chemistrycancer carecancer managementtumor targetingmtap-deficient pancreatic cancerenzyme inhibitiononcology

Abstract C026: Concurrent Inhibition of the Ras Erk-Mapk Pathway and Pikfyve as a Therapeutic Strategy for Pancreatic Cancer. Cancer Research (2024)

Jonathan M DeLibertyMallory K RoachClint A StalneckerRyan RobbElyse G SchechterNoah L PieperRunying YangScott BangKhalilah E TaylorKristina Drizyte-MillerJohn P MorrisChanning J DerAdrienne D CoxKirsten L Bryant

therapeutic strategycancer researchpancreatic cancerconcurrent inhibitionras erk-mapk pathway

Abstract C047: Improving the Efficacy of Dual Erk-Mapk and Autophagy Inhibition as a Therapeutic Strategy for Pancreatic Ductal Adenocarcinoma. Cancer Research (2024)

Jonathan M. DeLibertyMallory K. RoachNoah L. PieperKristina Drizyte-MillerElyse G. SchechterRunying YangChanning J. DerAdrienne D. CoxClint A. StalneckerKirsten L. Bryant

pancreatic ductal adenocarcinomaautophagypharmacologycancer immunotherapycancer researchcancer treatmenthealth sciencestherapeutic strategyradiation oncologymedicinal researchmolecular cancercancer carecancer managementcancer biologyautophagy inhibitionmetastasisliver cancerdual erk-mapkhepatologyleukemiacancer geneticsoncology

Defining the Kras- and Erk-Dependent Transcriptome in Kras-Mutant Cancers. UNC Libraries (2024)

Klomp, Jeffrey AKlomp, Jennifer EStalnecker, Clint ABryant, Kirsten LEdwards, A ColeDrizyte-Miller, KristinaHibshman, Priya SDiehl, J NathanielLee, Ye SMorales, Alexis JTaylor, Khalilah EPeng, SenTran, Nhan LHerring, Laura EPrevatte, Alex WBarker, Natalie KHover, Laura DHallin, JillChowdhury, SaikatCoker, OluwadaraLee, Hey MinGoodwin, Craig MGautam, PrsonOlson, PeterChristensen, James GShen, John PKopetz, ScottGraves, Lee MLim, Kian-HuatWang-Gillam, AndreaWennerberg, KristerCox, Adrienne DDer, Channing J

pathologygeneticstumor biologygenomicskras-mutant cancersmolecular biologygene expressiononcogenesmedicinal researchmolecular cancerrna biologycancer biologygenome biologyerk-dependent transcriptomeoncologygene functioncancer geneticscancer genomicstranscriptome

Determining the Erk-Regulated Phosphoproteome Driving Kras-Mutant Cancer. UNC Libraries (2024)

Klomp, Jennifer EDiehl, J NathanielKlomp, Jeffrey AEdwards, A ColeYang, RunyingMorales, Alexis JTaylor, Khalilah EDrizyte-Miller, KristinaBryant, Kirsten LSchaefer, AntjeJohnson, Jared LHuntsman, Emily MYaron, Tomer MPierobon, MariaelenaBaldelli, ElisaPrevatte, Alex WBarker, Natalie KHerring, Laura EPetricoin, Emanuel FGraves, Lee MCantley, Lewis CCox, Adrienne DDer, Channing JStalnecker, Clint A

pharmacologygeneticstumor biologyenzyme inhibitioncancer researchmolecular biologygene expressiononcogenesmedicinal researchmolecular cancercell regulationcancer biologykras-mutant cancermembrane biologycancer growthclinical proteomicscancer geneticscancer genomicsoncology

Kras Takes the Road to Destruction. Science (2024)

Adrienne D. CoxChanning J. Der

earth scienceastronomyspace scienceplanetary scienceplanetary sciences

“Undruggable Kras”: Druggable After All. Genes & Development (2024)

Adrienne D. CoxChanning J. Der

drug safetyundruggable kraspharmacologytherapeutic targetsdrug intolerancemolecular biologydrug discoverypharmacotherapysubstance use disordersmedicinal researchdrug resistancefuture medicinal chemistryapplied pharmacologyaddiction medicinepharmacokineticsmedicineorphan drugsmolecular pharmacologydrug treatment

Abstract 1075: Identification of Resistance Mechanisms to Direct Kras Inhibition in Pancreatic Cancer. Cancer Research (2023)

Andrew Michael WatersWen-Hsuan ChangClint StalneckerCole EdwardsRunying YangCraig M. GoodwinAdrienne D. CoxChanning J. Der

pharmacologyvascular biologytumor biologycancer immunotherapycancer researchpancreatic cancercancer treatmentoncogenesradiation oncologymedicinal researchkras inhibitionresistance mechanismscancer carecancer biologyneurologymolecular physiologyclinical researchcancer geneticscancer genomicsoncology

Abstract B009: Tead Inhibition Overcomes Yap1/Taz-Driven Resistance to Ras Inhibitors in Krasg12C-Mutant Cancers. Molecular Cancer Research (2023)

Alexander C. EdwardsClint A. StalneckerAlexis J. MoralesKhalilah E. TaylorJill HallinPeter OlsonTracy T. TangLars EngstromLeonard PostJames G. ChristensenAdrienne D. CoxChanning J. Der

anti-cancer agentscancer discoverypharmacologytumor biologycancer immunotherapyenzyme inhibitioncancer researchmolecular biologycancer treatmentoncogenesradiation oncologytead inhibitionmedicinal researchmolecular cancerdrug resistancecancer biologytumor targetingcancer geneticsoncology

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Adrienne Cox

Professor

University of North Carolina at Chapel Hill

Affiliations

School of Medicine

Pharmacology

Adrienne Cox is currently serving as a Pharmacology Professor at University of North Carolina At Chapel Hill.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Adrienne Cox

University of North Carolina at Chapel Hill

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1936: Keap1-Nrf2 Mediated Resistance Against Krasg12D Inhibitor in Pancreatic Ductal Adenocarcinoma. Cancer Research (2024)

Wen-Hsuan ChangAddison G. StameyAndrew M. WatersKirsten L. BryantAdrienne D. CoxChanning J. Der

Kristina Drizyte-MillerWen-Hsuan ChangAndrew M. WatersClint A. StalneckerJunning WangAndrew J. AguirreAdrienne D. CoxChanning J. Der

Abstract C026: Concurrent Inhibition of the Ras Erk-Mapk Pathway and Pikfyve as a Therapeutic Strategy for Pancreatic Cancer. Cancer Research (2024)

therapeutic strategycancer researchpancreatic cancerconcurrent inhibitionras erk-mapk pathway

Abstract C047: Improving the Efficacy of Dual Erk-Mapk and Autophagy Inhibition as a Therapeutic Strategy for Pancreatic Ductal Adenocarcinoma. Cancer Research (2024)

Jonathan M. DeLibertyMallory K. RoachNoah L. PieperKristina Drizyte-MillerElyse G. SchechterRunying YangChanning J. DerAdrienne D. CoxClint A. StalneckerKirsten L. Bryant

Defining the Kras- and Erk-Dependent Transcriptome in Kras-Mutant Cancers. UNC Libraries (2024)

Determining the Erk-Regulated Phosphoproteome Driving Kras-Mutant Cancer. UNC Libraries (2024)

Kras Takes the Road to Destruction. Science (2024)

Adrienne D. CoxChanning J. Der

earth scienceastronomyspace scienceplanetary scienceplanetary sciences

“Undruggable Kras”: Druggable After All. Genes & Development (2024)

Adrienne D. CoxChanning J. Der

Abstract 1075: Identification of Resistance Mechanisms to Direct Kras Inhibition in Pancreatic Cancer. Cancer Research (2023)

Andrew Michael WatersWen-Hsuan ChangClint StalneckerCole EdwardsRunying YangCraig M. GoodwinAdrienne D. CoxChanning J. Der

Abstract B009: Tead Inhibition Overcomes Yap1/Taz-Driven Resistance to Ras Inhibitors in Krasg12C-Mutant Cancers. Molecular Cancer Research (2023)

Alexander C. EdwardsClint A. StalneckerAlexis J. MoralesKhalilah E. TaylorJill HallinPeter OlsonTracy T. TangLars EngstromLeonard PostJames G. ChristensenAdrienne D. CoxChanning J. Der

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