Faculty

Institution

Unit

Venue

Roger Sunahara

Professor of Pharmacology

University of California, San Diego

Affiliations

School Of Medicine

Pharmacology

Roger Sunahara is currently serving as a Pharmacology Professor of Pharmacology at University of California, San Diego.

Honors

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Experiences

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Education

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Roger Sunahara

University of California, San Diego

Professor of Pharmacology

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pharmacology molecular biology biochemistry protein science neuroscience structural biology receptors enzymes signal transduction g protein-coupled receptor protein structure cell signaling neuropharmacology medicinal research structural molecular biology biological chemistry molecular pharmacology enzyme inhibition addiction biology substance use cocaine esterase bacterial cocaine esterase vascular biology addiction medicine receptor (biochemistry) substance addiction biomolecular structure molecular physiology redox biology addiction treatment molecular cell biology biomolecular interactions signaling pathways key site drug treatment protein assembly lipid science biological macromolecules molecular structure pharmacotherapy experimental pharmacology capillary electrophoresis lipid chemistry protein modeling alcohol dependence crystal structures protein biosynthesis enzyme specificity molecular complexes protein chemistry conformational studies rational drug design opioid overdose in vivo systems adenylyl cyclase mammalian adenylyl cyclase rhesus monkeys biocatalysis enzyme catalysis molecular substrates rna biology glycosylation cellular enzymology enzymatic modification lipid synthesis conformational changes ligand efficacy model lipid bilayer ligand-regulated oligomerization conformational landscape zinc inhibition adenylyl cyclase activity nanobody-stabilized active state u-opioid receptor bound morphinan antagonist mammalian adenylyl cyclases pharmacological research protein design protein engineering neuropsychopharmacology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structure and Dynamics Determine G Protein Coupling Specificity at a Class a Gpcr. Science Advances (2025)

Marina CasiraghiHaoqing WangPatrick C. BrennanChris HabrianHarald HübnerMaximilian F. SchmidtLuis MaulBiswaranjan PaniSherif M. F. M. BahrizBing XuNico StaffenTufa E. AssafaBohan ChenElizabeth WhiteRoger K. SunaharaAsuka InoueYang K. XiangRobert J. LefkowitzEhud Y. IsacoffNathaniel NucciPeter GmeinerMichael T. LerchBrian K. Kobilka

biomolecular structurebiophysicsstructural biologycomputational biologyprotein foldingprotein structureprotein assemblybiochemistrymolecular biologystructural molecular biologyg protein-coupled receptorprotein modelingprotein structure predictionprotein bioinformaticsprotein sciencemolecular biophysics

Author Correction: Constrained Catecholamines Gain β2Ar Selectivity Through Allosteric Effects on Pocket Dynamics. Nature Communications (2023)

Xinyu XuJeremy ShonbergJonas KaindlMary J. ClarkAnne StößelLuis MaulDaniel MayerHarald HübnerKunio HirataA. J. VenkatakrishnanRon O. DrorBrian K. KobilkaRoger K. SunaharaXiangyu LiuPeter Gmeiner

materials sciencepharmacologyallosteric effectsdrug discoverybiophysicspocket dynamicsprotein scienceauthor correction

Mapping the Conformational Landscape of the Stimulatory Heterotrimeric G Protein. Nature Structural & Molecular Biology (2023)

Shuya Kate HuangLouis-Philippe PicardRima S. M. RahmatullahAditya PandeyNed Van EpsRoger K. SunaharaOliver P. ErnstAdnan SljokaR. Scott Prosser

computational biologybiochemistryprotein sciencebiomolecular structuremolecular structureconformational landscapemolecular biophysicsstructural biologyprotein structurekey sitestructural molecular biologyg protein-coupled receptorprotein modelingconformational studiesbiophysicsprotein foldingmolecular biologybiological macromoleculesstructural bioinformatics

Non-Canonical β-Adrenergic Activation of Erk at Endosomes. Nature (2022)

Yonghoon KwonSohum MehtaMary ClarkGeneva WaltersYanghao ZhongHa Neul LeeRoger K. SunaharaJin Zhang

pharmacologygene expressionendocrinologyneurosciencecell biologynon-canonical b-adrenergic activation

A Photoswitchable Gpcr-Based Opsin for Presynaptic Inhibition. Neuron (2021)

Bryan A. CopitsRaaj GowrishankarPatrick R. O’NeillJun-Nan LiKasey S. GirvenJudy J. YooXenia MeshikKyle E. ParkerSkylar M. SpanglerAbigail J. ElerdingBobbie J. BrownSofia E. ShirleyKelly K.L. MaAlexis M. VasquezM. Christine StanderVani KalyanaramanSherri K. VogtVijay K. SamineniTommaso PatriarchiLin TianN. GautamRoger K. SunaharaRobert W. GereauMichael R. Bruchas

neurologyreceptorsneuroscienceneuronspresynaptic inhibitionmolecular biologyphotoswitchable gpcr-based opsinmedicinal researchneurophysiologyprotein science

Decision Letter: Common Coupling Map Advances Gpcr-G Protein Selectivity. (2021)

Roger Sunahara

bioinformaticsstructural biologycomputational biologyproteomicsproteome researchprotein structuremolecular informaticsbiochemistryclinical proteomicsmolecular biologybiomolecular engineeringstructural molecular biologyg protein-coupled receptorprotein bioinformaticsprotein modelingfunctional selectivityprotein assemblyprotein science

Decision Letter: Effector Membrane Translocation Biosensors Reveal G Protein and βArrestin Coupling Profiles of 100 Therapeutically Relevant Gpcrs. (2021)

Roger Sunahara

relevant gpcrsg protein-coupled receptorbiomedical engineeringbiosensors

Delineating the Conformational Landscape of the Adenosine A2A Receptor During G Protein Coupling. Cell (2021)

Shuya Kate HuangAditya PandeyDuy Phuoc TranNicolas L. VillanuevaAkio KitaoRoger K. SunaharaAdnan SljokaR. Scott Prosser

biochemistryprotein sciencebiomolecular structuremolecular structureconformational landscapereceptorsstructural biologyprotein structurekey sitestructural molecular biologyg protein-coupled receptorconformational studiesbiophysicssignal transductionreceptor (biochemistry)proteinlipid interactionprotein foldingmolecular biologybiological macromolecules

Integrative Rna-Omics Discovers Gnas Alternative Splicing as a Phenotypic Driver of Splicing Factor–Mutant Neoplasms. Cancer Discovery (2021)

Emily C. WheelerShailee VoraDaniel MayerAndriana G. KotiniMalgorzata OlszewskaSamuel S. ParkErnesto GuccioneJulie Teruya-FeldsteinLewis SilvermanRoger K. SunaharaGene W. YeoEirini P. Papapetrou

phenotypic driverrna biologygeneticscancer biologymolecular cancergenomicscancer researchcancer genomicsgenome biologygenome analysisgene expressiononcologycancer geneticscancer caredrug discoveryfactor-mutant neoplasmsknowledge discoverycancer discoverymolecular biologysystems biology

Leveraging Nonstructural Data to Predict Structures and Affinities of Protein–Ligand Complexes. Proceedings of the National Academy of Sciences (2021)

Joseph M. PaggiJulia A. BelkScott A. HollingsworthNicolas VillanuevaAlexander S. PowersMary J. ClarkAugustine G. ChemparathyJonathan E. TynanThomas K. LauRoger K. SunaharaRon O. Dror

nonstructural databioinformaticsbiophysicsmachine learningprotein structure predictionprotein-ligand complexes

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Roger Sunahara

Professor of Pharmacology

University of California, San Diego

Affiliations

School Of Medicine

Pharmacology

Roger Sunahara is currently serving as a Pharmacology Professor of Pharmacology at University of California, San Diego.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Roger Sunahara

University of California, San Diego

Professor of Pharmacology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structure and Dynamics Determine G Protein Coupling Specificity at a Class a Gpcr. Science Advances (2025)

Author Correction: Constrained Catecholamines Gain β2Ar Selectivity Through Allosteric Effects on Pocket Dynamics. Nature Communications (2023)

Xinyu XuJeremy ShonbergJonas KaindlMary J. ClarkAnne StößelLuis MaulDaniel MayerHarald HübnerKunio HirataA. J. VenkatakrishnanRon O. DrorBrian K. KobilkaRoger K. SunaharaXiangyu LiuPeter Gmeiner

materials sciencepharmacologyallosteric effectsdrug discoverybiophysicspocket dynamicsprotein scienceauthor correction

Mapping the Conformational Landscape of the Stimulatory Heterotrimeric G Protein. Nature Structural & Molecular Biology (2023)

Shuya Kate HuangLouis-Philippe PicardRima S. M. RahmatullahAditya PandeyNed Van EpsRoger K. SunaharaOliver P. ErnstAdnan SljokaR. Scott Prosser

Non-Canonical β-Adrenergic Activation of Erk at Endosomes. Nature (2022)

Yonghoon KwonSohum MehtaMary ClarkGeneva WaltersYanghao ZhongHa Neul LeeRoger K. SunaharaJin Zhang

pharmacologygene expressionendocrinologyneurosciencecell biologynon-canonical b-adrenergic activation

A Photoswitchable Gpcr-Based Opsin for Presynaptic Inhibition. Neuron (2021)

neurologyreceptorsneuroscienceneuronspresynaptic inhibitionmolecular biologyphotoswitchable gpcr-based opsinmedicinal researchneurophysiologyprotein science

Decision Letter: Common Coupling Map Advances Gpcr-G Protein Selectivity. (2021)

Roger Sunahara

Decision Letter: Effector Membrane Translocation Biosensors Reveal G Protein and βArrestin Coupling Profiles of 100 Therapeutically Relevant Gpcrs. (2021)

Roger Sunahara

relevant gpcrsg protein-coupled receptorbiomedical engineeringbiosensors

Delineating the Conformational Landscape of the Adenosine A2A Receptor During G Protein Coupling. Cell (2021)

Shuya Kate HuangAditya PandeyDuy Phuoc TranNicolas L. VillanuevaAkio KitaoRoger K. SunaharaAdnan SljokaR. Scott Prosser

Integrative Rna-Omics Discovers Gnas Alternative Splicing as a Phenotypic Driver of Splicing Factor–Mutant Neoplasms. Cancer Discovery (2021)

Emily C. WheelerShailee VoraDaniel MayerAndriana G. KotiniMalgorzata OlszewskaSamuel S. ParkErnesto GuccioneJulie Teruya-FeldsteinLewis SilvermanRoger K. SunaharaGene W. YeoEirini P. Papapetrou

Leveraging Nonstructural Data to Predict Structures and Affinities of Protein–Ligand Complexes. Proceedings of the National Academy of Sciences (2021)

Joseph M. PaggiJulia A. BelkScott A. HollingsworthNicolas VillanuevaAlexander S. PowersMary J. ClarkAugustine G. ChemparathyJonathan E. TynanThomas K. LauRoger K. SunaharaRon O. Dror

nonstructural databioinformaticsbiophysicsmachine learningprotein structure predictionprotein-ligand complexes

1
2
3
4
5
13
10 / page

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