Faculty

Institution

Unit

Venue

M. Record

Emeritus Professor Professor

University of Wisconsin–Madison

Affiliations

College of Letters & Science

Chemistry

M. Record is currently serving as a Chemistry Emeritus Professor Professor at University of Wisconsin–Madison.

Honors

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Experiences

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Education

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M. Record

University of Wisconsin–Madison

Emeritus Professor Professor

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molecular biology biophysics biochemistry structural biology protein science genetics enzymes molecular biophysics rna biology gene expression membrane biology transcription regulation genome biology protein structure biophysical chemistry structural molecular biology thermodynamics molecular microbiology biochemical sciences gene regulation escherichia coli nucleic acids biomolecular interactions protein expression molecular science experimental biophysics molecular physiology bacteriology transcription initiation biological chemistry osmotic stress glycine betaine biopolymers protein chemistry molecular regulation molecular biotechnology enzyme catalysis enzyme inhibition biomolecular structure dna analysis microbial physiology molecular research preferential interaction coefficients preferential interactions rna polymerase protein-dna interactions open complex formation redox biology clinical microbiology protein transport enzyme specificity thermodynamic analysis ion effects helical dna salt dependence solute effects applied microbiology quantum chemistry biochemical interaction single molecule biophysics proteinlipid interaction molecular kinetics osmoregulation bacteriophages cell regulation biophysical modeling lac repressor protein surface protein processes molecular diagnostics surface chemistry protein synthesis chemical thermodynamics protein modeling oligonucleotides benchmark studies quantitative biology transcription (biology) protein interactions

Notable Scholarly Works

Notable Federal Grants

Collaborators

Conformational Changes in the Steps of Initial Transcription. Biophysical Journal (2024)

Max RectorRenxi LiM. Thomas Record

biophysicstranscription regulationgene expressioninitial transcriptionmolecular biologyconformational changesbiochemistry

Clamp Interactions With +3/+6 Duplex and Upstream-To-Downstream Allosteric Effects in Late Steps of Forming a Stable Rna Polymerase-Promoter Open Complex. Journal of Molecular Biology (2023)

Hao-Che WangKrysta StroncekM. Thomas Record

geneticsbiomolecular engineeringenzymesmolecular biotechnologymolecular biologyupstream-to-downstream allosteric effectsrna biologyprotein sciencemembrane biologyclamp interactions

High-Throughput, Fluorescent-Aptamer-Based Measurements of Steady-State Transcription Rates for the Mycobacterium Tuberculosis Rna Polymerase. Nucleic Acids Research (2023)

Drake JensenAna Ruiz ManzanoMaxwell RectorEric J TomkoM Thomas RecordEric A Galburt

tuberculosisgenome biologyproteomicsfluorescent-aptamer-based measurementsmolecular scienceenzymesmolecular diagnosticsnucleic acidsbioinformaticshigh throughput sequencingnucleic acid amplificationdna sequencingsteady-state transcription ratesgenomicsgeneticsgene expression profilingmolecular biologyrna biologymicrobiology

Quantifying Amide–Aromatic Interactions at Molecular and Atomic Levels: Experimentally Determined Enthalpic and Entropic Contributions to Interactions of Amide Sp 2 O, N, C and Sp 3 C Unified Atoms With Naphthalene Sp 2 C Atoms in Water. Biochemistry (2023)

Emily ZytkiewiczIrina A. ShkelXian ChengAnuchit RupanyaKate McClureRezwana KarimSumin YangFelix YangM. Thomas Record

physicsatomic levelsatomic physicsamide-aromatic interactionsquantum chemistrycoordination chemistryunified atoms

Thermodynamics of E. Coli Ssb Phase Separation. Effects of Monovalent Salt Concentration and Type and Intrinsically Disordered Linker Modifications. Biophysical Journal (2023)

Alexander G. KozlovIrina A. ShkelM. Thomas RecordTimothy M. Lohman

monovalent salt concentrationmolecular biophysicsbiophysicsprotein structurestructural biologyphase separationprotein sciencedisordered linker modificationsmicrobiologycell biology

How Glutamate Promotes Liquid-Liquid Phase Separation and Dna Binding Cooperativity of E. Coli Ssb Protein. Journal of Molecular Biology (2022)

Alexander G. KozlovXian ChengHongshan ZhangMin Kyung ShinnElizabeth WeilandBinh NguyenIrina A. ShkelEmily ZytkiewiczIlya J. FinkelsteinM. Thomas RecordTimothy M. Lohman

liquid-liquid phase separationmolecular researchprotein structuregenome biologybiomolecular interactionsproteinlipid interactionmolecular scienceprotein transportstructural biologyprotein sciencemembrane biologymolecular biophysicsmolecular and cellular biologymolecular physiologybiophysicsprotein geneticsgeneticsmolecular biologystructural molecular biology

Roles of Clamp Closing and Allosteric Effects of Discriminator and Upstream Interactions on Downstream Elements in Stabilizing an E. Coli Rna Polymerase-Promoter Open Complex. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Hao-Che WangKrysta StronekM. Thomas Record

applied microbiologyclinical microbiologymolecular regulationenzyme catalysisgenome biologybiomolecular interactionsmolecular microbiologyenzymesclamp closingbiochemical sciencesprotein sciencemicrobial pathogenesismolecular and cellular biologyupstream interactionsdownstream elementsgenome editingsystems biologymolecular biologyallosteric effectsmicrobiology

Step-By-Step Regulation of Productive and Abortive Transcription Initiation by Pyrophosphorolysis. Journal of Molecular Biology (2022)

Dylan PlaskonClaire EvensenKate HendersonBenjamin PalatnikTakahiro IshikuriHao-Che WangSarah DoughtyM. Thomas Record Jr.

gene regulationtranscription regulationabortive transcription initiationgeneticsmolecular regulationstep-by-step regulationmolecular biologyepigeneticsbiochemistry

Kinetics and Mechanism of E. Coli Transcription Initiation. Biophysical Journal (2021)

Dylan PlaskonKate HendersonLindsey FelthClaire EvensenSarah DykeCristen MolzahnTristan GuntherGuanyu LiaoIrina A. ShkelM. Thomas Record

molecular biophysicsbiophysicsgene expressiontranscription regulationmicrobial physiologygenomic mechanismstranscription (biology)geneticsenzymesmolecular biologyprotein expressionprotein sciencemolecular physiologygene regulation

Temperature Effects on Rna Polymerase Initiation Kinetics Reveal Which Open Complex Initiates and That Bubble Collapse is Stepwise. Proceedings of the National Academy of Sciences (2021)

Dylan M. PlaskonKate L. HendersonLindsey C. FelthCristen M. MolzahnClaire EvensenSarah DykeIrina A. ShkelM. Thomas Record

biophysicsbubble collapserna biologymolecular biologystructural biologytemperature effectsbiochemistry

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M. Record

Emeritus Professor Professor

University of Wisconsin–Madison

Affiliations

College of Letters & Science

Chemistry

M. Record is currently serving as a Chemistry Emeritus Professor Professor at University of Wisconsin–Madison.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

M. Record

University of Wisconsin–Madison

Emeritus Professor Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Conformational Changes in the Steps of Initial Transcription. Biophysical Journal (2024)

Max RectorRenxi LiM. Thomas Record

biophysicstranscription regulationgene expressioninitial transcriptionmolecular biologyconformational changesbiochemistry

Clamp Interactions With +3/+6 Duplex and Upstream-To-Downstream Allosteric Effects in Late Steps of Forming a Stable Rna Polymerase-Promoter Open Complex. Journal of Molecular Biology (2023)

Hao-Che WangKrysta StroncekM. Thomas Record

geneticsbiomolecular engineeringenzymesmolecular biotechnologymolecular biologyupstream-to-downstream allosteric effectsrna biologyprotein sciencemembrane biologyclamp interactions

High-Throughput, Fluorescent-Aptamer-Based Measurements of Steady-State Transcription Rates for the Mycobacterium Tuberculosis Rna Polymerase. Nucleic Acids Research (2023)

Drake JensenAna Ruiz ManzanoMaxwell RectorEric J TomkoM Thomas RecordEric A Galburt

Emily ZytkiewiczIrina A. ShkelXian ChengAnuchit RupanyaKate McClureRezwana KarimSumin YangFelix YangM. Thomas Record

physicsatomic levelsatomic physicsamide-aromatic interactionsquantum chemistrycoordination chemistryunified atoms

Thermodynamics of E. Coli Ssb Phase Separation. Effects of Monovalent Salt Concentration and Type and Intrinsically Disordered Linker Modifications. Biophysical Journal (2023)

Alexander G. KozlovIrina A. ShkelM. Thomas RecordTimothy M. Lohman

monovalent salt concentrationmolecular biophysicsbiophysicsprotein structurestructural biologyphase separationprotein sciencedisordered linker modificationsmicrobiologycell biology

How Glutamate Promotes Liquid-Liquid Phase Separation and Dna Binding Cooperativity of E. Coli Ssb Protein. Journal of Molecular Biology (2022)

Alexander G. KozlovXian ChengHongshan ZhangMin Kyung ShinnElizabeth WeilandBinh NguyenIrina A. ShkelEmily ZytkiewiczIlya J. FinkelsteinM. Thomas RecordTimothy M. Lohman

Hao-Che WangKrysta StronekM. Thomas Record

Step-By-Step Regulation of Productive and Abortive Transcription Initiation by Pyrophosphorolysis. Journal of Molecular Biology (2022)

Dylan PlaskonClaire EvensenKate HendersonBenjamin PalatnikTakahiro IshikuriHao-Che WangSarah DoughtyM. Thomas Record Jr.

gene regulationtranscription regulationabortive transcription initiationgeneticsmolecular regulationstep-by-step regulationmolecular biologyepigeneticsbiochemistry

Kinetics and Mechanism of E. Coli Transcription Initiation. Biophysical Journal (2021)

Dylan PlaskonKate HendersonLindsey FelthClaire EvensenSarah DykeCristen MolzahnTristan GuntherGuanyu LiaoIrina A. ShkelM. Thomas Record

Temperature Effects on Rna Polymerase Initiation Kinetics Reveal Which Open Complex Initiates and That Bubble Collapse is Stepwise. Proceedings of the National Academy of Sciences (2021)

Dylan M. PlaskonKate L. HendersonLindsey C. FelthCristen M. MolzahnClaire EvensenSarah DykeIrina A. ShkelM. Thomas Record

biophysicsbubble collapserna biologymolecular biologystructural biologytemperature effectsbiochemistry

1
2
3
4
5
23
10 / page

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molecular biology

structural biology

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proteomics

Tania A. Baker

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biotechnology advance

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cellular enzymology

Elizabeth Komives

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